3

Mining Archaeal Proteomes for Eukaryotic Proteins with Novel Functions

PACE 3

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Orthologs in Archaea	Gene	Blast Expect	Paralogs
Pyrococcus abyssi	PAB0401	0.0
Pyrococcus furiosus	Pf_1483021	2e-77
Pyrococcus horikoshii	PH1577	2e-87
Aeropyrum pernix	APE1363	2e-15
Archaeoglobus fulgidus
Methanobacterium thermoautotrophicum
Methanococcus jannaschii
Homologs in Eucarya
Human
Yeast	Yor021cp  S. cerevisiae
Other
Size of P. abyssi protein	205 aa.
Best Hits outside Archaea	Gene	Blast Expect
Best Eucaryotic Hit	Yor021cp	1e-14	S. cerevisiae
Best Bacterial Hit	AAC38080.1	0.49	E. coli
Module (Pfam, Prosite, Prints)
PRODOM domain
PDB hit
COG group	COG2428 Uncharacterized conserved protein
KOG group	No KOG assigned, since present only in Neurospora, Saccharomyces and Plasmodium
Gene Environment in Archaea	Not conserved: informational : translation initiation + DNA topoisomerase		See Environment
Phylogeny	See Unrooted Distance Tree
Function Prediction	Uncharacterized