27

Mining Archaeal Proteomes for Eukaryotic Proteins with Novel Functions

PACE 27

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Orthologs in Archaea	Gene	Blast Expect	Paralogs
Pyrococcus abyssi	PAB2349	1e-149
Pyrococcus furiosus	Pf_1832970	1e-123
Pyrococcus horikoshii	PH0006	1e-136
Aeropyrum pernix	APE1483	1e-13
Archaeoglobus fulgidus	AF0625	2e-34
Methanobacterium thermoautotrophicum
Methanococcus jannaschii	MJ0166	2e-23
Homologs in Eucarya
Human
Yeast
Other	AAD20081.1   A. thaliana
Size of P. abyssi protein	272 aa.
Best Hits outside Archaea	Gene	Blast Expect
Best Eucaryotic Hit	AAD20081.1	3e-12	A. thaliana
Best Bacterial Hit	MUTB_PORGI	8.0	P. gingivalis
Module (Pfam, Prosite, Prints)
PRODOM module
PDB hit
COG group	COG1650 : Uncharacterized protein conserved in archaea
KOG group	NO KOG = only a Arabidopsis homologue (NP_178474, uncharacterized)
Gene Environment in Archaea	Not conserved: ribosomal proteins//DNA ligase		See Environment
Phylogeny	See Unrooted Distance Tree
Function Prediction	uncharacterized