6

Mining Archaeal Proteomes for Eukaryotic Proteins with Novel Functions

PACE 6

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Orthologs in Archaea	Gene	Blast Expect	Paralogs
Pyrococcus abyssi	PAB0418	e-133
Pyrococcus furiosus	Pf_1466680	e-125
Pyrococcus horikoshii	PH1552	e-129
Aeropyrum pernix	APE1167	4e-52
Archaeoglobus fulgidus	AF0491	2e-71
Methanobacterium thermoautotrophicum	MTH685	9e-69
Methanococcus jannaschii	MJ0592	4e-72
Homologs in Eucarya
Human	BAA91905.1, Q9Y3A5
Yeast	YLR022c  S. cerevisiae, O14179 S. pombe
Other	AAF63104.1 A. thaliana, AAF50645.1 D. melanogaster, Q23202 C. elegans
Size of P. abyssi protein	236 aa.
Best Hits outside Archaea	Gene	Blast Expect
Best Eucaryotic Hit	BAA91905.1	1e-18	H. sapiens
Best Bacterial Hit	aq_1886	3.0	A. aeolicus
Module (Pfam, Prosite, Prints)	PF01172 : uncharacterized protein family UPF0023
PRODOM domain
PDB hit
COG group	COG1500 : predicted exosome subunit
KOG group	KOG2917 (Hs 7705811) = predicted exosome subunit, human homologue is Shwachman-Bodian-Diamond syndrome protein (autosomal recessive disorder with clinical features that include pancreatic exocrine insufficiency, hematological dysfunction and skeletal abnormalities)
Gene Environment in Archaea	HIGHLY CONSERVED: psmA/ribonuclease PH		See Environment
Phylogeny	See Unrooted Distance Tree
Function Prediction	Operational

Red= new annotations