31

Mining Archaeal Proteomes for Eukaryotic Proteins with Novel Functions

PACE 31

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Orthologs in Archaea	Gene	Blast Expect	Paralogs
Pyrococcus abyssi	PAB0160	1e-111
Pyrococcus furiosus	Pf_1779105	7e-69
Pyrococcus horikoshii	PH0259	7e-84
Aeropyrum pernix
Archaeoglobus fulgidus	AF0706	6e-32
Methanobacterium thermoautotrophicum	MTH1592	5e-27
Methanococcus jannaschii	MJ0933	3e-31
Homologs in Eucarya
Human	AK001798
Yeast
Other	AC007260  A. thaliana, CG10171D. melanogaster
Size of P. abyssi protein	237 aa.
Best Hits outside Archaea	Gene	Blast Expect
Best Eucaryotic Hit	AC007260	1e-15	A. thaliana
Best Bacterial Hit	SLL0875	3e-18	Synechocystis
Module (Pfam, Prosite, Prints)	PF01940: Integral membrane protein DUF92
PRODOM module
PDB hit
COG group	COG1836 Predicted membrane protein
KOG group	KOG4491 (Hs21361720, HsM8922783) = Predicted membrane protein
Gene Environment in Archaea	Not conserved		See Environment
Phylogeny	See Unrooted Distance Tree
Function Prediction	uncharacterized

Red= new annotations