33

Mining Archaeal Proteomes for Eukaryotic Proteins with Novel Functions

 

 

PACE 33

Orthologs in Archaea

 Gene

Blast Expect

Paralogs

Pyrococcus abyssi

 PAB0757

 

   

Pyrococcus furiosus

 

 

 

Pyrococcus horikoshii

 

 

 

Aeropyrum pernix

 

 

 

Archaeoglobus fulgidus

 

 

 

Methanobacterium thermoautotrophicum

 

 

 

Methanococcus jannaschii

 

 

 

Homologs in Eucarya

Human

 

Yeast

 

Other

 

 

Size of P. abyssi protein

 

Best Hits outside Archaea

Gene

Blast Expect

 

Best Eucaryotic Hit

  

 

 

Best Bacterial Hit

   

 

 

 

Pfam module

 

PRODOM module

 

PDB hit

 

COG group

COG1937 : Predicted nucleotide kinase

KOG group KOG3347 (Hs7706212) = Predicted nucleotide kinase/nuclear ptoein involved in oxidative stress response. Human homologue is TAF2G/TAFII31, small subunit of TFIID complex and P53 cofactor . Involved in transcription repression/silencing. Yeast homologue is Fap7

Gene Environment in Archaea

 

Phylogeny

 

 

Function Prediction