15

Mining Archaeal Proteomes for Eukaryotic Proteins with Novel Functions

 

 

PACE 15

Orthologs in Archaea

Gene

Blast Expect

Paralogs

Pyrococcus abyssi

PAB1287

5e-99

 

Pyrococcus furiosus

Pf_403030

6e-66 

 

Pyrococcus horikoshii

PH0347

1e-65

 

Aeropyrum pernix

APE2359

6e-12

 

Archaeoglobus fulgidus

AF1432

4e-09

AF1224

Methanobacterium thermoautotrophicum

 

 

 

Methanococcus jannaschii

 

 

 

Homologs in Eucarya

Human

CGI-130 protein

Yeast

YGL101w YBR242w S. cerevisiae , T41359 S. pombe

Other

AAC63656.1 A. thaliana, AAF52408.1 D. melanogaster, F45F2.9 C elegans

 

Size of P. abyssi protein

179aa 

Best Hits outside Archaea

Gene

Blast Expect

 

Best Eucaryotic Hit

AAC63656.1

6e-17

 A. thaliana

Best Bacterial Hit

BAA87710.1

3e-07

 A. tumefaciens

 

Module (Pfam, Posite, Prints)

PF01966 : HD domain

PRODOM domain

transmembrane/uridylyltransferase

PDB hit

 

COG group

COG1896 : Predicted hydrolases of HD superfamily

KOG group KOG3197 (Hs7705624) = Predicted hydrolases of HD superfamily

Gene Environment in Archaea

Not conserved:
fonctional (enzymes)

See Environment

Phylogeny

 See Unrooted Distance Tree

 

Function Prediction

 Uncharacterized