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Mining Archaeal Proteomes for Eukaryotic Proteins with Novel Functions

Orthologs in Archaea	Gene	Blast Expect	Paralogs
Pyrococcus abyssi	PAB1215	0.0
Pyrococcus furiosus	Pf_1751970	0.0
Pyrococcus horikoshii	PH1867	0.0
Aeropyrum pernix
Archaeoglobus fulgidus	AF2402	1e-130
Methanobacterium thermoautotrophicum	MTH817	1e-158
Methanococcus jannaschii	MJ1136	1e-145
Homologs in Eucarya
Human	BAA91600.1
Yeast	SPAC29A4.20 S. pombe ,CG15433 D. melanogaster , YPL086c S.cerevisiae
Other	CAB58418.1 L. major

Size of P. abyssi protein	589aa
Best Hits outside Archaea	Gene	Blast Expect
Best Eucaryotic Hit	ZK863.3	1e-115	C. elegans
Best Bacterial Hit	TM1103	7e-19	T. maritima

Module (Pfam, Prosite, Prints)	Acetyltransferase
PRODOM domain
PDB hit
COG group	COG1243 : ELP3 Histone acetyltransferase
KOG group	KOG2535 (Hs21361689, HsM8922418) = RNA polymerase II elongation complex, subunit ELP3/histone acetyltransferase. Mutations in components of human Elongator complex may be linked to familial dysautonomia
Gene Environment in Archaea	Not conserved: fonctional (enzymes)	See Environment
Phylogeny	See Unrooted Distance Tree

Function Prediction	Uncharacterized

Red= new annotations