21

Mining Archaeal Proteomes for Eukaryotic Proteins with Novel Functions

PACE 21

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Orthologs in Archaea	Gene	Blast Expect	Paralogs
Pyrococcus abyssi	PAB2029	0.0	PAB1092
Pyrococcus furiosus	Pf_1634600	0.0	Pf_283979
Pyrococcus horikoshii	PH1680	0.0	PH0300
Aeropyrum pernix	APE0537	1e-49
Archaeoglobus fulgidus	AF1595	1e-73
Methanobacterium thermoautotrophicum	MTH1186	2e-65	MTH1742
Methanococcus jannaschii	MJ1157	3e-57
Homologs in Eucarya
Human
Yeast	SPBC2G5.03 S. pombe, P53088 S. cerevisiae
Other	F4I1.8  A. thaliana, AAF58991.1 D. melanogaster, F29C4.6 C. elegans, VEG136 D. discoideum
Size of P. abyssi protein	323 aa.
Best Hits outside Archaea	Gene	Blast Expect
Best Eucaryotic Hit	F4I1.8	2e-46	A. thaliana
Best Bacterial Hit	TM0197	1e-49	T. maritima
Module (Pfam, Prosite, Prints)	PF01171: Uncharacterized protein family UPF0012
PRODOM module
PDB hit	GMP-synthetase (XMP-aminase)
COG group	COG0037: MesJ Predicted ATPase of the PP-loop superfamily implicated in cell cycle control
KOG group	KOG2840 (Hs21687159) = Uncharacterized conserved protein with similarity to predicted ATPase of the PP-loop superfamily
Gene Environment in Archaea	Not conserved		See Environment
Phylogeny	See Unrooted Distance Tree
Function Prediction	uncharacterized