26

Mining Archaeal Proteomes for Eukaryotic Proteins with Novel Functions

PACE 26

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Orthologs in Archaea	Gene	Blast Expect	Paralogs
Pyrococcus abyssi	PAB2314	1e-111
Pyrococcus furiosus	Pf_58363	1e-100
Pyrococcus horikoshii	PH0043	1e-103
Aeropyrum pernix	APE0445	8e-20
Archaeoglobus fulgidus	AF0206	8e-33
Methanobacterium thermoautotrophicum	MTH1318	2e-29
Methanococcus jannaschii
Homologs in Eucarya
Human	CGI-108
Yeast	AL023590 S. pombe
Other	CG6249 D. menlanogaster
Size of P. abyssi protein	199 aa.
Best Hits outside Archaea	Gene	Blast Expect
Best Eucaryotic Hit	CG6249	6e-08	D. menlanogaster
Best Bacterial Hit	RP504	0.006	R. prowazekii
Module (Pfam, Prosite, Prints)	PS50126: S1 RNA Binding domain
PRODOM module
PDB hit	PNPase fragment: s1 RNA binding domain
COG group	COG1096: Predicted RNA-binding protein
KOG group	KOG3409 (Hs7705612) = Exosomal 3’-5’ exoribonuclease complex, subunit ski4 (Csl4). The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly (A) shortening. The association of the human protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein42 and ribosomal RNA-processing protein 46
Gene Environment in Archaea	CONSERVED: methylase/ polymerase// RNA helicase/ transcription regulation		See Environment
Phylogeny	See Unrooted Distance Tree
Function Prediction	informational

Red= new annotations