20

Mining Archaeal Proteomes for Eukaryotic Proteins with Novel Functions

PACE 20

---

Orthologs in Archaea	Gene	Blast Expect	Paralogs
Pyrococcus abyssi	PAB2013	0.0	PAB0967
Pyrococcus furiosus	Pf_1658725	0.0	Pf_327695
Pyrococcus horikoshii	PH1645	0.0	PH0589
Aeropyrum pernix
Archaeoglobus fulgidus
Methanobacterium thermoautotrophicum
Methanococcus jannaschii	MJ1604	1e-112
Homologs in Eucarya
Human
Yeast
Other	C50D2.7 C. elegans
Size of P. abyssi protein	451 aa.
Best Hits outside Archaea	Gene	Blast Expect
Best Eucaryotic Hit	C50D2.7	5e-04	C. elegans
Best Bacterial Hit	AAF27700.1	6.5	S. pneumoniae
Module (Pfam, Prosite, Prints)
PRODOM module	Acyl transf domain : FAS proteins (Fatty Acid Synthetase)
PDB hit
COG group	COG4809 = Archaeal ADP-dependent phosphofructokinase/glucokinase (ADP-specific and involved in a pathway deviant from the classical Embden-Meyerhoff pathway)
KOG group	KOG4184 (Hs21361961, HsM13775184) = Predicted sugar kinase. Present only in Metazoans
Gene Environment in Archaea	Not conserved: fonctional (enzymes)		See Environment
Phylogeny	See Unrooted Distance Tree
Function Prediction	operational

Red= new annotations