30

Mining Archaeal Proteomes for Eukaryotic Proteins with Novel Functions

PACE 30

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Orthologs in Archaea	Gene	Blast Expect	Paralogs
Pyrococcus abyssi	PAB0370	1e-168
Pyrococcus furiosus	Pf_1529200	1e-139
Pyrococcus horikoshii	PH1626	1e-145
Aeropyrum pernix	APE1771	7e-40
Archaeoglobus fulgidus	AF2310	2e-49
Methanobacterium thermoautotrophicum	MTH45	6e-58
Methanococcus jannaschii	MJ0403	1e-46
Homologs in Eucarya
Human	CGI-27
Yeast	C4H3.04C S. pombe, YJR008w S. cerevisiae
Other	AAD23663.1  A. thaliana, AAF54889.1 D. melanogaster, C37C3.8 C. elegans
Size of P. abyssi protein	291 aa.
Best Hits outside Archaea	Gene	Blast Expect
Best Eucaryotic Hit	AAD23663.1	3e-19	A. thaliana
Best Bacterial Hit	TM0087	3e-36	T. maritima
Module (Pfam, Prosite, Prints)	PF01875: Protein of unknown function DUF52
PRODOM module
PDB hit
COG group	COG1355 : Predicted dioxygenase
KOG group	KOG3086 (Hs7705720, Hs13641722, Hs13646632) = Predicted dioxygenase
Gene Environment in Archaea	CONSERVED: informational: ribosomal proteins/ EIF-6/ DNA ligase/ RNA polymerase		See Environment
Phylogeny	See Unrooted Distance Tree
Function Prediction	uncharacterized

Red= new annotations