4

Mining Archaeal Proteomes for Eukaryotic Proteins with Novel Functions

 

 

PACE 4

Orthologs in Archaea

Gene

Blast Expect

Paralogs

Pyrococcus abyssi

PAB0405

1e-142

PAB1013

Pyrococcus furiosus

Pf_1477390

1e-127

Pf_379215

Pyrococcus horikoshii

PH1567

1e-131

PH0512

Aeropyrum pernix

APE0751

9e-37

APE1602  

Archaeoglobus fulgidus

AF1804

5e-42

AF2426

Methanobacterium thermoautotrophicum

MTH1005

2e-41

 

Methanococcus jannaschii

MJ0444

2e-34

MJ1073

Homologs in Eucarya

Human

NP_003822.1

Yeast

YOR119c RIO1 S. cerevisae, SPAC10F6.10 S. pombe

Other

ZK632.3 C. elegans, AAD23014.1 A. thaliana, CG11660 D. melanogaster, AAC26079.1 A. nidulans

 

Size of P. abyssi protein

266 aa.

Best Hits outside Archaea

Gene

Blast Expect

 

Best Eucaryotic Hit

ZK632.3

2e-30

 C. elegans

Best Bacterial Hit

A75301

4e-12

D. radiodurans

 

Module (Pfam, Prosite, Prints)

PF01163 : RIO1 family -
PS01245 : RIO1 -
PS50011 : Eukaryotic protein kinase -
PS00109 : Tyrosine Kinase

PRODOM domain

Extragenic suppressor of the BIMD6

PDB hit

P38 Map Kinase inhibitor complex

COG group

COG1718 : RIO1 Serine/threonine protein kinase involved in cell cycle control

KOG group KOG2270 (Hs13899340) = Serine/threonine protein kinase involved in cell cycle control (exit from mitosis in yeast)

Gene Environment in Archaea

CONSERVED :
informational aIF-1A// PACE 4-PACE 5 // DNA topo

See Environment

Phylogeny

 See Unrooted Distance Tree

 

Function Prediction

 Informational