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Mining Archaeal Proteomes for Eukaryotic Proteins with Novel Functions

Orthologs in Archaea	Gene	Blast Expect	Paralogs
Pyrococcus abyssi	PAB1561	0.0	PAB0067
Pyrococcus furiosus	Pf_594519	0.0	Pf_89099
Pyrococcus horikoshii	PH0909	0.0	PH0109
Aeropyrum pernix
Archaeoglobus fulgidus	AF1388	0.0	AF1960
Methanobacterium thermoautotrophicum	MTH1634	0.0	MTH487
Methanococcus jannaschii	MJ0104	1e-150
Homologs in Eucarya
Human	NP_002171.1, A47500, AAA70430.1
Yeast	T41580 S. pombe, YKL017c Nam7p SEN1 Yer176wp NP_012034.1 S. cerevisiae
Other	T18E12.6 A. thaliana , Q60560 M. auratus, NP_033238.1 M. musculus

Size of P. abyssi protein	653aa
Best Hits outside Archaea	Gene	Blast Expect
Best Eucaryotic Hit	T18E12.6	3e-92	A. thaliana
Best Bacterial Hit	TM0005	0.0	T. maritima

Module (Pfam, Prosite, Prints)	DEAD-like helicase superfamily - PF01443 : viral (superfamily 1) RNA helicase - PS00017 : ATP/GTP-binding
PRODOM domain	signalling/RNA metabolism/RNA helicase
PDB hit	helicase product complex
COG group	COG1112 : superfamily I DNA helicases and helicase subunits
KOG group	KOG1083 (Hs4504623) = Dna helicase. Human homologue is immunoglobin-binding protein 2, mutated in spinal muscular atrophy with muscular distress type 1 (SMARD1). It co-localizes with the RNA-processing machinery.
Gene Environment in Archaea	Not conserved	See Environment
Phylogeny	See Unrooted Distance Tree

Function Prediction	Informational : replication / repair

Red= new annotations