7

Mining Archaeal Proteomes for Eukaryotic Proteins with Novel Functions

PACE 7

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Orthologs in Archaea	Gene	Blast Expect	Paralogs
Pyrococcus abyssi	PAB0429	4e-65
Pyrococcus furiosus	Pf_1452568	9e-54
Pyrococcus horikoshii	PH1539	9e-54
Aeropyrum pernix	APE1661	3e-25
Archaeoglobus fulgidus	AF2095	1e-32
Methanobacterium thermoautotrophicum	MTH1697	5e-25
Methanococcus jannaschii	MJ0051	2e-25
Homologs in Eucarya
Human	CAB70696.1 , Q9Y3E5
Yeast	YBL057c S. cerevisiae, O13830 S. pombe
Other	AAF54101.1 O97067 D. melanogaster, O76387 C. elegans, AAF26989.1 A. thaliana, CAB62849.1 P. falciparum
Size of P. abyssi protein	121 aa.
Best Hits outside Archaea	Gene	Blast Expect
Best Eucaryotic Hit	CAB70696.1	1e-26	H. sapiens
Best Bacterial Hit	SC1B5.06c	0.13	S. coelicolor
Module (Pfam, Prosite, Prints)	PF01981 : Domain of unknown function DUF119
PRODOM domain
PDB hit
COG group	COG1990 : uncharacterized conserved protein
KOG group	KOG3283 (Hs7706351) : uncharacterized conserved protein
Gene Environment in Archaea	CONSERVED: polymerases		See Environment
Phylogeny	See Unrooted Distance Tree
Function Prediction	Informational : transcription / translation