29

Mining Archaeal Proteomes for Eukaryotic Proteins with Novel Functions

PACE 29

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Orthologs in Archaea	Gene	Blast Expect	Paralogs
Pyrococcus abyssi	PAB0620	1e-56
Pyrococcus furiosus	Pf_1036049	1e-52
Pyrococcus horikoshii	PH1060	1e-53
Aeropyrum pernix	_APE10397	1e-25
Archaeoglobus fulgidus	AF2068	5e-20
Methanobacterium thermoautotrophicum	MTH1615	1e-19
Methanococcus jannaschii	MJ0691	3e-22
Homologs in Eucarya
Human	NP_004699 programmed cell death 5
Yeast
Other	TF19_MOUSE M. musculus
Size of P. abyssi protein	115 aa.
Best Hits outside Archaea	Gene	Blast Expect
Best Eucaryotic Hit	NP_004699	7e-12	H. sapiens
Best Bacterial Hit	S30271	0.31	P. aeruginosa
Module (Pfam, Prosite, Prints)	PF01984: Protein of unknown function DUF122
PRODOM module	Process of apoptosis
PDB hit
COG group	COG2118 : DNA-binding protein
KOG group	KOG3431 (Hs4759224) = Apoptosis-related protein/predicted DNA-binding protein. Human homologue is TFAR19/programmed cell death 5. Cloned from a human leukemia cell line, it is upregulated in pancreatic adenocarcinoma
Gene Environment in Archaea	CONSERVED: informational : ribosomal proteins/ EIF-6/ DNA ligase/ RNA polymerase		See Environment
Phylogeny	See Unrooted Distance Tree
Function Prediction	informational / translation