22

Mining Archaeal Proteomes for Eukaryotic Proteins with Novel Functions

 

 

PACE 22

Orthologs in Archaea

Gene

Blast Expect

Paralogs

Pyrococcus abyssi

PAB2039

0.0

 

Pyrococcus furiosus

Pf_1597511

0.0

 

Pyrococcus horikoshii

PH1705

0.0

 

Aeropyrum pernix

MTH1039

4e-74

 

Archaeoglobus fulgidus

AF2261

4e-86

 

Methanobacterium thermoautotrophicum

MTH1039

2e-79

 

Methanococcus jannaschii

MJ0257

5e-68

 

Homologs in Eucarya

Human

BAA91891.1

Yeast

SPCC1020.08 S. pombe, YPL207w S. cerevisiae

Other

 

 

Size of P. abyssi protein

342 aa.

Best Hits outside Archaea

Gene

Blast Expect

 

Best Eucaryotic Hit

SPCC1020.08

3e-57

S. pombe

Best Bacterial Hit

aq_2060

9e-08

A. aeolicus

 

Module (Pfam, Prosite, Prints)

 PS50079: Bipartite nucleart localizing signal

PRODOM module

 

PDB hit

 

COG group

COG0731: Fe-S oxidoreductases

KOG group KOG1160 (Hs8922752, Hs22046590) = Fe-S oxidoreductase. Associated to a N-terminal flavodoxin

Gene Environment in Archaea

Not conserved:
informational : aIF-2/DNA repair REC

See Environment

Phylogeny

 See Unrooted Distance Tree

 

Function Prediction

 informational

Red= new annotations