24

Mining Archaeal Proteomes for Eukaryotic Proteins with Novel Functions

PACE 24

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Orthologs in Archaea	Gene	Blast Expect	Paralogs
Pyrococcus abyssi	PAB2159	1e-112	PAB0615
Pyrococcus furiosus	Pf_1877089	3e-90	Pf_1045164
Pyrococcus horikoshii	PH1887	4e-91	PH1069
Aeropyrum pernix	APE0816	6e-12
Archaeoglobus fulgidus	AF2059	4e-25
Methanobacterium thermoautotrophicum
Methanococcus jannaschii	MJ1510	7e-32
Homologs in Eucarya
Human
Yeast	CAB61781.1 S. pombe
Other	AAD48952.1 A. thaliana
Size of P. abyssi protein	206 aa.
Best Hits outside Archaea	Gene	Blast Expect
Best Eucaryotic Hit	AAD48952.1	2e-14	A. thaliana
Best Bacterial Hit	Cj1140	1.1	C. jejeuni
Module (Pfam, Prosite, Prints)
PRODOM module	Phenylalanine ammonia-lyase
PDB hit
COG group	COG1590 : Uncharacterized conserved protein
KOG group	KOG1228 (Hs17440764) = Uncharacterized conserved protein
Gene Environment in Archaea	CONSERVED: helicases		See Environment
Phylogeny	See Unrooted Distance Tree
Function Prediction	informational