17

Mining Archaeal Proteomes for Eukaryotic Proteins with Novel Functions

PACE 17

---

Orthologs in Archaea	Gene	Blast Expect	Paralogs
Pyrococcus abyssi	PAB1684	1e-106
Pyrococcus furiosus	Pf_1015156	7e-87
Pyrococcus horikoshii	PH1223	1e-98
Aeropyrum pernix	APE1949	4e-15
Archaeoglobus fulgidus	AF0783	9e-30
Methanobacterium thermoautotrophicum	MTH1834	7e-39
Methanococcus jannaschii	MJ0530	2e-45
Homologs in Eucarya
Human	NP_003895.1 zinc finger protein 259
Yeast	ZPR1_SCHPO AAC33515.1 S. pombe, Zpr1p S. cerevisiae
Other	NP_035882.1 M. musculus, W03F9.1 C. elegans , AAF46456.1 D. melanogaster
Size of P. abyssi protein	211 aa.
Best Hits outside Archaea	Gene	Blast Expect
Best Eucaryotic Hit	NP_035882.1	1e-10	M. musculus
Best Bacterial Hit	TP0567	0.66	T. pallidum
Module (Pfam, Prosite, Prints)
PRODOM module	ZPR1 : signaling molecule/binds to the EF-1 alpha
PDB hit
COG group	COG1779: (C4-type Zn finger family)
KOG group	KOG2703 (Hs4508021, Hs20551575) = C4-type ZN-finger protein. Human homologue is ZPR1, a protein with possible nucleolar function associated with EF1alpha and possibly involved in pre-rRNA expression.
Gene Environment in Archaea	Not conserved		See Environment
Phylogeny	See Unrooted Distance Tree
Function Prediction	uncharacterized