4

Mining Archaeal Proteomes for Eukaryotic Proteins with Novel Functions

PACE 4

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Orthologs in Archaea	Gene	Blast Expect	Paralogs
Pyrococcus abyssi	PAB0405	1e-142	PAB1013
Pyrococcus furiosus	Pf_1477390	1e-127	Pf_379215
Pyrococcus horikoshii	PH1567	1e-131	PH0512
Aeropyrum pernix	APE0751	9e-37	APE1602
Archaeoglobus fulgidus	AF1804	5e-42	AF2426
Methanobacterium thermoautotrophicum	MTH1005	2e-41
Methanococcus jannaschii	MJ0444	2e-34	MJ1073
Homologs in Eucarya
Human	NP_003822.1
Yeast	YOR119c RIO1 S. cerevisae, SPAC10F6.10 S. pombe
Other	ZK632.3 C. elegans, AAD23014.1 A. thaliana, CG11660 D. melanogaster, AAC26079.1 A. nidulans
Size of P. abyssi protein	266 aa.
Best Hits outside Archaea	Gene	Blast Expect
Best Eucaryotic Hit	ZK632.3	2e-30	C. elegans
Best Bacterial Hit	A75301	4e-12	D. radiodurans
Module (Pfam, Prosite, Prints)	PF01163 : RIO1 family - PS01245 : RIO1 - PS50011 : Eukaryotic protein kinase - PS00109 : Tyrosine Kinase
PRODOM domain	Extragenic suppressor of the BIMD6
PDB hit	P38 Map Kinase inhibitor complex
COG group	COG1718 : RIO1 Serine/threonine protein kinase involved in cell cycle control
KOG group	KOG2270 (Hs13899340) = Serine/threonine protein kinase involved in cell cycle control (exit from mitosis in yeast)
Gene Environment in Archaea	CONSERVED : informational aIF-1A// PACE 4-PACE 5 // DNA topo		See Environment
Phylogeny	See Unrooted Distance Tree
Function Prediction	Informational