18

Mining Archaeal Proteomes for Eukaryotic Proteins with Novel Functions

PACE 18

---

Orthologs in Archaea	Gene	Blast Expect	Paralogs
Pyrococcus abyssi	PAB1283	1e-35	PAB1719 PAB0923
Pyrococcus furiosus	Pf_407242	1e-35
Pyrococcus horikoshii	PH0338	1e-35	PH0997 PH0644
Aeropyrum pernix	APE1385	1e-27	APE0557
Archaeoglobus fulgidus	AF1257	8e-09
Methanobacterium thermoautotrophicum	MTH724	0.0
Methanococcus jannaschii	MJ0710	5e-50	MJ0438
Homologs in Eucarya
Human
Yeast	YOL124c S. cerevisiae
Other	CG1074 D. melanogaster
Size of P. abyssi protein	332 aa.
Best Hits outside Archaea	Gene	Blast Expect
Best Eucaryotic Hit	CG1074	2e-13	D. melanogaster
Best Bacterial Hit	DR1669	3e-09	D. radiodurans
Module (Pfam, Prosite, Prints)	PS50193; SAM (and some other nucleotide) binding motif
PRODOM module	Methyltransferase/ transferase/ modification methylase restiction system DNA
PDB hit	Adenine-n6-methyltransferase
COG group	COG1041: Predicted DNA modification methylase
KOG group	KOG2671 (Hs11141893) = Putative RNA methylase
Gene Environment in Archaea	Not conserved: fonctional (enzymes)		See Environment
Phylogeny	See Unrooted Distance Tree
Function Prediction	informational / methylase