23

Mining Archaeal Proteomes for Eukaryotic Proteins with Novel Functions

PACE 23

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Orthologs in Archaea	Gene	Blast Expect	Paralogs
Pyrococcus abyssi	PAB2119	1e-149
Pyrococcus furiosus	Pf_1685025	1e-129
Pyrococcus horikoshii	PH1779	1e-141
Aeropyrum pernix	APE0226	5e-29
Archaeoglobus fulgidus	AF1926	4e-44
Methanobacterium thermoautotrophicum	MTH1	3e-48
Methanococcus jannaschii
Homologs in Eucarya
Human	AAF16744.1 DKFZp566D143.1
Yeast
Other	CG12128 D. melanogaster, B0361.6 C. elegans
Size of P. abyssi protein	258 aa.
Best Hits outside Archaea	Gene	Blast Expect
Best Eucaryotic Hit	AAF16744.1	3e-26	H. sapiens
Best Bacterial Hit	-	-	-
Module (Pfam, Prosite, Prints)
PRODOM module	Ribosomal proteins
PDB hit
COG group	COG2106: Uncharacterized conserved protein
KOG group	KOG3925 (Hs7705449) = Uncharacterized conserved protein
Gene Environment in Archaea	HIGHLY CONSERVED: ribosomal proteins		See Environment
Phylogeny	See Unrooted Distance Tree
Function Prediction	informational / translation