14

Mining Archaeal Proteomes for Eukaryotic Proteins with Novel Functions

 

 

PACE 14

Orthologs in Archaea

Gene

Blast Expect

Paralogs

Pyrococcus abyssi

PAB1215

0.0

 

Pyrococcus furiosus

Pf_1751970

0.0

 

Pyrococcus horikoshii

PH1867

0.0

 

Aeropyrum pernix

 

 

 

Archaeoglobus fulgidus

AF2402

1e-130

 

Methanobacterium thermoautotrophicum

MTH817

1e-158

 

Methanococcus jannaschii

MJ1136

1e-145

 

Homologs in Eucarya

Human

BAA91600.1

Yeast

SPAC29A4.20 S. pombe ,CG15433 D. melanogaster , YPL086c  S.cerevisiae

Other

CAB58418.1 L. major

 

Size of P. abyssi protein

589aa

Best Hits outside Archaea

Gene

Blast Expect

 

Best Eucaryotic Hit

ZK863.3

1e-115

C. elegans

Best Bacterial Hit

TM1103

7e-19

 T. maritima

 

Module (Pfam, Prosite, Prints)

Acetyltransferase

PRODOM domain

 

PDB hit

 

COG group

COG1243 : ELP3 Histone acetyltransferase

KOG group KOG2535 (Hs21361689, HsM8922418) = RNA polymerase II elongation complex, subunit ELP3/histone acetyltransferase. Mutations in components of human Elongator complex may be linked to familial dysautonomia

Gene Environment in Archaea

Not conserved:
fonctional (enzymes)

See Environment

Phylogeny

 See Unrooted Distance Tree

 

Function Prediction

 Uncharacterized

Red= new annotations