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Mining Archaeal Proteomes for Eukaryotic Proteins with Novel Functions

Orthologs in Archaea	Gene	Blast Expect	Paralogs
Pyrococcus abyssi	PAB2272	0.0	PAB0505, PAB1538
Pyrococcus furiosus	Pf_96568	1e-144	Pf_1330590
Pyrococcus horikoshii	PH0115	1e-133	PH1416, PH0793
Aeropyrum pernix	APE1106	3e-26	APE0815
Archaeoglobus fulgidus	AF0704	3e-41	AF1973
Methanobacterium thermoautotrophicum	MTH1873	3e-32	MTH1200
Methanococcus jannaschii	MJ0883	2e-29	MJ1557
Homologs in Eucarya
Human	KIAA1393
Yeast
Other	CAB87411.1 A. thaliana, CG12032 D. melanogaster

Size of P. abyssi protein	333 aa.
Best Hits outside Archaea	Gene	Blast Expect
Best Eucaryotic Hit	CAB87411.1	2e-14	A. thaliana
Best Bacterial Hit	G75565	0.005	D. radiodurans

Module (Pfam, Prosite, Prints)	PS50193: SAM (and some other nucleotide) binding motif
PRODOM module	Methyltransferase/transferase
PDB hit	rRNA methyltransferase
COG group	COG0500 SAM-dependent methyltransferases
KOG group	KOG1227 (Hs8923676) = Putative methyltransferase KOG2078 (Hs14752839) = tRNA modification enzyme. Yeast homologue is Trm5, a G-Met-transferase involved in methionin biosynthesis
Gene Environment in Archaea	HIGHLY CONSERVED: moA//REC/polC/polB	See Environment
Phylogeny	See Unrooted Distance Tree

Function Prediction	informational / methylase

Red= new annotations