Kluyveromyces lactis hits in KOG database:
-> Back to Kluyveromyces lactis
STATUS legend: good = match length > 50 % of orf length, number of best KOG matches > 1/4 total number of matched KOGs suspect: MH = multiple hits in KOG database, number of best KOG matches < 1/4 total number of matched KOGs suspect: LH = Less than 3 Hits in KOG database suspect: HSP = match length <= 40 % of orf length suspect: Pn = expect value (Pn) for best match is near cut off value (1e-07) suspect: %id = % identity of best hits is less than 25% over matched length normal = all the restLast modified Monday January 30 14:23:35 2006
Revision 1 (03/04) ORF STATUS Function Best KOG Functional category Pathways and functional systems Code
r_klactI0013 good QR KOG0143 General function prediction only Iron/ascorbate family oxidoreductases r_klactI0013 good QR KOG0143 Secondary metabolites biosynthesis, transport and catabolism Iron/ascorbate family oxidoreductases r_klactI0023 good G KOG2504 Carbohydrate transport and metabolism Monocarboxylate transporter r_klactI0037 good R KOG1382 General function prediction only Multiple inositol polyphosphate phosphatase r_klactI0048 good R KOG2960 General function prediction only Protein involved in thiamine biosynthesis and DNA damage tolerance r_klactI0055 good T KOG3797 Signal transduction mechanisms Peripheral-type benzodiazepine receptor and related proteins r_klactI0070 suspect: LH O KOG0867 Posttranslational modification, protein turnover, chaperones Glutathione S-transferase r_klactI0079 check: MH D KOG0964 Cell cycle control, cell division, chromosome partitioning Structural maintenance of chromosome protein 3 (sister chromatid cohesion complex Cohesin, subunit SMC3) r_klactI0082 good H KOG3210 Coenzyme transport and metabolism Imidazoleglycerol-phosphate synthase subunit H-like r_klactI0089 good H KOG1606 Coenzyme transport and metabolism Stationary phase-induced protein, SOR/SNZ family r_klactI0094 good O KOG1868 Posttranslational modification, protein turnover, chaperones Ubiquitin C-terminal hydrolase r_klactI0099 good C KOG0042 Energy production and conversion Glycerol-3-phosphate dehydrogenase r_klactI0118 good DT KOG2867 Cell cycle control, cell division, chromosome partitioning Phosphotyrosyl phosphatase activator r_klactI0118 good DT KOG2867 Signal transduction mechanisms Phosphotyrosyl phosphatase activator r_klactI0156 check: MH D KOG3056 Cell cycle control, cell division, chromosome partitioning Protein required for S-phase initiation or completion r_klactI0165 check: MH S KOG4674 Function unknown Uncharacterized conserved coiled-coil protein r_klactI0167.1 check: MH J KOG0003 Translation, ribosomal structure and biogenesis Ubiquitin/60s ribosomal protein L40 fusion r_klactI0176 good T KOG0519 Signal transduction mechanisms Sensory transduction histidine kinase r_klactI0186 good J KOG1147 Translation, ribosomal structure and biogenesis Glutamyl-tRNA synthetase r_klactI0194 normal S KOG2861 Function unknown Uncharacterized conserved protein r_klactI0204 good K KOG2402 Transcription Paf1/RNA polymerase II complex, RTF1 component (involved in regulation of TATA box-binding protein) r_klactI0208 good A KOG2777 RNA processing and modification tRNA-specific adenosine deaminase 1 r_klactI0210 suspect: Pn T KOG2209 Signal transduction mechanisms Oxysterol-binding protein r_klactI0219 suspect: LH UY KOG2274 Intracellular trafficking, secretion, and vesicular transport Predicted importin 9 r_klactI0219 suspect: LH UY KOG2274 Nuclear structure Predicted importin 9 r_klactI0228 good DO KOG3437 Cell cycle control, cell division, chromosome partitioning Anaphase-promoting complex (APC), subunit 10 r_klactI0228 good DO KOG3437 Posttranslational modification, protein turnover, chaperones Anaphase-promoting complex (APC), subunit 10 r_klactI0237 good YU KOG1992 Intracellular trafficking, secretion, and vesicular transport Nuclear export receptor CSE1/CAS (importin beta superfamily) r_klactI0237 good YU KOG1992 Nuclear structure Nuclear export receptor CSE1/CAS (importin beta superfamily) r_klactI0241 normal K KOG1561 Transcription CCAAT-binding factor, subunit B (HAP2) r_klactI0251 good J KOG2311 Translation, ribosomal structure and biogenesis NAD/FAD-utilizing protein possibly involved in translation r_klactI0252 suspect: Pn C KOG0557 Energy production and conversion Dihydrolipoamide acetyltransferase r_klactI0259 good F KOG0237 Nucleotide transport and metabolism Glycinamide ribonucleotide synthetase (GARS)/Aminoimidazole ribonucleotide synthetase (AIRS) r_klactI0263 check: MH C KOG0756 Energy production and conversion Mitochondrial tricarboxylate/dicarboxylate carrier proteins r_klactI0273 good E KOG2276 Amino acid transport and metabolism Metalloexopeptidases r_klactI0277 good U KOG2176 Intracellular trafficking, secretion, and vesicular transport Exocyst complex, subunit SEC15 r_klactI0278 good R KOG3943 General function prediction only THUMP domain-containing proteins r_klactI0281 good S KOG3318 Function unknown Predicted membrane protein r_klactI0296 check: MH O KOG0724 Posttranslational modification, protein turnover, chaperones Zuotin and related molecular chaperones (DnaJ superfamily), contains DNA-binding domains r_klactI0305 good D KOG2073 Cell cycle control, cell division, chromosome partitioning SAP family cell cycle dependent phosphatase-associated protein r_klactI0320 good H KOG1370 Coenzyme transport and metabolism S-adenosylhomocysteine hydrolase r_klactI0327 good R KOG1477 General function prediction only SPRY domain-containing proteins r_klactI0329 suspect: LH C KOG4075 Energy production and conversion Cytochrome c oxidase, subunit IV/COX5b r_klactI0331 good O KOG1635 Posttranslational modification, protein turnover, chaperones Peptide methionine sulfoxide reductase r_klactI0341 good L KOG2520 Replication, recombination and repair 5'-3' exonuclease r_klactI0352 normal K KOG1601 Transcription GATA-4/5/6 transcription factors r_klactI0360 good GOU KOG1444 Carbohydrate transport and metabolism Nucleotide-sugar transporter VRG4/SQV-7 r_klactI0360 good GOU KOG1444 Intracellular trafficking, secretion, and vesicular transport Nucleotide-sugar transporter VRG4/SQV-7 r_klactI0360 good GOU KOG1444 Posttranslational modification, protein turnover, chaperones Nucleotide-sugar transporter VRG4/SQV-7 r_klactI0364 suspect: LH J KOG4599 Translation, ribosomal structure and biogenesis Putative mitochondrial/chloroplast ribosomal protein L45 r_klactI0368 good R KOG3109 General function prediction only Haloacid dehalogenase-like hydrolase r_klactI0385 check: MH R KOG0927 General function prediction only Predicted transporter (ABC superfamily) r_klactI0403 good R KOG4131 General function prediction only Ngg1-interacting factor 3 protein NIF3L1 r_klactI0404 good T KOG3348 Signal transduction mechanisms BolA (bacterial stress-induced morphogen)-related protein r_klactI0420 check: MH Z KOG0242 Cytoskeleton Kinesin-like protein r_klactI0434 good R KOG4155 General function prediction only FOG: WD40 repeat r_klactI0437 suspect: LH U KOG3202 Intracellular trafficking, secretion, and vesicular transport SNARE protein TLG1/Syntaxin 6 r_klactI0445 good P KOG0252 Inorganic ion transport and metabolism Inorganic phosphate transporter r_klactI0453 good IR KOG1269 General function prediction only SAM-dependent methyltransferases r_klactI0453 good IR KOG1269 Lipid transport and metabolism SAM-dependent methyltransferases r_klactI0493 suspect: LH M KOG4701 Cell wall/membrane/envelope biogenesis Chitinase r_klactI0499 good L KOG2095 Replication, recombination and repair DNA polymerase iota/DNA damage inducible protein r_klactI0501 suspect: LH I KOG0817 Lipid transport and metabolism Acyl-CoA-binding protein r_klactI0511.1 suspect: Pn E KOG0259 Amino acid transport and metabolism Tyrosine aminotransferase r_klactI0511 good J KOG0886 Translation, ribosomal structure and biogenesis 40S ribosomal protein S2 r_klactI0523 suspect: LH R KOG2343 General function prediction only Glucose-repressible protein and related proteins r_klactI0525 good R KOG2383 General function prediction only Predicted ATPase r_klactI0535 good A KOG2047 RNA processing and modification mRNA splicing factor r_klactI0539 good C KOG1647 Energy production and conversion Vacuolar H+-ATPase V1 sector, subunit D r_klactI0545 good OPR KOG2195 General function prediction only Transferrin receptor and related proteins containing the protease-associated (PA) domain r_klactI0545 good OPR KOG2195 Inorganic ion transport and metabolism Transferrin receptor and related proteins containing the protease-associated (PA) domain r_klactI0545 good OPR KOG2195 Posttranslational modification, protein turnover, chaperones Transferrin receptor and related proteins containing the protease-associated (PA) domain r_klactI0550 good J KOG0438 Translation, ribosomal structure and biogenesis Mitochondrial/chloroplast ribosomal protein L2 r_klactI0557 good U KOG1162 Intracellular trafficking, secretion, and vesicular transport Predicted small molecule transporter r_klactI0559 good S KOG4709 Function unknown Uncharacterized conserved protein r_klactI0564 good S KOG0858 Function unknown Predicted membrane protein r_klactI0573 good I KOG3717 Lipid transport and metabolism Carnitine O-acyltransferase CRAT r_klactI0574 suspect: LH R KOG3362 General function prediction only Predicted BBOX Zn-finger protein r_klactI0580 good O KOG2628 Posttranslational modification, protein turnover, chaperones Farnesyl cysteine-carboxyl methyltransferase r_klactI0589 good K KOG2169 Transcription Zn-finger transcription factor r_klactI0593 good G KOG3076 Carbohydrate transport and metabolism 5'-phosphoribosylglycinamide formyltransferase r_klactI0595 check: MH O KOG0173 Posttranslational modification, protein turnover, chaperones 20S proteasome, regulatory subunit beta type PSMB7/PSMB10/PUP1 r_klactI0602 suspect: LH U KOG1953 Intracellular trafficking, secretion, and vesicular transport Targeting complex (TRAPP) subunit r_klactI0613 good A KOG1774 RNA processing and modification Small nuclear ribonucleoprotein E r_klactI0623 good U KOG2081 Intracellular trafficking, secretion, and vesicular transport Nuclear transport regulator r_klactI0629 good I KOG1362 Lipid transport and metabolism Choline transporter-like protein r_klactI0650 good E KOG0806 Amino acid transport and metabolism Carbon-nitrogen hydrolase r_klactI0653 good E KOG3923 Amino acid transport and metabolism D-aspartate oxidase r_klactI0659 check: MH T KOG0660 Signal transduction mechanisms Mitogen-activated protein kinase r_klactI0691 good G KOG2772 Carbohydrate transport and metabolism Transaldolase r_klactI0705 suspect: LH R KOG1721 General function prediction only FOG: Zn-finger r_klactI0718 good O KOG0854 Posttranslational modification, protein turnover, chaperones Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes r_klactI0734 check: MH T KOG0583 Signal transduction mechanisms Serine/threonine protein kinase r_klactI0746 good J KOG2315 Translation, ribosomal structure and biogenesis Predicted translation initiation factor related to eIF-3a r_klactI0749 good T KOG2210 Signal transduction mechanisms Oxysterol-binding protein r_klactI0769 check: MH BK KOG1827 Chromatin structure and dynamics Chromatin remodeling complex RSC, subunit RSC1/Polybromo and related proteins r_klactI0769 check: MH BK KOG1827 Transcription Chromatin remodeling complex RSC, subunit RSC1/Polybromo and related proteins r_klactI0804 check: MH L KOG0390 Replication, recombination and repair DNA repair protein, SNF2 family r_klactI0817 suspect: LH S KOG3114 Function unknown Uncharacterized conserved protein r_klactI0824 good J KOG3051 Translation, ribosomal structure and biogenesis RNA binding/translational regulation protein of the SUA5 family r_klactI0835 check: MH P KOG0202 Inorganic ion transport and metabolism Ca2+ transporting ATPase r_klactI0858 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactI0860 good R KOG3115 General function prediction only Methyltransferase-like protein r_klactI0880 check: MH I KOG1175 Lipid transport and metabolism Acyl-CoA synthetase r_klactI0900 good R KOG3043 General function prediction only Predicted hydrolase related to dienelactone hydrolase r_klactI0936 good V KOG1707 Defense mechanisms Predicted Ras related/Rac-GTP binding protein r_klactI0941 check: MH O KOG0184 Posttranslational modification, protein turnover, chaperones 20S proteasome, regulatory subunit alpha type PSMA3/PRE10 r_klactI0945 suspect: %id S KOG4674 Function unknown Uncharacterized conserved coiled-coil protein r_klactI0948 good J KOG2314 Translation, ribosomal structure and biogenesis Translation initiation factor 3, subunit b (eIF-3b) r_klactI0952 good T KOG3348 Signal transduction mechanisms BolA (bacterial stress-induced morphogen)-related protein r_klactI0955 good T KOG2313 Signal transduction mechanisms Stress-induced protein UVI31+ r_klactI0957 good E KOG3373 Amino acid transport and metabolism Glycine cleavage system H protein (lipoate-binding) r_klactI0966 good T KOG3689 Signal transduction mechanisms Cyclic nucleotide phosphodiesterase r_klactI0974 suspect: LH JT KOG3791 Signal transduction mechanisms Predicted RNA-binding protein involved in translational regulation r_klactI0974 suspect: LH JT KOG3791 Translation, ribosomal structure and biogenesis Predicted RNA-binding protein involved in translational regulation r_klactI0978 suspect: LH A KOG1895 RNA processing and modification mRNA cleavage and polyadenylation factor II complex, subunit PTA1 r_klactI0985 good K KOG1657 Transcription CCAAT-binding factor, subunit C (HAP5) r_klactI0990 good U KOG2527 Intracellular trafficking, secretion, and vesicular transport Sorting nexin SNX11 r_klactI0999 good P KOG1291 Inorganic ion transport and metabolism Mn2+ and Fe2+ transporters of the NRAMP family r_klactI1001.1 suspect: LH R KOG1824 General function prediction only TATA-binding protein-interacting protein r_klactI1009 check: MH T KOG0583 Signal transduction mechanisms Serine/threonine protein kinase r_klactI1014 suspect: %id L KOG1121 Replication, recombination and repair Tam3-transposase (Ac family) r_klactI1023 good U KOG0860 Intracellular trafficking, secretion, and vesicular transport Synaptobrevin/VAMP-like protein r_klactI1036 good Z KOG0160 Cytoskeleton Myosin class V heavy chain r_klactI1047 suspect: Pn TZ KOG1923 Cytoskeleton Rac1 GTPase effector FRL r_klactI1047 suspect: Pn TZ KOG1923 Signal transduction mechanisms Rac1 GTPase effector FRL r_klactI1052 good E KOG4165 Amino acid transport and metabolism Gamma-glutamyl phosphate reductase r_klactI1062 good R KOG0206 General function prediction only P-type ATPase r_klactI1069 good A KOG3064 RNA processing and modification RNA-binding nuclear protein (MAK16) containing a distinct C4 Zn-finger r_klactI1075 good T KOG3417 Signal transduction mechanisms Ras1 guanine nucleotide exchange factor r_klactI1086 good G KOG2533 Carbohydrate transport and metabolism Permease of the major facilitator superfamily r_klactI1109 normal R KOG1618 General function prediction only Predicted phosphatase r_klactI1113 good S KOG2936 Function unknown Uncharacterized conserved protein r_klactI1123 suspect: LH R KOG0017 General function prediction only FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations r_klactI1130 check: MH O KOG0360 Posttranslational modification, protein turnover, chaperones Chaperonin complex component, TCP-1 alpha subunit (CCT1) r_klactI1132 check: MH R KOG0393 General function prediction only Ras-related small GTPase, Rho type r_klactI1143 good J KOG1461 Translation, ribosomal structure and biogenesis Translation initiation factor 2B, epsilon subunit (eIF-2Bepsilon/GCD6) r_klactI1151 good T KOG0229 Signal transduction mechanisms Phosphatidylinositol-4-phosphate 5-kinase r_klactI1177 good R KOG4288 General function prediction only Predicted oxidoreductase r_klactI1181 good J KOG1465 Translation, ribosomal structure and biogenesis Translation initiation factor 2B, beta subunit (eIF-2Bbeta/GCD7) r_klactI1187 check: MH U KOG0096 Intracellular trafficking, secretion, and vesicular transport GTPase Ran/TC4/GSP1 (nuclear protein transport pathway), small G protein superfamily r_klactI1196 good A KOG3454 RNA processing and modification U1 snRNP-specific protein C r_klactI1203 check: MH J KOG0460 Translation, ribosomal structure and biogenesis Mitochondrial translation elongation factor Tu r_klactI1208 suspect: HSP R KOG1721 General function prediction only FOG: Zn-finger r_klactI1214 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactI1222 good R KOG2321 General function prediction only WD40 repeat protein r_klactI1228 good U KOG3887 Intracellular trafficking, secretion, and vesicular transport Predicted small GTPase involved in nuclear protein import r_klactI1237 good J KOG0401 Translation, ribosomal structure and biogenesis Translation initiation factor 4F, ribosome/mRNA-bridging subunit (eIF-4G) r_klactI1242 check: MH O KOG0728 Posttranslational modification, protein turnover, chaperones 26S proteasome regulatory complex, ATPase RPT6 r_klactI1245 good R KOG3349 General function prediction only Predicted glycosyltransferase r_klactI1246 suspect: LH R KOG4253 General function prediction only Tryptophan-rich basic nuclear protein r_klactI1249 good TDK KOG3092 Cell cycle control, cell division, chromosome partitioning Casein kinase II, beta subunit r_klactI1249 good TDK KOG3092 Signal transduction mechanisms Casein kinase II, beta subunit r_klactI1249 good TDK KOG3092 Transcription Casein kinase II, beta subunit r_klactI1251 good O KOG3192 Posttranslational modification, protein turnover, chaperones Mitochondrial J-type chaperone r_klactI1260 good O KOG1193 Posttranslational modification, protein turnover, chaperones Arginyl-tRNA-protein transferase r_klactI1268 suspect: LH YU KOG2022 Intracellular trafficking, secretion, and vesicular transport Nuclear transport receptor LGL2 (importin beta superfamily) r_klactI1268 suspect: LH YU KOG2022 Nuclear structure Nuclear transport receptor LGL2 (importin beta superfamily) r_klactI1275 good E KOG0634 Amino acid transport and metabolism Aromatic amino acid aminotransferase and related proteins r_klactI1285 check: MH DK KOG0973 Cell cycle control, cell division, chromosome partitioning Histone transcription regulator HIRA, WD repeat superfamily r_klactI1285 check: MH DK KOG0973 Transcription Histone transcription regulator HIRA, WD repeat superfamily r_klactI1301 check: MH E KOG0454 Amino acid transport and metabolism 3-isopropylmalate dehydratase (aconitase superfamily) r_klactI1313 suspect: HSP F KOG2056 Nucleotide transport and metabolism Equilibrative nucleoside transporter protein r_klactI1319 good S KOG3292 Function unknown Predicted membrane protein r_klactI1322 check: MH O KOG0182 Posttranslational modification, protein turnover, chaperones 20S proteasome, regulatory subunit alpha type PSMA6/SCL1 r_klactI1331 good IT KOG1435 Lipid transport and metabolism Sterol reductase/lamin B receptor r_klactI1331 good IT KOG1435 Signal transduction mechanisms Sterol reductase/lamin B receptor r_klactI1335 check: MH O KOG0176 Posttranslational modification, protein turnover, chaperones 20S proteasome, regulatory subunit alpha type PSMA5/PUP2 r_klactI1338 check: MH BK KOG1472 Chromatin structure and dynamics Histone acetyltransferase SAGA/ADA, catalytic subunit PCAF/GCN5 and related proteins r_klactI1338 check: MH BK KOG1472 Transcription Histone acetyltransferase SAGA/ADA, catalytic subunit PCAF/GCN5 and related proteins r_klactI1345 good H KOG2337 Coenzyme transport and metabolism Ubiquitin activating E1 enzyme-like protein r_klactI1349 good J KOG2613 Translation, ribosomal structure and biogenesis NMD protein affecting ribosome stability and mRNA decay r_klactI1361 check: MH A KOG0340 RNA processing and modification ATP-dependent RNA helicase r_klactI1370 good R KOG1489 General function prediction only Predicted GTP-binding protein (ODN superfamily) r_klactI1377 check: MH DO KOG1155 Cell cycle control, cell division, chromosome partitioning Anaphase-promoting complex (APC), Cdc23 subunit r_klactI1377 check: MH DO KOG1155 Posttranslational modification, protein turnover, chaperones Anaphase-promoting complex (APC), Cdc23 subunit r_klactI1392 good A KOG1795 RNA processing and modification U5 snRNP spliceosome subunit r_klactI1406 check: MH L KOG1805 Replication, recombination and repair DNA replication helicase r_klactI1421 check: MH A KOG0108 RNA processing and modification mRNA cleavage and polyadenylation factor I complex, subunit RNA15 r_klactI1433 normal K KOG0627 Transcription Heat shock transcription factor r_klactI1448 good G KOG3147 Carbohydrate transport and metabolism 6-phosphogluconolactonase - like protein r_klactI1459 good K KOG1598 Transcription Transcription initiation factor TFIIIB, Brf1 subunit r_klactI1465 good DZ KOG2229 Cell cycle control, cell division, chromosome partitioning Protein required for actin cytoskeleton organization and cell cycle progression r_klactI1465 good DZ KOG2229 Cytoskeleton Protein required for actin cytoskeleton organization and cell cycle progression r_klactI1474 good C KOG2799 Energy production and conversion Succinyl-CoA synthetase, beta subunit r_klactI1479 good S KOG1589 Function unknown Uncharacterized conserved protein r_klactI1488 good TU KOG0251 Intracellular trafficking, secretion, and vesicular transport Clathrin assembly protein AP180 and related proteins, contain ENTH domain r_klactI1488 good TU KOG0251 Signal transduction mechanisms Clathrin assembly protein AP180 and related proteins, contain ENTH domain r_klactI1500 good G KOG2440 Carbohydrate transport and metabolism Pyrophosphate-dependent phosphofructo-1-kinase r_klactI1507 good I KOG2822 Lipid transport and metabolism Sphingoid base-phosphate phosphatase r_klactI1509 good I KOG2822 Lipid transport and metabolism Sphingoid base-phosphate phosphatase r_klactI1530 good Z KOG3595 Cytoskeleton Dyneins, heavy chain r_klactI1534 check: MH R KOG0393 General function prediction only Ras-related small GTPase, Rho type r_klactI1537 good J KOG2187 Translation, ribosomal structure and biogenesis tRNA uracil-5-methyltransferase and related tRNA-modifying enzymes r_klactI1552 good G KOG1950 Carbohydrate transport and metabolism Glycosyl transferase, family 8 - glycogenin r_klactI1558 check: MH J KOG0327 Translation, ribosomal structure and biogenesis Translation initiation factor 4F, helicase subunit (eIF-4A) and related helicases r_klactI1560 good S KOG1685 Function unknown Uncharacterized conserved protein r_klactI1566 good G KOG4472 Carbohydrate transport and metabolism Glycolipid 2-alpha-mannosyltransferase (alpha-1,2-mannosyltransferase) r_klactI1570 good K KOG2351 Transcription RNA polymerase II, fourth largest subunit r_klactI1578 check: MH R KOG0667 General function prediction only Dual-specificity tyrosine-phosphorylation regulated kinase r_klactI1584 good U KOG1652 Intracellular trafficking, secretion, and vesicular transport Mitochondrial import inner membrane translocase, subunit TIM17 r_klactI1594 good H KOG2900 Coenzyme transport and metabolism Biotin synthase r_klactI1597 good I KOG1471 Lipid transport and metabolism Phosphatidylinositol transfer protein SEC14 and related proteins r_klactI1609 good K KOG3095 Transcription Transcription initiation factor IIE, beta subunit r_klactI1623 good R KOG2425 General function prediction only Nuclear protein involved in cell morphogenesis and cell surface growth r_klactI1652 good G KOG2533 Carbohydrate transport and metabolism Permease of the major facilitator superfamily r_klactI1658 good GM KOG4748 Carbohydrate transport and metabolism Subunit of Golgi mannosyltransferase complex r_klactI1658 good GM KOG4748 Cell wall/membrane/envelope biogenesis Subunit of Golgi mannosyltransferase complex r_klactI1670 good C KOG3015 Energy production and conversion F1-ATP synthase assembly protein r_klactI1671 good O KOG3501 Posttranslational modification, protein turnover, chaperones Molecular chaperone Prefoldin, subunit 1 r_klactI1680 good J KOG3353 Translation, ribosomal structure and biogenesis 60S ribosomal protein L22 r_klactI1684.1 good J KOG3353 Translation, ribosomal structure and biogenesis 60S ribosomal protein L22 r_klactI1690 check: MH K KOG0963 Transcription Transcription factor/CCAAT displacement protein CDP1 r_klactI1701 suspect: HSP B KOG1279 Chromatin structure and dynamics Chromatin remodeling factor subunit and related transcription factors r_klactI1728 good E KOG2275 Amino acid transport and metabolism Aminoacylase ACY1 and related metalloexopeptidases r_klactI1752 check: MH U KOG4442 Intracellular trafficking, secretion, and vesicular transport Clathrin coat binding protein/Huntingtin interacting protein HIP1, involved in regulation of endocytosis r_klactI1768 good P KOG2474 Inorganic ion transport and metabolism Zinc transporter and related ZIP domain-containing proteins r_klactI1770 good E KOG1289 Amino acid transport and metabolism Amino acid transporters r_klactI1778 check: MH J KOG0468 Translation, ribosomal structure and biogenesis U5 snRNP-specific protein r_klactI1783 good A KOG3080 RNA processing and modification Nucleolar protein-like/EBNA1-binding protein r_klactI1790 good H KOG0711 Coenzyme transport and metabolism Polyprenyl synthetase r_klactI1791 suspect: LH C KOG4116 Energy production and conversion Ubiquinol cytochrome c reductase, subunit QCR8 r_klactI1798 good T KOG0032 Signal transduction mechanisms Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily r_klactI1800 good J KOG0901 Translation, ribosomal structure and biogenesis 60S ribosomal protein L14/L17/L23 r_klactI1809 check: MH D KOG0590 Cell cycle control, cell division, chromosome partitioning Checkpoint kinase and related serine/threonine protein kinases r_klactI1822 good E KOG1286 Amino acid transport and metabolism Amino acid transporters r_klactI1830 good E KOG1286 Amino acid transport and metabolism Amino acid transporters r_klactI1837 good R KOG1347 General function prediction only Uncharacterized membrane protein, predicted efflux pump r_klactI1842 good B KOG1973 Chromatin structure and dynamics Chromatin remodeling protein, contains PHD Zn-finger r_klactI1848 good R KOG3165 General function prediction only Predicted nucleic-acid-binding protein, contains PIN domain r_klactI1857 good J KOG1195 Translation, ribosomal structure and biogenesis Arginyl-tRNA synthetase r_klactI1865 check: MH O KOG0548 Posttranslational modification, protein turnover, chaperones Molecular co-chaperone STI1 r_klactI1870 good S KOG1338 Function unknown Uncharacterized conserved protein r_klactI1874 good D KOG1036 Cell cycle control, cell division, chromosome partitioning Mitotic spindle checkpoint protein BUB3, WD repeat superfamily r_klactI1889 good BK KOG2684 Chromatin structure and dynamics Sirtuin 5 and related class III sirtuins (SIR2 family) r_klactI1889 good BK KOG2684 Transcription Sirtuin 5 and related class III sirtuins (SIR2 family) r_klactI1890.1 good J KOG3411 Translation, ribosomal structure and biogenesis 40S ribosomal protein S19 r_klactI1892.1 good J KOG1714 Translation, ribosomal structure and biogenesis 60s ribosomal protein L18 r_klactI1895 good J KOG1714 Translation, ribosomal structure and biogenesis 60s ribosomal protein L18 r_klactI1905 good G KOG2504 Carbohydrate transport and metabolism Monocarboxylate transporter r_klactI1912 good O KOG0541 Posttranslational modification, protein turnover, chaperones Alkyl hydroperoxide reductase/peroxiredoxin r_klactI1935 good L KOG1906 Replication, recombination and repair DNA polymerase sigma r_klactI1936 good J KOG3429 Translation, ribosomal structure and biogenesis Predicted peptidyl-tRNA hydrolase r_klactI1943 check: MH T KOG0578 Signal transduction mechanisms p21-activated serine/threonine protein kinase r_klactI1956 good S KOG1848 Function unknown Uncharacterized conserved protein r_klactI1973 good U KOG2058 Intracellular trafficking, secretion, and vesicular transport Ypt/Rab GTPase activating protein r_klactI1977 suspect: LH L KOG0011 Replication, recombination and repair Nucleotide excision repair factor NEF2, RAD23 component r_klactI1989 good R KOG2214 General function prediction only Predicted esterase of the alpha-beta hydrolase superfamily r_klactI1998 good U KOG3907 Intracellular trafficking, secretion, and vesicular transport ZIP-like zinc transporter proteins r_klactI2009 good S KOG3140 Function unknown Predicted membrane protein r_klactI2011 good A KOG2837 RNA processing and modification Protein containing a U1-type Zn-finger and implicated in RNA splicing or processing r_klactI2016 good O KOG2661 Posttranslational modification, protein turnover, chaperones Peptidase family M48 r_klactI2026 check: MH A KOG0924 RNA processing and modification mRNA splicing factor ATP-dependent RNA helicase r_klactI2036 suspect: LH J KOG0458 Translation, ribosomal structure and biogenesis Elongation factor 1 alpha r_klactI2044 check: MH J KOG0458 Translation, ribosomal structure and biogenesis Elongation factor 1 alpha r_klactI2047 good U KOG3894 Intracellular trafficking, secretion, and vesicular transport SNARE protein Syntaxin 18/UFE1 r_klactI2053 good F KOG0673 Nucleotide transport and metabolism Thymidylate synthase r_klactI2073 good YU KOG4121 Intracellular trafficking, secretion, and vesicular transport Nuclear pore complex, Nup133 component (sc Nup133) r_klactI2073 good YU KOG4121 Nuclear structure Nuclear pore complex, Nup133 component (sc Nup133) r_klactI2075 good J KOG3031 Translation, ribosomal structure and biogenesis Protein required for biogenesis of the ribosomal 60S subunit r_klactI2079 good H KOG0089 Coenzyme transport and metabolism Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase r_klactI2085 check: MH U KOG1092 Intracellular trafficking, secretion, and vesicular transport Ypt/Rab-specific GTPase-activating protein GYP1 r_klactI2087 good R KOG1947 General function prediction only Leucine rich repeat proteins, some proteins contain F-box r_klactI2091 good A KOG1258 RNA processing and modification mRNA processing protein r_klactI2121 good A KOG1898 RNA processing and modification Splicing factor 3b, subunit 3 r_klactI2132 suspect: LH GQ KOG2741 Carbohydrate transport and metabolism Dimeric dihydrodiol dehydrogenase r_klactI2132 suspect: LH GQ KOG2741 Secondary metabolites biosynthesis, transport and catabolism Dimeric dihydrodiol dehydrogenase r_klactI2157 good C KOG2495 Energy production and conversion NADH-dehydrogenase (ubiquinone) r_klactI2172 check: MH AJ KOG0123 RNA processing and modification Polyadenylate-binding protein (RRM superfamily) r_klactI2172 check: MH AJ KOG0123 Translation, ribosomal structure and biogenesis Polyadenylate-binding protein (RRM superfamily) r_klactI2177 check: MH S KOG1843 Function unknown Uncharacterized conserved protein r_klactI2193 good E KOG1316 Amino acid transport and metabolism Argininosuccinate lyase r_klactI2199 check: MH J KOG0555 Translation, ribosomal structure and biogenesis Asparaginyl-tRNA synthetase r_klactI2203 good J KOG4163 Translation, ribosomal structure and biogenesis Prolyl-tRNA synthetase r_klactI2212 good E KOG3923 Amino acid transport and metabolism D-aspartate oxidase r_klactI2225 good I KOG3964 Lipid transport and metabolism Phosphatidylglycerolphosphate synthase r_klactI2233 good U KOG1688 Intracellular trafficking, secretion, and vesicular transport Golgi proteins involved in ER retention (RER) r_klactI2235 good J KOG2869 Translation, ribosomal structure and biogenesis Meiotic cell division protein Pelota/DOM34 r_klactI2243 good S KOG3350 Function unknown Uncharacterized conserved protein r_klactI2260 good U KOG1690 Intracellular trafficking, secretion, and vesicular transport emp24/gp25L/p24 family of membrane trafficking proteins r_klactI2267 good R KOG1273 General function prediction only WD40 repeat protein r_klactI2272 check: MH DO KOG0305 Cell cycle control, cell division, chromosome partitioning Anaphase promoting complex, Cdc20, Cdh1, and Ama1 subunits r_klactI2272 check: MH DO KOG0305 Posttranslational modification, protein turnover, chaperones Anaphase promoting complex, Cdc20, Cdh1, and Ama1 subunits r_klactI2281 good L KOG0851 Replication, recombination and repair Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins r_klactI2289 check: MH R KOG0266 General function prediction only WD40 repeat-containing protein r_klactI2299 check: MH P KOG0204 Inorganic ion transport and metabolism Calcium transporting ATPase r_klactI2305 good J KOG4133 Translation, ribosomal structure and biogenesis tRNA splicing endonuclease r_klactI2325 check: MH P KOG0205 Inorganic ion transport and metabolism Plasma membrane H+-transporting ATPase r_klactI2336 good CR KOG0134 Energy production and conversion NADH:flavin oxidoreductase/12-oxophytodienoate reductase r_klactI2336 good CR KOG0134 General function prediction only NADH:flavin oxidoreductase/12-oxophytodienoate reductase r_klactI2348 normal J KOG2049 Translation, ribosomal structure and biogenesis Translational repressor MPT5/PUF4 and related RNA-binding proteins (Puf superfamily) r_klactI2364 suspect: LH R KOG0017 General function prediction only FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations r_klactI2374 good Z KOG2001 Cytoskeleton Gamma-tubulin complex, DGRIP84/SPC97 component r_klactI2383.1 suspect: Pn IT KOG3668 Lipid transport and metabolism Phosphatidylinositol transfer protein r_klactI2383.1 suspect: Pn IT KOG3668 Signal transduction mechanisms Phosphatidylinositol transfer protein r_klactI2385 good G KOG2670 Carbohydrate transport and metabolism Enolase r_klactI2389 good P KOG3386 Inorganic ion transport and metabolism Copper transporter r_klactI2392 good Q KOG1399 Secondary metabolites biosynthesis, transport and catabolism Flavin-containing monooxygenase r_klactI2406 good TI KOG4136 Lipid transport and metabolism Predicted mitochondrial cholesterol transporter r_klactI2406 good TI KOG4136 Signal transduction mechanisms Predicted mitochondrial cholesterol transporter r_klactI2423 good G KOG2653 Carbohydrate transport and metabolism 6-phosphogluconate dehydrogenase r_klactI2427 suspect: LH U KOG0946 Intracellular trafficking, secretion, and vesicular transport ER-Golgi vesicle-tethering protein p115 r_klactI2430 check: MH C KOG0761 Energy production and conversion Mitochondrial carrier protein CGI-69 r_klactI2441 good L KOG2520 Replication, recombination and repair 5'-3' exonuclease r_klactI2452 good G KOG2533 Carbohydrate transport and metabolism Permease of the major facilitator superfamily r_klactI2464 good D KOG1517 Cell cycle control, cell division, chromosome partitioning Guanine nucleotide binding protein MIP1 r_klactI2473 good MO KOG2407 Cell wall/membrane/envelope biogenesis GPI transamidase complex, GPI16/PIG-T component, involved in glycosylphosphatidylinositol anchor biosynthesis r_klactI2473 good MO KOG2407 Posttranslational modification, protein turnover, chaperones GPI transamidase complex, GPI16/PIG-T component, involved in glycosylphosphatidylinositol anchor biosynthesis r_klactI2481 good A KOG0213 RNA processing and modification Splicing factor 3b, subunit 1 r_klactI2485 good U KOG1060 Intracellular trafficking, secretion, and vesicular transport Vesicle coat complex AP-3, beta subunit r_klactI2486.1 suspect: Pn G KOG3734 Carbohydrate transport and metabolism Predicted phosphoglycerate mutase r_klactI2495 good R KOG3087 General function prediction only Serine/threonine protein kinase r_klactI2503 good J KOG1247 Translation, ribosomal structure and biogenesis Methionyl-tRNA synthetase r_klactI2509 check: MH A KOG0342 RNA processing and modification ATP-dependent RNA helicase pitchoune r_klactI2525 check: MH T KOG0032 Signal transduction mechanisms Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily r_klactI2530 good H KOG2698 Coenzyme transport and metabolism GTP cyclohydrolase I r_klactI2544 good P KOG1743 Inorganic ion transport and metabolism Ferric reductase-like proteins r_klactI2553 check: MH O KOG0732 Posttranslational modification, protein turnover, chaperones AAA+-type ATPase containing the bromodomain r_klactI2557 good J KOG1211 Translation, ribosomal structure and biogenesis Amidases r_klactI2561 suspect: Pn U KOG0946 Intracellular trafficking, secretion, and vesicular transport ER-Golgi vesicle-tethering protein p115 r_klactI2576 check: MH A KOG0952 RNA processing and modification DNA/RNA helicase MER3/SLH1, DEAD-box superfamily r_klactI2579 good S KOG4484 Function unknown Uncharacterized conserved protein r_klactI2594 good O KOG1358 Posttranslational modification, protein turnover, chaperones Serine palmitoyltransferase r_klactI2601 good OE KOG1282 Amino acid transport and metabolism Serine carboxypeptidases (lysosomal cathepsin A) r_klactI2601 good OE KOG1282 Posttranslational modification, protein turnover, chaperones Serine carboxypeptidases (lysosomal cathepsin A) r_klactI2619 good K KOG0008 Transcription Transcription initiation factor TFIID, subunit TAF1 r_klactI2632 good L KOG2248 Replication, recombination and repair 3'-5' exonuclease r_klactI2643 good F KOG0572 Nucleotide transport and metabolism Glutamine phosphoribosylpyrophosphate amidotransferase r_klactI2649 check: MH U KOG0057 Intracellular trafficking, secretion, and vesicular transport Mitochondrial Fe/S cluster exporter, ABC superfamily r_klactI2653 check: MH O KOG0863 Posttranslational modification, protein turnover, chaperones 20S proteasome, regulatory subunit alpha type PSMA1/PRE5 r_klactI2659 good R KOG2214 General function prediction only Predicted esterase of the alpha-beta hydrolase superfamily r_klactI2667 suspect: HSP T KOG0519 Signal transduction mechanisms Sensory transduction histidine kinase r_klactI2675 good B KOG2084 Chromatin structure and dynamics Predicted histone tail methylase containing SET domain r_klactI2678 suspect: LH S KOG4781 Function unknown Uncharacterized conserved protein r_klactI2684 good H KOG3093 Coenzyme transport and metabolism 5-formyltetrahydrofolate cyclo-ligase r_klactI2689 good E KOG0975 Amino acid transport and metabolism Branched chain aminotransferase BCAT1, pyridoxal phosphate enzymes type IV superfamily r_klactI2702 good R KOG1721 General function prediction only FOG: Zn-finger r_klactI2705 good I KOG4178 Lipid transport and metabolism Soluble epoxide hydrolase r_klactI2716 good G KOG0228 Carbohydrate transport and metabolism Beta-fructofuranosidase (invertase) r_klactI2729 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactI2739 good J KOG1728 Translation, ribosomal structure and biogenesis 40S ribosomal protein S11 r_klactI2751 check: MH CR KOG1197 Energy production and conversion Predicted quinone oxidoreductase r_klactI2751 check: MH CR KOG1197 General function prediction only Predicted quinone oxidoreductase r_klactI2758 good J KOG2509 Translation, ribosomal structure and biogenesis Seryl-tRNA synthetase r_klactI2764 check: MH J KOG0328 Translation, ribosomal structure and biogenesis Predicted ATP-dependent RNA helicase FAL1, involved in rRNA maturation, DEAD-box superfamily r_klactI2766 good U KOG0809 Intracellular trafficking, secretion, and vesicular transport SNARE protein TLG2/Syntaxin 16 r_klactI2788 good O KOG1872 Posttranslational modification, protein turnover, chaperones Ubiquitin-specific protease r_klactI2797 good E KOG1286 Amino acid transport and metabolism Amino acid transporters r_klactI2804 good J KOG2102 Translation, ribosomal structure and biogenesis Exosomal 3'-5' exoribonuclease complex, subunit Rrp44/Dis3 r_klactI2813 check: MH EJ KOG0062 Amino acid transport and metabolism ATPase component of ABC transporters with duplicated ATPase domains/Translation elongation factor EF-3b r_klactI2813 check: MH EJ KOG0062 Translation, ribosomal structure and biogenesis ATPase component of ABC transporters with duplicated ATPase domains/Translation elongation factor EF-3b r_klactI2821 good R KOG2061 General function prediction only Uncharacterized MYND Zn-finger protein r_klactI2829 check: MH J KOG1145 Translation, ribosomal structure and biogenesis Mitochondrial translation initiation factor 2 (IF-2; GTPase) r_klactI2834 good I KOG3889 Lipid transport and metabolism Predicted gamma-butyrobetaine,2-oxoglutarate dioxygenase r_klactI2847 good G KOG1367 Carbohydrate transport and metabolism 3-phosphoglycerate kinase r_klactI2848.1 suspect: LH T KOG3577 Signal transduction mechanisms Smoothened and related G-protein-coupled receptors r_klactI2852 good L KOG2534 Replication, recombination and repair DNA polymerase IV (family X) r_klactI2856 suspect: LH S KOG4829 Function unknown Uncharacterized conserved protein r_klactI2886 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactI2899 good T KOG3979 Signal transduction mechanisms FGF receptor activating protein 1 r_klactI2907 good G KOG0470 Carbohydrate transport and metabolism 1,4-alpha-glucan branching enzyme/starch branching enzyme II r_klactI2912 check: MH O KOG0416 Posttranslational modification, protein turnover, chaperones Ubiquitin-protein ligase r_klactI2928 check: MH U KOG4224 Intracellular trafficking, secretion, and vesicular transport Armadillo repeat protein VAC8 required for vacuole fusion, inheritance and cytosol-to-vacuole protein targeting r_klactI2939 suspect: LH S KOG2585 Function unknown Uncharacterized conserved protein r_klactI2942 check: MH R KOG0395 General function prediction only Ras-related GTPase r_klactI2945 good R KOG0725 General function prediction only Reductases with broad range of substrate specificities r_klactI2954 good R KOG2645 General function prediction only Type I phosphodiesterase/nucleotide pyrophosphatase r_klactI2972 suspect: LH R KOG2979 General function prediction only Protein involved in DNA repair r_klactI2975 good J KOG0554 Translation, ribosomal structure and biogenesis Asparaginyl-tRNA synthetase (mitochondrial) r_klactI3002 good K KOG1874 Transcription KEKE-like motif-containing transcription regulator (Rlr1)/suppressor of sin4 r_klactI3012 good ZT KOG2675 Cytoskeleton Adenylate cyclase-associated protein (CAP/Srv2p) r_klactI3012 good ZT KOG2675 Signal transduction mechanisms Adenylate cyclase-associated protein (CAP/Srv2p) r_klactI3016 suspect: LH J KOG3301 Translation, ribosomal structure and biogenesis Ribosomal protein S4 r_klactI3019 good S KOG4051 Function unknown Uncharacterized conserved protein r_klactI3022 check: MH O KOG0544 Posttranslational modification, protein turnover, chaperones FKBP-type peptidyl-prolyl cis-trans isomerase r_klactI3038 good E KOG1286 Amino acid transport and metabolism Amino acid transporters r_klactI3047 good DT KOG3687 Cell cycle control, cell division, chromosome partitioning Tuberin - Rap/ran-GTPase-activating protein r_klactI3047 good DT KOG3687 Signal transduction mechanisms Tuberin - Rap/ran-GTPase-activating protein r_klactI3049 good J KOG2916 Translation, ribosomal structure and biogenesis Translation initiation factor 2, alpha subunit (eIF-2alpha) r_klactI3054 good R KOG3086 General function prediction only Predicted dioxygenase r_klactI3059 good G KOG0657 Carbohydrate transport and metabolism Glyceraldehyde 3-phosphate dehydrogenase r_klactI3086 suspect: LH TV KOG4297 Defense mechanisms C-type lectin r_klactI3086 suspect: LH TV KOG4297 Signal transduction mechanisms C-type lectin r_klactI3137 suspect: LH R KOG3138 General function prediction only Predicted N-acetyltransferase r_klactI3144 suspect: HSP C KOG0536 Energy production and conversion Flavohemoprotein b5+b5R r_klactI3147 suspect: LH C KOG0538 Energy production and conversion Glycolate oxidase r_klactI3157 good R KOG0017 General function prediction only FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations r_klactI3159 good R KOG0017 General function prediction only FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations r_klactII0010 suspect: Pn QR KOG0143 General function prediction only Iron/ascorbate family oxidoreductases r_klactII0010 suspect: Pn QR KOG0143 Secondary metabolites biosynthesis, transport and catabolism Iron/ascorbate family oxidoreductases r_klactII0020.1 good G KOG2504 Carbohydrate transport and metabolism Monocarboxylate transporter r_klactII0020 good G KOG2504 Carbohydrate transport and metabolism Monocarboxylate transporter r_klactII0042.1 suspect: LH P KOG4480 Inorganic ion transport and metabolism Heme oxygenase r_klactII0043 good G KOG0471 Carbohydrate transport and metabolism Alpha-amylase r_klactII0050 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactII0060 good R KOG1382 General function prediction only Multiple inositol polyphosphate phosphatase r_klactII0080 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactII0089 good E KOG1289 Amino acid transport and metabolism Amino acid transporters r_klactII0100 good E KOG1401 Amino acid transport and metabolism Acetylornithine aminotransferase r_klactII0109 check: MH Q KOG0024 Secondary metabolites biosynthesis, transport and catabolism Sorbitol dehydrogenase r_klactII0131 suspect: Pn OJ KOG2590 Posttranslational modification, protein turnover, chaperones RNA-binding protein LARP/SRO9 and related La domain proteins r_klactII0131 suspect: Pn OJ KOG2590 Translation, ribosomal structure and biogenesis RNA-binding protein LARP/SRO9 and related La domain proteins r_klactII0134 good R KOG1234 General function prediction only ABC (ATP binding cassette) 1 protein r_klactII0142 check: MH A KOG0925 RNA processing and modification mRNA splicing factor ATP-dependent RNA helicase r_klactII0149 good G KOG1616 Carbohydrate transport and metabolism Protein involved in Snf1 protein kinase complex assembly r_klactII0154 suspect: HSP R KOG1721 General function prediction only FOG: Zn-finger r_klactII0162 good K KOG3168 Transcription U1 snRNP component r_klactII0170 check: MH U KOG0087 Intracellular trafficking, secretion, and vesicular transport GTPase Rab11/YPT3, small G protein superfamily r_klactII0192 good R KOG2840 General function prediction only Uncharacterized conserved protein with similarity to predicted ATPase of the PP-loop superfamily r_klactII0197 check: MH Z KOG0245 Cytoskeleton Kinesin-like protein r_klactII0198.1 good Z KOG3430 Cytoskeleton Dynein light chain type 1 r_klactII0203 good U KOG2273 Intracellular trafficking, secretion, and vesicular transport Membrane coat complex Retromer, subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins r_klactII0205 good O KOG2908 Posttranslational modification, protein turnover, chaperones 26S proteasome regulatory complex, subunit RPN9/PSMD13 r_klactII0208 good J KOG0122 Translation, ribosomal structure and biogenesis Translation initiation factor 3, subunit g (eIF-3g) r_klactII0211 suspect: LH J KOG3505 Translation, ribosomal structure and biogenesis Mitochondrial/chloroplast ribosomal protein L33-like r_klactII0223 good K KOG1999 Transcription RNA polymerase II transcription elongation factor DSIF/SUPT5H/SPT5 r_klactII0227 good U KOG1691 Intracellular trafficking, secretion, and vesicular transport emp24/gp25L/p24 family of membrane trafficking proteins r_klactII0233 good RO KOG2019 General function prediction only Metalloendoprotease HMP1 (insulinase superfamily) r_klactII0233 good RO KOG2019 Posttranslational modification, protein turnover, chaperones Metalloendoprotease HMP1 (insulinase superfamily) r_klactII0238 normal A KOG0106 RNA processing and modification Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) r_klactII0246 good T KOG1363 Signal transduction mechanisms Predicted regulator of the ubiquitin pathway (contains UAS and UBX domains) r_klactII0248 good R KOG1331 General function prediction only Predicted methyltransferase r_klactII0253 good MO KOG2459 Cell wall/membrane/envelope biogenesis GPI transamidase complex, GPI17/PIG-S component, involved in glycosylphosphatidylinositol anchor biosynthesis r_klactII0253 good MO KOG2459 Posttranslational modification, protein turnover, chaperones GPI transamidase complex, GPI17/PIG-S component, involved in glycosylphosphatidylinositol anchor biosynthesis r_klactII0258 good K KOG3219 Transcription Transcription initiation factor TFIID, subunit TAF11 r_klactII0260 good O KOG2918 Posttranslational modification, protein turnover, chaperones Carboxymethyl transferase r_klactII0265 good TR KOG0374 General function prediction only Serine/threonine specific protein phosphatase PP1, catalytic subunit r_klactII0265 good TR KOG0374 Signal transduction mechanisms Serine/threonine specific protein phosphatase PP1, catalytic subunit r_klactII0268 good S KOG2257 Function unknown N-acetylglucosaminyltransferase complex, subunit PIG-P, required for phosphatidylinositol biosynthesis r_klactII0286 good S KOG2765 Function unknown Predicted membrane protein r_klactII0289 suspect: LH O KOG2603 Posttranslational modification, protein turnover, chaperones Oligosaccharyltransferase, gamma subunit r_klactII0302 good L KOG2994 Replication, recombination and repair Uracil DNA glycosylase r_klactII0310 good DK KOG3924 Cell cycle control, cell division, chromosome partitioning Putative protein methyltransferase involved in meiosis and transcriptional silencing (Dot1) r_klactII0310 good DK KOG3924 Transcription Putative protein methyltransferase involved in meiosis and transcriptional silencing (Dot1) r_klactII0314 good F KOG1712 Nucleotide transport and metabolism Adenine phosphoribosyl transferases r_klactII0333 good R KOG4372 General function prediction only Predicted alpha/beta hydrolase r_klactII0338 good C KOG1231 Energy production and conversion Proteins containing the FAD binding domain r_klactII0344 good J KOG0187 Translation, ribosomal structure and biogenesis 40S ribosomal protein S17 r_klactII0353 good B KOG0457 Chromatin structure and dynamics Histone acetyltransferase complex SAGA/ADA, subunit ADA2 r_klactII0356 good R KOG2396 General function prediction only HAT (Half-A-TPR) repeat-containing protein r_klactII0362 good J KOG1624 Translation, ribosomal structure and biogenesis Mitochondrial/chloroplast ribosomal protein L4 r_klactII0367 good J KOG3311 Translation, ribosomal structure and biogenesis Ribosomal protein S18 r_klactII0373 check: MH R KOG0490 General function prediction only Transcription factor, contains HOX domain r_klactII0386 good I KOG3770 Lipid transport and metabolism Acid sphingomyelinase and PHM5 phosphate metabolism protein r_klactII0391 good O KOG0852 Posttranslational modification, protein turnover, chaperones Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes r_klactII0405 suspect: LH R KOG4431 General function prediction only Uncharacterized protein, induced by hypoxia r_klactII0408 good F KOG0707 Nucleotide transport and metabolism Guanylate kinase r_klactII0416 good P KOG1965 Inorganic ion transport and metabolism Sodium/hydrogen exchanger protein r_klactII0429 good L KOG4141 Replication, recombination and repair DNA repair and recombination protein RAD52/RAD22 r_klactII0452 check: MH OK KOG0939 Posttranslational modification, protein turnover, chaperones E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein r_klactII0452 check: MH OK KOG0939 Transcription E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein r_klactII0467 suspect: Pn K KOG1015 Transcription Transcription regulator XNP/ATRX, DEAD-box superfamily r_klactII0471 good S KOG2542 Function unknown Uncharacterized conserved protein (YdiU family) r_klactII0480 good O KOG2004 Posttranslational modification, protein turnover, chaperones Mitochondrial ATP-dependent protease PIM1/LON r_klactII0502 check: MH U KOG0276 Intracellular trafficking, secretion, and vesicular transport Vesicle coat complex COPI, beta' subunit r_klactII0506 check: MH D KOG4589 Cell cycle control, cell division, chromosome partitioning Cell division protein FtsJ r_klactII0508 good J KOG1570 Translation, ribosomal structure and biogenesis 60S ribosomal protein L10A r_klactII0514 suspect: HSP R KOG1674 General function prediction only Cyclin r_klactII0518 check: MH U KOG0077 Intracellular trafficking, secretion, and vesicular transport Vesicle coat complex COPII, GTPase subunit SAR1 r_klactII0526 good J KOG1951 Translation, ribosomal structure and biogenesis GTP-binding protein AARP2 involved in 40S ribosome biogenesis r_klactII0535 good B KOG1245 Chromatin structure and dynamics Chromatin remodeling complex WSTF-ISWI, large subunit (contains heterochromatin localization, PHD and BROMO domains) r_klactII0539 good C KOG2873 Energy production and conversion Ubiquinol cytochrome c reductase assembly protein CBP3 r_klactII0544 suspect: LH HK KOG2598 Coenzyme transport and metabolism Phosphomethylpyrimidine kinase r_klactII0544 suspect: LH HK KOG2598 Transcription Phosphomethylpyrimidine kinase r_klactII0546 good A KOG1644 RNA processing and modification U2-associated snRNP A' protein r_klactII0561 good R KOG0955 General function prediction only PHD finger protein BR140/LIN-49 r_klactII0562 good A KOG2386 RNA processing and modification mRNA capping enzyme, guanylyltransferase (alpha) subunit r_klactII0565 suspect: LH J KOG3928 Translation, ribosomal structure and biogenesis Mitochondrial ribosome small subunit component, mediator of apoptosis DAP3 r_klactII0571 good J KOG2553 Translation, ribosomal structure and biogenesis Pseudouridylate synthase r_klactII0574 good J KOG3492 Translation, ribosomal structure and biogenesis Ribosome biogenesis protein NIP7 r_klactII0580 suspect: %id U KOG2376 Intracellular trafficking, secretion, and vesicular transport Signal recognition particle, subunit Srp72 r_klactII0588 check: MH A KOG0335 RNA processing and modification ATP-dependent RNA helicase r_klactII0590 check: MH D KOG0580 Cell cycle control, cell division, chromosome partitioning Serine/threonine protein kinase r_klactII0598 good R KOG1337 General function prediction only N-methyltransferase r_klactII0608 good M KOG0853 Cell wall/membrane/envelope biogenesis Glycosyltransferase r_klactII0612 good B KOG4140 Chromatin structure and dynamics Nuclear protein Ataxin-7 r_klactII0618 good C KOG2258 Energy production and conversion Glycerophosphoryl diester phosphodiesterase r_klactII0620 good L KOG3084 Replication, recombination and repair NADH pyrophosphatase I of the Nudix family of hydrolases r_klactII0627 good S KOG1566 Function unknown Conserved protein Mo25 r_klactII0630 good U KOG2760 Intracellular trafficking, secretion, and vesicular transport Vacuolar sorting protein VPS36 r_klactII0639 good I KOG0064 Lipid transport and metabolism Peroxisomal long-chain acyl-CoA transporter, ABC superfamily r_klactII0667 good E KOG0622 Amino acid transport and metabolism Ornithine decarboxylase r_klactII0696 suspect: LH S KOG3131 Function unknown Uncharacterized conserved protein r_klactII0707 good FE KOG1448 Amino acid transport and metabolism Ribose-phosphate pyrophosphokinase r_klactII0707 good FE KOG1448 Nucleotide transport and metabolism Ribose-phosphate pyrophosphokinase r_klactII0716 check: MH R KOG0017 General function prediction only FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations r_klactII0726 check: MH R KOG1539 General function prediction only WD repeat protein r_klactII0733 good U KOG2063 Intracellular trafficking, secretion, and vesicular transport Vacuolar assembly/sorting proteins VPS39/VAM6/VPS3 r_klactII0743 suspect: LH S KOG4843 Function unknown Uncharacterized conserved protein r_klactII0749.1 suspect: LH P KOG3927 Inorganic ion transport and metabolism Na+/K+ ATPase, beta subunit r_klactII0749 good J KOG0893 Translation, ribosomal structure and biogenesis 60S ribosomal protein L31 r_klactII0752 good J KOG2335 Translation, ribosomal structure and biogenesis tRNA-dihydrouridine synthase r_klactII0756 check: MH O KOG0978 Posttranslational modification, protein turnover, chaperones E3 ubiquitin ligase involved in syntaxin degradation r_klactII0773 normal KD KOG4124 Cell cycle control, cell division, chromosome partitioning Putative transcriptional repressor regulating G2/M transition r_klactII0773 normal KD KOG4124 Transcription Putative transcriptional repressor regulating G2/M transition r_klactII0779 good R KOG2333 General function prediction only Uncharacterized conserved protein r_klactII0781 good V KOG1962 Defense mechanisms B-cell receptor-associated protein and related proteins r_klactII0795 good K KOG1474 Transcription Transcription initiation factor TFIID, subunit BDF1 and related bromodomain proteins r_klactII0803 suspect: LH G KOG1950 Carbohydrate transport and metabolism Glycosyl transferase, family 8 - glycogenin r_klactII0808 good G KOG1583 Carbohydrate transport and metabolism UDP-N-acetylglucosamine transporter r_klactII0815 check: MH A KOG0947 RNA processing and modification Cytoplasmic exosomal RNA helicase SKI2, DEAD-box superfamily r_klactII0817 good A KOG0947 RNA processing and modification Cytoplasmic exosomal RNA helicase SKI2, DEAD-box superfamily r_klactII0825 check: MH O KOG0730 Posttranslational modification, protein turnover, chaperones AAA+-type ATPase r_klactII0833 good U KOG1302 Intracellular trafficking, secretion, and vesicular transport Vacuolar sorting protein VPS33/slp1 (Sec1 family) r_klactII0842 suspect: LH C KOG4527 Energy production and conversion Cytochrome c oxidase, subunit VIIc/COX8 r_klactII0846 suspect: LH DR KOG4739 Cell cycle control, cell division, chromosome partitioning Uncharacterized protein involved in synaptonemal complex formation r_klactII0846 suspect: LH DR KOG4739 General function prediction only Uncharacterized protein involved in synaptonemal complex formation r_klactII0853 good C KOG1526 Energy production and conversion NADP-dependent isocitrate dehydrogenase r_klactII0862 good R KOG2978 General function prediction only Dolichol-phosphate mannosyltransferase r_klactII0868 good G KOG3625 Carbohydrate transport and metabolism Alpha amylase r_klactII0877 good G KOG3625 Carbohydrate transport and metabolism Alpha amylase r_klactII0887 suspect: LH U KOG4573 Intracellular trafficking, secretion, and vesicular transport Phosphoprotein involved in cytoplasm to vacuole targeting and autophagy r_klactII0893 good R KOG1721 General function prediction only FOG: Zn-finger r_klactII0896 good K KOG3405 Transcription RNA polymerase subunit K r_klactII0901 good T KOG0027 Signal transduction mechanisms Calmodulin and related proteins (EF-Hand superfamily) r_klactII0914 good A KOG1127 RNA processing and modification TPR repeat-containing protein r_klactII0918 good K KOG2587 Transcription RNA polymerase III (C) subunit r_klactII0924 good C KOG2583 Energy production and conversion Ubiquinol cytochrome c reductase, subunit QCR2 r_klactII0935 check: MH RT KOG0598 General function prediction only Ribosomal protein S6 kinase and related proteins r_klactII0935 check: MH RT KOG0598 Signal transduction mechanisms Ribosomal protein S6 kinase and related proteins r_klactII0943 good G KOG2429 Carbohydrate transport and metabolism Glycosyl hydrolase, family 47 r_klactII0950 good J KOG0378 Translation, ribosomal structure and biogenesis 40S ribosomal protein S4 r_klactII0951 suspect: LH J KOG0893 Translation, ribosomal structure and biogenesis 60S ribosomal protein L31 r_klactII0955 good F KOG4419 Nucleotide transport and metabolism 5' nucleotidase r_klactII0976 good O KOG3359 Posttranslational modification, protein turnover, chaperones Dolichyl-phosphate-mannose:protein O-mannosyl transferase r_klactII0981 good F KOG4313 Nucleotide transport and metabolism Thiamine pyrophosphokinase r_klactII0987 good C KOG4129 Energy production and conversion Exopolyphosphatases and related proteins r_klactII0988 suspect: LH S KOG4784 Function unknown Uncharacterized conserved protein r_klactII1002 good E KOG0455 Amino acid transport and metabolism Homoserine dehydrogenase r_klactII1012 good T KOG3572 Signal transduction mechanisms Uncharacterized conserved protein, contains DEP domain r_klactII1015 good O KOG2884 Posttranslational modification, protein turnover, chaperones 26S proteasome regulatory complex, subunit RPN10/PSMD4 r_klactII1023 check: MH P KOG0560 Inorganic ion transport and metabolism Sulfite reductase (ferredoxin) r_klactII1025 good P KOG0560 Inorganic ion transport and metabolism Sulfite reductase (ferredoxin) r_klactII1037 good R KOG3009 General function prediction only Predicted carbohydrate kinase, contains PfkB domain r_klactII1041 good U KOG3489 Intracellular trafficking, secretion, and vesicular transport Mitochondrial import inner membrane translocase, subunit TIM8 r_klactII1056 suspect: %id K KOG4673 Transcription Transcription factor TMF, TATA element modulatory factor r_klactII1075 good YU KOG1991 Intracellular trafficking, secretion, and vesicular transport Nuclear transport receptor RANBP7/RANBP8 (importin beta superfamily) r_klactII1075 good YU KOG1991 Nuclear structure Nuclear transport receptor RANBP7/RANBP8 (importin beta superfamily) r_klactII1091 good K KOG2239 Transcription Transcription factor containing NAC and TS-N domains r_klactII1094 suspect: LH S KOG2846 Function unknown Predicted membrane protein r_klactII1096 suspect: LH S KOG4487 Function unknown Uncharacterized conserved protein r_klactII1099 good G KOG2431 Carbohydrate transport and metabolism 1, 2-alpha-mannosidase r_klactII1104 good E KOG0053 Amino acid transport and metabolism Cystathionine beta-lyases/cystathionine gamma-synthases r_klactII1112 good F KOG4145 Nucleotide transport and metabolism Allantoicase r_klactII1118 good R KOG2497 General function prediction only Predicted methyltransferase r_klactII1139 good R KOG1721 General function prediction only FOG: Zn-finger r_klactII1144 good J KOG2335 Translation, ribosomal structure and biogenesis tRNA-dihydrouridine synthase r_klactII1152 good OPR KOG2195 General function prediction only Transferrin receptor and related proteins containing the protease-associated (PA) domain r_klactII1152 good OPR KOG2195 Inorganic ion transport and metabolism Transferrin receptor and related proteins containing the protease-associated (PA) domain r_klactII1152 good OPR KOG2195 Posttranslational modification, protein turnover, chaperones Transferrin receptor and related proteins containing the protease-associated (PA) domain r_klactII1155 good O KOG0865 Posttranslational modification, protein turnover, chaperones Cyclophilin type peptidyl-prolyl cis-trans isomerase r_klactII1164 good F KOG2056 Nucleotide transport and metabolism Equilibrative nucleoside transporter protein r_klactII1165 suspect: LH U KOG3368 Intracellular trafficking, secretion, and vesicular transport Transport protein particle (TRAPP) complex subunit r_klactII1185 good I KOG2480 Lipid transport and metabolism 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase r_klactII1190 suspect: HSP O KOG0552 Posttranslational modification, protein turnover, chaperones FKBP-type peptidyl-prolyl cis-trans isomerase r_klactII1191.1 good J KOG1694 Translation, ribosomal structure and biogenesis 60s ribosomal protein L6 r_klactII1206 good R KOG1012 General function prediction only Ca2+-dependent lipid-binding protein CLB1/vesicle protein vp115/Granuphilin A, contains C2 domain r_klactII1212 good U KOG2069 Intracellular trafficking, secretion, and vesicular transport Golgi transport complex subunit r_klactII1217 good C KOG2957 Energy production and conversion Vacuolar H+-ATPase V0 sector, subunit d r_klactII1222 suspect: HSP R KOG1947 General function prediction only Leucine rich repeat proteins, some proteins contain F-box r_klactII1232 suspect: Pn R KOG1110 General function prediction only Putative steroid membrane receptor Hpr6.6/25-Dx r_klactII1248 suspect: %id U KOG3771 Intracellular trafficking, secretion, and vesicular transport Amphiphysin r_klactII1252 good G KOG2426 Carbohydrate transport and metabolism Dihydroxyacetone kinase/glycerone kinase r_klactII1255 good KLB KOG0526 Chromatin structure and dynamics Nucleosome-binding factor SPN, POB3 subunit r_klactII1255 good KLB KOG0526 Replication, recombination and repair Nucleosome-binding factor SPN, POB3 subunit r_klactII1255 good KLB KOG0526 Transcription Nucleosome-binding factor SPN, POB3 subunit r_klactII1266 good U KOG2667 Intracellular trafficking, secretion, and vesicular transport COPII vesicle protein r_klactII1285 good L KOG1514 Replication, recombination and repair Origin recognition complex, subunit 1, and related proteins r_klactII1288 check: MH R KOG1673 General function prediction only Ras GTPases r_klactII1291 good J KOG1628 Translation, ribosomal structure and biogenesis 40S ribosomal protein S3A r_klactII1307 good D KOG0987 Cell cycle control, cell division, chromosome partitioning DNA helicase PIF1/RRM3 r_klactII1312 good L KOG2875 Replication, recombination and repair 8-oxoguanine DNA glycosylase r_klactII1315 good J KOG3331 Translation, ribosomal structure and biogenesis Mitochondrial/chloroplast ribosomal protein L4/L29 r_klactII1317 good A KOG3460 RNA processing and modification Small nuclear ribonucleoprotein (snRNP) LSM3 r_klactII1328 good R KOG2968 General function prediction only Predicted esterase of the alpha-beta hydrolase superfamily (Neuropathy target esterase), contains cAMP-binding domains r_klactII1334 check: MH E KOG1402 Amino acid transport and metabolism Ornithine aminotransferase r_klactII1343 good R KOG1577 General function prediction only Aldo/keto reductase family proteins r_klactII1344 suspect: LH R KOG1577 General function prediction only Aldo/keto reductase family proteins r_klactII1345.1 suspect: Pn R KOG1577 General function prediction only Aldo/keto reductase family proteins r_klactII1348 suspect: LH G KOG2504 Carbohydrate transport and metabolism Monocarboxylate transporter r_klactII1350 suspect: LH G KOG2504 Carbohydrate transport and metabolism Monocarboxylate transporter r_klactII1352 good G KOG2504 Carbohydrate transport and metabolism Monocarboxylate transporter r_klactII1381 good S KOG4032 Function unknown Uncharacterized conserved protein r_klactII1384 check: MH R KOG0375 General function prediction only Serine-threonine phosphatase 2B, catalytic subunit r_klactII1386 good F KOG2550 Nucleotide transport and metabolism IMP dehydrogenase/GMP reductase r_klactII1389 good F KOG2550 Nucleotide transport and metabolism IMP dehydrogenase/GMP reductase r_klactII1404 good A KOG1801 RNA processing and modification tRNA-splicing endonuclease positive effector (SEN1) r_klactII1410 good K KOG0214 Transcription RNA polymerase II, second largest subunit r_klactII1415 suspect: LH J KOG4089 Translation, ribosomal structure and biogenesis Predicted mitochondrial ribosomal protein L23 r_klactII1418 good S KOG3319 Function unknown Predicted membrane protein r_klactII1422 good I KOG0817 Lipid transport and metabolism Acyl-CoA-binding protein r_klactII1429 good YU KOG1241 Intracellular trafficking, secretion, and vesicular transport Karyopherin (importin) beta 1 r_klactII1429 good YU KOG1241 Nuclear structure Karyopherin (importin) beta 1 r_klactII1430 good I KOG3146 Lipid transport and metabolism Dolichyl pyrophosphate phosphatase and related acid phosphatases r_klactII1434 good G KOG0234 Carbohydrate transport and metabolism Fructose-6-phosphate 2-kinase/fructose-2,6-biphosphatase r_klactII1437.1 good J KOG3401 Translation, ribosomal structure and biogenesis 60S ribosomal protein L26 r_klactII1442 suspect: LH S KOG4836 Function unknown Uncharacterized conserved protein r_klactII1470 good M KOG0916 Cell wall/membrane/envelope biogenesis 1,3-beta-glucan synthase/callose synthase catalytic subunit r_klactII1476 good R KOG2382 General function prediction only Predicted alpha/beta hydrolase r_klactII1486 good J KOG0815 Translation, ribosomal structure and biogenesis 60S acidic ribosomal protein P0 r_klactII1505 suspect: HSP Z KOG4462 Cytoskeleton WASP-interacting protein VRP1/WIP, contains WH2 domain r_klactII1507 good O KOG3355 Posttranslational modification, protein turnover, chaperones Mitochondrial sulfhydryl oxidase involved in the biogenesis of cytosolic Fe/S proteins r_klactII1514 check: MH O KOG0737 Posttranslational modification, protein turnover, chaperones AAA+-type ATPase r_klactII1521 good T KOG2141 Signal transduction mechanisms Protein involved in high osmolarity signaling pathway r_klactII1528 suspect: HSP U KOG0864 Intracellular trafficking, secretion, and vesicular transport Ran-binding protein RANBP1 and related RanBD domain proteins r_klactII1536 good J KOG1767 Translation, ribosomal structure and biogenesis 40S ribosomal protein S25 r_klactII1546 good S KOG2721 Function unknown Uncharacterized conserved protein r_klactII1558 good K KOG0216 Transcription RNA polymerase I, second largest subunit r_klactII1568 good S KOG2989 Function unknown Uncharacterized conserved protein r_klactII1573 good I KOG1455 Lipid transport and metabolism Lysophospholipase r_klactII1592 check: MH A KOG1802 RNA processing and modification RNA helicase nonsense mRNA reducing factor (pNORF1) r_klactII1599 good R KOG3508 General function prediction only GTPase-activating protein r_klactII1604 good I KOG1471 Lipid transport and metabolism Phosphatidylinositol transfer protein SEC14 and related proteins r_klactII1616 check: MH T KOG0583 Signal transduction mechanisms Serine/threonine protein kinase r_klactII1630 check: MH O KOG0735 Posttranslational modification, protein turnover, chaperones AAA+-type ATPase r_klactII1632 check: MH U KOG0935 Intracellular trafficking, secretion, and vesicular transport Clathrin adaptor complex, small subunit r_klactII1634 good F KOG3327 Nucleotide transport and metabolism Thymidylate kinase/adenylate kinase r_klactII1641 good V KOG1720 Defense mechanisms Protein tyrosine phosphatase CDC14 r_klactII1644 good L KOG3014 Replication, recombination and repair Protein involved in establishing cohesion between sister chromatids during DNA replication r_klactII1647 good TZ KOG4203 Cytoskeleton Armadillo/beta-Catenin/plakoglobin r_klactII1647 good TZ KOG4203 Signal transduction mechanisms Armadillo/beta-Catenin/plakoglobin r_klactII1652 suspect: LH O KOG0356 Posttranslational modification, protein turnover, chaperones Mitochondrial chaperonin, Cpn60/Hsp60p r_klactII1655 good E KOG2770 Amino acid transport and metabolism Aminomethyl transferase r_klactII1667 good E KOG1286 Amino acid transport and metabolism Amino acid transporters r_klactII1674 good R KOG0255 General function prediction only Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) r_klactII1679 good I KOG1505 Lipid transport and metabolism Lysophosphatidic acid acyltransferase LPAAT and related acyltransferases r_klactII1684 good I KOG1179 Lipid transport and metabolism Very long-chain acyl-CoA synthetase/fatty acid transporter r_klactII1690 good C KOG1531 Energy production and conversion F0F1-type ATP synthase, gamma subunit r_klactII1702 suspect: HSP KIT KOG1620 Lipid transport and metabolism Inositol polyphosphate multikinase, component of the ARGR transcription regulatory complex r_klactII1702 suspect: HSP KIT KOG1620 Signal transduction mechanisms Inositol polyphosphate multikinase, component of the ARGR transcription regulatory complex r_klactII1702 suspect: HSP KIT KOG1620 Transcription Inositol polyphosphate multikinase, component of the ARGR transcription regulatory complex r_klactII1721 good H KOG2586 Coenzyme transport and metabolism Pyridoxamine-phosphate oxidase r_klactII1731 good L KOG3303 Replication, recombination and repair Predicted alpha-helical protein, potentially involved in replication/repair r_klactII1738 good OKT KOG1499 Posttranslational modification, protein turnover, chaperones Protein arginine N-methyltransferase PRMT1 and related enzymes r_klactII1738 good OKT KOG1499 Signal transduction mechanisms Protein arginine N-methyltransferase PRMT1 and related enzymes r_klactII1738 good OKT KOG1499 Transcription Protein arginine N-methyltransferase PRMT1 and related enzymes r_klactII1740 good A KOG1475 RNA processing and modification Ribosomal protein RPL1/RPL2/RL4L4 r_klactII1747 suspect: LH R KOG1337 General function prediction only N-methyltransferase r_klactII1759 check: MH T KOG0616 Signal transduction mechanisms cAMP-dependent protein kinase catalytic subunit (PKA) r_klactII1775 good R KOG2816 General function prediction only Predicted transporter ADD1 (major facilitator superfamily) r_klactII1784 good T KOG2124 Signal transduction mechanisms Glycosylphosphatidylinositol anchor synthesis protein r_klactII1792 suspect: %id O KOG0714 Posttranslational modification, protein turnover, chaperones Molecular chaperone (DnaJ superfamily) r_klactII1846 good G KOG0234 Carbohydrate transport and metabolism Fructose-6-phosphate 2-kinase/fructose-2,6-biphosphatase r_klactII1850 good U KOG1107 Intracellular trafficking, secretion, and vesicular transport Membrane coat complex Retromer, subunit VPS35 r_klactII1863 check: MH D KOG0601 Cell cycle control, cell division, chromosome partitioning Cyclin-dependent kinase WEE1 r_klactII1864 good J KOG1754 Translation, ribosomal structure and biogenesis 40S ribosomal protein S15/S22 r_klactII1871 good J KOG0407 Translation, ribosomal structure and biogenesis 40S ribosomal protein S14 r_klactII1885 good TU KOG1786 Intracellular trafficking, secretion, and vesicular transport Lysosomal trafficking regulator LYST and related BEACH and WD40 repeat proteins r_klactII1885 good TU KOG1786 Signal transduction mechanisms Lysosomal trafficking regulator LYST and related BEACH and WD40 repeat proteins r_klactII1889 good GE KOG1441 Amino acid transport and metabolism Glucose-6-phosphate/phosphate and phosphoenolpyruvate/phosphate antiporter r_klactII1889 good GE KOG1441 Carbohydrate transport and metabolism Glucose-6-phosphate/phosphate and phosphoenolpyruvate/phosphate antiporter r_klactII1901 good J KOG2145 Translation, ribosomal structure and biogenesis Cytoplasmic tryptophanyl-tRNA synthetase r_klactII1906 good H KOG1284 Coenzyme transport and metabolism Bifunctional GTP cyclohydrolase II/3,4-dihydroxy-2butanone-4-phosphate synthase r_klactII1909 good I KOG3071 Lipid transport and metabolism Fatty acyl-CoA elongase/Polyunsaturated fatty acid specific elongation enzyme r_klactII1922 check: MH T KOG4305 Signal transduction mechanisms RhoGEF GTPase r_klactII1926 good Z KOG3155 Cytoskeleton Actin-related protein Arp2/3 complex, subunit ARPC3 r_klactII1928.1 suspect: Pn H KOG0089 Coenzyme transport and metabolism Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase r_klactII1928 check: MH O KOG0102 Posttranslational modification, protein turnover, chaperones Molecular chaperones mortalin/PBP74/GRP75, HSP70 superfamily r_klactII1942 good R KOG3780 General function prediction only Thioredoxin binding protein TBP-2/VDUP1 r_klactII1958 suspect: HSP R KOG1721 General function prediction only FOG: Zn-finger r_klactII1959.1 good J KOG1754 Translation, ribosomal structure and biogenesis 40S ribosomal protein S15/S22 r_klactII1960.1 good J KOG1754 Translation, ribosomal structure and biogenesis 40S ribosomal protein S15/S22 r_klactII1970 good G KOG2533 Carbohydrate transport and metabolism Permease of the major facilitator superfamily r_klactII1971 good O KOG1752 Posttranslational modification, protein turnover, chaperones Glutaredoxin and related proteins r_klactII1974 good K KOG3490 Transcription Transcription elongation factor SPT4 r_klactII1978 suspect: LH OU KOG1239 Intracellular trafficking, secretion, and vesicular transport Inner membrane protein translocase involved in respiratory chain assembly r_klactII1978 suspect: LH OU KOG1239 Posttranslational modification, protein turnover, chaperones Inner membrane protein translocase involved in respiratory chain assembly r_klactII1991 good F KOG1907 Nucleotide transport and metabolism Phosphoribosylformylglycinamidine synthase r_klactII1994 good I KOG0873 Lipid transport and metabolism C-4 sterol methyl oxidase r_klactII2012 good DZU KOG2655 Cell cycle control, cell division, chromosome partitioning Septin family protein (P-loop GTPase) r_klactII2012 good DZU KOG2655 Cytoskeleton Septin family protein (P-loop GTPase) r_klactII2012 good DZU KOG2655 Intracellular trafficking, secretion, and vesicular transport Septin family protein (P-loop GTPase) r_klactII2017 good T KOG0037 Signal transduction mechanisms Ca2+-binding protein, EF-Hand protein superfamily r_klactII2022 good J KOG3344 Translation, ribosomal structure and biogenesis 40s ribosomal protein s10 r_klactII2026 good R KOG1944 General function prediction only Peroxisomal membrane protein MPV17 and related proteins r_klactII2041 check: MH P KOG0208 Inorganic ion transport and metabolism Cation transport ATPase r_klactII2055 good A KOG1070 RNA processing and modification rRNA processing protein Rrp5 r_klactII2074 suspect: HSP K KOG4011 Transcription Transcription initiation factor TFIID, subunit TAF7 r_klactII2095 check: MH BK KOG0386 Chromatin structure and dynamics Chromatin remodeling complex SWI/SNF, component SWI2 and related ATPases (DNA/RNA helicase superfamily) r_klactII2095 check: MH BK KOG0386 Transcription Chromatin remodeling complex SWI/SNF, component SWI2 and related ATPases (DNA/RNA helicase superfamily) r_klactII2102 check: MH Q KOG1205 Secondary metabolites biosynthesis, transport and catabolism Predicted dehydrogenase r_klactII2117 good F KOG1018 Nucleotide transport and metabolism Cytosine deaminase FCY1 and related enzymes r_klactII2123 suspect: LH O KOG0714 Posttranslational modification, protein turnover, chaperones Molecular chaperone (DnaJ superfamily) r_klactII2126 good E KOG0795 Amino acid transport and metabolism Chorismate mutase r_klactII2127 check: MH C KOG0758 Energy production and conversion Mitochondrial carnitine-acylcarnitine carrier protein r_klactII2137 suspect: LH U KOG4173 Intracellular trafficking, secretion, and vesicular transport Alpha-SNAP protein r_klactII2143 good KL KOG2487 Replication, recombination and repair RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB4 r_klactII2143 good KL KOG2487 Transcription RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB4 r_klactII2159 good D KOG1810 Cell cycle control, cell division, chromosome partitioning Cell cycle-associated protein r_klactII2180 suspect: LH O KOG2177 Posttranslational modification, protein turnover, chaperones Predicted E3 ubiquitin ligase r_klactII2200 good JIT KOG1212 Lipid transport and metabolism Amidases r_klactII2200 good JIT KOG1212 Signal transduction mechanisms Amidases r_klactII2200 good JIT KOG1212 Translation, ribosomal structure and biogenesis Amidases r_klactII2203 good G KOG1050 Carbohydrate transport and metabolism Trehalose-6-phosphate synthase component TPS1 and related subunits r_klactII2208 good T KOG0698 Signal transduction mechanisms Serine/threonine protein phosphatase r_klactII2215 good K KOG2473 Transcription RNA polymerase III transcription factor (TF)IIIC subunit r_klactII2223 good AD KOG3414 Cell cycle control, cell division, chromosome partitioning Component of the U4/U6.U5 snRNP/mitosis protein DIM1 r_klactII2223 good AD KOG3414 RNA processing and modification Component of the U4/U6.U5 snRNP/mitosis protein DIM1 r_klactII2232 good J KOG2298 Translation, ribosomal structure and biogenesis Glycyl-tRNA synthetase and related class II tRNA synthetase r_klactII2237 check: MH R KOG0118 General function prediction only FOG: RRM domain r_klactII2241 good J KOG0052 Translation, ribosomal structure and biogenesis Translation elongation factor EF-1 alpha/Tu r_klactII2248 good TU KOG4504 Intracellular trafficking, secretion, and vesicular transport Cation-independent mannose-6-phosphate receptor CI-MPR r_klactII2248 good TU KOG4504 Signal transduction mechanisms Cation-independent mannose-6-phosphate receptor CI-MPR r_klactII2258 good Q KOG0023 Secondary metabolites biosynthesis, transport and catabolism Alcohol dehydrogenase, class V r_klactII2283 good G KOG0523 Carbohydrate transport and metabolism Transketolase r_klactII2286 good T KOG3217 Signal transduction mechanisms Protein tyrosine phosphatase r_klactII2292 suspect: HSP K KOG2150 Transcription CCR4-NOT transcriptional regulation complex, NOT5 subunit r_klactII2302 good Q KOG1178 Secondary metabolites biosynthesis, transport and catabolism Non-ribosomal peptide synthetase/alpha-aminoadipate reductase and related enzymes r_klactII2310 check: MH L KOG1002 Replication, recombination and repair Nucleotide excision repair protein RAD16 r_klactII2328 normal R KOG1124 General function prediction only FOG: TPR repeat r_klactII2336 good L KOG3041 Replication, recombination and repair Nucleoside diphosphate-sugar hydrolase of the MutT (NUDIX) family r_klactII2341 good E KOG1562 Amino acid transport and metabolism Spermidine synthase r_klactII2346 good B KOG1342 Chromatin structure and dynamics Histone deacetylase complex, catalytic component RPD3 r_klactII2351 good O KOG2941 Posttranslational modification, protein turnover, chaperones Beta-1,4-mannosyltransferase r_klactII2354 good T KOG0027 Signal transduction mechanisms Calmodulin and related proteins (EF-Hand superfamily) r_klactII2370 suspect: LH WV KOG1216 Defense mechanisms von Willebrand factor and related coagulation proteins r_klactII2370 suspect: LH WV KOG1216 Extracellular structures von Willebrand factor and related coagulation proteins r_klactII2374 good CU KOG1119 Energy production and conversion Mitochondrial Fe-S cluster biosynthesis protein ISA2 (contains a HesB-like domain) r_klactII2374 good CU KOG1119 Intracellular trafficking, secretion, and vesicular transport Mitochondrial Fe-S cluster biosynthesis protein ISA2 (contains a HesB-like domain) r_klactII2381 check: MH O KOG2015 Posttranslational modification, protein turnover, chaperones NEDD8-activating complex, catalytic component UBA3 r_klactII2384 good P KOG4554 Inorganic ion transport and metabolism Protein involved in inorganic phosphate transport r_klactII2390 good U KOG4635 Intracellular trafficking, secretion, and vesicular transport Vacuolar import and degradation protein r_klactII2396 good O KOG0911 Posttranslational modification, protein turnover, chaperones Glutaredoxin-related protein r_klactII2401 good C KOG1575 Energy production and conversion Voltage-gated shaker-like K+ channel, subunit beta/KCNAB r_klactII2419 check: MH Q KOG0065 Secondary metabolites biosynthesis, transport and catabolism Pleiotropic drug resistance proteins (PDR1-15), ABC superfamily r_klactII2454 check: MH R KOG0594 General function prediction only Protein kinase PCTAIRE and related kinases r_klactII2458 check: MH I KOG1014 Lipid transport and metabolism 17 beta-hydroxysteroid dehydrogenase type 3, HSD17B3 r_klactII2466 good R KOG1947 General function prediction only Leucine rich repeat proteins, some proteins contain F-box r_klactII2475 suspect: HSP O KOG1039 Posttranslational modification, protein turnover, chaperones Predicted E3 ubiquitin ligase r_klactII2491 good E KOG1286 Amino acid transport and metabolism Amino acid transporters r_klactII2501 check: MH O KOG0551 Posttranslational modification, protein turnover, chaperones Hsp90 co-chaperone CNS1 (contains TPR repeats) r_klactII2512 good G KOG4472 Carbohydrate transport and metabolism Glycolipid 2-alpha-mannosyltransferase (alpha-1,2-mannosyltransferase) r_klactII2518 good G KOG0223 Carbohydrate transport and metabolism Aquaporin (major intrinsic protein family) r_klactII2531 good A KOG1869 RNA processing and modification Splicing coactivator SRm160/300, subunit SRm300 r_klactII2564 good I KOG3750 Lipid transport and metabolism Inositol phospholipid synthesis protein, Scs3p r_klactII2572 good I KOG0497 Lipid transport and metabolism Oxidosqualene-lanosterol cyclase and related proteins r_klactII2579 check: MH R KOG1124 General function prediction only FOG: TPR repeat r_klactII2598 suspect: LH G KOG2161 Carbohydrate transport and metabolism Glucosidase I r_klactII2599 good U KOG1666 Intracellular trafficking, secretion, and vesicular transport V-SNARE r_klactII2602 good C KOG3309 Energy production and conversion Ferredoxin r_klactII2608 suspect: Pn S KOG4674 Function unknown Uncharacterized conserved coiled-coil protein r_klactII2634 suspect: HSP K KOG0773 Transcription Transcription factor MEIS1 and related HOX domain proteins r_klactII2637 good A KOG0121 RNA processing and modification Nuclear cap-binding protein complex, subunit CBP20 (RRM superfamily) r_klactII2645 good TR KOG0374 General function prediction only Serine/threonine specific protein phosphatase PP1, catalytic subunit r_klactII2645 good TR KOG0374 Signal transduction mechanisms Serine/threonine specific protein phosphatase PP1, catalytic subunit r_klactII2661 good R KOG0118 General function prediction only FOG: RRM domain r_klactII2688 good S KOG1910 Function unknown Uncharacterized conserved protein r_klactII2705 check: MH R KOG0393 General function prediction only Ras-related small GTPase, Rho type r_klactII2708 good J KOG1741 Translation, ribosomal structure and biogenesis Mitochondrial/chloroplast ribosomal protein S14/S29 r_klactII2720 good E KOG0189 Amino acid transport and metabolism Phosphoadenosine phosphosulfate reductase r_klactII2723 good K KOG3046 Transcription Transcription factor, subunit of SRB subcomplex of RNA polymerase II r_klactII2728 suspect: LH R KOG2444 General function prediction only WD40 repeat protein r_klactII2750 check: MH O KOG0739 Posttranslational modification, protein turnover, chaperones AAA+-type ATPase r_klactII2757 good E KOG0571 Amino acid transport and metabolism Asparagine synthase (glutamine-hydrolyzing) r_klactII2763 good J KOG2154 Translation, ribosomal structure and biogenesis Predicted nucleolar protein involved in ribosome biogenesis r_klactII2772 check: MH R KOG0376 General function prediction only Serine-threonine phosphatase 2A, catalytic subunit r_klactII2776 good S KOG2974 Function unknown Uncharacterized conserved protein r_klactII2780 check: MH Z KOG0239 Cytoskeleton Kinesin (KAR3 subfamily) r_klactII2785 good I KOG2847 Lipid transport and metabolism Phosphate acyltransferase r_klactII2807 good P KOG0682 Inorganic ion transport and metabolism Ammonia permease r_klactII2820 check: MH A KOG0299 RNA processing and modification U3 snoRNP-associated protein (contains WD40 repeats) r_klactII2830 good R KOG1274 General function prediction only WD40 repeat protein r_klactII2838 good YU KOG3091 Intracellular trafficking, secretion, and vesicular transport Nuclear pore complex, p54 component (sc Nup57) r_klactII2838 good YU KOG3091 Nuclear structure Nuclear pore complex, p54 component (sc Nup57) r_klactII2844 good S KOG1793 Function unknown Uncharacterized conserved protein r_klactII2845 good J KOG1749 Translation, ribosomal structure and biogenesis 40S ribosomal protein S23 r_klactII2848 suspect: LH J KOG1749 Translation, ribosomal structure and biogenesis 40S ribosomal protein S23 r_klactII2854 good R KOG3234 General function prediction only Acetyltransferase, (GNAT) family r_klactII2859 suspect: HSP U KOG1073 Intracellular trafficking, secretion, and vesicular transport Uncharacterized mRNA-associated protein RAP55 r_klactII2864 check: MH C KOG0769 Energy production and conversion Predicted mitochondrial carrier protein r_klactII2868 good S KOG1043 Function unknown Ca2+-binding transmembrane protein LETM1/MRS7 r_klactII2872 good G KOG0234 Carbohydrate transport and metabolism Fructose-6-phosphate 2-kinase/fructose-2,6-biphosphatase r_klactII2886 good A KOG1856 RNA processing and modification Transcription elongation factor SPT6 r_klactII2899 good C KOG1563 Energy production and conversion Mitochondrial protein Surfeit 1/SURF1/SHY1, required for expression of cytochrome oxidase r_klactII2903 good J KOG2646 Translation, ribosomal structure and biogenesis Ribosomal protein S5 r_klactII2917 suspect: HSP K KOG0527 Transcription HMG-box transcription factor r_klactII2937 check: MH O KOG0731 Posttranslational modification, protein turnover, chaperones AAA+-type ATPase containing the peptidase M41 domain r_klactII2940 good O KOG0731 Posttranslational modification, protein turnover, chaperones AAA+-type ATPase containing the peptidase M41 domain r_klactII2947 good DZ KOG3000 Cell cycle control, cell division, chromosome partitioning Microtubule-binding protein involved in cell cycle control r_klactII2947 good DZ KOG3000 Cytoskeleton Microtubule-binding protein involved in cell cycle control r_klactII2953 good I KOG1256 Lipid transport and metabolism Long-chain acyl-CoA synthetases (AMP-forming) r_klactII2956 good A KOG4206 RNA processing and modification Spliceosomal protein snRNP-U1A/U2B r_klactII2963 good H KOG1276 Coenzyme transport and metabolism Protoporphyrinogen oxidase r_klactII2973 good A KOG0922 RNA processing and modification DEAH-box RNA helicase r_klactII2974 good O KOG0177 Posttranslational modification, protein turnover, chaperones 20S proteasome, regulatory subunit beta type PSMB2/PRE1 r_klactII2979 good L KOG2851 Replication, recombination and repair Eukaryotic-type DNA primase, catalytic (small) subunit r_klactII2996 good S KOG1043 Function unknown Ca2+-binding transmembrane protein LETM1/MRS7 r_klactII3002 suspect: LH A KOG4394 RNA processing and modification RNase P subunit that is not also a subunit of RNase MRP, involved in pre-tRNA processing r_klactII3009 check: MH O KOG0183 Posttranslational modification, protein turnover, chaperones 20S proteasome, regulatory subunit alpha type PSMA7/PRE6 r_klactII3030 check: MH T KOG0660 Signal transduction mechanisms Mitogen-activated protein kinase r_klactII3037 check: MH T KOG1240 Signal transduction mechanisms Protein kinase containing WD40 repeats r_klactII3043 check: MH T KOG0660 Signal transduction mechanisms Mitogen-activated protein kinase r_klactII3046 suspect: LH R KOG4366 General function prediction only Predicted thioesterase r_klactII3055 good O KOG2157 Posttranslational modification, protein turnover, chaperones Predicted tubulin-tyrosine ligase r_klactII3057 good U KOG3480 Intracellular trafficking, secretion, and vesicular transport Mitochondrial import inner membrane translocase, subunits TIM10/TIM12 r_klactII3062 good R KOG0381 General function prediction only HMG box-containing protein r_klactII3065 good L KOG1636 Replication, recombination and repair DNA polymerase delta processivity factor (proliferating cell nuclear antigen) r_klactII3068 good R KOG3139 General function prediction only N-acetyltransferase r_klactII3091 check: MH C KOG1159 Energy production and conversion NADP-dependent flavoprotein reductase r_klactII3097 good J KOG2783 Translation, ribosomal structure and biogenesis Phenylalanyl-tRNA synthetase r_klactII3099 good J KOG3422 Translation, ribosomal structure and biogenesis Mitochondrial ribosomal protein L16 r_klactII3102 check: MH DL KOG2035 Cell cycle control, cell division, chromosome partitioning Replication factor C, subunit RFC3 r_klactII3102 check: MH DL KOG2035 Replication, recombination and repair Replication factor C, subunit RFC3 r_klactII3109 good U KOG1077 Intracellular trafficking, secretion, and vesicular transport Vesicle coat complex AP-2, alpha subunit r_klactII3113 good R KOG3157 General function prediction only Proline synthetase co-transcribed protein r_klactII3121 good D KOG2513 Cell cycle control, cell division, chromosome partitioning Protein required for meiotic chromosome segregation r_klactII3128 good L KOG1625 Replication, recombination and repair DNA polymerase alpha-primase complex, polymerase-associated subunit B r_klactII3145 good H KOG1284 Coenzyme transport and metabolism Bifunctional GTP cyclohydrolase II/3,4-dihydroxy-2butanone-4-phosphate synthase r_klactII3155 good O KOG2090 Posttranslational modification, protein turnover, chaperones Metalloendopeptidase family - mitochondrial intermediate peptidase r_klactII3165 good S KOG2618 Function unknown Uncharacterized conserved protein r_klactII3171 good H KOG2525 Coenzyme transport and metabolism Folylpolyglutamate synthase r_klactII3182 check: MH C KOG2456 Energy production and conversion Aldehyde dehydrogenase r_klactII3195 check: MH Z KOG0162 Cytoskeleton Myosin class I heavy chain r_klactII3203 check: MH EH KOG4166 Amino acid transport and metabolism Thiamine pyrophosphate-requiring enzyme r_klactII3203 check: MH EH KOG4166 Coenzyme transport and metabolism Thiamine pyrophosphate-requiring enzyme r_klactII3212 suspect: LH G KOG4754 Carbohydrate transport and metabolism Predicted phosphoglycerate mutase r_klactII3219 suspect: LH L KOG2326 Replication, recombination and repair DNA-binding subunit of a DNA-dependent protein kinase (Ku80 autoantigen) r_klactII3227 good G KOG0625 Carbohydrate transport and metabolism Phosphoglucomutase r_klactII3231 check: MH RT KOG0598 General function prediction only Ribosomal protein S6 kinase and related proteins r_klactII3231 check: MH RT KOG0598 Signal transduction mechanisms Ribosomal protein S6 kinase and related proteins r_klactII3242 normal K KOG2434 Transcription RNA polymerase I transcription factor r_klactII3249 good R KOG1477 General function prediction only SPRY domain-containing proteins r_klactII3264 good S KOG0283 Function unknown WD40 repeat-containing protein r_klactII3271 check: MH C KOG0755 Energy production and conversion Mitochondrial oxaloacetate carrier protein r_klactII3276 good I KOG1602 Lipid transport and metabolism Cis-prenyltransferase r_klactII3289 good R KOG4409 General function prediction only Predicted hydrolase/acyltransferase (alpha/beta hydrolase superfamily) r_klactII3300 check: MH I KOG1180 Lipid transport and metabolism Acyl-CoA synthetase r_klactII3305 good L KOG3752 Replication, recombination and repair Ribonuclease H r_klactII3309 good TZ KOG3699 Cytoskeleton Cytoskeletal protein Adducin r_klactII3309 good TZ KOG3699 Signal transduction mechanisms Cytoskeletal protein Adducin r_klactII3324 good K KOG1946 Transcription RNA polymerase I transcription factor UAF r_klactII3327 good J KOG1765 Translation, ribosomal structure and biogenesis Regulator of ribosome synthesis r_klactII3338 good U KOG2114 Intracellular trafficking, secretion, and vesicular transport Vacuolar assembly/sorting protein PEP5/VPS11 r_klactII3342 check: MH T KOG0198 Signal transduction mechanisms MEKK and related serine/threonine protein kinases r_klactII3347 good R KOG1432 General function prediction only Predicted DNA repair exonuclease SIA1 r_klactII3354 suspect: LH UE KOG3715 Amino acid transport and metabolism LST7 amino acid permease Golgi transport protein r_klactII3354 suspect: LH UE KOG3715 Intracellular trafficking, secretion, and vesicular transport LST7 amino acid permease Golgi transport protein r_klactII3360 good F KOG2700 Nucleotide transport and metabolism Adenylosuccinate lyase r_klactII3369 check: MH BK KOG1827 Chromatin structure and dynamics Chromatin remodeling complex RSC, subunit RSC1/Polybromo and related proteins r_klactII3369 check: MH BK KOG1827 Transcription Chromatin remodeling complex RSC, subunit RSC1/Polybromo and related proteins r_klactII3379 good E KOG1287 Amino acid transport and metabolism Amino acid transporters r_klactII3385 good A KOG2245 RNA processing and modification Poly(A) polymerase and related nucleotidyltransferases r_klactII3392 good UR KOG0446 General function prediction only Vacuolar sorting protein VPS1, dynamin, and related proteins r_klactII3392 good UR KOG0446 Intracellular trafficking, secretion, and vesicular transport Vacuolar sorting protein VPS1, dynamin, and related proteins r_klactII3396 good P KOG0635 Inorganic ion transport and metabolism Adenosine 5'-phosphosulfate kinase r_klactII3398 good U KOG3230 Intracellular trafficking, secretion, and vesicular transport Vacuolar assembly/sorting protein DID4 r_klactII3403 suspect: LH J KOG4708 Translation, ribosomal structure and biogenesis Mitochondrial ribosomal protein MRP17 r_klactII3412 good J KOG3421 Translation, ribosomal structure and biogenesis 60S ribosomal protein L14 r_klactII3414 suspect: LH J KOG3421 Translation, ribosomal structure and biogenesis 60S ribosomal protein L14 r_klactII3425.1 suspect: Pn KR KOG1267 General function prediction only Mitochondrial transcription termination factor, mTERF r_klactII3425.1 suspect: Pn KR KOG1267 Transcription Mitochondrial transcription termination factor, mTERF r_klactII3430 good Z KOG0836 Cytoskeleton F-actin capping protein, alpha subunit r_klactII3435 suspect: HSP T KOG2199 Signal transduction mechanisms Signal transducing adaptor protein STAM/STAM2 r_klactII3438 good U KOG1607 Intracellular trafficking, secretion, and vesicular transport Protein transporter of the TRAM (translocating chain-associating membrane) superfamily r_klactII3443 good J KOG0832 Translation, ribosomal structure and biogenesis Mitochondrial/chloroplast ribosomal protein S2 r_klactII3446 good A KOG0816 RNA processing and modification Protein involved in mRNA turnover r_klactII3461 suspect: HSP O KOG0170 Posttranslational modification, protein turnover, chaperones E3 ubiquitin protein ligase r_klactII3468 check: MH T KOG0578 Signal transduction mechanisms p21-activated serine/threonine protein kinase r_klactII3474 suspect: LH L KOG2401 Replication, recombination and repair Predicted MutS-related protein involved in mismatch repair r_klactII3495 good DL KOG1969 Cell cycle control, cell division, chromosome partitioning DNA replication checkpoint protein CHL12/CTF18 r_klactII3495 good DL KOG1969 Replication, recombination and repair DNA replication checkpoint protein CHL12/CTF18 r_klactII3501 normal K KOG1318 Transcription Helix loop helix transcription factor EB r_klactII3529 suspect: LH E KOG0806 Amino acid transport and metabolism Carbon-nitrogen hydrolase r_klactII3541 good K KOG2907 Transcription RNA polymerase I transcription factor TFIIS, subunit A12.2/RPA12 r_klactII3549 check: MH O KOG0357 Posttranslational modification, protein turnover, chaperones Chaperonin complex component, TCP-1 epsilon subunit (CCT5) r_klactII3553 check: MH Z KOG0678 Cytoskeleton Actin-related protein Arp2/3 complex, subunit Arp3 r_klactII3560 good HK KOG2598 Coenzyme transport and metabolism Phosphomethylpyrimidine kinase r_klactII3560 good HK KOG2598 Transcription Phosphomethylpyrimidine kinase r_klactII3579 good L KOG0891 Replication, recombination and repair DNA-dependent protein kinase r_klactII3580 suspect: LH S KOG4774 Function unknown Uncharacterized conserved protein r_klactII3581 good L KOG0989 Replication, recombination and repair Replication factor C, subunit RFC4 r_klactII3594 good YUJ KOG2021 Intracellular trafficking, secretion, and vesicular transport Nuclear mRNA export factor receptor LOS1/Exportin-t (importin beta superfamily) r_klactII3594 good YUJ KOG2021 Nuclear structure Nuclear mRNA export factor receptor LOS1/Exportin-t (importin beta superfamily) r_klactII3594 good YUJ KOG2021 Translation, ribosomal structure and biogenesis Nuclear mRNA export factor receptor LOS1/Exportin-t (importin beta superfamily) r_klactII3599 good F KOG3222 Nucleotide transport and metabolism Inosine triphosphate pyrophosphatase r_klactII3605.1 suspect: Pn IG KOG1340 Carbohydrate transport and metabolism Prosaposin r_klactII3605.1 suspect: Pn IG KOG1340 Lipid transport and metabolism Prosaposin r_klactII3605 good R KOG0567 General function prediction only HEAT repeat-containing protein r_klactII3612 good L KOG1532 Replication, recombination and repair GTPase XAB1, interacts with DNA repair protein XPA r_klactII3615 good S KOG3188 Function unknown Uncharacterized conserved protein r_klactII3629 good I KOG4142 Lipid transport and metabolism Phospholipid methyltransferase r_klactII3640 check: MH Q KOG0055 Secondary metabolites biosynthesis, transport and catabolism Multidrug/pheromone exporter, ABC superfamily r_klactII3643 check: MH O KOG2012 Posttranslational modification, protein turnover, chaperones Ubiquitin activating enzyme UBA1 r_klactII3647 good T KOG3329 Signal transduction mechanisms RAN guanine nucleotide release factor r_klactII3659 good DZU KOG2655 Cell cycle control, cell division, chromosome partitioning Septin family protein (P-loop GTPase) r_klactII3659 good DZU KOG2655 Cytoskeleton Septin family protein (P-loop GTPase) r_klactII3659 good DZU KOG2655 Intracellular trafficking, secretion, and vesicular transport Septin family protein (P-loop GTPase) r_klactII3663 check: MH E KOG4201 Amino acid transport and metabolism Anthranilate synthase component II r_klactII3669 good I KOG1889 Lipid transport and metabolism Putative phosphoinositide phosphatase r_klactII3676 check: MH I KOG0301 Lipid transport and metabolism Phospholipase A2-activating protein (contains WD40 repeats) r_klactII3682 check: MH C KOG0767 Energy production and conversion Mitochondrial phosphate carrier protein r_klactII3693 good C KOG3378 Energy production and conversion Hemoglobin-like flavoprotein r_klactII3735 good Q KOG1399 Secondary metabolites biosynthesis, transport and catabolism Flavin-containing monooxygenase r_klactII3739 good V KOG1502 Defense mechanisms Flavonol reductase/cinnamoyl-CoA reductase r_klactII3740 good V KOG1502 Defense mechanisms Flavonol reductase/cinnamoyl-CoA reductase r_klactII3746 good E KOG1286 Amino acid transport and metabolism Amino acid transporters r_klactII3756 good R KOG1577 General function prediction only Aldo/keto reductase family proteins r_klactII3764 good E KOG1404 Amino acid transport and metabolism Alanine-glyoxylate aminotransferase AGT2 r_klactII3789 good C KOG0538 Energy production and conversion Glycolate oxidase r_klactII3791 good J KOG2317 Translation, ribosomal structure and biogenesis Putative translation initiation inhibitor UK114/IBM1 r_klactII3806 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactII3819 normal G KOG2024 Carbohydrate transport and metabolism Beta-Glucuronidase GUSB (glycosylhydrolase superfamily 2) r_klactIII0013 good QR KOG0143 General function prediction only Iron/ascorbate family oxidoreductases r_klactIII0013 good QR KOG0143 Secondary metabolites biosynthesis, transport and catabolism Iron/ascorbate family oxidoreductases r_klactIII0023.1 good G KOG2504 Carbohydrate transport and metabolism Monocarboxylate transporter r_klactIII0023 good G KOG2504 Carbohydrate transport and metabolism Monocarboxylate transporter r_klactIII0056 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactIII0091 good K KOG0773 Transcription Transcription factor MEIS1 and related HOX domain proteins r_klactIII0105 good E KOG1250 Amino acid transport and metabolism Threonine/serine dehydratases r_klactIII0119 suspect: LH U KOG0946 Intracellular trafficking, secretion, and vesicular transport ER-Golgi vesicle-tethering protein p115 r_klactIII0123 good JD KOG2874 Cell cycle control, cell division, chromosome partitioning rRNA processing protein r_klactIII0123 good JD KOG2874 Translation, ribosomal structure and biogenesis rRNA processing protein r_klactIII0128 good S KOG4604 Function unknown Uncharacterized conserved protein r_klactIII0137 good O KOG2089 Posttranslational modification, protein turnover, chaperones Metalloendopeptidase family - saccharolysin & thimet oligopeptidase r_klactIII0155 good K KOG2097 Transcription Predicted N6-adenine methylase involved in transcription regulation r_klactIII0175 good AR KOG1098 General function prediction only Putative SAM-dependent rRNA methyltransferase SPB1 r_klactIII0175 good AR KOG1098 RNA processing and modification Putative SAM-dependent rRNA methyltransferase SPB1 r_klactIII0192 good C KOG3440 Energy production and conversion Ubiquinol cytochrome c reductase, subunit QCR7 r_klactIII0201 good H KOG2201 Coenzyme transport and metabolism Pantothenate kinase PanK and related proteins r_klactIII0203 suspect: LH Z KOG0516 Cytoskeleton Dystonin, GAS (Growth-arrest-specific protein), and related proteins r_klactIII0213 suspect: LH S KOG1894 Function unknown Uncharacterized conserved protein r_klactIII0215 suspect: LH R KOG1773 General function prediction only Stress responsive protein r_klactIII0226 check: MH T KOG0201 Signal transduction mechanisms Serine/threonine protein kinase r_klactIII0240 good O KOG0549 Posttranslational modification, protein turnover, chaperones FKBP-type peptidyl-prolyl cis-trans isomerase r_klactIII0247 good S KOG2103 Function unknown Uncharacterized conserved protein r_klactIII0260 good O KOG0190 Posttranslational modification, protein turnover, chaperones Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit) r_klactIII0265 good U KOG3834 Intracellular trafficking, secretion, and vesicular transport Golgi reassembly stacking protein GRASP65, contains PDZ domain r_klactIII0270 good G KOG1369 Carbohydrate transport and metabolism Hexokinase r_klactIII0277 good S KOG0293 Function unknown WD40 repeat-containing protein r_klactIII0287 good OJ KOG2590 Posttranslational modification, protein turnover, chaperones RNA-binding protein LARP/SRO9 and related La domain proteins r_klactIII0287 good OJ KOG2590 Translation, ribosomal structure and biogenesis RNA-binding protein LARP/SRO9 and related La domain proteins r_klactIII0306 good O KOG1752 Posttranslational modification, protein turnover, chaperones Glutaredoxin and related proteins r_klactIII0312 suspect: LH U KOG1087 Intracellular trafficking, secretion, and vesicular transport Cytosolic sorting protein GGA2/TOM1 r_klactIII0316 good O KOG0856 Posttranslational modification, protein turnover, chaperones Predicted pilin-like transcription factor r_klactIII0324 good A KOG4008 RNA processing and modification rRNA processing protein RRP7 r_klactIII0326 good S KOG4100 Function unknown Uncharacterized conserved protein r_klactIII0332 good E KOG2697 Amino acid transport and metabolism Histidinol dehydrogenase r_klactIII0338 check: MH ZR KOG4568 Cytoskeleton Cytoskeleton-associated protein and related proteins r_klactIII0338 check: MH ZR KOG4568 General function prediction only Cytoskeleton-associated protein and related proteins r_klactIII0344 suspect: HSP S KOG3017 Function unknown Defense-related protein containing SCP domain r_klactIII0381 good E KOG1286 Amino acid transport and metabolism Amino acid transporters r_klactIII0386 good O KOG1769 Posttranslational modification, protein turnover, chaperones Ubiquitin-like proteins r_klactIII0398 check: MH D KOG0588 Cell cycle control, cell division, chromosome partitioning Serine/threonine protein kinase r_klactIII0402 good CR KOG0134 Energy production and conversion NADH:flavin oxidoreductase/12-oxophytodienoate reductase r_klactIII0402 good CR KOG0134 General function prediction only NADH:flavin oxidoreductase/12-oxophytodienoate reductase r_klactIII0410 good Q KOG1263 Secondary metabolites biosynthesis, transport and catabolism Multicopper oxidases r_klactIII0417 good R KOG4679 General function prediction only Uncharacterized protein PSP1 (suppressor of DNA polymerase alpha mutations in yeast) r_klactIII0423 good R KOG3346 General function prediction only Phosphatidylethanolamine binding protein r_klactIII0429 good I KOG3030 Lipid transport and metabolism Lipid phosphate phosphatase and related enzymes of the PAP2 family r_klactIII0437 good H KOG1506 Coenzyme transport and metabolism S-adenosylmethionine synthetase r_klactIII0440 suspect: LH S KOG0917 Function unknown Uncharacterized conserved protein r_klactIII0454 suspect: LH J KOG3475 Translation, ribosomal structure and biogenesis 60S ribosomal protein L37 r_klactIII0466 good J KOG3073 Translation, ribosomal structure and biogenesis Protein required for 18S rRNA maturation and 40S ribosome biogenesis r_klactIII0490 check: MH U KOG0058 Intracellular trafficking, secretion, and vesicular transport Peptide exporter, ABC superfamily r_klactIII0504 good GC KOG1192 Carbohydrate transport and metabolism UDP-glucuronosyl and UDP-glucosyl transferase r_klactIII0504 good GC KOG1192 Energy production and conversion UDP-glucuronosyl and UDP-glucosyl transferase r_klactIII0507 good T KOG3873 Signal transduction mechanisms Sphingomyelinase family protein r_klactIII0516 good S KOG2970 Function unknown Predicted membrane protein r_klactIII0526 good P KOG1172 Inorganic ion transport and metabolism Na+-independent Cl/HCO3 exchanger AE1 and related transporters (SLC4 family) r_klactIII0531 good C KOG0069 Energy production and conversion Glyoxylate/hydroxypyruvate reductase (D-isomer-specific 2-hydroxy acid dehydrogenase superfamily) r_klactIII0548 good K KOG1932 Transcription TATA binding protein associated factor r_klactIII0553 good S KOG1396 Function unknown Uncharacterized conserved protein r_klactIII0557 suspect: HSP D KOG0653 Cell cycle control, cell division, chromosome partitioning Cyclin B and related kinase-activating proteins r_klactIII0567 suspect: LH L KOG1974 Replication, recombination and repair DNA topoisomerase I-interacting protein r_klactIII0574 good E KOG1305 Amino acid transport and metabolism Amino acid transporter protein r_klactIII0586 suspect: LH U KOG4324 Intracellular trafficking, secretion, and vesicular transport Guanine nucleotide exchange factor r_klactIII0601 good TZ KOG1922 Cytoskeleton Rho GTPase effector BNI1 and related formins r_klactIII0601 good TZ KOG1922 Signal transduction mechanisms Rho GTPase effector BNI1 and related formins r_klactIII0617 good E KOG1286 Amino acid transport and metabolism Amino acid transporters r_klactIII0630 good E KOG1286 Amino acid transport and metabolism Amino acid transporters r_klactIII0642 check: MH TU KOG0903 Intracellular trafficking, secretion, and vesicular transport Phosphatidylinositol 4-kinase, involved in intracellular trafficking and secretion r_klactIII0642 check: MH TU KOG0903 Signal transduction mechanisms Phosphatidylinositol 4-kinase, involved in intracellular trafficking and secretion r_klactIII0644 good S KOG2986 Function unknown Uncharacterized conserved protein r_klactIII0647 good Z KOG2027 Cytoskeleton Spindle pole body protein r_klactIII0656 good K KOG2076 Transcription RNA polymerase III transcription factor TFIIIC r_klactIII0662 good O KOG1816 Posttranslational modification, protein turnover, chaperones Ubiquitin fusion-degradation protein r_klactIII0672 suspect: LH R KOG4711 General function prediction only Predicted membrane protein r_klactIII0675 good I KOG1470 Lipid transport and metabolism Phosphatidylinositol transfer protein PDR16 and related proteins r_klactIII0677 suspect: LH O KOG0716 Posttranslational modification, protein turnover, chaperones Molecular chaperone (DnaJ superfamily) r_klactIII0679 good S KOG3094 Function unknown Predicted membrane protein r_klactIII0699 good L KOG1798 Replication, recombination and repair DNA polymerase epsilon, catalytic subunit A r_klactIII0702 suspect: LH L KOG2543 Replication, recombination and repair Origin recognition complex, subunit 5 r_klactIII0708 suspect: LH R KOG2950 General function prediction only Uncharacterized protein involved in protein-protein interaction, contains polyproline-binding GYF domain r_klactIII0709 suspect: LH S KOG4595 Function unknown Uncharacterized conserved protein r_klactIII0713 good P KOG1603 Inorganic ion transport and metabolism Copper chaperone r_klactIII0743 good HC KOG3855 Coenzyme transport and metabolism Monooxygenase involved in coenzyme Q (ubiquinone) biosynthesis r_klactIII0743 good HC KOG3855 Energy production and conversion Monooxygenase involved in coenzyme Q (ubiquinone) biosynthesis r_klactIII0750 good H KOG2544 Coenzyme transport and metabolism Dihydropteroate synthase/7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase/Dihydroneopterin aldolase r_klactIII0754 good O KOG4400 Posttranslational modification, protein turnover, chaperones E3 ubiquitin ligase interacting with arginine methyltransferase r_klactIII0763 suspect: LH R KOG4155 General function prediction only FOG: WD40 repeat r_klactIII0768 good J KOG4548 Translation, ribosomal structure and biogenesis Mitochondrial ribosomal protein L17 r_klactIII0774 suspect: LH AK KOG0132 RNA processing and modification RNA polymerase II C-terminal domain-binding protein RA4, contains RPR and RRM domains r_klactIII0774 suspect: LH AK KOG0132 Transcription RNA polymerase II C-terminal domain-binding protein RA4, contains RPR and RRM domains r_klactIII0785 check: MH L KOG0962 Replication, recombination and repair DNA repair protein RAD50, ABC-type ATPase/SMC superfamily r_klactIII0791 good G KOG2517 Carbohydrate transport and metabolism Ribulose kinase and related carbohydrate kinases r_klactIII0795 suspect: LH K KOG4183 Transcription RNA polymerase I 49 kDa subunit r_klactIII0796 good O KOG0714 Posttranslational modification, protein turnover, chaperones Molecular chaperone (DnaJ superfamily) r_klactIII0809 good J KOG2007 Translation, ribosomal structure and biogenesis Cysteinyl-tRNA synthetase r_klactIII0812 good L KOG1508 Replication, recombination and repair DNA replication factor/protein phosphatase inhibitor SET/SPR-2 r_klactIII0815 suspect: LH S KOG3869 Function unknown Uncharacterized conserved protein r_klactIII0818 good J KOG1770 Translation, ribosomal structure and biogenesis Translation initiation factor 1 (eIF-1/SUI1) r_klactIII0823 good Z KOG0980 Cytoskeleton Actin-binding protein SLA2/Huntingtin-interacting protein Hip1 r_klactIII0840 good S KOG1822 Function unknown Uncharacterized conserved protein r_klactIII0855.1 suspect: LH U KOG0058 Intracellular trafficking, secretion, and vesicular transport Peptide exporter, ABC superfamily r_klactIII0863 suspect: LH U KOG3745 Intracellular trafficking, secretion, and vesicular transport Exocyst subunit - Sec10p r_klactIII0866 good A KOG0007 RNA processing and modification Splicing factor 3a, subunit 1 r_klactIII0872 suspect: LH TZ KOG4406 Cytoskeleton CDC42 Rho GTPase-activating protein r_klactIII0872 suspect: LH TZ KOG4406 Signal transduction mechanisms CDC42 Rho GTPase-activating protein r_klactIII0885 suspect: HSP T KOG3417 Signal transduction mechanisms Ras1 guanine nucleotide exchange factor r_klactIII0893 good CE KOG0453 Amino acid transport and metabolism Aconitase/homoaconitase (aconitase superfamily) r_klactIII0893 good CE KOG0453 Energy production and conversion Aconitase/homoaconitase (aconitase superfamily) r_klactIII0905 good P KOG1281 Inorganic ion transport and metabolism Na+/dicarboxylate, Na+/tricarboxylate and phosphate transporters r_klactIII0918 check: MH O KOG1870 Posttranslational modification, protein turnover, chaperones Ubiquitin C-terminal hydrolase r_klactIII0920 good G KOG2855 Carbohydrate transport and metabolism Ribokinase r_klactIII0925 suspect: LH J KOG1613 Translation, ribosomal structure and biogenesis Exosomal 3'-5' exoribonuclease complex, subunit Rrp43 r_klactIII0930 good I KOG3071 Lipid transport and metabolism Fatty acyl-CoA elongase/Polyunsaturated fatty acid specific elongation enzyme r_klactIII0942 suspect: HSP K KOG1878 Transcription Nuclear receptor coregulator SMRT/SMRTER, contains Myb-like domains r_klactIII0953 good LD KOG2227 Cell cycle control, cell division, chromosome partitioning Pre-initiation complex, subunit CDC6, AAA+ superfamily ATPase r_klactIII0953 good LD KOG2227 Replication, recombination and repair Pre-initiation complex, subunit CDC6, AAA+ superfamily ATPase r_klactIII0954 good U KOG1655 Intracellular trafficking, secretion, and vesicular transport Protein involved in vacuolar protein sorting r_klactIII0959 good H KOG1270 Coenzyme transport and metabolism Methyltransferases r_klactIII0966 good R KOG2897 General function prediction only DNA-binding protein YL1 and related proteins r_klactIII0970 good L KOG2108 Replication, recombination and repair 3'-5' DNA helicase r_klactIII0975 good UZ KOG1961 Cytoskeleton Vacuolar sorting protein VPS52/suppressor of actin Sac2 r_klactIII0975 good UZ KOG1961 Intracellular trafficking, secretion, and vesicular transport Vacuolar sorting protein VPS52/suppressor of actin Sac2 r_klactIII0978 check: MH L KOG0991 Replication, recombination and repair Replication factor C, subunit RFC2 r_klactIII0980 good S KOG2967 Function unknown Uncharacterized conserved protein r_klactIII0985 good S KOG2913 Function unknown Predicted membrane protein r_klactIII0988 suspect: LH Z KOG0160 Cytoskeleton Myosin class V heavy chain r_klactIII1002 check: MH D KOG0596 Cell cycle control, cell division, chromosome partitioning Dual specificity; serine/threonine and tyrosine kinase r_klactIII1007 check: MH Z KOG0677 Cytoskeleton Actin-related protein Arp2/3 complex, subunit Arp2 r_klactIII1014 check: MH U KOG0938 Intracellular trafficking, secretion, and vesicular transport Adaptor complexes medium subunit family r_klactIII1021 good FE KOG1448 Amino acid transport and metabolism Ribose-phosphate pyrophosphokinase r_klactIII1021 good FE KOG1448 Nucleotide transport and metabolism Ribose-phosphate pyrophosphokinase r_klactIII1027 check: MH D KOG0590 Cell cycle control, cell division, chromosome partitioning Checkpoint kinase and related serine/threonine protein kinases r_klactIII1035 good S KOG2118 Function unknown Predicted membrane protein, contains two CBS domains r_klactIII1045 good C KOG2711 Energy production and conversion Glycerol-3-phosphate dehydrogenase/dihydroxyacetone 3-phosphate reductase r_klactIII1051 good E KOG1706 Amino acid transport and metabolism Argininosuccinate synthase r_klactIII1057 good R KOG3675 General function prediction only Dipeptidyl peptidase III r_klactIII1062 good G KOG0235 Carbohydrate transport and metabolism Phosphoglycerate mutase r_klactIII1080 good I KOG1737 Lipid transport and metabolism Oxysterol-binding protein r_klactIII1083 check: MH I KOG3719 Lipid transport and metabolism Carnitine O-acyltransferase CPT2/YAT1 r_klactIII1088 check: MH T KOG0198 Signal transduction mechanisms MEKK and related serine/threonine protein kinases r_klactIII1094 check: MH D KOG0591 Cell cycle control, cell division, chromosome partitioning NIMA (never in mitosis)-related G2-specific serine/threonine protein kinase r_klactIII1098 good F KOG2835 Nucleotide transport and metabolism Phosphoribosylamidoimidazole-succinocarboxamide synthase r_klactIII1112 good YU KOG2023 Intracellular trafficking, secretion, and vesicular transport Nuclear transport receptor Karyopherin-beta2/Transportin (importin beta superfamily) r_klactIII1112 good YU KOG2023 Nuclear structure Nuclear transport receptor Karyopherin-beta2/Transportin (importin beta superfamily) r_klactIII1118 good F KOG2584 Nucleotide transport and metabolism Dihydroorotase and related enzymes r_klactIII1121 good U KOG1693 Intracellular trafficking, secretion, and vesicular transport emp24/gp25L/p24 family of membrane trafficking proteins r_klactIII1128 check: MH L KOG1167 Replication, recombination and repair Serine/threonine protein kinase of the CDC7 subfamily involved in DNA synthesis, repair and recombination r_klactIII1131 good I KOG1639 Lipid transport and metabolism Steroid reductase required for elongation of the very long chain fatty acids r_klactIII1136 good A KOG1596 RNA processing and modification Fibrillarin and related nucleolar RNA-binding proteins r_klactIII1148 good R KOG3912 General function prediction only Predicted integral membrane protein r_klactIII1162 check: MH Q KOG0065 Secondary metabolites biosynthesis, transport and catabolism Pleiotropic drug resistance proteins (PDR1-15), ABC superfamily r_klactIII1166 good O KOG3313 Posttranslational modification, protein turnover, chaperones Molecular chaperone Prefoldin, subunit 3 r_klactIII1167 suspect: LH S KOG4463 Function unknown Uncharacterized conserved protein r_klactIII1174 check: MH A KOG0346 RNA processing and modification RNA helicase r_klactIII1177 good A KOG1137 RNA processing and modification mRNA cleavage and polyadenylation factor II complex, BRR5 (CPSF subunit) r_klactIII1196 good J KOG2726 Translation, ribosomal structure and biogenesis Mitochondrial polypeptide chain release factor r_klactIII1202 good I KOG0016 Lipid transport and metabolism Enoyl-CoA hydratase/isomerase r_klactIII1206 good R KOG2920 General function prediction only Predicted methyltransferase r_klactIII1218 good M KOG4701 Cell wall/membrane/envelope biogenesis Chitinase r_klactIII1233 suspect: HSP TZ KOG3671 Cytoskeleton Actin regulatory protein (Wiskott-Aldrich syndrome protein) r_klactIII1233 suspect: HSP TZ KOG3671 Signal transduction mechanisms Actin regulatory protein (Wiskott-Aldrich syndrome protein) r_klactIII1236 suspect: LH JO KOG0009 Posttranslational modification, protein turnover, chaperones Ubiquitin-like/40S ribosomal S30 protein fusion r_klactIII1236 suspect: LH JO KOG0009 Translation, ribosomal structure and biogenesis Ubiquitin-like/40S ribosomal S30 protein fusion r_klactIII1239 good HE KOG2790 Amino acid transport and metabolism Phosphoserine aminotransferase r_klactIII1239 good HE KOG2790 Coenzyme transport and metabolism Phosphoserine aminotransferase r_klactIII1246 check: MH J KOG0462 Translation, ribosomal structure and biogenesis Elongation factor-type GTP-binding protein r_klactIII1259 good PQ KOG0039 Inorganic ion transport and metabolism Ferric reductase, NADH/NADPH oxidase and related proteins r_klactIII1259 good PQ KOG0039 Secondary metabolites biosynthesis, transport and catabolism Ferric reductase, NADH/NADPH oxidase and related proteins r_klactIII1308 good J KOG1465 Translation, ribosomal structure and biogenesis Translation initiation factor 2B, beta subunit (eIF-2Bbeta/GCD7) r_klactIII1317 check: MH U KOG0096 Intracellular trafficking, secretion, and vesicular transport GTPase Ran/TC4/GSP1 (nuclear protein transport pathway), small G protein superfamily r_klactIII1326 good A KOG3454 RNA processing and modification U1 snRNP-specific protein C r_klactIII1333 check: MH J KOG0460 Translation, ribosomal structure and biogenesis Mitochondrial translation elongation factor Tu r_klactIII1337 good E KOG2410 Amino acid transport and metabolism Gamma-glutamyltransferase r_klactIII1349 suspect: Pn B KOG2510 Chromatin structure and dynamics SWI-SNF chromatin-remodeling complex protein r_klactIII1368 suspect: LH R KOG0017 General function prediction only FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations r_klactIII1380 check: MH KL KOG1001 Replication, recombination and repair Helicase-like transcription factor HLTF/DNA helicase RAD5, DEAD-box superfamily r_klactIII1380 check: MH KL KOG1001 Transcription Helicase-like transcription factor HLTF/DNA helicase RAD5, DEAD-box superfamily r_klactIII1393 good OUT KOG2729 Intracellular trafficking, secretion, and vesicular transport ER vesicle integral membrane protein involved in establishing cell polarity, signaling and protein degradation r_klactIII1393 good OUT KOG2729 Posttranslational modification, protein turnover, chaperones ER vesicle integral membrane protein involved in establishing cell polarity, signaling and protein degradation r_klactIII1393 good OUT KOG2729 Signal transduction mechanisms ER vesicle integral membrane protein involved in establishing cell polarity, signaling and protein degradation r_klactIII1409 normal R KOG0118 General function prediction only FOG: RRM domain r_klactIII1419 good I KOG1600 Lipid transport and metabolism Fatty acid desaturase r_klactIII1425 good C KOG1764 Energy production and conversion 5'-AMP-activated protein kinase, gamma subunit r_klactIII1432 check: MH O KOG0419 Posttranslational modification, protein turnover, chaperones Ubiquitin-protein ligase r_klactIII1434 good T KOG0787 Signal transduction mechanisms Dehydrogenase kinase r_klactIII1445 good O KOG3439 Posttranslational modification, protein turnover, chaperones Protein conjugation factor involved in autophagy r_klactIII1460 check: MH C KOG0369 Energy production and conversion Pyruvate carboxylase r_klactIII1468 good KL KOG4086 Replication, recombination and repair Transcriptional regulator SOH1 r_klactIII1468 good KL KOG4086 Transcription Transcriptional regulator SOH1 r_klactIII1480 check: MH O KOG0802 Posttranslational modification, protein turnover, chaperones E3 ubiquitin ligase r_klactIII1483 good R KOG3335 General function prediction only Predicted coiled-coil protein r_klactIII1485 check: MH B KOG1757 Chromatin structure and dynamics Histone 2A r_klactIII1497 good I KOG1325 Lipid transport and metabolism Lysophospholipase r_klactIII1500 suspect: LH K KOG2341 Transcription TATA box binding protein (TBP)-associated factor, RNA polymerase II r_klactIII1505 good A KOG3980 RNA processing and modification RNA 3'-terminal phosphate cyclase r_klactIII1509 good U KOG2273 Intracellular trafficking, secretion, and vesicular transport Membrane coat complex Retromer, subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins r_klactIII1513 suspect: LH I KOG3177 Lipid transport and metabolism Oligoketide cyclase/lipid transport protein r_klactIII1520 good S KOG4090 Function unknown Uncharacterized conserved protein r_klactIII1527 good L KOG0981 Replication, recombination and repair DNA topoisomerase I r_klactIII1529 check: MH D KOG0575 Cell cycle control, cell division, chromosome partitioning Polo-like serine/threonine protein kinase r_klactIII1535 good K KOG4392 Transcription RNA polymerase, subunit L r_klactIII1550 good B KOG4204 Chromatin structure and dynamics Histone deacetylase complex, SIN3 component r_klactIII1556 check: MH R KOG1314 General function prediction only DHHC-type Zn-finger protein r_klactIII1559 good L KOG2327 Replication, recombination and repair DNA-binding subunit of a DNA-dependent protein kinase (Ku70 autoantigen) r_klactIII1564 good K KOG2338 Transcription Transcriptional effector CCR4-related protein r_klactIII1579 good J KOG2102 Translation, ribosomal structure and biogenesis Exosomal 3'-5' exoribonuclease complex, subunit Rrp44/Dis3 r_klactIII1588 good C KOG2495 Energy production and conversion NADH-dehydrogenase (ubiquinone) r_klactIII1595 good T KOG3886 Signal transduction mechanisms GTP-binding protein r_klactIII1597 good J KOG2255 Translation, ribosomal structure and biogenesis Peptidyl-tRNA hydrolase r_klactIII1601 good O KOG3273 Posttranslational modification, protein turnover, chaperones Predicted RNA-binding protein Pno1p interacting with Nob1p and involved in 26S proteasome assembly r_klactIII1618 check: MH O KOG0727 Posttranslational modification, protein turnover, chaperones 26S proteasome regulatory complex, ATPase RPT3 r_klactIII1622 good G KOG4123 Carbohydrate transport and metabolism Putative alpha 1,2 mannosyltransferase r_klactIII1627 good YU KOG1991 Intracellular trafficking, secretion, and vesicular transport Nuclear transport receptor RANBP7/RANBP8 (importin beta superfamily) r_klactIII1627 good YU KOG1991 Nuclear structure Nuclear transport receptor RANBP7/RANBP8 (importin beta superfamily) r_klactIII1630 good K KOG0871 Transcription Class 2 transcription repressor NC2, beta subunit (Dr1) r_klactIII1638 good R KOG4547 General function prediction only WD40 repeat-containing protein r_klactIII1649 good G KOG2504 Carbohydrate transport and metabolism Monocarboxylate transporter r_klactIII1656 good QR KOG0143 General function prediction only Iron/ascorbate family oxidoreductases r_klactIII1656 good QR KOG0143 Secondary metabolites biosynthesis, transport and catabolism Iron/ascorbate family oxidoreductases r_klactIII1662 good F KOG2938 Nucleotide transport and metabolism Predicted inosine-uridine preferring nucleoside hydrolase r_klactIII1663 good QI KOG0157 Lipid transport and metabolism Cytochrome P450 CYP4/CYP19/CYP26 subfamilies r_klactIII1663 good QI KOG0157 Secondary metabolites biosynthesis, transport and catabolism Cytochrome P450 CYP4/CYP19/CYP26 subfamilies r_klactIII1674 good K KOG3298 Transcription DNA-directed RNA polymerase subunit E' r_klactIII1676.1 suspect: Pn R KOG0619 General function prediction only FOG: Leucine rich repeat r_klactIII1680 good S KOG3190 Function unknown Uncharacterized conserved protein r_klactIII1681 good P KOG1530 Inorganic ion transport and metabolism Rhodanese-related sulfurtransferase r_klactIII1683 good P KOG1530 Inorganic ion transport and metabolism Rhodanese-related sulfurtransferase r_klactIII1687 good G KOG0235 Carbohydrate transport and metabolism Phosphoglycerate mutase r_klactIII1691 good L KOG2310 Replication, recombination and repair DNA repair exonuclease MRE11 r_klactIII1696 good T KOG3170 Signal transduction mechanisms Conserved phosducin-like protein r_klactIII1702 check: MH O KOG1867 Posttranslational modification, protein turnover, chaperones Ubiquitin-specific protease r_klactIII1706 good E KOG2551 Amino acid transport and metabolism Phospholipase/carboxyhydrolase r_klactIII1710 good E KOG2551 Amino acid transport and metabolism Phospholipase/carboxyhydrolase r_klactIII1721 good I KOG4519 Lipid transport and metabolism Phosphomevalonate kinase r_klactIII1735 suspect: HSP O KOG4597 Posttranslational modification, protein turnover, chaperones Serine proteinase inhibitor (KU family) with thrombospondin repeats r_klactIII1742 suspect: LH R KOG1931 General function prediction only Putative transmembrane protein r_klactIII1743 good H KOG4132 Coenzyme transport and metabolism Uroporphyrinogen III synthase UROS/HEM4 r_klactIII1750 good F KOG1622 Nucleotide transport and metabolism GMP synthase r_klactIII1754 suspect: LH A KOG0106 RNA processing and modification Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) r_klactIII1765 check: MH T KOG1290 Signal transduction mechanisms Serine/threonine protein kinase r_klactIII1783 check: MH O KOG0712 Posttranslational modification, protein turnover, chaperones Molecular chaperone (DnaJ superfamily) r_klactIII1791 check: MH AD KOG0050 Cell cycle control, cell division, chromosome partitioning mRNA splicing protein CDC5 (Myb superfamily) r_klactIII1791 check: MH AD KOG0050 RNA processing and modification mRNA splicing protein CDC5 (Myb superfamily) r_klactIII1799 good R KOG1877 General function prediction only Putative transmembrane protein cmp44E r_klactIII1801 good R KOG2220 General function prediction only Predicted signal transduction protein r_klactIII1805 good J KOG1384 Translation, ribosomal structure and biogenesis tRNA delta(2)-isopentenylpyrophosphate transferase r_klactIII1809 good Z KOG2530 Cytoskeleton Members of tubulin/FtsZ family r_klactIII1815 good G KOG2798 Carbohydrate transport and metabolism Putative trehalase r_klactIII1822 check: MH Z KOG0313 Cytoskeleton Microtubule binding protein YTM1 (contains WD40 repeats) r_klactIII1826 good R KOG3767 General function prediction only Sideroflexin r_klactIII1828 good I KOG1511 Lipid transport and metabolism Mevalonate kinase MVK/ERG12 r_klactIII1838 good C KOG2189 Energy production and conversion Vacuolar H+-ATPase V0 sector, subunit a r_klactIII1843 check: MH S KOG0295 Function unknown WD40 repeat-containing protein r_klactIII1853 check: MH D KOG0590 Cell cycle control, cell division, chromosome partitioning Checkpoint kinase and related serine/threonine protein kinases r_klactIII1873 good B KOG4652 Chromatin structure and dynamics HORMA domain r_klactIII1879 good E KOG2414 Amino acid transport and metabolism Putative Xaa-Pro aminopeptidase r_klactIII1888 good C KOG2536 Energy production and conversion MAM33, mitochondrial matrix glycoprotein r_klactIII1902 good T KOG0789 Signal transduction mechanisms Protein tyrosine phosphatase r_klactIII1907.1 good J KOG3424 Translation, ribosomal structure and biogenesis 40S ribosomal protein S24 r_klactIII1916 good C KOG2450 Energy production and conversion Aldehyde dehydrogenase r_klactIII1927 good UO KOG4580 Intracellular trafficking, secretion, and vesicular transport Component of vacuolar transporter chaperone (Vtc) involved in vacuole fusion r_klactIII1927 good UO KOG4580 Posttranslational modification, protein turnover, chaperones Component of vacuolar transporter chaperone (Vtc) involved in vacuole fusion r_klactIII1933 good U KOG2286 Intracellular trafficking, secretion, and vesicular transport Exocyst complex subunit SEC6 r_klactIII1948 good F KOG1112 Nucleotide transport and metabolism Ribonucleotide reductase, alpha subunit r_klactIII1955 good M KOG3364 Cell wall/membrane/envelope biogenesis Membrane protein involved in organellar division r_klactIII1957 good R KOG1271 General function prediction only Methyltransferases r_klactIII1960 good U KOG0864 Intracellular trafficking, secretion, and vesicular transport Ran-binding protein RANBP1 and related RanBD domain proteins r_klactIII1963 good Z KOG3380 Cytoskeleton Actin-related protein Arp2/3 complex, subunit ARPC5 r_klactIII1971 good E KOG2436 Amino acid transport and metabolism Acetylglutamate kinase/acetylglutamate synthase r_klactIII1978 check: MH A KOG0113 RNA processing and modification U1 small nuclear ribonucleoprotein (RRM superfamily) r_klactIII1988 good K KOG2068 Transcription MOT2 transcription factor r_klactIII2003 good C KOG1260 Energy production and conversion Isocitrate lyase r_klactIII2024 suspect: Pn K KOG4210 Transcription Nuclear localization sequence binding protein r_klactIII2037 good R KOG2914 General function prediction only Predicted haloacid-halidohydrolase and related hydrolases r_klactIII2043 good IQ KOG1394 Lipid transport and metabolism 3-oxoacyl-(acyl-carrier-protein) synthase (I and II) r_klactIII2043 good IQ KOG1394 Secondary metabolites biosynthesis, transport and catabolism 3-oxoacyl-(acyl-carrier-protein) synthase (I and II) r_klactIII2046 good I KOG1640 Lipid transport and metabolism Predicted steroid reductase r_klactIII2052 suspect: LH J KOG1790 Translation, ribosomal structure and biogenesis 60s ribosomal protein L34 r_klactIII2060 good R KOG1674 General function prediction only Cyclin r_klactIII2066 good J KOG2317 Translation, ribosomal structure and biogenesis Putative translation initiation inhibitor UK114/IBM1 r_klactIII2071.1 good J KOG1790 Translation, ribosomal structure and biogenesis 60s ribosomal protein L34 r_klactIII2079 check: MH P KOG0210 Inorganic ion transport and metabolism P-type ATPase r_klactIII2084 good G KOG3147 Carbohydrate transport and metabolism 6-phosphogluconolactonase - like protein r_klactIII2094 check: MH J KOG1224 Translation, ribosomal structure and biogenesis Para-aminobenzoate (PABA) synthase ABZ1 r_klactIII2096 good O KOG3493 Posttranslational modification, protein turnover, chaperones Ubiquitin-like protein r_klactIII2101 check: MH GT KOG0372 Carbohydrate transport and metabolism Serine/threonine specific protein phosphatase involved in glycogen accumulation, PP2A-related r_klactIII2101 check: MH GT KOG0372 Signal transduction mechanisms Serine/threonine specific protein phosphatase involved in glycogen accumulation, PP2A-related r_klactIII2109 check: MH T KOG4645 Signal transduction mechanisms MAPKKK (MAP kinase kinase kinase) SSK2 and related serine/threonine protein kinases r_klactIII2115 check: MH S KOG0271 Function unknown Notchless-like WD40 repeat-containing protein r_klactIII2117 suspect: LH S KOG4034 Function unknown Uncharacterized conserved protein NOF (Neighbor of FAU) r_klactIII2120 good MU KOG2516 Cell wall/membrane/envelope biogenesis Protein involved in dolichol pathway for N-glycosylation (mannosyltransferase family) r_klactIII2120 good MU KOG2516 Intracellular trafficking, secretion, and vesicular transport Protein involved in dolichol pathway for N-glycosylation (mannosyltransferase family) r_klactIII2126 good H KOG2743 Coenzyme transport and metabolism Cobalamin synthesis protein r_klactIII2129 check: MH O KOG0880 Posttranslational modification, protein turnover, chaperones Peptidyl-prolyl cis-trans isomerase r_klactIII2137 good UI KOG4540 Intracellular trafficking, secretion, and vesicular transport Putative lipase essential for disintegration of autophagic bodies inside the vacuole r_klactIII2137 good UI KOG4540 Lipid transport and metabolism Putative lipase essential for disintegration of autophagic bodies inside the vacuole r_klactIII2141 good H KOG2599 Coenzyme transport and metabolism Pyridoxal/pyridoxine/pyridoxamine kinase r_klactIII2153 suspect: LH U KOG0771 Intracellular trafficking, secretion, and vesicular transport Prolactin regulatory element-binding protein/Protein transport protein SEC12p r_klactIII2160 check: MH L KOG0287 Replication, recombination and repair Postreplication repair protein RAD18 r_klactIII2168 good K KOG2294 Transcription Transcription factor of the Forkhead/HNF3 family r_klactIII2174 good K KOG3404 Transcription G10 protein/predicted nuclear transcription regulator r_klactIII2206 good M KOG0916 Cell wall/membrane/envelope biogenesis 1,3-beta-glucan synthase/callose synthase catalytic subunit r_klactIII2207 good R KOG1124 General function prediction only FOG: TPR repeat r_klactIII2208 good S KOG3299 Function unknown Uncharacterized conserved protein r_klactIII2220 check: MH A KOG0291 RNA processing and modification WD40-repeat-containing subunit of the 18S rRNA processing complex r_klactIII2227 good S KOG2676 Function unknown Uncharacterized conserved protein r_klactIII2234 good E KOG2616 Amino acid transport and metabolism Pyridoxalphosphate-dependent enzyme/predicted threonine synthase r_klactIII2242 good BK KOG2570 Chromatin structure and dynamics SWI/SNF transcription activation complex subunit r_klactIII2242 good BK KOG2570 Transcription SWI/SNF transcription activation complex subunit r_klactIII2251 suspect: LH S KOG2357 Function unknown Uncharacterized conserved protein r_klactIII2254 check: MH R KOG0504 General function prediction only FOG: Ankyrin repeat r_klactIII2258 good L KOG3314 Replication, recombination and repair Ku70-binding protein r_klactIII2265 good I KOG0380 Lipid transport and metabolism Sterol O-acyltransferase/Diacylglycerol O-acyltransferase r_klactIII2268 suspect: LH U KOG3081 Intracellular trafficking, secretion, and vesicular transport Vesicle coat complex COPI, epsilon subunit r_klactIII2284 good F KOG1436 Nucleotide transport and metabolism Dihydroorotate dehydrogenase r_klactIII2288 good A KOG1272 RNA processing and modification WD40-repeat-containing subunit of the 18S rRNA processing complex r_klactIII2295 good O KOG2062 Posttranslational modification, protein turnover, chaperones 26S proteasome regulatory complex, subunit RPN2/PSMD1 r_klactIII2301 good E KOG0068 Amino acid transport and metabolism D-3-phosphoglycerate dehydrogenase, D-isomer-specific 2-hydroxy acid dehydrogenase superfamily r_klactIII2311 suspect: LH S KOG4814 Function unknown Uncharacterized conserved protein r_klactIII2332 good S KOG2722 Function unknown Predicted membrane protein r_klactIII2336 good O KOG3470 Posttranslational modification, protein turnover, chaperones Beta-tubulin folding cofactor A r_klactIII2350 good R KOG1533 General function prediction only Predicted GTPase r_klactIII2353 good O KOG1556 Posttranslational modification, protein turnover, chaperones 26S proteasome regulatory complex, subunit RPN8/PSMD7 r_klactIII2360 good H KOG1380 Coenzyme transport and metabolism Heme A farnesyltransferase r_klactIII2368 good J KOG1462 Translation, ribosomal structure and biogenesis Translation initiation factor 2B, gamma subunit (eIF-2Bgamma/GCD1) r_klactIII2373 check: MH O KOG0651 Posttranslational modification, protein turnover, chaperones 26S proteasome regulatory complex, ATPase RPT4 r_klactIII2376 good R KOG0562 General function prediction only Predicted hydrolase (HIT family) r_klactIII2385 check: MH ZD KOG0028 Cell cycle control, cell division, chromosome partitioning Ca2+-binding protein (centrin/caltractin), EF-Hand superfamily protein r_klactIII2385 check: MH ZD KOG0028 Cytoskeleton Ca2+-binding protein (centrin/caltractin), EF-Hand superfamily protein r_klactIII2392 suspect: %id ZR KOG4568 Cytoskeleton Cytoskeleton-associated protein and related proteins r_klactIII2392 suspect: %id ZR KOG4568 General function prediction only Cytoskeleton-associated protein and related proteins r_klactIII2398 good MOI KOG1111 Cell wall/membrane/envelope biogenesis N-acetylglucosaminyltransferase complex, subunit PIG-A/SPT14, required for phosphatidylinositol biosynthesis/Sulfolipid synthase r_klactIII2398 good MOI KOG1111 Lipid transport and metabolism N-acetylglucosaminyltransferase complex, subunit PIG-A/SPT14, required for phosphatidylinositol biosynthesis/Sulfolipid synthase r_klactIII2398 good MOI KOG1111 Posttranslational modification, protein turnover, chaperones N-acetylglucosaminyltransferase complex, subunit PIG-A/SPT14, required for phosphatidylinositol biosynthesis/Sulfolipid synthase r_klactIII2405 good OPR KOG2195 General function prediction only Transferrin receptor and related proteins containing the protease-associated (PA) domain r_klactIII2405 good OPR KOG2195 Inorganic ion transport and metabolism Transferrin receptor and related proteins containing the protease-associated (PA) domain r_klactIII2405 good OPR KOG2195 Posttranslational modification, protein turnover, chaperones Transferrin receptor and related proteins containing the protease-associated (PA) domain r_klactIII2410 good R KOG1110 General function prediction only Putative steroid membrane receptor Hpr6.6/25-Dx r_klactIII2419 good A KOG3763 RNA processing and modification mRNA export factor TAP/MEX67 r_klactIII2424 check: MH O KOG0721 Posttranslational modification, protein turnover, chaperones Molecular chaperone (DnaJ superfamily) r_klactIII2428 good R KOG3138 General function prediction only Predicted N-acetyltransferase r_klactIII2450 good L KOG0968 Replication, recombination and repair DNA polymerase zeta, catalytic subunit r_klactIII2453 good B KOG2084 Chromatin structure and dynamics Predicted histone tail methylase containing SET domain r_klactIII2457 good V KOG1529 Defense mechanisms Mercaptopyruvate sulfurtransferase/thiosulfate sulfurtransferase r_klactIII2461 good A KOG2749 RNA processing and modification mRNA cleavage and polyadenylation factor IA/II complex, subunit CLP1 r_klactIII2469 check: MH L KOG1977 Replication, recombination and repair DNA mismatch repair protein - MLH3 family r_klactIII2486.1 check: MH FR KOG3379 General function prediction only Diadenosine polyphosphate hydrolase and related proteins of the histidine triad (HIT) family r_klactIII2486.1 check: MH FR KOG3379 Nucleotide transport and metabolism Diadenosine polyphosphate hydrolase and related proteins of the histidine triad (HIT) family r_klactIII2493 good K KOG3169 Transcription RNA polymerase II transcriptional regulation mediator r_klactIII2497 check: MH O KOG0880 Posttranslational modification, protein turnover, chaperones Peptidyl-prolyl cis-trans isomerase r_klactIII2504 good MO KOG3144 Cell wall/membrane/envelope biogenesis Ethanolamine-P-transferase GPI11/PIG-F, involved in glycosylphosphatidylinositol anchor biosynthesis r_klactIII2504 good MO KOG3144 Posttranslational modification, protein turnover, chaperones Ethanolamine-P-transferase GPI11/PIG-F, involved in glycosylphosphatidylinositol anchor biosynthesis r_klactIII2511 good A KOG1896 RNA processing and modification mRNA cleavage and polyadenylation factor II complex, subunit CFT1 (CPSF subunit) r_klactIII2515 good E KOG1154 Amino acid transport and metabolism Gamma-glutamyl kinase r_klactIII2517 good S KOG4356 Function unknown Uncharacterized conserved protein r_klactIII2521 good R KOG1347 General function prediction only Uncharacterized membrane protein, predicted efflux pump r_klactIII2528 good KU KOG2773 Intracellular trafficking, secretion, and vesicular transport Apoptosis antagonizing transcription factor/protein transport protein r_klactIII2528 good KU KOG2773 Transcription Apoptosis antagonizing transcription factor/protein transport protein r_klactIII2533 good C KOG1662 Energy production and conversion Mitochondrial F1F0-ATP synthase, subunit OSCP/ATP5 r_klactIII2539 check: MH I KOG0874 Lipid transport and metabolism Sphingolipid hydroxylase r_klactIII2548 good U KOG1986 Intracellular trafficking, secretion, and vesicular transport Vesicle coat complex COPII, subunit SEC23 r_klactIII2552 suspect: Pn S KOG4674 Function unknown Uncharacterized conserved coiled-coil protein r_klactIII2562 good E KOG1383 Amino acid transport and metabolism Glutamate decarboxylase/sphingosine phosphate lyase r_klactIII2573 good S KOG4503 Function unknown Uncharacterized conserved membrane protein r_klactIII2578 check: MH E KOG2455 Amino acid transport and metabolism Delta-1-pyrroline-5-carboxylate dehydrogenase r_klactIII2590 good J KOG2102 Translation, ribosomal structure and biogenesis Exosomal 3'-5' exoribonuclease complex, subunit Rrp44/Dis3 r_klactIII2592 good J KOG4759 Translation, ribosomal structure and biogenesis Ribosome recycling factor r_klactIII2598 check: MH C KOG1772 Energy production and conversion Vacuolar H+-ATPase V1 sector, subunit G r_klactIII2600.1 check: MH C KOG1772 Energy production and conversion Vacuolar H+-ATPase V1 sector, subunit G r_klactIII2606 good R KOG2858 General function prediction only Uncharacterized conserved protein r_klactIII2614 good I KOG1600 Lipid transport and metabolism Fatty acid desaturase r_klactIII2620 good U KOG0781 Intracellular trafficking, secretion, and vesicular transport Signal recognition particle receptor, alpha subunit r_klactIII2628 check: MH A KOG4150 RNA processing and modification Predicted ATP-dependent RNA helicase r_klactIII2632 good A KOG2669 RNA processing and modification Regulator of nuclear mRNA r_klactIII2649 check: MH J KOG1035 Translation, ribosomal structure and biogenesis eIF-2alpha kinase GCN2 r_klactIII2654 good I KOG3030 Lipid transport and metabolism Lipid phosphate phosphatase and related enzymes of the PAP2 family r_klactIII2660 good CR KOG1198 Energy production and conversion Zinc-binding oxidoreductase r_klactIII2660 good CR KOG1198 General function prediction only Zinc-binding oxidoreductase r_klactIII2663 suspect: %id U KOG0946 Intracellular trafficking, secretion, and vesicular transport ER-Golgi vesicle-tethering protein p115 r_klactIII2673 good BK KOG2626 Chromatin structure and dynamics Histone H3 (Lys4) methyltransferase complex, subunit CPS60/ASH2/BRE2 r_klactIII2673 good BK KOG2626 Transcription Histone H3 (Lys4) methyltransferase complex, subunit CPS60/ASH2/BRE2 r_klactIII2675 good U KOG2273 Intracellular trafficking, secretion, and vesicular transport Membrane coat complex Retromer, subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins r_klactIII2679 good F KOG1018 Nucleotide transport and metabolism Cytosine deaminase FCY1 and related enzymes r_klactIII2683 good E KOG2551 Amino acid transport and metabolism Phospholipase/carboxyhydrolase r_klactIII2691 good EO KOG1046 Amino acid transport and metabolism Puromycin-sensitive aminopeptidase and related aminopeptidases r_klactIII2691 good EO KOG1046 Posttranslational modification, protein turnover, chaperones Puromycin-sensitive aminopeptidase and related aminopeptidases r_klactIII2706 good J KOG1614 Translation, ribosomal structure and biogenesis Exosomal 3'-5' exoribonuclease complex, subunit Rrp45 r_klactIII2714 good R KOG2914 General function prediction only Predicted haloacid-halidohydrolase and related hydrolases r_klactIII2717 good S KOG2861 Function unknown Uncharacterized conserved protein r_klactIII2726 good R KOG1134 General function prediction only Uncharacterized conserved protein r_klactIII2740 good J KOG0688 Translation, ribosomal structure and biogenesis Peptide chain release factor 1 (eRF1) r_klactIII2745 check: MH A KOG0347 RNA processing and modification RNA helicase r_klactIII2753 suspect: LH J KOG3311 Translation, ribosomal structure and biogenesis Ribosomal protein S18 r_klactIII2762 good L KOG1978 Replication, recombination and repair DNA mismatch repair protein - MLH2/PMS1/Pms2 family r_klactIII2773 check: MH F KOG0036 Nucleotide transport and metabolism Predicted mitochondrial carrier protein r_klactIII2781 good I KOG2763 Lipid transport and metabolism Acyl-CoA thioesterase r_klactIII2790 good TU KOG0998 Intracellular trafficking, secretion, and vesicular transport Synaptic vesicle protein EHS-1 and related EH domain proteins r_klactIII2790 good TU KOG0998 Signal transduction mechanisms Synaptic vesicle protein EHS-1 and related EH domain proteins r_klactIII2791 suspect: Pn K KOG1913 Transcription Regucalcin gene promoter region-related protein (RGPR) r_klactIII2794 check: MH O KOG0363 Posttranslational modification, protein turnover, chaperones Chaperonin complex component, TCP-1 beta subunit (CCT2) r_klactIII2802 suspect: LH R KOG3780 General function prediction only Thioredoxin binding protein TBP-2/VDUP1 r_klactIII2815 check: MH K KOG4210 Transcription Nuclear localization sequence binding protein r_klactIII2829 suspect: LH R KOG0017 General function prediction only FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations r_klactIII2846 good D KOG2464 Cell cycle control, cell division, chromosome partitioning Serine/threonine kinase (haspin family) r_klactIII2852 good O KOG2292 Posttranslational modification, protein turnover, chaperones Oligosaccharyltransferase, STT3 subunit r_klactIII2855 good P KOG3182 Inorganic ion transport and metabolism Predicted cation transporter r_klactIII2861 good R KOG2948 General function prediction only Predicted metal-binding protein r_klactIII2867 good U KOG2604 Intracellular trafficking, secretion, and vesicular transport Subunit of cis-Golgi transport vesicle tethering complex - Sec34p r_klactIII2869 suspect: LH S KOG3451 Function unknown Uncharacterized conserved protein r_klactIII2876 good U KOG2066 Intracellular trafficking, secretion, and vesicular transport Vacuolar assembly/sorting protein VPS41 r_klactIII2884 good BD KOG3105 Cell cycle control, cell division, chromosome partitioning DNA-binding centromere protein B (CENP-B) r_klactIII2884 good BD KOG3105 Chromatin structure and dynamics DNA-binding centromere protein B (CENP-B) r_klactIII2888 good I KOG3006 Lipid transport and metabolism Transthyretin and related proteins r_klactIII2897 good A KOG3045 RNA processing and modification Predicted RNA methylase involved in rRNA processing r_klactIII2901 good R KOG3195 General function prediction only Uncharacterized membrane protein NPD008/CGI-148 r_klactIII2921 check: MH R KOG0017 General function prediction only FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations r_klactIII2924 suspect: LH U KOG3498 Intracellular trafficking, secretion, and vesicular transport Preprotein translocase, gamma subunit r_klactIII2929 good A KOG3911 RNA processing and modification Nucleolar protein NOP52/RRP1 r_klactIII2932 check: MH R KOG0395 General function prediction only Ras-related GTPase r_klactIII2934 good J KOG2241 Translation, ribosomal structure and biogenesis tRNA-binding protein r_klactIII2942 good S KOG2890 Function unknown Predicted membrane protein r_klactIII2946 check: MH R KOG0017 General function prediction only FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations r_klactIII2956 suspect: HSP GO KOG4157 Carbohydrate transport and metabolism beta-1,6-N-acetylglucosaminyltransferase, contains WSC domain r_klactIII2956 suspect: HSP GO KOG4157 Posttranslational modification, protein turnover, chaperones beta-1,6-N-acetylglucosaminyltransferase, contains WSC domain r_klactIII2960 good S KOG2936 Function unknown Uncharacterized conserved protein r_klactIII2968 good IT KOG1435 Lipid transport and metabolism Sterol reductase/lamin B receptor r_klactIII2968 good IT KOG1435 Signal transduction mechanisms Sterol reductase/lamin B receptor r_klactIII2989 check: MH R KOG0017 General function prediction only FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations r_klactIII2996 good J KOG2050 Translation, ribosomal structure and biogenesis Puf family RNA-binding protein r_klactIII2999 suspect: LH U KOG2063 Intracellular trafficking, secretion, and vesicular transport Vacuolar assembly/sorting proteins VPS39/VAM6/VPS3 r_klactIII3004 good J KOG2278 Translation, ribosomal structure and biogenesis RNA:NAD 2'-phosphotransferase TPT1 r_klactIII3010 good RT KOG0748 General function prediction only Predicted membrane proteins, contain hemolysin III domain r_klactIII3010 good RT KOG0748 Signal transduction mechanisms Predicted membrane proteins, contain hemolysin III domain r_klactIII3021 check: MH T KOG0592 Signal transduction mechanisms 3-phosphoinositide-dependent protein kinase (PDK1) r_klactIII3024 good Z KOG0676 Cytoskeleton Actin and related proteins r_klactIII3025 good B KOG1745 Chromatin structure and dynamics Histones H3 and H4 r_klactIII3031 good D KOG2398 Cell cycle control, cell division, chromosome partitioning Predicted proline-serine-threonine phosphatase-interacting protein (PSTPIP) r_klactIII3048 good S KOG3481 Function unknown Uncharacterized conserved protein r_klactIII3059 good R KOG0725 General function prediction only Reductases with broad range of substrate specificities r_klactIII3062 good DZ KOG1727 Cell cycle control, cell division, chromosome partitioning Microtubule-binding protein (translationally controlled tumor protein) r_klactIII3062 good DZ KOG1727 Cytoskeleton Microtubule-binding protein (translationally controlled tumor protein) r_klactIII3068 good D KOG0642 Cell cycle control, cell division, chromosome partitioning Cell-cycle nuclear protein, contains WD-40 repeats r_klactIII3074 suspect: LH T KOG2830 Signal transduction mechanisms Protein phosphatase 2A-associated protein r_klactIII3077 good K KOG3463 Transcription Transcription initiation factor IIA, gamma subunit r_klactIII3082 good O KOG0314 Posttranslational modification, protein turnover, chaperones Predicted E3 ubiquitin ligase r_klactIII3088 good S KOG3870 Function unknown Uncharacterized conserved protein r_klactIII3091 check: MH U KOG0087 Intracellular trafficking, secretion, and vesicular transport GTPase Rab11/YPT3, small G protein superfamily r_klactIII3099 good L KOG2671 Replication, recombination and repair Putative RNA methylase r_klactIII3106 check: MH A KOG4205 RNA processing and modification RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 r_klactIII3117 good U KOG2667 Intracellular trafficking, secretion, and vesicular transport COPII vesicle protein r_klactIII3125 check: MH T KOG3519 Signal transduction mechanisms Invasion-inducing protein TIAM1/CDC24 and related RhoGEF GTPases r_klactIII3132 good C KOG2415 Energy production and conversion Electron transfer flavoprotein ubiquinone oxidoreductase r_klactIII3143 suspect: LH I KOG2508 Lipid transport and metabolism Predicted phospholipase r_klactIII3152 good D KOG0653 Cell cycle control, cell division, chromosome partitioning Cyclin B and related kinase-activating proteins r_klactIII3174 good CO KOG3996 Energy production and conversion Holocytochrome c synthase/heme-lyase r_klactIII3174 good CO KOG3996 Posttranslational modification, protein turnover, chaperones Holocytochrome c synthase/heme-lyase r_klactIII3180 good R KOG0619 General function prediction only FOG: Leucine rich repeat r_klactIII3192 suspect: LH T KOG3589 Signal transduction mechanisms G protein signaling regulators r_klactIII3210 good U KOG0811 Intracellular trafficking, secretion, and vesicular transport SNARE protein PEP12/VAM3/Syntaxin 7/Syntaxin 17 r_klactIII3220 good L KOG0970 Replication, recombination and repair DNA polymerase alpha, catalytic subunit r_klactIII3226 good E KOG1304 Amino acid transport and metabolism Amino acid transporters r_klactIII3240 good V KOG1572 Defense mechanisms Predicted protein tyrosine phosphatase r_klactIII3243 good DO KOG1746 Cell cycle control, cell division, chromosome partitioning Defender against cell death protein/oligosaccharyltransferase, epsilon subunit r_klactIII3243 good DO KOG1746 Posttranslational modification, protein turnover, chaperones Defender against cell death protein/oligosaccharyltransferase, epsilon subunit r_klactIII3247 good R KOG0395 General function prediction only Ras-related GTPase r_klactIII3252 normal B KOG1973 Chromatin structure and dynamics Chromatin remodeling protein, contains PHD Zn-finger r_klactIII3257 check: MH C KOG0758 Energy production and conversion Mitochondrial carnitine-acylcarnitine carrier protein r_klactIII3261 good G KOG4472 Carbohydrate transport and metabolism Glycolipid 2-alpha-mannosyltransferase (alpha-1,2-mannosyltransferase) r_klactIII3272 suspect: %id YU KOG4719 Intracellular trafficking, secretion, and vesicular transport Nuclear pore complex protein r_klactIII3272 suspect: %id YU KOG4719 Nuclear structure Nuclear pore complex protein r_klactIII3276.1 good J KOG3320 Translation, ribosomal structure and biogenesis 40S ribosomal protein S7 r_klactIII3280 suspect: LH J KOG3320 Translation, ribosomal structure and biogenesis 40S ribosomal protein S7 r_klactIII3287 good G KOG3075 Carbohydrate transport and metabolism Ribose 5-phosphate isomerase r_klactIII3291 check: MH U KOG0071 Intracellular trafficking, secretion, and vesicular transport GTP-binding ADP-ribosylation factor Arf6 (dArf3) r_klactIII3307 good R KOG3628 General function prediction only Predicted AMP-binding protein r_klactIII3310 suspect: Pn S KOG2722 Function unknown Predicted membrane protein r_klactIII3321 good R KOG1763 General function prediction only Uncharacterized conserved protein, contains CCCH-type Zn-finger r_klactIII3326 good T KOG0700 Signal transduction mechanisms Protein phosphatase 2C/pyruvate dehydrogenase (lipoamide) phosphatase r_klactIII3331 check: MH U KOG0092 Intracellular trafficking, secretion, and vesicular transport GTPase Rab5/YPT51 and related small G protein superfamily GTPases r_klactIII3336 good G KOG2798 Carbohydrate transport and metabolism Putative trehalase r_klactIII3343 suspect: Pn PT KOG3609 Inorganic ion transport and metabolism Receptor-activated Ca2+-permeable cation channels (STRPC family) r_klactIII3343 suspect: Pn PT KOG3609 Signal transduction mechanisms Receptor-activated Ca2+-permeable cation channels (STRPC family) r_klactIII3362 check: MH R KOG0393 General function prediction only Ras-related small GTPase, Rho type r_klactIII3377 good B KOG0355 Chromatin structure and dynamics DNA topoisomerase type II r_klactIII3395 good R KOG1012 General function prediction only Ca2+-dependent lipid-binding protein CLB1/vesicle protein vp115/Granuphilin A, contains C2 domain r_klactIII3400 good O KOG2603 Posttranslational modification, protein turnover, chaperones Oligosaccharyltransferase, gamma subunit r_klactIII3411 good O KOG1863 Posttranslational modification, protein turnover, chaperones Ubiquitin carboxyl-terminal hydrolase r_klactIII3418 good O KOG1863 Posttranslational modification, protein turnover, chaperones Ubiquitin carboxyl-terminal hydrolase r_klactIII3420 good R KOG3351 General function prediction only Predicted nucleotidyltransferase r_klactIII3425 good R KOG2140 General function prediction only Uncharacterized conserved protein r_klactIII3448 good M KOG0916 Cell wall/membrane/envelope biogenesis 1,3-beta-glucan synthase/callose synthase catalytic subunit r_klactIII3471 good AD KOG2809 Cell cycle control, cell division, chromosome partitioning Telomerase elongation inhibitor/RNA maturation protein PINX1 r_klactIII3471 good AD KOG2809 RNA processing and modification Telomerase elongation inhibitor/RNA maturation protein PINX1 r_klactIII3479 good YU KOG2171 Intracellular trafficking, secretion, and vesicular transport Karyopherin (importin) beta 3 r_klactIII3479 good YU KOG2171 Nuclear structure Karyopherin (importin) beta 3 r_klactIII3513 good Q KOG0054 Secondary metabolites biosynthesis, transport and catabolism Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily r_klactIII3520 good L KOG3997 Replication, recombination and repair Major apurinic/apyrimidinic endonuclease/3'-repair diesterase APN1 r_klactIII3526 check: MH R KOG0586 General function prediction only Serine/threonine protein kinase r_klactIII3528 good G KOG1594 Carbohydrate transport and metabolism Uncharacterized enzymes related to aldose 1-epimerase r_klactIII3530 good O KOG3158 Posttranslational modification, protein turnover, chaperones HSP90 co-chaperone p23 r_klactIII3545 good O KOG0803 Posttranslational modification, protein turnover, chaperones Predicted E3 ubiquitin ligase r_klactIII3552 good G KOG1950 Carbohydrate transport and metabolism Glycosyl transferase, family 8 - glycogenin r_klactIII3555 check: MH A KOG0131 RNA processing and modification Splicing factor 3b, subunit 4 r_klactIII3562 good T KOG0788 Signal transduction mechanisms S-adenosylmethionine decarboxylase r_klactIII3568 good E KOG1383 Amino acid transport and metabolism Glutamate decarboxylase/sphingosine phosphate lyase r_klactIII3581 suspect: Pn T KOG0531 Signal transduction mechanisms Protein phosphatase 1, regulatory subunit, and related proteins r_klactIII3586 good G KOG3221 Carbohydrate transport and metabolism Glycolipid transfer protein r_klactIII3596 good J KOG2072 Translation, ribosomal structure and biogenesis Translation initiation factor 3, subunit a (eIF-3a) r_klactIII3603 check: MH O KOG0741 Posttranslational modification, protein turnover, chaperones AAA+-type ATPase r_klactIII3608 good R KOG1729 General function prediction only FYVE finger containing protein r_klactIII3610 suspect: LH K KOG2857 Transcription Predicted MYND Zn-finger protein/hormone receptor interactor r_klactIII3616 good J KOG2963 Translation, ribosomal structure and biogenesis RNA-binding protein required for 60S ribosomal subunit biogenesis r_klactIII3620 check: MH A KOG0330 RNA processing and modification ATP-dependent RNA helicase r_klactIII3628 good KL KOG2074 Replication, recombination and repair RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB1 r_klactIII3628 good KL KOG2074 Transcription RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB1 r_klactIII3634 good O KOG0101 Posttranslational modification, protein turnover, chaperones Molecular chaperones HSP70/HSC70, HSP70 superfamily r_klactIII3647 good J KOG2363 Translation, ribosomal structure and biogenesis Protein subunit of nuclear ribonuclease P (RNase P) r_klactIII3663 suspect: LH K KOG1510 Transcription RNA polymerase II holoenzyme and mediator subcomplex, subunit SURB7/SRB7 r_klactIII3672 good O KOG3359 Posttranslational modification, protein turnover, chaperones Dolichyl-phosphate-mannose:protein O-mannosyl transferase r_klactIII3682 good O KOG3800 Posttranslational modification, protein turnover, chaperones Predicted E3 ubiquitin ligase containing RING finger, subunit of transcription/repair factor TFIIH and CDK-activating kinase assembly factor r_klactIII3686 good S KOG4066 Function unknown Cell growth regulatory protein CGR11 r_klactIII3692 suspect: LH J KOG4778 Translation, ribosomal structure and biogenesis Mitochondrial ribosomal protein L28 r_klactIII3721 good MOT KOG1550 Cell wall/membrane/envelope biogenesis Extracellular protein SEL-1 and related proteins r_klactIII3721 good MOT KOG1550 Posttranslational modification, protein turnover, chaperones Extracellular protein SEL-1 and related proteins r_klactIII3721 good MOT KOG1550 Signal transduction mechanisms Extracellular protein SEL-1 and related proteins r_klactIII3729 check: MH H KOG1360 Coenzyme transport and metabolism 5-aminolevulinate synthase r_klactIII3735 suspect: LH U KOG1792 Intracellular trafficking, secretion, and vesicular transport Reticulon r_klactIII3742 good CE KOG0453 Amino acid transport and metabolism Aconitase/homoaconitase (aconitase superfamily) r_klactIII3742 good CE KOG0453 Energy production and conversion Aconitase/homoaconitase (aconitase superfamily) r_klactIII3745.1 suspect: LH O KOG0907 Posttranslational modification, protein turnover, chaperones Thioredoxin r_klactIII3745 good H KOG2892 Coenzyme transport and metabolism Porphobilinogen deaminase r_klactIII3749 good A KOG1258 RNA processing and modification mRNA processing protein r_klactIII3755 good P KOG2399 Inorganic ion transport and metabolism K+-dependent Na+:Ca2+ antiporter r_klactIII3758 good H KOG3110 Coenzyme transport and metabolism Riboflavin kinase r_klactIII3763 good A KOG2412 RNA processing and modification Nuclear-export-signal (NES)-containing protein/polyadenylated-RNA export factor r_klactIII3770 good J KOG0398 Translation, ribosomal structure and biogenesis Mitochondrial/chloroplast ribosomal protein L5/L7 r_klactIII3776 check: MH U KOG1058 Intracellular trafficking, secretion, and vesicular transport Vesicle coat complex COPI, beta subunit r_klactIII3789 good A KOG3167 RNA processing and modification Box H/ACA snoRNP component, involved in ribosomal RNA pseudouridinylation r_klactIII3791 good R KOG0118 General function prediction only FOG: RRM domain r_klactIII3795 check: MH A KOG0333 RNA processing and modification U5 snRNP-like RNA helicase subunit r_klactIII3800 good R KOG1125 General function prediction only TPR repeat-containing protein r_klactIII3806 good GM KOG4748 Carbohydrate transport and metabolism Subunit of Golgi mannosyltransferase complex r_klactIII3806 good GM KOG4748 Cell wall/membrane/envelope biogenesis Subunit of Golgi mannosyltransferase complex r_klactIII3811 check: MH A KOG0331 RNA processing and modification ATP-dependent RNA helicase r_klactIII3819 good E KOG1289 Amino acid transport and metabolism Amino acid transporters r_klactIII3822 suspect: LH U KOG2273 Intracellular trafficking, secretion, and vesicular transport Membrane coat complex Retromer, subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins r_klactIII3830 suspect: LH U KOG4056 Intracellular trafficking, secretion, and vesicular transport Translocase of outer mitochondrial membrane complex, subunit TOM20 r_klactIII3846 good U KOG0929 Intracellular trafficking, secretion, and vesicular transport Guanine nucleotide exchange factor r_klactIII3848 good S KOG1705 Function unknown Uncharacterized conserved protein, contains CXXC motifs r_klactIII3852 good O KOG0800 Posttranslational modification, protein turnover, chaperones FOG: Predicted E3 ubiquitin ligase r_klactIII3855 good W KOG1747 Extracellular structures Protein tyrosine kinase 9/actin monomer-binding protein r_klactIII3876 good R KOG2238 General function prediction only Uncharacterized conserved protein TEX2, contains PH domain r_klactIII3894 check: MH TBLD KOG0890 Cell cycle control, cell division, chromosome partitioning Protein kinase of the PI-3 kinase family involved in mitotic growth, DNA repair and meiotic recombination r_klactIII3894 check: MH TBLD KOG0890 Chromatin structure and dynamics Protein kinase of the PI-3 kinase family involved in mitotic growth, DNA repair and meiotic recombination r_klactIII3894 check: MH TBLD KOG0890 Replication, recombination and repair Protein kinase of the PI-3 kinase family involved in mitotic growth, DNA repair and meiotic recombination r_klactIII3894 check: MH TBLD KOG0890 Signal transduction mechanisms Protein kinase of the PI-3 kinase family involved in mitotic growth, DNA repair and meiotic recombination r_klactIII3895 good D KOG3484 Cell cycle control, cell division, chromosome partitioning Cyclin-dependent protein kinase CDC28, regulatory subunit CKS1, and related proteins r_klactIII3900 good D KOG0822 Cell cycle control, cell division, chromosome partitioning Protein kinase inhibitor r_klactIII3916 good E KOG1286 Amino acid transport and metabolism Amino acid transporters r_klactIII3923 good K KOG2680 Transcription DNA helicase TIP49, TBP-interacting protein r_klactIII3925 good C KOG0232 Energy production and conversion Vacuolar H+-ATPase V0 sector, subunits c/c' r_klactIII3930 good U KOG0810 Intracellular trafficking, secretion, and vesicular transport SNARE protein Syntaxin 1 and related proteins r_klactIII3972 suspect: HSP R KOG1721 General function prediction only FOG: Zn-finger r_klactIII3993 good R KOG2977 General function prediction only Glycosyltransferase r_klactIII4007 check: MH EJ KOG0062 Amino acid transport and metabolism ATPase component of ABC transporters with duplicated ATPase domains/Translation elongation factor EF-3b r_klactIII4007 check: MH EJ KOG0062 Translation, ribosomal structure and biogenesis ATPase component of ABC transporters with duplicated ATPase domains/Translation elongation factor EF-3b r_klactIII4010 good EH KOG2644 Amino acid transport and metabolism 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes r_klactIII4010 good EH KOG2644 Coenzyme transport and metabolism 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes r_klactIII4011 good S KOG4093 Function unknown Uncharacterized conserved protein r_klactIII4015 good P KOG1485 Inorganic ion transport and metabolism Mitochondrial Fe2+ transporter MMT1 and related transporters (cation diffusion facilitator superfamily) r_klactIII4022 good R KOG1246 General function prediction only DNA-binding protein jumonji/RBP2/SMCY, contains JmjC domain r_klactIII4030 check: MH Z KOG1374 Cytoskeleton Gamma tubulin r_klactIII4033 good TZ KOG4035 Cytoskeleton Coeffector of mDia Rho GTPase, regulates actin polymerization and cell adhesion turnover r_klactIII4033 good TZ KOG4035 Signal transduction mechanisms Coeffector of mDia Rho GTPase, regulates actin polymerization and cell adhesion turnover r_klactIII4039 good O KOG1498 Posttranslational modification, protein turnover, chaperones 26S proteasome regulatory complex, subunit RPN5/PSMD12 r_klactIII4047 good J KOG2147 Translation, ribosomal structure and biogenesis Nucleolar protein involved in 40S ribosome biogenesis r_klactIII4057 good R KOG2173 General function prediction only Integral membrane protein r_klactIII4063 suspect: LH K KOG3122 Transcription DNA-directed RNA polymerase III subunit r_klactIII4066 good B KOG3118 Chromatin structure and dynamics Disrupter of silencing SAS10 r_klactIII4075 check: MH L KOG0221 Replication, recombination and repair Mismatch repair ATPase MSH5 (MutS family) r_klactIII4080 good D KOG0653 Cell cycle control, cell division, chromosome partitioning Cyclin B and related kinase-activating proteins r_klactIII4103 good S KOG4328 Function unknown WD40 protein r_klactIII4107 check: MH T KOG0581 Signal transduction mechanisms Mitogen-activated protein kinase kinase (MAP2K) r_klactIII4113 check: MH A KOG0326 RNA processing and modification ATP-dependent RNA helicase r_klactIII4123 good F KOG3984 Nucleotide transport and metabolism Purine nucleoside phosphorylase r_klactIII4127 check: MH U KOG1332 Intracellular trafficking, secretion, and vesicular transport Vesicle coat complex COPII, subunit SEC13 r_klactIII4136 good MOT KOG1550 Cell wall/membrane/envelope biogenesis Extracellular protein SEL-1 and related proteins r_klactIII4136 good MOT KOG1550 Posttranslational modification, protein turnover, chaperones Extracellular protein SEL-1 and related proteins r_klactIII4136 good MOT KOG1550 Signal transduction mechanisms Extracellular protein SEL-1 and related proteins r_klactIII4141 suspect: LH N KOG3896 Cell motility Dynactin, subunit p62 r_klactIII4149 suspect: HSP F KOG2056 Nucleotide transport and metabolism Equilibrative nucleoside transporter protein r_klactIII4151 good A KOG3503 RNA processing and modification H/ACA snoRNP complex, subunit NOP10 r_klactIII4159 good I KOG1737 Lipid transport and metabolism Oxysterol-binding protein r_klactIII4167 good P KOG0252 Inorganic ion transport and metabolism Inorganic phosphate transporter r_klactIII4173 good P KOG0252 Inorganic ion transport and metabolism Inorganic phosphate transporter r_klactIII4179 good Z KOG1376 Cytoskeleton Alpha tubulin r_klactIII4187 good V KOG4730 Defense mechanisms D-arabinono-1, 4-lactone oxidase r_klactIII4191 good HC KOG0534 Coenzyme transport and metabolism NADH-cytochrome b-5 reductase r_klactIII4191 good HC KOG0534 Energy production and conversion NADH-cytochrome b-5 reductase r_klactIII4196 suspect: LH R KOG0274 General function prediction only Cdc4 and related F-box and WD-40 proteins r_klactIII4204 good L KOG2228 Replication, recombination and repair Origin recognition complex, subunit 4 r_klactIII4213 good R KOG1729 General function prediction only FYVE finger containing protein r_klactIII4218 good E KOG0053 Amino acid transport and metabolism Cystathionine beta-lyases/cystathionine gamma-synthases r_klactIII4229 suspect: LH R KOG0017 General function prediction only FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations r_klactIII4235 good R KOG1721 General function prediction only FOG: Zn-finger r_klactIII4240 good DR KOG3433 Cell cycle control, cell division, chromosome partitioning Protein involved in meiotic recombination/predicted coiled-coil protein r_klactIII4240 good DR KOG3433 General function prediction only Protein involved in meiotic recombination/predicted coiled-coil protein r_klactIII4246 suspect: HSP T KOG0703 Signal transduction mechanisms Predicted GTPase-activating protein r_klactIII4250 check: MH OUT KOG0595 Intracellular trafficking, secretion, and vesicular transport Serine/threonine-protein kinase involved in autophagy r_klactIII4250 check: MH OUT KOG0595 Posttranslational modification, protein turnover, chaperones Serine/threonine-protein kinase involved in autophagy r_klactIII4250 check: MH OUT KOG0595 Signal transduction mechanisms Serine/threonine-protein kinase involved in autophagy r_klactIII4257 suspect: Pn G KOG4472 Carbohydrate transport and metabolism Glycolipid 2-alpha-mannosyltransferase (alpha-1,2-mannosyltransferase) r_klactIII4260 suspect: %id U KOG0946 Intracellular trafficking, secretion, and vesicular transport ER-Golgi vesicle-tethering protein p115 r_klactIII4273 check: MH O KOG0420 Posttranslational modification, protein turnover, chaperones Ubiquitin-protein ligase r_klactIII4295 check: MH T KOG0902 Signal transduction mechanisms Phosphatidylinositol 4-kinase r_klactIII4303 good CE KOG0453 Amino acid transport and metabolism Aconitase/homoaconitase (aconitase superfamily) r_klactIII4303 good CE KOG0453 Energy production and conversion Aconitase/homoaconitase (aconitase superfamily) r_klactIII4313 good G KOG2504 Carbohydrate transport and metabolism Monocarboxylate transporter r_klactIII4338 check: MH A KOG0344 RNA processing and modification ATP-dependent RNA helicase r_klactIII4342 suspect: LH C KOG4103 Energy production and conversion Mitochondrial F1F0-ATP synthase, subunit g/ATP20 r_klactIII4351 good E KOG2348 Amino acid transport and metabolism Urea transporter r_klactIII4360 good OE KOG1282 Amino acid transport and metabolism Serine carboxypeptidases (lysosomal cathepsin A) r_klactIII4360 good OE KOG1282 Posttranslational modification, protein turnover, chaperones Serine carboxypeptidases (lysosomal cathepsin A) r_klactIII4361.1 suspect: Pn T KOG0230 Signal transduction mechanisms Phosphatidylinositol-4-phosphate 5-kinase and related FYVE finger-containing proteins r_klactIII4364 check: MH L KOG0478 Replication, recombination and repair DNA replication licensing factor, MCM4 component r_klactIII4373 good T KOG2126 Signal transduction mechanisms Glycosylphosphatidylinositol anchor synthesis protein r_klactIII4378 check: MH A KOG0063 RNA processing and modification RNAse L inhibitor, ABC superfamily r_klactIII4388 check: MH K KOG0384 Transcription Chromodomain-helicase DNA-binding protein r_klactIII4395 check: MH AJ KOG0123 RNA processing and modification Polyadenylate-binding protein (RRM superfamily) r_klactIII4395 check: MH AJ KOG0123 Translation, ribosomal structure and biogenesis Polyadenylate-binding protein (RRM superfamily) r_klactIII4398 good O KOG0417 Posttranslational modification, protein turnover, chaperones Ubiquitin-protein ligase r_klactIII4417 good R KOG0206 General function prediction only P-type ATPase r_klactIII4434 good J KOG2159 Translation, ribosomal structure and biogenesis tRNA nucleotidyltransferase/poly(A) polymerase r_klactIII4443 check: MH L KOG0958 Replication, recombination and repair DNA damage-responsive repressor GIS1/RPH1, jumonji superfamily r_klactIII4454 good L KOG0217 Replication, recombination and repair Mismatch repair ATPase MSH6 (MutS family) r_klactIII4457 good F KOG3078 Nucleotide transport and metabolism Adenylate kinase r_klactIII4465 good KL KOG1131 Replication, recombination and repair RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, 5'-3' helicase subunit RAD3 r_klactIII4465 good KL KOG1131 Transcription RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, 5'-3' helicase subunit RAD3 r_klactIII4478 check: MH A KOG0951 RNA processing and modification RNA helicase BRR2, DEAD-box superfamily r_klactIII4482 good DL KOG1970 Cell cycle control, cell division, chromosome partitioning Checkpoint RAD17-RFC complex, RAD17/RAD24 component r_klactIII4482 good DL KOG1970 Replication, recombination and repair Checkpoint RAD17-RFC complex, RAD17/RAD24 component r_klactIII4486 check: MH R KOG0017 General function prediction only FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations r_klactIII4492 good R KOG3010 General function prediction only Methyltransferase r_klactIII4507 good R KOG2382 General function prediction only Predicted alpha/beta hydrolase r_klactIII4523 suspect: LH A KOG2253 RNA processing and modification U1 snRNP complex, subunit SNU71 and related PWI-motif proteins r_klactIII4528 check: MH E KOG1481 Amino acid transport and metabolism Cysteine synthase r_klactIII4536 good H KOG3199 Coenzyme transport and metabolism Nicotinamide mononucleotide adenylyl transferase r_klactIII4548 good I KOG2803 Lipid transport and metabolism Choline phosphate cytidylyltransferase/Predicted CDP-ethanolamine synthase r_klactIII4556 good A KOG2808 RNA processing and modification U5 snRNP-associated RNA splicing factor r_klactIII4559 suspect: LH K KOG2905 Transcription Transcription initiation factor IIF, small subunit (RAP30) r_klactIII4560 good J KOG3499 Translation, ribosomal structure and biogenesis 60S ribosomal protein L38 r_klactIII4567 suspect: LH R KOG3669 General function prediction only Uncharacterized conserved protein, contains dysferlin, TECPR and PH domains r_klactIII4569 good O KOG1813 Posttranslational modification, protein turnover, chaperones Predicted E3 ubiquitin ligase r_klactIII4572 good D KOG2166 Cell cycle control, cell division, chromosome partitioning Cullins r_klactIII4577 good BK KOG2656 Chromatin structure and dynamics DNA methyltransferase 1-associated protein-1 r_klactIII4577 good BK KOG2656 Transcription DNA methyltransferase 1-associated protein-1 r_klactIII4594 suspect: LH S KOG4674 Function unknown Uncharacterized conserved coiled-coil protein r_klactIII4600 good LB KOG1005 Chromatin structure and dynamics Telomerase catalytic subunit/reverse transcriptase TERT r_klactIII4600 good LB KOG1005 Replication, recombination and repair Telomerase catalytic subunit/reverse transcriptase TERT r_klactIII4602 good A KOG2771 RNA processing and modification Subunit of tRNA-specific adenosine-34 deaminase r_klactIII4612 good BK KOG1649 Chromatin structure and dynamics SWI-SNF chromatin remodeling complex, Snf5 subunit r_klactIII4612 good BK KOG1649 Transcription SWI-SNF chromatin remodeling complex, Snf5 subunit r_klactIII4615.1 suspect: Pn K KOG1668 Transcription Elongation factor 1 beta/delta chain r_klactIII4617 good K KOG1668 Transcription Elongation factor 1 beta/delta chain r_klactIII4624 suspect: LH U KOG2079 Intracellular trafficking, secretion, and vesicular transport Vacuolar assembly/sorting protein VPS8 r_klactIII4629 good IE KOG1430 Amino acid transport and metabolism C-3 sterol dehydrogenase/3-beta-hydroxysteroid dehydrogenase and related dehydrogenases r_klactIII4629 good IE KOG1430 Lipid transport and metabolism C-3 sterol dehydrogenase/3-beta-hydroxysteroid dehydrogenase and related dehydrogenases r_klactIII4632 good S KOG1088 Function unknown Uncharacterized conserved protein r_klactIII4635 check: MH R KOG0610 General function prediction only Putative serine/threonine protein kinase r_klactIII4641 check: MH L KOG0218 Replication, recombination and repair Mismatch repair MSH3 r_klactIII4655 good K KOG1831 Transcription Negative regulator of transcription r_klactIII4659 good DKT KOG2952 Cell cycle control, cell division, chromosome partitioning Cell cycle control protein r_klactIII4659 good DKT KOG2952 Signal transduction mechanisms Cell cycle control protein r_klactIII4659 good DKT KOG2952 Transcription Cell cycle control protein r_klactIII4662 check: MH O KOG0418 Posttranslational modification, protein turnover, chaperones Ubiquitin-protein ligase r_klactIII4671 good G KOG2533 Carbohydrate transport and metabolism Permease of the major facilitator superfamily r_klactIII4687 good E KOG1939 Amino acid transport and metabolism Oxoprolinase r_klactIII4692 good E KOG0172 Amino acid transport and metabolism Lysine-ketoglutarate reductase/saccharopine dehydrogenase r_klactIII4701 good V KOG1572 Defense mechanisms Predicted protein tyrosine phosphatase r_klactIII4705 suspect: LH T KOG0116 Signal transduction mechanisms RasGAP SH3 binding protein rasputin, contains NTF2 and RRM domains r_klactIII4714 good A KOG0304 RNA processing and modification mRNA deadenylase subunit r_klactIII4719 good R KOG2423 General function prediction only Nucleolar GTPase r_klactIII4722 good R KOG2423 General function prediction only Nucleolar GTPase r_klactIII4726 good K KOG3152 Transcription TBP-binding protein, activator of basal transcription (contains rrm motif) r_klactIII4734 good R KOG2742 General function prediction only Predicted oxidoreductase r_klactIII4739 good E KOG2348 Amino acid transport and metabolism Urea transporter r_klactIII4751 suspect: %id R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactIII4767 good E KOG1939 Amino acid transport and metabolism Oxoprolinase r_klactIII4773 good G KOG2533 Carbohydrate transport and metabolism Permease of the major facilitator superfamily r_klactIII4792 good F KOG2584 Nucleotide transport and metabolism Dihydroorotase and related enzymes r_klactIII4818 suspect: Pn PT KOG3599 Inorganic ion transport and metabolism Ca2+-modulated nonselective cation channel polycystin r_klactIII4818 suspect: Pn PT KOG3599 Signal transduction mechanisms Ca2+-modulated nonselective cation channel polycystin r_klactIII4833 suspect: %id Q KOG0158 Secondary metabolites biosynthesis, transport and catabolism Cytochrome P450 CYP3/CYP5/CYP6/CYP9 subfamilies r_klactIII4853 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactIII4879 good R KOG1382 General function prediction only Multiple inositol polyphosphate phosphatase r_klactIII4883 good F KOG1436 Nucleotide transport and metabolism Dihydroorotate dehydrogenase r_klactIII4891 good C KOG3857 Energy production and conversion Alcohol dehydrogenase, class IV r_klactIII4902 check: MH R KOG0017 General function prediction only FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations r_klactIII4903 check: MH R KOG0017 General function prediction only FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations r_klactIII4937 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactIII4938 suspect: LH O KOG2903 Posttranslational modification, protein turnover, chaperones Predicted glutathione S-transferase r_klactIII4942 good O KOG2903 Posttranslational modification, protein turnover, chaperones Predicted glutathione S-transferase r_klactIII4944 suspect: LH G KOG1203 Carbohydrate transport and metabolism Predicted dehydrogenase r_klactIV0012 suspect: Pn QR KOG0143 General function prediction only Iron/ascorbate family oxidoreductases r_klactIV0012 suspect: Pn QR KOG0143 Secondary metabolites biosynthesis, transport and catabolism Iron/ascorbate family oxidoreductases r_klactIV0022.1 good G KOG2504 Carbohydrate transport and metabolism Monocarboxylate transporter r_klactIV0022 good G KOG2504 Carbohydrate transport and metabolism Monocarboxylate transporter r_klactIV0044.1 suspect: LH P KOG4480 Inorganic ion transport and metabolism Heme oxygenase r_klactIV0045 good G KOG0471 Carbohydrate transport and metabolism Alpha-amylase r_klactIV0052 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactIV0061 good R KOG1382 General function prediction only Multiple inositol polyphosphate phosphatase r_klactIV0107 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactIV0128 suspect: LH O KOG2879 Posttranslational modification, protein turnover, chaperones Predicted E3 ubiquitin ligase r_klactIV0132 good F KOG3721 Nucleotide transport and metabolism Mitochondrial endonuclease r_klactIV0138 good LT KOG0133 Replication, recombination and repair Deoxyribodipyrimidine photolyase/cryptochrome r_klactIV0138 good LT KOG0133 Signal transduction mechanisms Deoxyribodipyrimidine photolyase/cryptochrome r_klactIV0153 good O KOG4127 Posttranslational modification, protein turnover, chaperones Renal dipeptidase r_klactIV0166 suspect: Pn E KOG1939 Amino acid transport and metabolism Oxoprolinase r_klactIV0173 check: MH R KOG0017 General function prediction only FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations r_klactIV0181 good A KOG0820 RNA processing and modification Ribosomal RNA adenine dimethylase r_klactIV0197 good T KOG0169 Signal transduction mechanisms Phosphoinositide-specific phospholipase C r_klactIV0219 suspect: LH U KOG0946 Intracellular trafficking, secretion, and vesicular transport ER-Golgi vesicle-tethering protein p115 r_klactIV0224 check: MH U KOG0058 Intracellular trafficking, secretion, and vesicular transport Peptide exporter, ABC superfamily r_klactIV0228 suspect: LH C KOG3495 Energy production and conversion Mitochondrial F1F0-ATP synthase, subunit epsilon/ATP15 r_klactIV0240 good K KOG1926 Transcription Predicted regulator of rRNA gene transcription (MYB-binding protein) r_klactIV0244 check: MH B KOG0264 Chromatin structure and dynamics Nucleosome remodeling factor, subunit CAF1/NURF55/MSI1 r_klactIV0252 check: MH R KOG1230 General function prediction only Protein containing repeated kelch motifs r_klactIV0256 good G KOG2537 Carbohydrate transport and metabolism Phosphoglucomutase/phosphomannomutase r_klactIV0265 good C KOG1317 Energy production and conversion Fumarase r_klactIV0276 good O KOG1153 Posttranslational modification, protein turnover, chaperones Subtilisin-related protease/Vacuolar protease B r_klactIV0283 good R KOG3164 General function prediction only Uncharacterized proteins of PilT N-term./Vapc superfamily r_klactIV0291 check: MH Z KOG0243 Cytoskeleton Kinesin-like protein r_klactIV0297 good P KOG3789 Inorganic ion transport and metabolism Nitrogen permease regulator NLRG/NPR2 r_klactIV0311 good L KOG0966 Replication, recombination and repair ATP-dependent DNA ligase IV r_klactIV0316 good S KOG3154 Function unknown Uncharacterized conserved protein r_klactIV0326 check: MH R KOG0553 General function prediction only TPR repeat-containing protein r_klactIV0335 good GE KOG2575 Amino acid transport and metabolism Glucosyltransferase - Alg6p r_klactIV0335 good GE KOG2575 Carbohydrate transport and metabolism Glucosyltransferase - Alg6p r_klactIV0343 check: MH R KOG0394 General function prediction only Ras-related GTPase r_klactIV0351 good R KOG1674 General function prediction only Cyclin r_klactIV0361 good J KOG2206 Translation, ribosomal structure and biogenesis Exosome 3'-5' exoribonuclease complex, subunit PM/SCL-100 (Rrp6) r_klactIV0368 good RT KOG0748 General function prediction only Predicted membrane proteins, contain hemolysin III domain r_klactIV0368 good RT KOG0748 Signal transduction mechanisms Predicted membrane proteins, contain hemolysin III domain r_klactIV0375 good A KOG2634 RNA processing and modification Initiator tRNA phosphoribosyl-transferase r_klactIV0384 good M KOG3332 Cell wall/membrane/envelope biogenesis N-acetylglucosaminyl phosphatidylinositol de-N-acetylase r_klactIV0417 good R KOG0118 General function prediction only FOG: RRM domain r_klactIV0424 good O KOG1339 Posttranslational modification, protein turnover, chaperones Aspartyl protease r_klactIV0435 good E KOG1579 Amino acid transport and metabolism Homocysteine S-methyltransferase r_klactIV0442 good G KOG1220 Carbohydrate transport and metabolism Phosphoglucomutase/phosphomannomutase r_klactIV0449 good K KOG0323 Transcription TFIIF-interacting CTD phosphatases, including NLI-interacting factor r_klactIV0456 suspect: LH K KOG4336 Transcription TBP-associated transcription factor Prodos r_klactIV0460 check: MH I KOG0539 Lipid transport and metabolism Sphingolipid fatty acid hydroxylase r_klactIV0480 good O KOG4130 Posttranslational modification, protein turnover, chaperones Prenyl protein protease r_klactIV0489 good H KOG1540 Coenzyme transport and metabolism Ubiquinone biosynthesis methyltransferase COQ5 r_klactIV0513 check: MH OR KOG0010 General function prediction only Ubiquitin-like protein r_klactIV0513 check: MH OR KOG0010 Posttranslational modification, protein turnover, chaperones Ubiquitin-like protein r_klactIV0523 good F KOG1377 Nucleotide transport and metabolism Uridine 5'- monophosphate synthase/orotate phosphoribosyltransferase r_klactIV0528 good U KOG3198 Intracellular trafficking, secretion, and vesicular transport Signal recognition particle, subunit Srp19 r_klactIV0537 good ZUD KOG2101 Cell cycle control, cell division, chromosome partitioning Intermediate filament-like protein, sorting nexins, and related proteins containing PX (PhoX) domain(s) r_klactIV0537 good ZUD KOG2101 Cytoskeleton Intermediate filament-like protein, sorting nexins, and related proteins containing PX (PhoX) domain(s) r_klactIV0537 good ZUD KOG2101 Intracellular trafficking, secretion, and vesicular transport Intermediate filament-like protein, sorting nexins, and related proteins containing PX (PhoX) domain(s) r_klactIV0542 normal AD KOG2809 Cell cycle control, cell division, chromosome partitioning Telomerase elongation inhibitor/RNA maturation protein PINX1 r_klactIV0542 normal AD KOG2809 RNA processing and modification Telomerase elongation inhibitor/RNA maturation protein PINX1 r_klactIV0552 good U KOG3065 Intracellular trafficking, secretion, and vesicular transport SNAP-25 (synaptosome-associated protein) component of SNARE complex r_klactIV0554 good J KOG3185 Translation, ribosomal structure and biogenesis Translation initiation factor 6 (eIF-6) r_klactIV0563 suspect: LH T KOG4363 Signal transduction mechanisms Putative growth response protein r_klactIV0575 good O KOG1357 Posttranslational modification, protein turnover, chaperones Serine palmitoyltransferase r_klactIV0581 good R KOG0927 General function prediction only Predicted transporter (ABC superfamily) r_klactIV0586 suspect: LH S KOG2913 Function unknown Predicted membrane protein r_klactIV0598 suspect: HSP TU KOG0998 Intracellular trafficking, secretion, and vesicular transport Synaptic vesicle protein EHS-1 and related EH domain proteins r_klactIV0598 suspect: HSP TU KOG0998 Signal transduction mechanisms Synaptic vesicle protein EHS-1 and related EH domain proteins r_klactIV0604 good S KOG3783 Function unknown Uncharacterized conserved protein r_klactIV0610 good O KOG1815 Posttranslational modification, protein turnover, chaperones Predicted E3 ubiquitin ligase r_klactIV0614 check: MH Z KOG0679 Cytoskeleton Actin-related protein - Arp4p/Act3p r_klactIV0619 good M KOG1854 Cell wall/membrane/envelope biogenesis Mitochondrial inner membrane protein (mitofilin) r_klactIV0633 check: MH U KOG0092 Intracellular trafficking, secretion, and vesicular transport GTPase Rab5/YPT51 and related small G protein superfamily GTPases r_klactIV0645 good I KOG2208 Lipid transport and metabolism Vigilin r_klactIV0646 good S KOG3017 Function unknown Defense-related protein containing SCP domain r_klactIV0655 suspect: HSP S KOG3017 Function unknown Defense-related protein containing SCP domain r_klactIV0662 good S KOG3274 Function unknown Uncharacterized conserved protein, AMMECR1 r_klactIV0666 good O KOG0191 Posttranslational modification, protein turnover, chaperones Thioredoxin/protein disulfide isomerase r_klactIV0669 good J KOG3203 Translation, ribosomal structure and biogenesis Mitochondrial/chloroplast ribosomal protein L13 r_klactIV0679 check: MH Z KOG0303 Cytoskeleton Actin-binding protein Coronin, contains WD40 repeats r_klactIV0686 good O KOG2164 Posttranslational modification, protein turnover, chaperones Predicted E3 ubiquitin ligase r_klactIV0687 suspect: LH U KOG4072 Intracellular trafficking, secretion, and vesicular transport Signal peptidase complex, subunit SPC25 r_klactIV0690 good Q KOG1201 Secondary metabolites biosynthesis, transport and catabolism Hydroxysteroid 17-beta dehydrogenase 11 r_klactIV0699 good T KOG4305 Signal transduction mechanisms RhoGEF GTPase r_klactIV0706 good C KOG0538 Energy production and conversion Glycolate oxidase r_klactIV0711 good U KOG0861 Intracellular trafficking, secretion, and vesicular transport SNARE protein YKT6, synaptobrevin/VAMP syperfamily r_klactIV0715 good S KOG4149 Function unknown Uncharacterized conserved protein r_klactIV0718 good A KOG2184 RNA processing and modification Tuftelin-interacting protein TIP39, contains G-patch domain r_klactIV0728 good J KOG1637 Translation, ribosomal structure and biogenesis Threonyl-tRNA synthetase r_klactIV0732 good R KOG2105 General function prediction only Predicted metal-dependent hydrolase, contains AlaS domain r_klactIV0736 good T KOG0531 Signal transduction mechanisms Protein phosphatase 1, regulatory subunit, and related proteins r_klactIV0742 good CIQ KOG1748 Energy production and conversion Acyl carrier protein/NADH-ubiquinone oxidoreductase, NDUFAB1/SDAP subunit r_klactIV0742 good CIQ KOG1748 Lipid transport and metabolism Acyl carrier protein/NADH-ubiquinone oxidoreductase, NDUFAB1/SDAP subunit r_klactIV0742 good CIQ KOG1748 Secondary metabolites biosynthesis, transport and catabolism Acyl carrier protein/NADH-ubiquinone oxidoreductase, NDUFAB1/SDAP subunit r_klactIV0754 good T KOG1998 Signal transduction mechanisms Signaling protein DOCK180 r_klactIV0755 suspect: LH R KOG3037 General function prediction only Cell membrane glycoprotein r_klactIV0761 good F KOG2902 Nucleotide transport and metabolism Dihydroorotase r_klactIV0767 good J KOG2648 Translation, ribosomal structure and biogenesis Diphthamide biosynthesis protein r_klactIV0773 good G KOG2533 Carbohydrate transport and metabolism Permease of the major facilitator superfamily r_klactIV0776 check: MH T KOG0034 Signal transduction mechanisms Ca2+/calmodulin-dependent protein phosphatase (calcineurin subunit B), EF-Hand superfamily protein r_klactIV0783 good K KOG3786 Transcription RNA polymerase II assessory factor Cdc73p r_klactIV0793 good A KOG0920 RNA processing and modification ATP-dependent RNA helicase A r_klactIV0800 good L KOG3084 Replication, recombination and repair NADH pyrophosphatase I of the Nudix family of hydrolases r_klactIV0809 good T KOG1164 Signal transduction mechanisms Casein kinase (serine/threonine/tyrosine protein kinase) r_klactIV0816 check: MH T KOG0616 Signal transduction mechanisms cAMP-dependent protein kinase catalytic subunit (PKA) r_klactIV0820 good J KOG1715 Translation, ribosomal structure and biogenesis Mitochondrial/chloroplast ribosomal protein L12 r_klactIV0821 good K KOG2691 Transcription RNA polymerase II subunit 9 r_klactIV0855 good K KOG0627 Transcription Heat shock transcription factor r_klactIV0863 good C KOG1231 Energy production and conversion Proteins containing the FAD binding domain r_klactIV0868 suspect: LH L KOG2401 Replication, recombination and repair Predicted MutS-related protein involved in mismatch repair r_klactIV0875.1 suspect: LH R KOG0017 General function prediction only FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations r_klactIV0876.1 good J KOG3184 Translation, ribosomal structure and biogenesis 60S ribosomal protein L7 r_klactIV0876.2 suspect: LH OPR KOG2195 General function prediction only Transferrin receptor and related proteins containing the protease-associated (PA) domain r_klactIV0876.2 suspect: LH OPR KOG2195 Inorganic ion transport and metabolism Transferrin receptor and related proteins containing the protease-associated (PA) domain r_klactIV0876.2 suspect: LH OPR KOG2195 Posttranslational modification, protein turnover, chaperones Transferrin receptor and related proteins containing the protease-associated (PA) domain r_klactIV0888 check: MH Q KOG0065 Secondary metabolites biosynthesis, transport and catabolism Pleiotropic drug resistance proteins (PDR1-15), ABC superfamily r_klactIV0897 good FH KOG2466 Coenzyme transport and metabolism Uridine permease/thiamine transporter/allantoin transport r_klactIV0897 good FH KOG2466 Nucleotide transport and metabolism Uridine permease/thiamine transporter/allantoin transport r_klactIV0915 check: MH Q KOG0065 Secondary metabolites biosynthesis, transport and catabolism Pleiotropic drug resistance proteins (PDR1-15), ABC superfamily r_klactIV0921 good M KOG2571 Cell wall/membrane/envelope biogenesis Chitin synthase/hyaluronan synthase (glycosyltransferases) r_klactIV0935 good M KOG2571 Cell wall/membrane/envelope biogenesis Chitin synthase/hyaluronan synthase (glycosyltransferases) r_klactIV0940 good R KOG1491 General function prediction only Predicted GTP-binding protein (ODN superfamily) r_klactIV0945 good C KOG2792 Energy production and conversion Putative cytochrome C oxidase assembly protein r_klactIV0949 check: MH DT KOG0373 Cell cycle control, cell division, chromosome partitioning Serine/threonine specific protein phosphatase involved in cell cycle control, PP2A-related r_klactIV0949 check: MH DT KOG0373 Signal transduction mechanisms Serine/threonine specific protein phosphatase involved in cell cycle control, PP2A-related r_klactIV0954 good D KOG2688 Cell cycle control, cell division, chromosome partitioning Transcription-associated recombination protein - Thp1p r_klactIV0961 good F KOG0888 Nucleotide transport and metabolism Nucleoside diphosphate kinase r_klactIV0967 suspect: LH A KOG1295 RNA processing and modification Nonsense-mediated decay protein Upf3 r_klactIV0969 suspect: LH S KOG4643 Function unknown Uncharacterized coiled-coil protein r_klactIV0976 good A KOG3428 RNA processing and modification Small nuclear ribonucleoprotein SMD1 and related snRNPs r_klactIV0987 check: MH J KOG0556 Translation, ribosomal structure and biogenesis Aspartyl-tRNA synthetase r_klactIV0997 good R KOG0289 General function prediction only mRNA splicing factor r_klactIV1001 good O KOG1651 Posttranslational modification, protein turnover, chaperones Glutathione peroxidase r_klactIV1011 good F KOG2056 Nucleotide transport and metabolism Equilibrative nucleoside transporter protein r_klactIV1014 good C KOG3477 Energy production and conversion Putative cytochrome c oxidase, subunit COX19 r_klactIV1025 good E KOG0053 Amino acid transport and metabolism Cystathionine beta-lyases/cystathionine gamma-synthases r_klactIV1040 good Q KOG0054 Secondary metabolites biosynthesis, transport and catabolism Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily r_klactIV1059 good P KOG0207 Inorganic ion transport and metabolism Cation transport ATPase r_klactIV1065 good DZU KOG2655 Cell cycle control, cell division, chromosome partitioning Septin family protein (P-loop GTPase) r_klactIV1065 good DZU KOG2655 Cytoskeleton Septin family protein (P-loop GTPase) r_klactIV1065 good DZU KOG2655 Intracellular trafficking, secretion, and vesicular transport Septin family protein (P-loop GTPase) r_klactIV1069 good BD KOG4563 Cell cycle control, cell division, chromosome partitioning Cell cycle-regulated histone H1-binding protein r_klactIV1069 good BD KOG4563 Chromatin structure and dynamics Cell cycle-regulated histone H1-binding protein r_klactIV1077 suspect: HSP K KOG0048 Transcription Transcription factor, Myb superfamily r_klactIV1101 suspect: LH S KOG4002 Function unknown Uncharacterized integral membrane protein r_klactIV1104.1 suspect: Pn R KOG0619 General function prediction only FOG: Leucine rich repeat r_klactIV1104.2 suspect: LH C KOG2759 Energy production and conversion Vacuolar H+-ATPase V1 sector, subunit H r_klactIV1104.3 suspect: Pn R KOG2096 General function prediction only WD40 repeat protein r_klactIV1104 good O KOG0101 Posttranslational modification, protein turnover, chaperones Molecular chaperones HSP70/HSC70, HSP70 superfamily r_klactIV1110 check: MH C KOG0752 Energy production and conversion Mitochondrial solute carrier protein r_klactIV1111 good C KOG0752 Energy production and conversion Mitochondrial solute carrier protein r_klactIV1122 suspect: %id F KOG1292 Nucleotide transport and metabolism Xanthine/uracil transporters r_klactIV1126 good S KOG2972 Function unknown Uncharacterized conserved protein r_klactIV1130 good C KOG3432 Energy production and conversion Vacuolar H+-ATPase V1 sector, subunit F r_klactIV1135 suspect: LH S KOG1181 Function unknown FOG: Low-complexity r_klactIV1145 good C KOG2403 Energy production and conversion Succinate dehydrogenase, flavoprotein subunit r_klactIV1154 good A KOG2863 RNA processing and modification RNA lariat debranching enzyme r_klactIV1157 good HC KOG0534 Coenzyme transport and metabolism NADH-cytochrome b-5 reductase r_klactIV1157 good HC KOG0534 Energy production and conversion NADH-cytochrome b-5 reductase r_klactIV1166 good G KOG3974 Carbohydrate transport and metabolism Predicted sugar kinase r_klactIV1169 good K KOG3233 Transcription RNA polymerase III, subunit C34 r_klactIV1177 check: MH Q KOG0061 Secondary metabolites biosynthesis, transport and catabolism Transporter, ABC superfamily (Breast cancer resistance protein) r_klactIV1181 good O KOG3946 Posttranslational modification, protein turnover, chaperones Glutaminyl cyclase r_klactIV1198 check: MH T KOG0230 Signal transduction mechanisms Phosphatidylinositol-4-phosphate 5-kinase and related FYVE finger-containing proteins r_klactIV1204 good S KOG2110 Function unknown Uncharacterized conserved protein, contains WD40 repeats r_klactIV1212 good R KOG3780 General function prediction only Thioredoxin binding protein TBP-2/VDUP1 r_klactIV1221 check: MH OU KOG2391 Intracellular trafficking, secretion, and vesicular transport Vacuolar sorting protein/ubiquitin receptor VPS23 r_klactIV1221 check: MH OU KOG2391 Posttranslational modification, protein turnover, chaperones Vacuolar sorting protein/ubiquitin receptor VPS23 r_klactIV1230 suspect: %id U KOG0946 Intracellular trafficking, secretion, and vesicular transport ER-Golgi vesicle-tethering protein p115 r_klactIV1233 good J KOG2529 Translation, ribosomal structure and biogenesis Pseudouridine synthase r_klactIV1239 good O KOG0714 Posttranslational modification, protein turnover, chaperones Molecular chaperone (DnaJ superfamily) r_klactIV1246 check: MH R KOG0315 General function prediction only G-protein beta subunit-like protein (contains WD40 repeats) r_klactIV1255 good K KOG3712 Transcription RFX family transcription factor r_klactIV1263 good J KOG3184 Translation, ribosomal structure and biogenesis 60S ribosomal protein L7 r_klactIV1267 check: MH E KOG0786 Amino acid transport and metabolism 3-isopropylmalate dehydrogenase r_klactIV1273 good E KOG1549 Amino acid transport and metabolism Cysteine desulfurase NFS1 r_klactIV1277 check: MH C KOG0768 Energy production and conversion Mitochondrial carrier protein PET8 r_klactIV1280 good D KOG0798 Cell cycle control, cell division, chromosome partitioning Uncharacterized conserved protein r_klactIV1293 good R KOG0118 General function prediction only FOG: RRM domain r_klactIV1304 suspect: LH R KOG0017 General function prediction only FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations r_klactIV1313 suspect: LH J KOG1790 Translation, ribosomal structure and biogenesis 60s ribosomal protein L34 r_klactIV1318 good C KOG3352 Energy production and conversion Cytochrome c oxidase, subunit Vb/COX4 r_klactIV1324 good J KOG1768 Translation, ribosomal structure and biogenesis 40s ribosomal protein S26 r_klactIV1332 good J KOG2472 Translation, ribosomal structure and biogenesis Phenylalanyl-tRNA synthetase beta subunit r_klactIV1340 good S KOG2385 Function unknown Uncharacterized conserved protein r_klactIV1343.1 good J KOG3434 Translation, ribosomal structure and biogenesis 60S ribosomal protein L22 r_klactIV1346 good D KOG0440 Cell cycle control, cell division, chromosome partitioning Cell cycle-associated protein Mob1-1 r_klactIV1357 good KL KOG1038 Replication, recombination and repair Mitochondrial/chloroplast DNA-directed RNA polymerase RPO41, provides primers for DNA replication-initiation r_klactIV1357 good KL KOG1038 Transcription Mitochondrial/chloroplast DNA-directed RNA polymerase RPO41, provides primers for DNA replication-initiation r_klactIV1365 good Z KOG1375 Cytoskeleton Beta tubulin r_klactIV1369 good S KOG4002 Function unknown Uncharacterized integral membrane protein r_klactIV1372 check: MH TU KOG0084 Intracellular trafficking, secretion, and vesicular transport GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins r_klactIV1372 check: MH TU KOG0084 Signal transduction mechanisms GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins r_klactIV1375 good S KOG3269 Function unknown Predicted membrane protein r_klactIV1384 good Z KOG0676 Cytoskeleton Actin and related proteins r_klactIV1387 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactIV1390 good U KOG3372 Intracellular trafficking, secretion, and vesicular transport Signal peptidase complex subunit r_klactIV1397 good R KOG4197 General function prediction only FOG: PPR repeat r_klactIV1401 suspect: LH S KOG4851 Function unknown Uncharacterized conserved protein r_klactIV1407 check: MH J KOG0465 Translation, ribosomal structure and biogenesis Mitochondrial elongation factor r_klactIV1414 good Q KOG1263 Secondary metabolites biosynthesis, transport and catabolism Multicopper oxidases r_klactIV1419 good Q KOG0024 Secondary metabolites biosynthesis, transport and catabolism Sorbitol dehydrogenase r_klactIV1427 good K KOG1875 Transcription Thyroid hormone receptor-associated coactivator complex component (TRAP170) r_klactIV1431 good S KOG1032 Function unknown Uncharacterized conserved protein, contains GRAM domain r_klactIV1436 good TO KOG3288 Posttranslational modification, protein turnover, chaperones OTU-like cysteine protease r_klactIV1436 good TO KOG3288 Signal transduction mechanisms OTU-like cysteine protease r_klactIV1437 good A KOG3408 RNA processing and modification U1-like Zn-finger-containing protein, probabl erole in RNA processing/splicing r_klactIV1441 good J KOG0857 Translation, ribosomal structure and biogenesis 60s ribosomal protein L10 r_klactIV1451 good I KOG3189 Lipid transport and metabolism Phosphomannomutase r_klactIV1456 good S KOG3156 Function unknown Uncharacterized membrane protein r_klactIV1461 good S KOG1426 Function unknown FOG: RCC1 domain r_klactIV1464 check: MH U KOG3251 Intracellular trafficking, secretion, and vesicular transport Golgi SNAP receptor complex member r_klactIV1475 suspect: LH T KOG1453 Signal transduction mechanisms Chimaerin and related Rho GTPase activating proteins r_klactIV1481 suspect: LH U KOG3838 Intracellular trafficking, secretion, and vesicular transport Mannose lectin ERGIC-53, involved in glycoprotein traffic r_klactIV1490 good Q KOG1208 Secondary metabolites biosynthesis, transport and catabolism Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) r_klactIV1495 good O KOG1339 Posttranslational modification, protein turnover, chaperones Aspartyl protease r_klactIV1502 check: MH Z KOG0242 Cytoskeleton Kinesin-like protein r_klactIV1504 normal O KOG1752 Posttranslational modification, protein turnover, chaperones Glutaredoxin and related proteins r_klactIV1510 good R KOG2730 General function prediction only Methylase r_klactIV1521 good R KOG1838 General function prediction only Alpha/beta hydrolase r_klactIV1534 good J KOG0437 Translation, ribosomal structure and biogenesis Leucyl-tRNA synthetase r_klactIV1536 good Q KOG1208 Secondary metabolites biosynthesis, transport and catabolism Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) r_klactIV1539 good R KOG1311 General function prediction only DHHC-type Zn-finger proteins r_klactIV1545 good F KOG1096 Nucleotide transport and metabolism Adenosine monophosphate deaminase r_klactIV1557 good O KOG1439 Posttranslational modification, protein turnover, chaperones RAB proteins geranylgeranyltransferase component A (RAB escort protein) r_klactIV1562 good P KOG1650 Inorganic ion transport and metabolism Predicted K+/H+-antiporter r_klactIV1576 good Z KOG2046 Cytoskeleton Calponin r_klactIV1584 good S KOG2722 Function unknown Predicted membrane protein r_klactIV1590 check: MH O KOG0715 Posttranslational modification, protein turnover, chaperones Molecular chaperone (DnaJ superfamily) r_klactIV1597 good OPR KOG2195 General function prediction only Transferrin receptor and related proteins containing the protease-associated (PA) domain r_klactIV1597 good OPR KOG2195 Inorganic ion transport and metabolism Transferrin receptor and related proteins containing the protease-associated (PA) domain r_klactIV1597 good OPR KOG2195 Posttranslational modification, protein turnover, chaperones Transferrin receptor and related proteins containing the protease-associated (PA) domain r_klactIV1602 suspect: LH Z KOG0613 Cytoskeleton Projectin/twitchin and related proteins r_klactIV1613 good S KOG4071 Function unknown Uncharacterized conserved protein r_klactIV1618 good E KOG2436 Amino acid transport and metabolism Acetylglutamate kinase/acetylglutamate synthase r_klactIV1623 good A KOG1642 RNA processing and modification Ribonuclease, T2 family r_klactIV1635 good T KOG0789 Signal transduction mechanisms Protein tyrosine phosphatase r_klactIV1643 good YU KOG1993 Intracellular trafficking, secretion, and vesicular transport Nuclear transport receptor KAP120 (importin beta superfamily) r_klactIV1643 good YU KOG1993 Nuclear structure Nuclear transport receptor KAP120 (importin beta superfamily) r_klactIV1653 suspect: LH H KOG2511 Coenzyme transport and metabolism Nicotinic acid phosphoribosyltransferase r_klactIV1665 good R KOG1963 General function prediction only WD40 repeat protein r_klactIV1668 good K KOG3497 Transcription DNA-directed RNA polymerase, subunit RPB10 r_klactIV1676 good UR KOG0446 General function prediction only Vacuolar sorting protein VPS1, dynamin, and related proteins r_klactIV1676 good UR KOG0446 Intracellular trafficking, secretion, and vesicular transport Vacuolar sorting protein VPS1, dynamin, and related proteins r_klactIV1680 suspect: LH B KOG4012 Chromatin structure and dynamics Histone H1 r_klactIV1695 check: MH R KOG0286 General function prediction only G-protein beta subunit r_klactIV1696 good K KOG3149 Transcription Transcription initiation factor IIF, auxiliary subunit r_klactIV1701 good K KOG3149 Transcription Transcription initiation factor IIF, auxiliary subunit r_klactIV1709 suspect: %id Z KOG0161 Cytoskeleton Myosin class II heavy chain r_klactIV1717 check: MH L KOG1968 Replication, recombination and repair Replication factor C, subunit RFC1 (large subunit) r_klactIV1726 good O KOG2100 Posttranslational modification, protein turnover, chaperones Dipeptidyl aminopeptidase r_klactIV1731 good J KOG0875 Translation, ribosomal structure and biogenesis 60S ribosomal protein L5 r_klactIV1739 good O KOG2540 Posttranslational modification, protein turnover, chaperones Cytochrome oxidase assembly factor COX11 r_klactIV1750 suspect: LH I KOG2926 Lipid transport and metabolism Malonyl-CoA:ACP transacylase r_klactIV1757 check: MH C KOG0754 Energy production and conversion Mitochondrial oxodicarboxylate carrier protein r_klactIV1765 suspect: LH S KOG3945 Function unknown Uncharacterized conserved protein r_klactIV1767 good K KOG3400 Transcription RNA polymerase subunit 8 r_klactIV1772 good C KOG3361 Energy production and conversion Iron binding protein involved in Fe-S cluster formation r_klactIV1800 good R KOG1632 General function prediction only Uncharacterized PHD Zn-finger protein r_klactIV1805 suspect: Pn B KOG0264 Chromatin structure and dynamics Nucleosome remodeling factor, subunit CAF1/NURF55/MSI1 r_klactIV1811 check: MH T KOG0581 Signal transduction mechanisms Mitogen-activated protein kinase kinase (MAP2K) r_klactIV1812 good O KOG3003 Posttranslational modification, protein turnover, chaperones Molecular chaperone of the GrpE family r_klactIV1822 check: MH T KOG0583 Signal transduction mechanisms Serine/threonine protein kinase r_klactIV1831 good G KOG2533 Carbohydrate transport and metabolism Permease of the major facilitator superfamily r_klactIV1834.1 good J KOG0887 Translation, ribosomal structure and biogenesis 60S ribosomal protein L35A/L37 r_klactIV1856 good Q KOG1399 Secondary metabolites biosynthesis, transport and catabolism Flavin-containing monooxygenase r_klactIV1866 good H KOG1324 Coenzyme transport and metabolism Dihydrofolate reductase r_klactIV1872 good T KOG2210 Signal transduction mechanisms Oxysterol-binding protein r_klactIV1882 check: MH D KOG0018 Cell cycle control, cell division, chromosome partitioning Structural maintenance of chromosome protein 1 (sister chromatid cohesion complex Cohesin, subunit SMC1) r_klactIV1897 check: MH R KOG0274 General function prediction only Cdc4 and related F-box and WD-40 proteins r_klactIV1901 good E KOG3923 Amino acid transport and metabolism D-aspartate oxidase r_klactIV1928 check: MH O KOG0715 Posttranslational modification, protein turnover, chaperones Molecular chaperone (DnaJ superfamily) r_klactIV1932 good A KOG1780 RNA processing and modification Small Nuclear ribonucleoprotein G r_klactIV1935 good M KOG3396 Cell wall/membrane/envelope biogenesis Glucosamine-phosphate N-acetyltransferase r_klactIV1944 good P KOG0682 Inorganic ion transport and metabolism Ammonia permease r_klactIV1958 good P KOG0682 Inorganic ion transport and metabolism Ammonia permease r_klactIV1966 suspect: LH W KOG3989 Extracellular structures Beta-2-glycoprotein I r_klactIV1974.1 suspect: Pn H KOG2524 Coenzyme transport and metabolism Cobyrinic acid a,c-diamide synthase r_klactIV1974 check: MH R KOG0605 General function prediction only NDR and related serine/threonine kinases r_klactIV1975.2 good J KOG3464 Translation, ribosomal structure and biogenesis 60S ribosomal protein L44 r_klactIV1988 check: MH J KOG0467 Translation, ribosomal structure and biogenesis Translation elongation factor 2/ribosome biogenesis protein RIA1 and related proteins r_klactIV2010 good K KOG3507 Transcription DNA-directed RNA polymerase, subunit RPB7.0 r_klactIV2021 good R KOG1535 General function prediction only Predicted fumarylacetoacetate hydralase r_klactIV2024 good F KOG3127 Nucleotide transport and metabolism Deoxycytidylate deaminase r_klactIV2027.1 suspect: LH S KOG4805 Function unknown Uncharacterized conserved protein r_klactIV2027 good I KOG2420 Lipid transport and metabolism Phosphatidylserine decarboxylase r_klactIV2041 good DO KOG1858 Cell cycle control, cell division, chromosome partitioning Anaphase-promoting complex (APC), subunit 1 (meiotic check point regulator/Tsg24) r_klactIV2041 good DO KOG1858 Posttranslational modification, protein turnover, chaperones Anaphase-promoting complex (APC), subunit 1 (meiotic check point regulator/Tsg24) r_klactIV2049 suspect: LH G KOG1616 Carbohydrate transport and metabolism Protein involved in Snf1 protein kinase complex assembly r_klactIV2053 check: MH K KOG4210 Transcription Nuclear localization sequence binding protein r_klactIV2064 suspect: LH J KOG1711 Translation, ribosomal structure and biogenesis Mitochondrial/chloroplast ribosomal protein L22 r_klactIV2069 good J KOG3181 Translation, ribosomal structure and biogenesis 40S ribosomal protein S3 r_klactIV2073 check: MH R KOG0393 General function prediction only Ras-related small GTPase, Rho type r_klactIV2078 good Q KOG1208 Secondary metabolites biosynthesis, transport and catabolism Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) r_klactIV2085 good R KOG0646 General function prediction only WD40 repeat protein r_klactIV2086 suspect: LH R KOG0118 General function prediction only FOG: RRM domain r_klactIV2104 check: MH D KOG0590 Cell cycle control, cell division, chromosome partitioning Checkpoint kinase and related serine/threonine protein kinases r_klactIV2107 good J KOG3257 Translation, ribosomal structure and biogenesis Mitochondrial/chloroplast ribosomal protein L11 r_klactIV2114 check: MH O KOG1870 Posttranslational modification, protein turnover, chaperones Ubiquitin C-terminal hydrolase r_klactIV2125 good E KOG2250 Amino acid transport and metabolism Glutamate/leucine/phenylalanine/valine dehydrogenases r_klactIV2129 good OT KOG1554 Posttranslational modification, protein turnover, chaperones COP9 signalosome, subunit CSN5 r_klactIV2129 good OT KOG1554 Signal transduction mechanisms COP9 signalosome, subunit CSN5 r_klactIV2137 good U KOG3225 Intracellular trafficking, secretion, and vesicular transport Mitochondrial import inner membrane translocase, subunit TIM22 r_klactIV2150 good U KOG0166 Intracellular trafficking, secretion, and vesicular transport Karyopherin (importin) alpha r_klactIV2167 suspect: LH M KOG1268 Cell wall/membrane/envelope biogenesis Glucosamine 6-phosphate synthetases, contain amidotransferase and phosphosugar isomerase domains r_klactIV2169 good J KOG3323 Translation, ribosomal structure and biogenesis D-Tyr-tRNA (Tyr) deacylase r_klactIV2179 good C KOG1158 Energy production and conversion NADP/FAD dependent oxidoreductase r_klactIV2187 suspect: LH S KOG4562 Function unknown Uncharacterized conserved protein (tumor-rejection antigen MAGE in humans) r_klactIV2191 good E KOG4750 Amino acid transport and metabolism Serine O-acetyltransferase r_klactIV2199 good I KOG1459 Lipid transport and metabolism Squalene synthetase r_klactIV2205 good S KOG4653 Function unknown Uncharacterized conserved protein r_klactIV2210 good R KOG0504 General function prediction only FOG: Ankyrin repeat r_klactIV2214 good J KOG2768 Translation, ribosomal structure and biogenesis Translation initiation factor 2, beta subunit (eIF-2beta) r_klactIV2238 good U KOG0780 Intracellular trafficking, secretion, and vesicular transport Signal recognition particle, subunit Srp54 r_klactIV2241 suspect: Pn UR KOG4677 General function prediction only Golgi integral membrane protein r_klactIV2241 suspect: Pn UR KOG4677 Intracellular trafficking, secretion, and vesicular transport Golgi integral membrane protein r_klactIV2264 good C KOG1351 Energy production and conversion Vacuolar H+-ATPase V1 sector, subunit B r_klactIV2280 check: MH O KOG0425 Posttranslational modification, protein turnover, chaperones Ubiquitin-protein ligase r_klactIV2293 suspect: LH OT KOG3986 Posttranslational modification, protein turnover, chaperones Protein phosphatase, regulatory subunit PPP1R3C/D r_klactIV2293 suspect: LH OT KOG3986 Signal transduction mechanisms Protein phosphatase, regulatory subunit PPP1R3C/D r_klactIV2304 check: MH L KOG0481 Replication, recombination and repair DNA replication licensing factor, MCM5 component r_klactIV2306 good A KOG3459 RNA processing and modification Small nuclear ribonucleoprotein (snRNP) Sm core protein r_klactIV2313 good T KOG3417 Signal transduction mechanisms Ras1 guanine nucleotide exchange factor r_klactIV2325 check: MH T KOG0585 Signal transduction mechanisms Ca2+/calmodulin-dependent protein kinase kinase beta and related serine/threonine protein kinases r_klactIV2330 check: MH O KOG0362 Posttranslational modification, protein turnover, chaperones Chaperonin complex component, TCP-1 theta subunit (CCT8) r_klactIV2341 good U KOG2180 Intracellular trafficking, secretion, and vesicular transport Late Golgi protein sorting complex, subunit Vps53 r_klactIV2344 good DZ KOG3285 Cell cycle control, cell division, chromosome partitioning Spindle assembly checkpoint protein r_klactIV2344 good DZ KOG3285 Cytoskeleton Spindle assembly checkpoint protein r_klactIV2347 good O KOG0529 Posttranslational modification, protein turnover, chaperones Protein geranylgeranyltransferase type II, alpha subunit r_klactIV2349 good D KOG0834 Cell cycle control, cell division, chromosome partitioning CDK9 kinase-activating protein cyclin T r_klactIV2356 check: MH A KOG0343 RNA processing and modification RNA Helicase r_klactIV2359 good T KOG1882 Signal transduction mechanisms Transcriptional regulator SNIP1, contains FHA domain r_klactIV2366.1 suspect: LH Q KOG1399 Secondary metabolites biosynthesis, transport and catabolism Flavin-containing monooxygenase r_klactIV2366 good O KOG0100 Posttranslational modification, protein turnover, chaperones Molecular chaperones GRP78/BiP/KAR2, HSP70 superfamily r_klactIV2372 check: MH O KOG0100 Posttranslational modification, protein turnover, chaperones Molecular chaperones GRP78/BiP/KAR2, HSP70 superfamily r_klactIV2382 good P KOG1291 Inorganic ion transport and metabolism Mn2+ and Fe2+ transporters of the NRAMP family r_klactIV2387 suspect: LH Y KOG2992 Nuclear structure Nucleolar GTPase/ATPase p130 r_klactIV2389 good J KOG1068 Translation, ribosomal structure and biogenesis Exosomal 3'-5' exoribonuclease complex, subunit Rrp41 and related exoribonucleases r_klactIV2394 good G KOG3893 Carbohydrate transport and metabolism Mannosyltransferase r_klactIV2416 good JU KOG2153 Intracellular trafficking, secretion, and vesicular transport Protein involved in the nuclear export of pre-ribosomes r_klactIV2416 good JU KOG2153 Translation, ribosomal structure and biogenesis Protein involved in the nuclear export of pre-ribosomes r_klactIV2421 good A KOG2600 RNA processing and modification U3 small nucleolar ribonucleoprotein (snoRNP) subunit - Mpp10p r_klactIV2428 good E KOG1303 Amino acid transport and metabolism Amino acid transporters r_klactIV2434 suspect: LH MW KOG1437 Cell wall/membrane/envelope biogenesis Fasciclin and related adhesion glycoproteins r_klactIV2434 suspect: LH MW KOG1437 Extracellular structures Fasciclin and related adhesion glycoproteins r_klactIV2447 good NI KOG2116 Cell motility Protein involved in plasmid maintenance/nuclear protein involved in lipid metabolism r_klactIV2447 good NI KOG2116 Lipid transport and metabolism Protein involved in plasmid maintenance/nuclear protein involved in lipid metabolism r_klactIV2451 check: MH C KOG0770 Energy production and conversion Predicted mitochondrial carrier protein r_klactIV2456 good O KOG2707 Posttranslational modification, protein turnover, chaperones Predicted metalloprotease with chaperone activity (RNAse H/HSP70 fold) r_klactIV2459 good S KOG2866 Function unknown Uncharacterized conserved protein r_klactIV2467 good L KOG1979 Replication, recombination and repair DNA mismatch repair protein - MLH1 family r_klactIV2478 good C KOG2450 Energy production and conversion Aldehyde dehydrogenase r_klactIV2485 good C KOG2450 Energy production and conversion Aldehyde dehydrogenase r_klactIV2489 check: MH K KOG0486 Transcription Transcription factor PTX1, contains HOX domain r_klactIV2493 good R KOG1477 General function prediction only SPRY domain-containing proteins r_klactIV2505 good R KOG1577 General function prediction only Aldo/keto reductase family proteins r_klactIV2511 good G KOG2504 Carbohydrate transport and metabolism Monocarboxylate transporter r_klactIV2533 good K KOG3901 Transcription Transcription initiation factor IID subunit r_klactIV2541 good OU KOG2608 Intracellular trafficking, secretion, and vesicular transport Endoplasmic reticulum membrane-associated oxidoreductin involved in disulfide bond formation r_klactIV2541 good OU KOG2608 Posttranslational modification, protein turnover, chaperones Endoplasmic reticulum membrane-associated oxidoreductin involved in disulfide bond formation r_klactIV2547 good U KOG2319 Intracellular trafficking, secretion, and vesicular transport Vacuolar assembly/sorting protein VPS9 r_klactIV2549 good E KOG0573 Amino acid transport and metabolism Asparagine synthase r_klactIV2553 good L KOG2841 Replication, recombination and repair Structure-specific endonuclease ERCC1-XPF, ERCC1 component r_klactIV2555 good O KOG3048 Posttranslational modification, protein turnover, chaperones Molecular chaperone Prefoldin, subunit 5 r_klactIV2565 good S KOG2172 Function unknown Uncharacterized conserved protein r_klactIV2569 check: MH O KOG0181 Posttranslational modification, protein turnover, chaperones 20S proteasome, regulatory subunit alpha type PSMA2/PRE8 r_klactIV2609 good I KOG1393 Lipid transport and metabolism Hydroxymethylglutaryl-CoA synthase r_klactIV2621 check: MH D KOG0600 Cell cycle control, cell division, chromosome partitioning Cdc2-related protein kinase r_klactIV2631.1 suspect: Pn TZ KOG3632 Cytoskeleton Peripheral benzodiazepine receptor PRAX-1 r_klactIV2631.1 suspect: Pn TZ KOG3632 Signal transduction mechanisms Peripheral benzodiazepine receptor PRAX-1 r_klactIV2632 good J KOG0466 Translation, ribosomal structure and biogenesis Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase) r_klactIV2654 check: MH I KOG3719 Lipid transport and metabolism Carnitine O-acyltransferase CPT2/YAT1 r_klactIV2661 good J KOG3291 Translation, ribosomal structure and biogenesis Ribosomal protein S7 r_klactIV2669 good K KOG2929 Transcription Transcription factor, component of CCR4 transcriptional complex r_klactIV2678 check: MH C KOG1350 Energy production and conversion F0F1-type ATP synthase, beta subunit r_klactIV2686 good E KOG3124 Amino acid transport and metabolism Pyrroline-5-carboxylate reductase r_klactIV2692 good R KOG1246 General function prediction only DNA-binding protein jumonji/RBP2/SMCY, contains JmjC domain r_klactIV2706 good O KOG2581 Posttranslational modification, protein turnover, chaperones 26S proteasome regulatory complex, subunit RPN3/PSMD3 r_klactIV2712 good R KOG2719 General function prediction only Metalloprotease r_klactIV2716 good TR KOG4561 General function prediction only Uncharacterized conserved protein, contains TBC domain r_klactIV2716 good TR KOG4561 Signal transduction mechanisms Uncharacterized conserved protein, contains TBC domain r_klactIV2724 good G KOG2854 Carbohydrate transport and metabolism Possible pfkB family carbohydrate kinase r_klactIV2734 good P KOG2399 Inorganic ion transport and metabolism K+-dependent Na+:Ca2+ antiporter r_klactIV2742 good I KOG4569 Lipid transport and metabolism Predicted lipase r_klactIV2745 good DT KOG0082 Cell cycle control, cell division, chromosome partitioning G-protein alpha subunit (small G protein superfamily) r_klactIV2745 good DT KOG0082 Signal transduction mechanisms G-protein alpha subunit (small G protein superfamily) r_klactIV2751 good R KOG3183 General function prediction only Predicted Zn-finger protein r_klactIV2761 good V KOG1502 Defense mechanisms Flavonol reductase/cinnamoyl-CoA reductase r_klactIV2768 good V KOG1502 Defense mechanisms Flavonol reductase/cinnamoyl-CoA reductase r_klactIV2777 check: MH T KOG1165 Signal transduction mechanisms Casein kinase (serine/threonine/tyrosine protein kinase) r_klactIV2793 good E KOG0634 Amino acid transport and metabolism Aromatic amino acid aminotransferase and related proteins r_klactIV2795 good O KOG1760 Posttranslational modification, protein turnover, chaperones Molecular chaperone Prefoldin, subunit 4 r_klactIV2806 good C KOG1335 Energy production and conversion Dihydrolipoamide dehydrogenase r_klactIV2813 good I KOG2468 Lipid transport and metabolism Dolichol kinase r_klactIV2827 good QI KOG0157 Lipid transport and metabolism Cytochrome P450 CYP4/CYP19/CYP26 subfamilies r_klactIV2827 good QI KOG0157 Secondary metabolites biosynthesis, transport and catabolism Cytochrome P450 CYP4/CYP19/CYP26 subfamilies r_klactIV2847 good R KOG1516 General function prediction only Carboxylesterase and related proteins r_klactIV2859 good G KOG2533 Carbohydrate transport and metabolism Permease of the major facilitator superfamily r_klactIV2867 good G KOG1369 Carbohydrate transport and metabolism Hexokinase r_klactIV2868 good O KOG3151 Posttranslational modification, protein turnover, chaperones 26S proteasome regulatory complex, subunit RPN12/PSMD8 r_klactIV2877 good U KOG2635 Intracellular trafficking, secretion, and vesicular transport Medium subunit of clathrin adaptor complex r_klactIV2892 check: MH A KOG0952 RNA processing and modification DNA/RNA helicase MER3/SLH1, DEAD-box superfamily r_klactIV2897 suspect: LH R KOG4197 General function prediction only FOG: PPR repeat r_klactIV2900 good O KOG0185 Posttranslational modification, protein turnover, chaperones 20S proteasome, regulatory subunit beta type PSMB4/PRE4 r_klactIV2922 good O KOG0867 Posttranslational modification, protein turnover, chaperones Glutathione S-transferase r_klactIV2937 check: MH Q KOG0158 Secondary metabolites biosynthesis, transport and catabolism Cytochrome P450 CYP3/CYP5/CYP6/CYP9 subfamilies r_klactIV2944 good P KOG0047 Inorganic ion transport and metabolism Catalase r_klactIV2946 suspect: LH S KOG2612 Function unknown Predicted integral membrane protein r_klactIV2949 good O KOG2817 Posttranslational modification, protein turnover, chaperones Predicted E3 ubiquitin ligase r_klactIV2950 good K KOG3473 Transcription RNA polymerase II transcription elongation factor Elongin/SIII, subunit elongin C r_klactIV2958 good U KOG2280 Intracellular trafficking, secretion, and vesicular transport Vacuolar assembly/sorting protein VPS16 r_klactIV2970.1 suspect: Pn R KOG4407 General function prediction only Predicted Rho GTPase-activating protein r_klactIV2970.2 suspect: LH PQ KOG0039 Inorganic ion transport and metabolism Ferric reductase, NADH/NADPH oxidase and related proteins r_klactIV2970.2 suspect: LH PQ KOG0039 Secondary metabolites biosynthesis, transport and catabolism Ferric reductase, NADH/NADPH oxidase and related proteins r_klactIV2970 check: MH A KOG0127 RNA processing and modification Nucleolar protein fibrillarin NOP77 (RRM superfamily) r_klactIV2977 check: MH K KOG0666 Transcription Cyclin C-dependent kinase CDK8 r_klactIV2990 check: MH J KOG0433 Translation, ribosomal structure and biogenesis Isoleucyl-tRNA synthetase r_klactIV2996 suspect: HSP R KOG1721 General function prediction only FOG: Zn-finger r_klactIV3001 good K KOG2240 Transcription RNA polymerase II general transcription factor BTF3 and related proteins r_klactIV3022 check: MH R KOG0594 General function prediction only Protein kinase PCTAIRE and related kinases r_klactIV3028 good S KOG3790 Function unknown Uncharacterized conserved protein r_klactIV3033 good A KOG0953 RNA processing and modification Mitochondrial RNA helicase SUV3, DEAD-box superfamily r_klactIV3038 good I KOG1390 Lipid transport and metabolism Acetyl-CoA acetyltransferase r_klactIV3039 good G KOG3354 Carbohydrate transport and metabolism Gluconate kinase r_klactIV3045 check: MH T KOG0583 Signal transduction mechanisms Serine/threonine protein kinase r_klactIV3050 good U KOG3369 Intracellular trafficking, secretion, and vesicular transport Transport protein particle (TRAPP) complex subunit r_klactIV3054 suspect: LH S KOG3683 Function unknown Uncharacterized conserved protein r_klactIV3062 good E KOG0564 Amino acid transport and metabolism 5,10-methylenetetrahydrofolate reductase r_klactIV3071 good L KOG0442 Replication, recombination and repair Structure-specific endonuclease ERCC1-XPF, catalytic component XPF/ERCC4 r_klactIV3081 suspect: LH K KOG2744 Transcription DNA-binding proteins Bright/BRCAA1/RBP1 and related proteins containing BRIGHT domain r_klactIV3084 good AJ KOG2573 RNA processing and modification Ribosome biogenesis protein - Nop56p/Sik1p r_klactIV3084 good AJ KOG2573 Translation, ribosomal structure and biogenesis Ribosome biogenesis protein - Nop56p/Sik1p r_klactIV3090 good O KOG3478 Posttranslational modification, protein turnover, chaperones Prefoldin subunit 6, KE2 family r_klactIV3092 good S KOG2969 Function unknown Uncharacterized conserved protein r_klactIV3105 good Q KOG0022 Secondary metabolites biosynthesis, transport and catabolism Alcohol dehydrogenase, class III r_klactIV3111 suspect: LH R KOG4198 General function prediction only RNA-binding Ran Zn-finger protein and related proteins r_klactIV3115 good F KOG3347 Nucleotide transport and metabolism Predicted nucleotide kinase/nuclear protein involved oxidative stress response r_klactIV3119 good KDR KOG2151 Cell cycle control, cell division, chromosome partitioning Predicted transcriptional regulator r_klactIV3119 good KDR KOG2151 General function prediction only Predicted transcriptional regulator r_klactIV3119 good KDR KOG2151 Transcription Predicted transcriptional regulator r_klactIV3137 suspect: LH P KOG4480 Inorganic ion transport and metabolism Heme oxygenase r_klactIV3145 good L KOG0967 Replication, recombination and repair ATP-dependent DNA ligase I r_klactIV3152.1 good J KOG3452 Translation, ribosomal structure and biogenesis 60S ribosomal protein L36 r_klactIV3158 good J KOG3278 Translation, ribosomal structure and biogenesis Mitochondrial/chloroplast ribosomal protein L28 r_klactIV3165 check: MH R KOG1102 General function prediction only Rab6 GTPase activator GAPCenA and related TBC domain proteins r_klactIV3171 good R KOG0255 General function prediction only Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) r_klactIV3177 good JIT KOG1212 Lipid transport and metabolism Amidases r_klactIV3177 good JIT KOG1212 Signal transduction mechanisms Amidases r_klactIV3177 good JIT KOG1212 Translation, ribosomal structure and biogenesis Amidases r_klactIV3214 check: MH L KOG0351 Replication, recombination and repair ATP-dependent DNA helicase r_klactIV3218 good G KOG2533 Carbohydrate transport and metabolism Permease of the major facilitator superfamily r_klactIV3232 good E KOG2040 Amino acid transport and metabolism Glycine dehydrogenase (decarboxylating) r_klactIV3242 good S KOG0290 Function unknown Conserved WD40 repeat-containing protein AN11 r_klactIV3245 good J KOG1740 Translation, ribosomal structure and biogenesis Predicted mitochondrial/chloroplast ribosomal protein S17 r_klactIV3246 good S KOG2632 Function unknown Rhomboid family proteins r_klactIV3254 good G KOG1581 Carbohydrate transport and metabolism UDP-galactose transporter related protein r_klactIV3260 good U KOG2460 Intracellular trafficking, secretion, and vesicular transport Signal recognition particle, subunit Srp68 r_klactIV3273 good T KOG2128 Signal transduction mechanisms Ras GTPase-activating protein family - IQGAP r_klactIV3283 good O KOG0019 Posttranslational modification, protein turnover, chaperones Molecular chaperone (HSP90 family) r_klactIV3290 good E KOG0503 Amino acid transport and metabolism Asparaginase r_klactIV3292 good QR KOG0143 General function prediction only Iron/ascorbate family oxidoreductases r_klactIV3292 good QR KOG0143 Secondary metabolites biosynthesis, transport and catabolism Iron/ascorbate family oxidoreductases r_klactIV3293 good HR KOG2303 Coenzyme transport and metabolism Predicted NAD synthase, contains CN hydrolase domain r_klactIV3293 good HR KOG2303 General function prediction only Predicted NAD synthase, contains CN hydrolase domain r_klactIV3297 good R KOG2564 General function prediction only Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold r_klactIV3302 good EO KOG1046 Amino acid transport and metabolism Puromycin-sensitive aminopeptidase and related aminopeptidases r_klactIV3302 good EO KOG1046 Posttranslational modification, protein turnover, chaperones Puromycin-sensitive aminopeptidase and related aminopeptidases r_klactIV3308 good R KOG3346 General function prediction only Phosphatidylethanolamine binding protein r_klactIV3315 good T KOG1379 Signal transduction mechanisms Serine/threonine protein phosphatase r_klactIV3322 good A KOG2051 RNA processing and modification Nonsense-mediated mRNA decay 2 protein r_klactIV3327 good R KOG1842 General function prediction only FYVE finger-containing protein r_klactIV3336 good R KOG2048 General function prediction only WD40 repeat protein r_klactIV3346 good BD KOG2025 Cell cycle control, cell division, chromosome partitioning Chromosome condensation complex Condensin, subunit G r_klactIV3346 good BD KOG2025 Chromatin structure and dynamics Chromosome condensation complex Condensin, subunit G r_klactIV3353 check: MH T KOG1027 Signal transduction mechanisms Serine/threonine protein kinase and endoribonuclease ERN1/IRE1, sensor of the unfolded protein response pathway r_klactIV3360 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactIV3381 good D KOG0987 Cell cycle control, cell division, chromosome partitioning DNA helicase PIF1/RRM3 r_klactIV3393 good TU KOG0998 Intracellular trafficking, secretion, and vesicular transport Synaptic vesicle protein EHS-1 and related EH domain proteins r_klactIV3393 good TU KOG0998 Signal transduction mechanisms Synaptic vesicle protein EHS-1 and related EH domain proteins r_klactIV3396 check: MH R KOG0126 General function prediction only Predicted RNA-binding protein (RRM superfamily) r_klactIV3406 check: MH O KOG0691 Posttranslational modification, protein turnover, chaperones Molecular chaperone (DnaJ superfamily) r_klactIV3414 suspect: LH Z KOG0613 Cytoskeleton Projectin/twitchin and related proteins r_klactIV3417 good U KOG2104 Intracellular trafficking, secretion, and vesicular transport Nuclear transport factor 2 r_klactIV3429 suspect: LH U KOG2148 Intracellular trafficking, secretion, and vesicular transport Exocyst protein Sec3 r_klactIV3441 good R KOG0354 General function prediction only DEAD-box like helicase r_klactIV3445 good J KOG2523 Translation, ribosomal structure and biogenesis Predicted RNA-binding protein with PUA domain r_klactIV3450 good O KOG3207 Posttranslational modification, protein turnover, chaperones Beta-tubulin folding cofactor E r_klactIV3454 good R KOG2484 General function prediction only GTPase r_klactIV3458 good K KOG1597 Transcription Transcription initiation factor TFIIB r_klactIV3463 good F KOG1386 Nucleotide transport and metabolism Nucleoside phosphatase r_klactIV3466 good T KOG4039 Signal transduction mechanisms Serine/threonine kinase TIP30/CC3 r_klactIV3471 suspect: %id Z KOG3121 Cytoskeleton Dynactin, subunit p25 r_klactIV3478 good G KOG2757 Carbohydrate transport and metabolism Mannose-6-phosphate isomerase r_klactIV3480 suspect: LH J KOG4771 Translation, ribosomal structure and biogenesis Nucleolar protein (NOP16) involved in 60S ribosomal subunit biogenesis r_klactIV3488 normal A KOG4209 RNA processing and modification Splicing factor RNPS1, SR protein superfamily r_klactIV3496 good R KOG0511 General function prediction only Ankyrin repeat protein r_klactIV3505 check: MH U KOG0566 Intracellular trafficking, secretion, and vesicular transport Inositol-1,4,5-triphosphate 5-phosphatase (synaptojanin), INP51/INP52/INP53 family r_klactIV3507 good O KOG2754 Posttranslational modification, protein turnover, chaperones Oligosaccharyltransferase, beta subunit r_klactIV3511 check: MH O KOG4098 Posttranslational modification, protein turnover, chaperones Molecular chaperone Prefoldin, subunit 2 r_klactIV3517 good G KOG1583 Carbohydrate transport and metabolism UDP-N-acetylglucosamine transporter r_klactIV3523 good D KOG3022 Cell cycle control, cell division, chromosome partitioning Predicted ATPase, nucleotide-binding r_klactIV3526 suspect: LH U KOG3385 Intracellular trafficking, secretion, and vesicular transport V-SNARE r_klactIV3534 good O KOG0191 Posttranslational modification, protein turnover, chaperones Thioredoxin/protein disulfide isomerase r_klactIV3536 check: MH C KOG0764 Energy production and conversion Mitochondrial FAD carrier protein r_klactIV3544 normal TG KOG4476 Carbohydrate transport and metabolism Gluconate transport-inducing protein r_klactIV3544 normal TG KOG4476 Signal transduction mechanisms Gluconate transport-inducing protein r_klactIV3561 suspect: LH K KOG0837 Transcription Transcriptional activator of the JUN family r_klactIV3565 good O KOG3129 Posttranslational modification, protein turnover, chaperones 26S proteasome regulatory complex, subunit PSMD9 r_klactIV3568 good O KOG4146 Posttranslational modification, protein turnover, chaperones Ubiquitin-like protein r_klactIV3580 good E KOG2367 Amino acid transport and metabolism Alpha-isopropylmalate synthase/homocitrate synthase r_klactIV3587 good U KOG0937 Intracellular trafficking, secretion, and vesicular transport Adaptor complexes medium subunit family r_klactIV3588 good O KOG0855 Posttranslational modification, protein turnover, chaperones Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes r_klactIV3605 suspect: LH GO KOG4157 Carbohydrate transport and metabolism beta-1,6-N-acetylglucosaminyltransferase, contains WSC domain r_klactIV3605 suspect: LH GO KOG4157 Posttranslational modification, protein turnover, chaperones beta-1,6-N-acetylglucosaminyltransferase, contains WSC domain r_klactIV3637 good S KOG2107 Function unknown Uncharacterized conserved protein, contains double-stranded beta-helix domain r_klactIV3642 suspect: LH S KOG2913 Function unknown Predicted membrane protein r_klactIV3656 good I KOG3888 Lipid transport and metabolism Gamma-butyrobetaine,2-oxoglutarate dioxygenase r_klactIV3658 good L KOG2795 Replication, recombination and repair Catalytic subunit of the meiotic double strand break transesterase r_klactIV3660 good U KOG1693 Intracellular trafficking, secretion, and vesicular transport emp24/gp25L/p24 family of membrane trafficking proteins r_klactIV3666 good O KOG0687 Posttranslational modification, protein turnover, chaperones 26S proteasome regulatory complex, subunit RPN7/PSMD6 r_klactIV3672 good P KOG0047 Inorganic ion transport and metabolism Catalase r_klactIV3701 good S KOG2054 Function unknown Nucleolar RNA-associated protein (NRAP) r_klactIV3708 good K KOG1521 Transcription RNA polymerase I and III, subunit RPA40/RPC40 r_klactIV3714 good A KOG2574 RNA processing and modification mRNA splicing factor PRP31 r_klactIV3719 check: MH R KOG0605 General function prediction only NDR and related serine/threonine kinases r_klactIV3727 good S KOG2476 Function unknown Uncharacterized conserved protein r_klactIV3733 check: MH R KOG0110 General function prediction only RNA-binding protein (RRM superfamily) r_klactIV3744 good J KOG0432 Translation, ribosomal structure and biogenesis Valyl-tRNA synthetase r_klactIV3747 good J KOG1069 Translation, ribosomal structure and biogenesis Exosomal 3'-5' exoribonuclease complex, subunit Rrp46 r_klactIV3751 check: MH C KOG0752 Energy production and conversion Mitochondrial solute carrier protein r_klactIV3756 good I KOG3240 Lipid transport and metabolism Phosphatidylinositol synthase r_klactIV3760 good TR KOG4561 General function prediction only Uncharacterized conserved protein, contains TBC domain r_klactIV3760 good TR KOG4561 Signal transduction mechanisms Uncharacterized conserved protein, contains TBC domain r_klactIV3783 good D KOG1849 Cell cycle control, cell division, chromosome partitioning Regulator of spindle pole body duplication r_klactIV3787 suspect: LH S KOG4346 Function unknown Uncharacterized conserved protein r_klactIV3800 good S KOG1910 Function unknown Uncharacterized conserved protein r_klactIV3812 check: MH R KOG4347 General function prediction only GTPase-activating protein VRP r_klactIV3816 good T KOG2980 Signal transduction mechanisms Integral membrane protease of the rhomboid family involved in different forms of regulated intramembrane proteolysis r_klactIV3823 good A KOG2481 RNA processing and modification Protein required for normal rRNA processing r_klactIV3849 good T KOG2262 Signal transduction mechanisms Sexual differentiation process protein ISP4 r_klactIV3865 good J KOG1468 Translation, ribosomal structure and biogenesis Predicted translation initiation factor related to eIF-2B alpha/beta/delta subunits (CIG2/IDI2) r_klactIV3872 check: MH I KOG1200 Lipid transport and metabolism Mitochondrial/plastidial beta-ketoacyl-ACP reductase r_klactIV3882 good D KOG0653 Cell cycle control, cell division, chromosome partitioning Cyclin B and related kinase-activating proteins r_klactIV3887 good D KOG0653 Cell cycle control, cell division, chromosome partitioning Cyclin B and related kinase-activating proteins r_klactIV3900 good O KOG0959 Posttranslational modification, protein turnover, chaperones N-arginine dibasic convertase NRD1 and related Zn2+-dependent endopeptidases, insulinase superfamily r_klactIV3913 good F KOG3370 Nucleotide transport and metabolism dUTPase r_klactIV3920 good U KOG3487 Intracellular trafficking, secretion, and vesicular transport TRAPP 20 K subunit r_klactIV3939 good S KOG0296 Function unknown Angio-associated migratory cell protein (contains WD40 repeats) r_klactIV3941 good H KOG3310 Coenzyme transport and metabolism Riboflavin synthase alpha chain r_klactIV3946 good O KOG1339 Posttranslational modification, protein turnover, chaperones Aspartyl protease r_klactIV3959 suspect: LH R KOG1293 General function prediction only Proteins containing armadillo/beta-catenin-like repeat r_klactIV3967 good C KOG1158 Energy production and conversion NADP/FAD dependent oxidoreductase r_klactIV3975 check: MH BD KOG0933 Cell cycle control, cell division, chromosome partitioning Structural maintenance of chromosome protein 2 (chromosome condensation complex Condensin, subunit E) r_klactIV3975 check: MH BD KOG0933 Chromatin structure and dynamics Structural maintenance of chromosome protein 2 (chromosome condensation complex Condensin, subunit E) r_klactIV3981 good J KOG2309 Translation, ribosomal structure and biogenesis 60s ribosomal protein L2/L8 r_klactIV3987 suspect: LH J KOG3504 Translation, ribosomal structure and biogenesis 60S ribosomal protein L29 r_klactIV3990 good J KOG3504 Translation, ribosomal structure and biogenesis 60S ribosomal protein L29 r_klactIV4017 good E KOG3055 Amino acid transport and metabolism Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase r_klactIV4020 good K KOG1522 Transcription RNA polymerase II, subunit POLR2C/RPB3 r_klactIV4028 good U KOG2580 Intracellular trafficking, secretion, and vesicular transport Mitochondrial import inner membrane translocase, subunit TIM44 r_klactIV4035 suspect: HSP Z KOG1003 Cytoskeleton Actin filament-coating protein tropomyosin r_klactIV4045.1 good O KOG3083 Posttranslational modification, protein turnover, chaperones Prohibitin r_klactIV4046 good O KOG3083 Posttranslational modification, protein turnover, chaperones Prohibitin r_klactIV4051 suspect: %id DO KOG2165 Cell cycle control, cell division, chromosome partitioning Anaphase-promoting complex (APC), subunit 2 r_klactIV4051 suspect: %id DO KOG2165 Posttranslational modification, protein turnover, chaperones Anaphase-promoting complex (APC), subunit 2 r_klactIV4056 good S KOG3077 Function unknown Uncharacterized conserved protein r_klactIV4059 suspect: HSP K KOG1142 Transcription Transcription initiation factor TFIID, subunit TAF12 (also component of histone acetyltransferase SAGA) r_klactIV4070 check: MH A KOG0306 RNA processing and modification WD40-repeat-containing subunit of the 18S rRNA processing complex r_klactIV4077 good I KOG0693 Lipid transport and metabolism Myo-inositol-1-phosphate synthase r_klactIV4088 good P KOG1558 Inorganic ion transport and metabolism Fe2+/Zn2+ regulated transporter r_klactIV4104 good R KOG1721 General function prediction only FOG: Zn-finger r_klactIV4115 good M KOG2686 Cell wall/membrane/envelope biogenesis Choline kinase r_klactIV4123 good C KOG0559 Energy production and conversion Dihydrolipoamide succinyltransferase (2-oxoglutarate dehydrogenase, E2 subunit) r_klactIV4145 suspect: HSP U KOG0946 Intracellular trafficking, secretion, and vesicular transport ER-Golgi vesicle-tethering protein p115 r_klactIV4154 good OPR KOG2195 General function prediction only Transferrin receptor and related proteins containing the protease-associated (PA) domain r_klactIV4154 good OPR KOG2195 Inorganic ion transport and metabolism Transferrin receptor and related proteins containing the protease-associated (PA) domain r_klactIV4154 good OPR KOG2195 Posttranslational modification, protein turnover, chaperones Transferrin receptor and related proteins containing the protease-associated (PA) domain r_klactIV4158 good R KOG1677 General function prediction only CCCH-type Zn-finger protein r_klactIV4162 good S KOG4018 Function unknown Uncharacterized conserved protein, contains RWD domain r_klactIV4168 suspect: LH F KOG2056 Nucleotide transport and metabolism Equilibrative nucleoside transporter protein r_klactIV4170 good O KOG0865 Posttranslational modification, protein turnover, chaperones Cyclophilin type peptidyl-prolyl cis-trans isomerase r_klactIV4181 good E KOG4777 Amino acid transport and metabolism Aspartate-semialdehyde dehydrogenase r_klactIV4185 suspect: LH F KOG1018 Nucleotide transport and metabolism Cytosine deaminase FCY1 and related enzymes r_klactIV4190 good UD KOG1860 Cell cycle control, cell division, chromosome partitioning Nuclear protein export factor r_klactIV4190 good UD KOG1860 Intracellular trafficking, secretion, and vesicular transport Nuclear protein export factor r_klactIV4202.1 suspect: Pn O KOG0714 Posttranslational modification, protein turnover, chaperones Molecular chaperone (DnaJ superfamily) r_klactIV4202 good P KOG4505 Inorganic ion transport and metabolism Na+/H+ antiporter r_klactIV4211 good E KOG1286 Amino acid transport and metabolism Amino acid transporters r_klactIV4219 suspect: Pn T KOG4225 Signal transduction mechanisms Sorbin and SH3 domain-containing protein r_klactIV4222 suspect: LH S KOG3228 Function unknown Uncharacterized conserved protein r_klactIV4238 good E KOG0186 Amino acid transport and metabolism Proline oxidase r_klactIV4246 normal R KOG2316 General function prediction only Predicted ATPase (PP-loop superfamily) r_klactIV4251 good U KOG1300 Intracellular trafficking, secretion, and vesicular transport Vesicle trafficking protein Sec1 r_klactIV4260 good G KOG2254 Carbohydrate transport and metabolism Predicted endo-1,3-beta-glucanase r_klactIV4266 good E KOG1562 Amino acid transport and metabolism Spermidine synthase r_klactIV4272 good S KOG3914 Function unknown WD repeat protein WDR4 r_klactIV4283 good U KOG2347 Intracellular trafficking, secretion, and vesicular transport Sec5 subunit of exocyst complex r_klactIV4284 good A KOG3172 RNA processing and modification Small nuclear ribonucleoprotein Sm D3 r_klactIV4292 good U KOG2034 Intracellular trafficking, secretion, and vesicular transport Vacuolar sorting protein PEP3/VPS18 r_klactIV4293 good K KOG3423 Transcription Transcription initiation factor TFIID, subunit TAF10 (also component of histone acetyltransferase SAGA) r_klactIV4299 good D KOG2260 Cell cycle control, cell division, chromosome partitioning Cell division cycle 37 protein, CDC37 r_klactIV4304 suspect: LH R KOG4532 General function prediction only WD40-like repeat containing protein r_klactIV4316 good L KOG3069 Replication, recombination and repair Peroxisomal NUDIX hydrolase r_klactIV4326 suspect: LH S KOG2722 Function unknown Predicted membrane protein r_klactIV4337 good I KOG1175 Lipid transport and metabolism Acyl-CoA synthetase r_klactIV4361 good U KOG0929 Intracellular trafficking, secretion, and vesicular transport Guanine nucleotide exchange factor r_klactIV4365 good H KOG1284 Coenzyme transport and metabolism Bifunctional GTP cyclohydrolase II/3,4-dihydroxy-2butanone-4-phosphate synthase r_klactIV4369 good KIT KOG1620 Lipid transport and metabolism Inositol polyphosphate multikinase, component of the ARGR transcription regulatory complex r_klactIV4369 good KIT KOG1620 Signal transduction mechanisms Inositol polyphosphate multikinase, component of the ARGR transcription regulatory complex r_klactIV4369 good KIT KOG1620 Transcription Inositol polyphosphate multikinase, component of the ARGR transcription regulatory complex r_klactIV4373 check: MH J KOG0459 Translation, ribosomal structure and biogenesis Polypeptide release factor 3 r_klactIV4379 good O KOG0710 Posttranslational modification, protein turnover, chaperones Molecular chaperone (small heat-shock protein Hsp26/Hsp42) r_klactIV4387.1 suspect: LH K KOG0048 Transcription Transcription factor, Myb superfamily r_klactIV4414.1 suspect: LH K KOG0048 Transcription Transcription factor, Myb superfamily r_klactIV4419.1 suspect: LH L KOG2851 Replication, recombination and repair Eukaryotic-type DNA primase, catalytic (small) subunit r_klactIV4440.1 suspect: LH K KOG0048 Transcription Transcription factor, Myb superfamily r_klactIV4445.1 suspect: LH S KOG4608 Function unknown Uncharacterized conserved protein r_klactIV4469.1 suspect: LH T KOG3521 Signal transduction mechanisms Predicted guanine nucleotide exchange factor r_klactIV4472 suspect: LH GOU KOG1442 Carbohydrate transport and metabolism GDP-fucose transporter r_klactIV4472 suspect: LH GOU KOG1442 Intracellular trafficking, secretion, and vesicular transport GDP-fucose transporter r_klactIV4472 suspect: LH GOU KOG1442 Posttranslational modification, protein turnover, chaperones GDP-fucose transporter r_klactIV4477.1 good R KOG0381 General function prediction only HMG box-containing protein r_klactIV4484 suspect: LH J KOG3933 Translation, ribosomal structure and biogenesis Mitochondrial ribosomal protein S28 r_klactIV4488 good B KOG4191 Chromatin structure and dynamics Histone acetyltransferases PCAF/SAGA/ADA, subunit TADA3L/NGG1 r_klactIV4490 check: MH O KOG0960 Posttranslational modification, protein turnover, chaperones Mitochondrial processing peptidase, beta subunit, and related enzymes (insulinase superfamily) r_klactIV4493 good CU KOG4097 Energy production and conversion Succinate dehydrogenase membrane anchor subunit and related proteins r_klactIV4493 good CU KOG4097 Intracellular trafficking, secretion, and vesicular transport Succinate dehydrogenase membrane anchor subunit and related proteins r_klactIV4503 suspect: LH A KOG1919 RNA processing and modification RNA pseudouridylate synthases r_klactIV4512 good BDL KOG1020 Cell cycle control, cell division, chromosome partitioning Sister chromatid cohesion protein SCC2/Nipped-B r_klactIV4512 good BDL KOG1020 Chromatin structure and dynamics Sister chromatid cohesion protein SCC2/Nipped-B r_klactIV4512 good BDL KOG1020 Replication, recombination and repair Sister chromatid cohesion protein SCC2/Nipped-B r_klactIV4519 good L KOG3662 Replication, recombination and repair Cell division control protein/predicted DNA repair exonuclease r_klactIV4527 good U KOG3745 Intracellular trafficking, secretion, and vesicular transport Exocyst subunit - Sec10p r_klactIV4529 good OC KOG1672 Energy production and conversion ATP binding protein r_klactIV4529 good OC KOG1672 Posttranslational modification, protein turnover, chaperones ATP binding protein r_klactIV4531.1 suspect: LH P KOG3826 Inorganic ion transport and metabolism Na+/H+ antiporter r_klactIV4531 check: MH J KOG0004 Translation, ribosomal structure and biogenesis Ubiquitin/40S ribosomal protein S27a fusion r_klactIV4542 good U KOG3336 Intracellular trafficking, secretion, and vesicular transport Predicted member of the intramitochondrial sorting protein family r_klactIV4546 good R KOG1311 General function prediction only DHHC-type Zn-finger proteins r_klactIV4561 good F KOG0833 Nucleotide transport and metabolism Cytidine deaminase r_klactIV4565 good O KOG2738 Posttranslational modification, protein turnover, chaperones Putative methionine aminopeptidase r_klactIV4569 check: MH O KOG0359 Posttranslational modification, protein turnover, chaperones Chaperonin complex component, TCP-1 zeta subunit (CCT6) r_klactIV4575 good U KOG1301 Intracellular trafficking, secretion, and vesicular transport Vesicle trafficking protein Sly1 (Sec1 family) r_klactIV4578 good L KOG1942 Replication, recombination and repair DNA helicase, TBP-interacting protein r_klactIV4582 good BK KOG2684 Chromatin structure and dynamics Sirtuin 5 and related class III sirtuins (SIR2 family) r_klactIV4582 good BK KOG2684 Transcription Sirtuin 5 and related class III sirtuins (SIR2 family) r_klactIV4584 good K KOG1534 Transcription Putative transcription factor FET5 r_klactIV4596 good YU KOG0845 Intracellular trafficking, secretion, and vesicular transport Nuclear pore complex, Nup98 component (sc Nup145/Nup100/Nup116) r_klactIV4596 good YU KOG0845 Nuclear structure Nuclear pore complex, Nup98 component (sc Nup145/Nup100/Nup116) r_klactIV4598 good S KOG3134 Function unknown Predicted membrane protein r_klactIV4603 good R KOG1134 General function prediction only Uncharacterized conserved protein r_klactIV4605 check: MH TU KOG0906 Intracellular trafficking, secretion, and vesicular transport Phosphatidylinositol 3-kinase VPS34, involved in signal transduction r_klactIV4605 check: MH TU KOG0906 Signal transduction mechanisms Phosphatidylinositol 3-kinase VPS34, involved in signal transduction r_klactIV4615 check: MH A KOG0342 RNA processing and modification ATP-dependent RNA helicase pitchoune r_klactIV4623 good H KOG3220 Coenzyme transport and metabolism Similar to bacterial dephospho-CoA kinase r_klactIV4634 good R KOG1337 General function prediction only N-methyltransferase r_klactIV4637 good CH KOG0325 Coenzyme transport and metabolism Lipoyltransferase r_klactIV4637 good CH KOG0325 Energy production and conversion Lipoyltransferase r_klactIV4639 good T KOG3872 Signal transduction mechanisms FOG: FHA domain r_klactIV4650 good H KOG3244 Coenzyme transport and metabolism Protein involved in ubiquinone biosynthesis r_klactIV4654 good G KOG2175 Carbohydrate transport and metabolism Protein predicted to be involved in carbohydrate metabolism r_klactIV4656.1 suspect: LH R KOG3564 General function prediction only GTPase-activating protein r_klactIV4657 good R KOG0725 General function prediction only Reductases with broad range of substrate specificities r_klactIV4664 check: MH TUZ KOG0704 Cytoskeleton ADP-ribosylation factor GTPase activator r_klactIV4664 check: MH TUZ KOG0704 Intracellular trafficking, secretion, and vesicular transport ADP-ribosylation factor GTPase activator r_klactIV4664 check: MH TUZ KOG0704 Signal transduction mechanisms ADP-ribosylation factor GTPase activator r_klactIV4667 normal I KOG3030 Lipid transport and metabolism Lipid phosphate phosphatase and related enzymes of the PAP2 family r_klactIV4672 suspect: LH KLB KOG0526 Chromatin structure and dynamics Nucleosome-binding factor SPN, POB3 subunit r_klactIV4672 suspect: LH KLB KOG0526 Replication, recombination and repair Nucleosome-binding factor SPN, POB3 subunit r_klactIV4672 suspect: LH KLB KOG0526 Transcription Nucleosome-binding factor SPN, POB3 subunit r_klactIV4677 good TR KOG2268 General function prediction only Serine/threonine protein kinase r_klactIV4677 good TR KOG2268 Signal transduction mechanisms Serine/threonine protein kinase r_klactIV4682.1 suspect: Pn TV KOG4297 Defense mechanisms C-type lectin r_klactIV4682.1 suspect: Pn TV KOG4297 Signal transduction mechanisms C-type lectin r_klactIV4686.1 suspect: LH R KOG0379 General function prediction only Kelch repeat-containing proteins r_klactIV4686.2 suspect: LH T KOG3570 Signal transduction mechanisms MAPK-activating protein DENN r_klactIV4687 good O KOG0101 Posttranslational modification, protein turnover, chaperones Molecular chaperones HSP70/HSC70, HSP70 superfamily r_klactIV4696 good T KOG0789 Signal transduction mechanisms Protein tyrosine phosphatase r_klactIV4697 good T KOG0789 Signal transduction mechanisms Protein tyrosine phosphatase r_klactIV4703 suspect: LH R KOG4711 General function prediction only Predicted membrane protein r_klactIV4712 suspect: LH U KOG2395 Intracellular trafficking, secretion, and vesicular transport Protein involved in vacuole import and degradation r_klactIV4742 good T KOG2197 Signal transduction mechanisms Ypt/Rab-specific GTPase-activating protein GYP7 and related proteins r_klactIV4753 suspect: LH T KOG0371 Signal transduction mechanisms Serine/threonine protein phosphatase 2A, catalytic subunit r_klactIV4766 suspect: LH T KOG4747 Signal transduction mechanisms Two-component phosphorelay intermediate involved in MAP kinase cascade regulation r_klactIV4775 good L KOG2028 Replication, recombination and repair ATPase related to the helicase subunit of the Holliday junction resolvase r_klactIV4776 good P KOG2882 Inorganic ion transport and metabolism p-Nitrophenyl phosphatase r_klactIV4779 good MU KOG2515 Cell wall/membrane/envelope biogenesis Mannosyltransferase r_klactIV4779 good MU KOG2515 Intracellular trafficking, secretion, and vesicular transport Mannosyltransferase r_klactIV4783 good F KOG1355 Nucleotide transport and metabolism Adenylosuccinate synthase r_klactIV4787 good A KOG3322 RNA processing and modification Ribonucleases P/MRP protein subunit r_klactIV4802 good FQ KOG3968 Nucleotide transport and metabolism Atrazine chlorohydrolase/guanine deaminase r_klactIV4802 good FQ KOG3968 Secondary metabolites biosynthesis, transport and catabolism Atrazine chlorohydrolase/guanine deaminase r_klactIV4804 good K KOG2424 Transcription Protein involved in transcription start site selection r_klactIV4807 good ZU KOG2674 Cytoskeleton Cysteine protease required for autophagy - Apg4p/Aut2p r_klactIV4807 good ZU KOG2674 Intracellular trafficking, secretion, and vesicular transport Cysteine protease required for autophagy - Apg4p/Aut2p r_klactIV4811 good R KOG0154 General function prediction only RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains r_klactIV4818 suspect: %id U KOG0946 Intracellular trafficking, secretion, and vesicular transport ER-Golgi vesicle-tethering protein p115 r_klactIV4824 check: MH O KOG0717 Posttranslational modification, protein turnover, chaperones Molecular chaperone (DnaJ superfamily) r_klactIV4834 good O KOG0867 Posttranslational modification, protein turnover, chaperones Glutathione S-transferase r_klactIV4837 suspect: LH K KOG2821 Transcription RNA polymerase II transcription elongation factor Elongin/SIII, subunit elongin A r_klactIV4840 good I KOG1470 Lipid transport and metabolism Phosphatidylinositol transfer protein PDR16 and related proteins r_klactIV4843 good I KOG1470 Lipid transport and metabolism Phosphatidylinositol transfer protein PDR16 and related proteins r_klactIV4845 good J KOG3409 Translation, ribosomal structure and biogenesis Exosomal 3'-5' exoribonuclease complex, subunit ski4 (Csl4) r_klactIV4877 good O KOG3525 Posttranslational modification, protein turnover, chaperones Subtilisin-like proprotein convertase r_klactIV4883 good Y KOG2439 Nuclear structure Nuclear architecture related protein r_klactIV4888 good G KOG0563 Carbohydrate transport and metabolism Glucose-6-phosphate 1-dehydrogenase r_klactIV4896 check: MH TZ KOG1703 Cytoskeleton Adaptor protein Enigma and related PDZ-LIM proteins r_klactIV4896 check: MH TZ KOG1703 Signal transduction mechanisms Adaptor protein Enigma and related PDZ-LIM proteins r_klactIV4907 good U KOG2993 Intracellular trafficking, secretion, and vesicular transport Cytoplasm to vacuole targeting protein r_klactIV4927 check: MH Q KOG0024 Secondary metabolites biosynthesis, transport and catabolism Sorbitol dehydrogenase r_klactIV4933 check: MH Q KOG1205 Secondary metabolites biosynthesis, transport and catabolism Predicted dehydrogenase r_klactIV4948 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactIV4955 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactIV4963 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactIV4966 good G KOG0471 Carbohydrate transport and metabolism Alpha-amylase r_klactIV4977.1 good G KOG2504 Carbohydrate transport and metabolism Monocarboxylate transporter r_klactIV4983 good G KOG2504 Carbohydrate transport and metabolism Monocarboxylate transporter r_klactIV4992 good QR KOG0143 General function prediction only Iron/ascorbate family oxidoreductases r_klactIV4992 good QR KOG0143 Secondary metabolites biosynthesis, transport and catabolism Iron/ascorbate family oxidoreductases r_klactMIT21 suspect: LH C KOG3025 Energy production and conversion Mitochondrial F1F0-ATP synthase, subunit c/ATP9/proteolipid r_klactMIT242 good C KOG4663 Energy production and conversion Cytochrome b r_klactMIT295 good C KOG4665 Energy production and conversion ATP synthase F0 subunit 6 and related proteins r_klactMIT310 good C KOG4769 Energy production and conversion Cytochrome c oxidase, subunit I r_klactMIT328 suspect: HSP C KOG4769 Energy production and conversion Cytochrome c oxidase, subunit I r_klactMIT345 normal C KOG4769 Energy production and conversion Cytochrome c oxidase, subunit I r_klactMIT362 suspect: LH C KOG4664 Energy production and conversion Cytochrome oxidase subunit III and related proteins r_klactMIT365 normal C KOG4769 Energy production and conversion Cytochrome c oxidase, subunit I r_klactMIT381 good C KOG4767 Energy production and conversion Cytochrome c oxidase, subunit II, and related proteins r_klactMIT413 good C KOG4664 Energy production and conversion Cytochrome oxidase subunit III and related proteins r_klactV0013 good QR KOG0143 General function prediction only Iron/ascorbate family oxidoreductases r_klactV0013 good QR KOG0143 Secondary metabolites biosynthesis, transport and catabolism Iron/ascorbate family oxidoreductases r_klactV0023 good G KOG2504 Carbohydrate transport and metabolism Monocarboxylate transporter r_klactV0040 suspect: LH D KOG3772 Cell cycle control, cell division, chromosome partitioning M-phase inducer phosphatase r_klactV0054 suspect: %id R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactV0058 suspect: %id R KOG3867 General function prediction only Sulfatase r_klactV0072 good T KOG2262 Signal transduction mechanisms Sexual differentiation process protein ISP4 r_klactV0090 good T KOG2262 Signal transduction mechanisms Sexual differentiation process protein ISP4 r_klactV0099 good R KOG1337 General function prediction only N-methyltransferase r_klactV0101 good Z KOG1735 Cytoskeleton Actin depolymerizing factor r_klactV0111 good E KOG1287 Amino acid transport and metabolism Amino acid transporters r_klactV0126 good Q KOG0054 Secondary metabolites biosynthesis, transport and catabolism Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily r_klactV0131 suspect: Pn R KOG0118 General function prediction only FOG: RRM domain r_klactV0138.1 suspect: Pn PT KOG2301 Inorganic ion transport and metabolism Voltage-gated Ca2+ channels, alpha1 subunits r_klactV0138.1 suspect: Pn PT KOG2301 Signal transduction mechanisms Voltage-gated Ca2+ channels, alpha1 subunits r_klactV0142 good J KOG3166 Translation, ribosomal structure and biogenesis 60S ribosomal protein L7A r_klactV0147 good G KOG2517 Carbohydrate transport and metabolism Ribulose kinase and related carbohydrate kinases r_klactV0155 good G KOG0224 Carbohydrate transport and metabolism Aquaporin (major intrinsic protein family) r_klactV0157 good U KOG3208 Intracellular trafficking, secretion, and vesicular transport SNARE protein GS28 r_klactV0163 good C KOG3049 Energy production and conversion Succinate dehydrogenase, Fe-S protein subunit r_klactV0187 good U KOG1809 Intracellular trafficking, secretion, and vesicular transport Vacuolar protein sorting-associated protein r_klactV0199 good S KOG0915 Function unknown Uncharacterized conserved protein r_klactV0204.1 suspect: LH DR KOG2739 Cell cycle control, cell division, chromosome partitioning Leucine-rich acidic nuclear protein r_klactV0204.1 suspect: LH DR KOG2739 General function prediction only Leucine-rich acidic nuclear protein r_klactV0206 good OR KOG0001 General function prediction only Ubiquitin and ubiquitin-like proteins r_klactV0206 good OR KOG0001 Posttranslational modification, protein turnover, chaperones Ubiquitin and ubiquitin-like proteins r_klactV0214 suspect: LH GO KOG4157 Carbohydrate transport and metabolism beta-1,6-N-acetylglucosaminyltransferase, contains WSC domain r_klactV0214 suspect: LH GO KOG4157 Posttranslational modification, protein turnover, chaperones beta-1,6-N-acetylglucosaminyltransferase, contains WSC domain r_klactV0221 good R KOG1721 General function prediction only FOG: Zn-finger r_klactV0229 good R KOG2750 General function prediction only Uncharacterized conserved protein similar to ATP/GTP-binding protein r_klactV0236 check: MH O KOG0733 Posttranslational modification, protein turnover, chaperones Nuclear AAA ATPase (VCP subfamily) r_klactV0244 good I KOG2208 Lipid transport and metabolism Vigilin r_klactV0264 check: MH T KOG1450 Signal transduction mechanisms Predicted Rho GTPase-activating protein r_klactV0267 good OU KOG1239 Intracellular trafficking, secretion, and vesicular transport Inner membrane protein translocase involved in respiratory chain assembly r_klactV0267 good OU KOG1239 Posttranslational modification, protein turnover, chaperones Inner membrane protein translocase involved in respiratory chain assembly r_klactV0277 good E KOG0634 Amino acid transport and metabolism Aromatic amino acid aminotransferase and related proteins r_klactV0291 check: MH O KOG1871 Posttranslational modification, protein turnover, chaperones Ubiquitin-specific protease r_klactV0331 good P KOG0876 Inorganic ion transport and metabolism Manganese superoxide dismutase r_klactV0336 good UO KOG1373 Intracellular trafficking, secretion, and vesicular transport Transport protein Sec61, alpha subunit r_klactV0336 good UO KOG1373 Posttranslational modification, protein turnover, chaperones Transport protein Sec61, alpha subunit r_klactV0354 good G KOG1458 Carbohydrate transport and metabolism Fructose-1,6-bisphosphatase r_klactV0357 good I KOG2848 Lipid transport and metabolism 1-acyl-sn-glycerol-3-phosphate acyltransferase r_klactV0363 good R KOG0118 General function prediction only FOG: RRM domain r_klactV0390 good O KOG3359 Posttranslational modification, protein turnover, chaperones Dolichyl-phosphate-mannose:protein O-mannosyl transferase r_klactV0399 good O KOG1463 Posttranslational modification, protein turnover, chaperones 26S proteasome regulatory complex, subunit RPN6/PSMD11 r_klactV0401 suspect: LH L KOG2134 Replication, recombination and repair Polynucleotide kinase 3' phosphatase r_klactV0404 good R KOG4727 General function prediction only U1-like Zn-finger protein r_klactV0422 good P KOG2825 Inorganic ion transport and metabolism Putative arsenite-translocating ATPase r_klactV0424.1 suspect: LH T KOG3575 Signal transduction mechanisms FOG: Hormone receptors r_klactV0435 check: MH D KOG0615 Cell cycle control, cell division, chromosome partitioning Serine/threonine protein kinase Chk2 and related proteins r_klactV0443 good L KOG0969 Replication, recombination and repair DNA polymerase delta, catalytic subunit r_klactV0448 good O KOG0714 Posttranslational modification, protein turnover, chaperones Molecular chaperone (DnaJ superfamily) r_klactV0461 good R KOG0206 General function prediction only P-type ATPase r_klactV0466 good M KOG2388 Cell wall/membrane/envelope biogenesis UDP-N-acetylglucosamine pyrophosphorylase r_klactV0487 good L KOG4062 Replication, recombination and repair 6-O-methylguanine-DNA methyltransferase MGMT/MGT1, involved in DNA repair r_klactV0493 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactV0496 good E KOG1250 Amino acid transport and metabolism Threonine/serine dehydratases r_klactV0500 suspect: LH KA KOG2868 RNA processing and modification Decapping enzyme complex component DCP1 r_klactV0500 suspect: LH KA KOG2868 Transcription Decapping enzyme complex component DCP1 r_klactV0508 suspect: LH U KOG4186 Intracellular trafficking, secretion, and vesicular transport Peroxisomal biogenesis protein (peroxin) r_klactV0513 suspect: LH S KOG1106 Function unknown Uncharacterized conserved protein r_klactV0522 good P KOG2002 Inorganic ion transport and metabolism TPR-containing nuclear phosphoprotein that regulates K(+) uptake r_klactV0533 good H KOG3243 Coenzyme transport and metabolism 6,7-dimethyl-8-ribityllumazine synthase r_klactV0537 good B KOG1342 Chromatin structure and dynamics Histone deacetylase complex, catalytic component RPD3 r_klactV0548 check: MH O KOG0736 Posttranslational modification, protein turnover, chaperones Peroxisome assembly factor 2 containing the AAA+-type ATPase domain r_klactV0550 good O KOG0723 Posttranslational modification, protein turnover, chaperones Molecular chaperone (DnaJ superfamily) r_klactV0565 check: MH R KOG1315 General function prediction only Predicted DHHC-type Zn-finger protein r_klactV0568 good J KOG1004 Translation, ribosomal structure and biogenesis Exosomal 3'-5' exoribonuclease complex subunit Rrp40 r_klactV0573 good I KOG1888 Lipid transport and metabolism Putative phosphoinositide phosphatase r_klactV0585 good DKT KOG2952 Cell cycle control, cell division, chromosome partitioning Cell cycle control protein r_klactV0585 good DKT KOG2952 Signal transduction mechanisms Cell cycle control protein r_klactV0585 good DKT KOG2952 Transcription Cell cycle control protein r_klactV0594 suspect: LH R KOG2602 General function prediction only Predicted cell surface protein homologous to bacterial outer membrane proteins r_klactV0608 good Z KOG1755 Cytoskeleton Profilin r_klactV0612 good S KOG2428 Function unknown Uncharacterized conserved protein r_klactV0615 good G KOG2806 Carbohydrate transport and metabolism Chitinase r_klactV0618 good U KOG3983 Intracellular trafficking, secretion, and vesicular transport Golgi protein r_klactV0624 good O KOG1863 Posttranslational modification, protein turnover, chaperones Ubiquitin carboxyl-terminal hydrolase r_klactV0628 good T KOG0044 Signal transduction mechanisms Ca2+ sensor (EF-Hand superfamily) r_klactV0631 good R KOG4061 General function prediction only DMQ mono-oxygenase/Ubiquinone biosynthesis protein COQ7/CLK-1/CAT5 r_klactV0638 good R KOG1901 General function prediction only Uncharacterized high-glucose-regulated protein r_klactV0645 check: MH O KOG0743 Posttranslational modification, protein turnover, chaperones AAA+-type ATPase r_klactV0649 good I KOG3035 Lipid transport and metabolism Isoamyl acetate-hydrolyzing esterase r_klactV0653 good F KOG1800 Nucleotide transport and metabolism Ferredoxin/adrenodoxin reductase r_klactV0656.1 suspect: Pn S KOG3098 Function unknown Uncharacterized conserved protein r_klactV0659 good A KOG1783 RNA processing and modification Small nuclear ribonucleoprotein F r_klactV0670 check: MH T KOG1453 Signal transduction mechanisms Chimaerin and related Rho GTPase activating proteins r_klactV0673 suspect: LH S KOG4620 Function unknown Uncharacterized conserved protein r_klactV0681 suspect: HSP IM KOG2547 Cell wall/membrane/envelope biogenesis Ceramide glucosyltransferase r_klactV0681 suspect: HSP IM KOG2547 Lipid transport and metabolism Ceramide glucosyltransferase r_klactV0703 good F KOG2835 Nucleotide transport and metabolism Phosphoribosylamidoimidazole-succinocarboxamide synthase r_klactV0711 good EH KOG1184 Amino acid transport and metabolism Thiamine pyrophosphate-requiring enzyme r_klactV0711 good EH KOG1184 Coenzyme transport and metabolism Thiamine pyrophosphate-requiring enzyme r_klactV0724 suspect: LH A KOG0533 RNA processing and modification RRM motif-containing protein r_klactV0729 suspect: LH A KOG0533 RNA processing and modification RRM motif-containing protein r_klactV0738 check: MH C KOG0769 Energy production and conversion Predicted mitochondrial carrier protein r_klactV0739 check: MH C KOG0758 Energy production and conversion Mitochondrial carnitine-acylcarnitine carrier protein r_klactV0745 good J KOG3449 Translation, ribosomal structure and biogenesis 60S acidic ribosomal protein P2 r_klactV0769 suspect: LH U KOG2273 Intracellular trafficking, secretion, and vesicular transport Membrane coat complex Retromer, subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins r_klactV0781 check: MH J KOG0469 Translation, ribosomal structure and biogenesis Elongation factor 2 r_klactV0785 good L KOG2379 Replication, recombination and repair Endonuclease MUS81 r_klactV0791 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactV0799 good U KOG3771 Intracellular trafficking, secretion, and vesicular transport Amphiphysin r_klactV0811 good TZ KOG2710 Cytoskeleton Rho GTPase-activating protein r_klactV0811 good TZ KOG2710 Signal transduction mechanisms Rho GTPase-activating protein r_klactV0817 check: MH O KOG2013 Posttranslational modification, protein turnover, chaperones SMT3/SUMO-activating complex, catalytic component UBA2 r_klactV0819 suspect: Pn O KOG3509 Posttranslational modification, protein turnover, chaperones Basement membrane-specific heparan sulfate proteoglycan (HSPG) core protein r_klactV0822 good E KOG0785 Amino acid transport and metabolism Isocitrate dehydrogenase, alpha subunit r_klactV0831 good R KOG1432 General function prediction only Predicted DNA repair exonuclease SIA1 r_klactV0852 good K KOG0627 Transcription Heat shock transcription factor r_klactV0860 good Z KOG0797 Cytoskeleton Actin-related protein r_klactV0866 check: MH R KOG0017 General function prediction only FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations r_klactV0868 good H KOG3153 Coenzyme transport and metabolism Thiamine pyrophosphokinase r_klactV0874 good K KOG3902 Transcription Histone acetyltransferase PCAF/SAGA, subunit SUPT3H/SPT3 r_klactV0879 good L KOG1968 Replication, recombination and repair Replication factor C, subunit RFC1 (large subunit) r_klactV0888 good U KOG3315 Intracellular trafficking, secretion, and vesicular transport Transport protein particle (TRAPP) complex subunit r_klactV0891 good R KOG3235 General function prediction only Subunit of the major N alpha-acetyltransferase r_klactV0899 good U KOG3325 Intracellular trafficking, secretion, and vesicular transport Membrane coat complex Retromer, subunit VPS29/PEP11 r_klactV0902 good J KOG2509 Translation, ribosomal structure and biogenesis Seryl-tRNA synthetase r_klactV0904.1 good J KOG3418 Translation, ribosomal structure and biogenesis 60S ribosomal protein L27 r_klactV0912 suspect: LH S KOG4674 Function unknown Uncharacterized conserved coiled-coil protein r_klactV0919 suspect: LH K KOG4109 Transcription Histone H3 (Lys4) methyltransferase complex, subunit CPS25/DPY-30 r_klactV0924 good U KOG3202 Intracellular trafficking, secretion, and vesicular transport SNARE protein TLG1/Syntaxin 6 r_klactV0934 good R KOG2852 General function prediction only Possible oxidoreductase r_klactV0942 check: MH T KOG0592 Signal transduction mechanisms 3-phosphoinositide-dependent protein kinase (PDK1) r_klactV0949 good P KOG0876 Inorganic ion transport and metabolism Manganese superoxide dismutase r_klactV0953 good E KOG1709 Amino acid transport and metabolism Guanidinoacetate methyltransferase and related proteins r_klactV0957 check: MH Q KOG0684 Secondary metabolites biosynthesis, transport and catabolism Cytochrome P450 r_klactV0969 suspect: %id Z KOG0613 Cytoskeleton Projectin/twitchin and related proteins r_klactV0990 suspect: LH R KOG0017 General function prediction only FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations r_klactV1014 good R KOG0255 General function prediction only Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) r_klactV1024 check: MH T KOG3601 Signal transduction mechanisms Adaptor protein GRB2, contains SH2 and SH3 domains r_klactV1031 check: MH O KOG0178 Posttranslational modification, protein turnover, chaperones 20S proteasome, regulatory subunit alpha type PSMA4/PRE9 r_klactV1035 good A KOG0152 RNA processing and modification Spliceosomal protein FBP11/Splicing factor PRP40 r_klactV1048 good J KOG2317 Translation, ribosomal structure and biogenesis Putative translation initiation inhibitor UK114/IBM1 r_klactV1051 good O KOG0417 Posttranslational modification, protein turnover, chaperones Ubiquitin-protein ligase r_klactV1056 good O KOG1339 Posttranslational modification, protein turnover, chaperones Aspartyl protease r_klactV1065 check: MH O KOG0802 Posttranslational modification, protein turnover, chaperones E3 ubiquitin ligase r_klactV1070 check: MH U KOG0277 Intracellular trafficking, secretion, and vesicular transport Peroxisomal targeting signal type 2 receptor r_klactV1081 good B KOG1279 Chromatin structure and dynamics Chromatin remodeling factor subunit and related transcription factors r_klactV1091 check: MH K KOG0385 Transcription Chromatin remodeling complex WSTF-ISWI, small subunit r_klactV1096 good T KOG1113 Signal transduction mechanisms cAMP-dependent protein kinase types I and II, regulatory subunit r_klactV1098 good S KOG3455 Function unknown Predicted membrane protein r_klactV1101 good Z KOG3174 Cytoskeleton F-actin capping protein, beta subunit r_klactV1103 check: MH TDK KOG0668 Cell cycle control, cell division, chromosome partitioning Casein kinase II, alpha subunit r_klactV1103 check: MH TDK KOG0668 Signal transduction mechanisms Casein kinase II, alpha subunit r_klactV1103 check: MH TDK KOG0668 Transcription Casein kinase II, alpha subunit r_klactV1111 good K KOG1414 Transcription Transcriptional activator FOSB/c-Fos and related bZIP transcription factors r_klactV1127 good K KOG2150 Transcription CCR4-NOT transcriptional regulation complex, NOT5 subunit r_klactV1134 check: MH O KOG0740 Posttranslational modification, protein turnover, chaperones AAA+-type ATPase r_klactV1139 suspect: LH L KOG3662 Replication, recombination and repair Cell division control protein/predicted DNA repair exonuclease r_klactV1144 check: MH O KOG0691 Posttranslational modification, protein turnover, chaperones Molecular chaperone (DnaJ superfamily) r_klactV1150 good A KOG3801 RNA processing and modification Uncharacterized conserved protein BCN92 r_klactV1157 good B KOG3844 Chromatin structure and dynamics Predicted component of NuA3 histone acetyltransferase complex r_klactV1160 suspect: Pn Z KOG0161 Cytoskeleton Myosin class II heavy chain r_klactV1163 good T KOG0787 Signal transduction mechanisms Dehydrogenase kinase r_klactV1165 good J KOG3162 Translation, ribosomal structure and biogenesis Mitochondrial/chloroplast ribosomal protein S18 r_klactV1177 good DA KOG2609 Cell cycle control, cell division, chromosome partitioning Cyclin D-interacting protein GCIP r_klactV1177 good DA KOG2609 RNA processing and modification Cyclin D-interacting protein GCIP r_klactV1186 good S KOG2342 Function unknown Uncharacterized conserved protein r_klactV1190 suspect: LH R KOG0255 General function prediction only Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) r_klactV1203 good P KOG0236 Inorganic ion transport and metabolism Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) r_klactV1218 good L KOG3818 Replication, recombination and repair DNA polymerase epsilon, subunit B r_klactV1219 good O KOG0366 Posttranslational modification, protein turnover, chaperones Protein geranylgeranyltransferase type II, beta subunit r_klactV1223 check: MH A KOG0272 RNA processing and modification U4/U6 small nuclear ribonucleoprotein Prp4 (contains WD40 repeats) r_klactV1232 check: MH O KOG2014 Posttranslational modification, protein turnover, chaperones SMT3/SUMO-activating complex, AOS1/RAD31 component r_klactV1233 good U KOG1986 Intracellular trafficking, secretion, and vesicular transport Vesicle coat complex COPII, subunit SEC23 r_klactV1240 good R KOG2552 General function prediction only Major facilitator superfamily permease - Cdc91p r_klactV1243.1 check: MH A KOG3482 RNA processing and modification Small nuclear ribonucleoprotein (snRNP) SMF r_klactV1250 suspect: LH O KOG4614 Posttranslational modification, protein turnover, chaperones Inner membrane protein required for assembly of the F0 sector of ATP synthase r_klactV1258 good U KOG3133 Intracellular trafficking, secretion, and vesicular transport 40 kDa farnesylated protein associated with peroxisomes r_klactV1259 check: MH O KOG0424 Posttranslational modification, protein turnover, chaperones Ubiquitin-protein ligase r_klactV1277 good O KOG0959 Posttranslational modification, protein turnover, chaperones N-arginine dibasic convertase NRD1 and related Zn2+-dependent endopeptidases, insulinase superfamily r_klactV1281 good J KOG3506 Translation, ribosomal structure and biogenesis 40S ribosomal protein S29 r_klactV1293 good S KOG1980 Function unknown Uncharacterized conserved protein r_klactV1299 good R KOG2785 General function prediction only C2H2-type Zn-finger protein r_klactV1306 good S KOG0212 Function unknown Uncharacterized conserved protein r_klactV1318 good K KOG1920 Transcription IkappaB kinase complex, IKAP component r_klactV1321 suspect: LH L KOG4141 Replication, recombination and repair DNA repair and recombination protein RAD52/RAD22 r_klactV1336 check: MH U KOG0946 Intracellular trafficking, secretion, and vesicular transport ER-Golgi vesicle-tethering protein p115 r_klactV1341 check: MH L KOG0250 Replication, recombination and repair DNA repair protein RAD18 (SMC family protein) r_klactV1349 check: MH J KOG0435 Translation, ribosomal structure and biogenesis Leucyl-tRNA synthetase r_klactV1358 good I KOG1470 Lipid transport and metabolism Phosphatidylinositol transfer protein PDR16 and related proteins r_klactV1365 good I KOG4667 Lipid transport and metabolism Predicted esterase r_klactV1379 good M KOG1322 Cell wall/membrane/envelope biogenesis GDP-mannose pyrophosphorylase/mannose-1-phosphate guanylyltransferase r_klactV1392 good FH KOG2466 Coenzyme transport and metabolism Uridine permease/thiamine transporter/allantoin transport r_klactV1392 good FH KOG2466 Nucleotide transport and metabolism Uridine permease/thiamine transporter/allantoin transport r_klactV1401 good S KOG4068 Function unknown Uncharacterized conserved protein r_klactV1409 good F KOG2387 Nucleotide transport and metabolism CTP synthase (UTP-ammonia lyase) r_klactV1414 good P KOG0441 Inorganic ion transport and metabolism Cu2+/Zn2+ superoxide dismutase SOD1 r_klactV1425 good U KOG3106 Intracellular trafficking, secretion, and vesicular transport ER lumen protein retaining receptor r_klactV1427 check: MH O KOG0179 Posttranslational modification, protein turnover, chaperones 20S proteasome, regulatory subunit beta type PSMB1/PRE7 r_klactV1437 good E KOG2275 Amino acid transport and metabolism Aminoacylase ACY1 and related metalloexopeptidases r_klactV1457 good O KOG0960 Posttranslational modification, protein turnover, chaperones Mitochondrial processing peptidase, beta subunit, and related enzymes (insulinase superfamily) r_klactV1466 good J KOG3291 Translation, ribosomal structure and biogenesis Ribosomal protein S7 r_klactV1474 good TU KOG0998 Intracellular trafficking, secretion, and vesicular transport Synaptic vesicle protein EHS-1 and related EH domain proteins r_klactV1474 good TU KOG0998 Signal transduction mechanisms Synaptic vesicle protein EHS-1 and related EH domain proteins r_klactV1484 good R KOG1089 General function prediction only Myotubularin-related phosphatidylinositol 3-phosphate 3-phosphatase MTM6 r_klactV1488 good R KOG3399 General function prediction only Predicted Yippee-type zinc-binding protein r_klactV1495 good PQ KOG0039 Inorganic ion transport and metabolism Ferric reductase, NADH/NADPH oxidase and related proteins r_klactV1495 good PQ KOG0039 Secondary metabolites biosynthesis, transport and catabolism Ferric reductase, NADH/NADPH oxidase and related proteins r_klactV1504.1 good U KOG1586 Intracellular trafficking, secretion, and vesicular transport Protein required for fusion of vesicles in vesicular transport, alpha-SNAP r_klactV1507.1 good J KOG0402 Translation, ribosomal structure and biogenesis 60S ribosomal protein L37 r_klactV1520 good A KOG1049 RNA processing and modification Polyadenylation factor I complex, subunit FIP1 r_klactV1542 check: MH R KOG4574 General function prediction only RNA-binding protein (contains RRM and Pumilio-like repeats) r_klactV1550 good R KOG1947 General function prediction only Leucine rich repeat proteins, some proteins contain F-box r_klactV1567 good J KOG2767 Translation, ribosomal structure and biogenesis Translation initiation factor 5 (eIF-5) r_klactV1571 good S KOG3060 Function unknown Uncharacterized conserved protein r_klactV1575 good S KOG3224 Function unknown Uncharacterized conserved protein r_klactV1576 good O KOG3355 Posttranslational modification, protein turnover, chaperones Mitochondrial sulfhydryl oxidase involved in the biogenesis of cytosolic Fe/S proteins r_klactV1584 good S KOG4267 Function unknown Predicted membrane protein r_klactV1594 good D KOG2688 Cell cycle control, cell division, chromosome partitioning Transcription-associated recombination protein - Thp1p r_klactV1600 good C KOG2759 Energy production and conversion Vacuolar H+-ATPase V1 sector, subunit H r_klactV1606 good E KOG0683 Amino acid transport and metabolism Glutamine synthetase r_klactV1610 good Z KOG0679 Cytoskeleton Actin-related protein - Arp4p/Act3p r_klactV1616 suspect: LH S KOG3856 Function unknown Uncharacterized conserved protein r_klactV1625 good J KOG1936 Translation, ribosomal structure and biogenesis Histidyl-tRNA synthetase r_klactV1633 good U KOG1983 Intracellular trafficking, secretion, and vesicular transport Tomosyn and related SNARE-interacting proteins r_klactV1641 check: MH T KOG0694 Signal transduction mechanisms Serine/threonine protein kinase r_klactV1655 good S KOG1008 Function unknown Uncharacterized conserved protein, contains WD40 repeats r_klactV1665 good R KOG0955 General function prediction only PHD finger protein BR140/LIN-49 r_klactV1670 good K KOG1318 Transcription Helix loop helix transcription factor EB r_klactV1674 good U KOG2887 Intracellular trafficking, secretion, and vesicular transport Membrane protein involved in ER to Golgi transport r_klactV1684 good R KOG3780 General function prediction only Thioredoxin binding protein TBP-2/VDUP1 r_klactV1690 good U KOG1062 Intracellular trafficking, secretion, and vesicular transport Vesicle coat complex AP-1, gamma subunit r_klactV1691.1 good U KOG1725 Intracellular trafficking, secretion, and vesicular transport Protein involved in membrane traffic (YOP1/TB2/DP1/HVA22 family) r_klactV1702 good G KOG4125 Carbohydrate transport and metabolism Acid trehalase r_klactV1708.1 suspect: Pn C KOG2189 Energy production and conversion Vacuolar H+-ATPase V0 sector, subunit a r_klactV1710.1 suspect: Pn YU KOG4719 Intracellular trafficking, secretion, and vesicular transport Nuclear pore complex protein r_klactV1710.1 suspect: Pn YU KOG4719 Nuclear structure Nuclear pore complex protein r_klactV1711.1 suspect: Pn K KOG1831 Transcription Negative regulator of transcription r_klactV1711 good C KOG1353 Energy production and conversion F0F1-type ATP synthase, alpha subunit r_klactV1715 good DKL KOG2496 Cell cycle control, cell division, chromosome partitioning Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit r_klactV1715 good DKL KOG2496 Replication, recombination and repair Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit r_klactV1715 good DKL KOG2496 Transcription Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit r_klactV1722 check: MH O KOG0734 Posttranslational modification, protein turnover, chaperones AAA+-type ATPase containing the peptidase M41 domain r_klactV1728.1 suspect: LH T KOG1187 Signal transduction mechanisms Serine/threonine protein kinase r_klactV1729 good BD KOG2328 Cell cycle control, cell division, chromosome partitioning Chromosome condensation complex Condensin, subunit H r_klactV1729 good BD KOG2328 Chromatin structure and dynamics Chromosome condensation complex Condensin, subunit H r_klactV1735 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactV1746 good S KOG4781 Function unknown Uncharacterized conserved protein r_klactV1753 check: MH T KOG0706 Signal transduction mechanisms Predicted GTPase-activating protein r_klactV1761 good J KOG0878 Translation, ribosomal structure and biogenesis 60S ribosomal protein L32 r_klactV1763 good U KOG0439 Intracellular trafficking, secretion, and vesicular transport VAMP-associated protein involved in inositol metabolism r_klactV1766 good R KOG2775 General function prediction only Metallopeptidase r_klactV1774 good E KOG1305 Amino acid transport and metabolism Amino acid transporter protein r_klactV1799 check: MH TBLD KOG0892 Cell cycle control, cell division, chromosome partitioning Protein kinase ATM/Tel1, involved in telomere length regulation and DNA repair r_klactV1799 check: MH TBLD KOG0892 Chromatin structure and dynamics Protein kinase ATM/Tel1, involved in telomere length regulation and DNA repair r_klactV1799 check: MH TBLD KOG0892 Replication, recombination and repair Protein kinase ATM/Tel1, involved in telomere length regulation and DNA repair r_klactV1799 check: MH TBLD KOG0892 Signal transduction mechanisms Protein kinase ATM/Tel1, involved in telomere length regulation and DNA repair r_klactV1801 good J KOG0901 Translation, ribosomal structure and biogenesis 60S ribosomal protein L14/L17/L23 r_klactV1808 suspect: HSP O KOG2164 Posttranslational modification, protein turnover, chaperones Predicted E3 ubiquitin ligase r_klactV1830 check: MH A KOG0284 RNA processing and modification Polyadenylation factor I complex, subunit PFS2 r_klactV1834 good G KOG0234 Carbohydrate transport and metabolism Fructose-6-phosphate 2-kinase/fructose-2,6-biphosphatase r_klactV1840 good K KOG0570 Transcription Transcriptional coactivator r_klactV1843 good O KOG2930 Posttranslational modification, protein turnover, chaperones SCF ubiquitin ligase, Rbx1 component r_klactV1848 good E KOG2797 Amino acid transport and metabolism Prephenate dehydratase r_klactV1852 good O KOG3281 Posttranslational modification, protein turnover, chaperones Mitochondrial F1-ATPase assembly protein r_klactV1864 good R KOG1128 General function prediction only Uncharacterized conserved protein, contains TPR repeats r_klactV1874 good S KOG3277 Function unknown Uncharacterized conserved protein r_klactV1883 good L KOG3108 Replication, recombination and repair Single-stranded DNA-binding replication protein A (RPA), medium (30 kD) subunit r_klactV1892 good J KOG2409 Translation, ribosomal structure and biogenesis KRR1-interacting protein involved in 40S ribosome biogenesis r_klactV1897 good S KOG3393 Function unknown Predicted membrane protein r_klactV1906 check: MH G KOG0658 Carbohydrate transport and metabolism Glycogen synthase kinase-3 r_klactV1915 good J KOG1751 Translation, ribosomal structure and biogenesis 60s ribosomal protein L23 r_klactV1916 good T KOG2322 Signal transduction mechanisms N-methyl-D-aspartate receptor glutamate-binding subunit r_klactV1920 good C KOG1494 Energy production and conversion NAD-dependent malate dehydrogenase r_klactV1927 good S KOG2811 Function unknown Uncharacterized conserved protein r_klactV1936 good G KOG4153 Carbohydrate transport and metabolism Fructose 1,6-bisphosphate aldolase r_klactV1941 suspect: LH O KOG0826 Posttranslational modification, protein turnover, chaperones Predicted E3 ubiquitin ligase involved in peroxisome organization r_klactV1948 suspect: LH J KOG3769 Translation, ribosomal structure and biogenesis Ribonuclease III domain proteins r_klactV1955 good J KOG1191 Translation, ribosomal structure and biogenesis Mitochondrial GTPase r_klactV1961 suspect: LH S KOG4704 Function unknown Uncharacterized conserved protein r_klactV1967 check: MH O KOG0426 Posttranslational modification, protein turnover, chaperones Ubiquitin-protein ligase r_klactV1980 good Q KOG0029 Secondary metabolites biosynthesis, transport and catabolism Amine oxidase r_klactV1994 good A KOG2781 RNA processing and modification U3 small nucleolar ribonucleoprotein (snoRNP) component r_klactV2016 check: MH O KOG0712 Posttranslational modification, protein turnover, chaperones Molecular chaperone (DnaJ superfamily) r_klactV2029 good EO KOG1046 Amino acid transport and metabolism Puromycin-sensitive aminopeptidase and related aminopeptidases r_klactV2029 good EO KOG1046 Posttranslational modification, protein turnover, chaperones Puromycin-sensitive aminopeptidase and related aminopeptidases r_klactV2043 check: MH S KOG0294 Function unknown WD40 repeat-containing protein r_klactV2047 suspect: LH E KOG0172 Amino acid transport and metabolism Lysine-ketoglutarate reductase/saccharopine dehydrogenase r_klactV2055 check: MH DO KOG1173 Cell cycle control, cell division, chromosome partitioning Anaphase-promoting complex (APC), Cdc16 subunit r_klactV2055 check: MH DO KOG1173 Posttranslational modification, protein turnover, chaperones Anaphase-promoting complex (APC), Cdc16 subunit r_klactV2063 good F KOG3079 Nucleotide transport and metabolism Uridylate kinase/adenylate kinase r_klactV2065 good Q KOG1204 Secondary metabolites biosynthesis, transport and catabolism Predicted dehydrogenase r_klactV2068 check: MH Q KOG1204 Secondary metabolites biosynthesis, transport and catabolism Predicted dehydrogenase r_klactV2074 good A KOG3741 RNA processing and modification Poly(A) ribonuclease subunit r_klactV2086 check: MH IE KOG0238 Amino acid transport and metabolism 3-Methylcrotonyl-CoA carboxylase, biotin-containing subunit/Propionyl-CoA carboxylase, alpha chain/Acetyl-CoA carboxylase, biotin carboxylase subunit r_klactV2086 check: MH IE KOG0238 Lipid transport and metabolism 3-Methylcrotonyl-CoA carboxylase, biotin-containing subunit/Propionyl-CoA carboxylase, alpha chain/Acetyl-CoA carboxylase, biotin carboxylase subunit r_klactV2091 good U KOG1607 Intracellular trafficking, secretion, and vesicular transport Protein transporter of the TRAM (translocating chain-associating membrane) superfamily r_klactV2095 good K KOG0794 Transcription CDK8 kinase-activating protein cyclin C r_klactV2111 good S KOG2340 Function unknown Uncharacterized conserved protein r_klactV2112 suspect: LH S KOG3808 Function unknown Uncharacterized conserved protein r_klactV2120 good A KOG2793 RNA processing and modification Putative N2,N2-dimethylguanosine tRNA methyltransferase r_klactV2130 good K KOG1952 Transcription Transcription factor NF-X1, contains NFX-type Zn2+-binding and R3H domains r_klactV2137 good E KOG0785 Amino acid transport and metabolism Isocitrate dehydrogenase, alpha subunit r_klactV2145 good D KOG2360 Cell cycle control, cell division, chromosome partitioning Proliferation-associated nucleolar protein (NOL1) r_klactV2154 good B KOG1343 Chromatin structure and dynamics Histone deacetylase complex, catalytic component HDA1 r_klactV2167 check: MH T KOG1989 Signal transduction mechanisms ARK protein kinase family r_klactV2170 good R KOG1188 General function prediction only WD40 repeat protein r_klactV2177 good K KOG2009 Transcription Transcription initiation factor TFIIIB, Bdp1 subunit r_klactV2182 suspect: LH MO KOG4551 Cell wall/membrane/envelope biogenesis GPI-GlcNAc transferase complex, PIG-H component, involved in glycosylphosphatidylinositol anchor biosynthesis r_klactV2182 suspect: LH MO KOG4551 Posttranslational modification, protein turnover, chaperones GPI-GlcNAc transferase complex, PIG-H component, involved in glycosylphosphatidylinositol anchor biosynthesis r_klactV2187 good S KOG4174 Function unknown Uncharacterized conserved protein r_klactV2195 good S KOG0396 Function unknown Uncharacterized conserved protein r_klactV2200 good E KOG1305 Amino acid transport and metabolism Amino acid transporter protein r_klactV2203 good V KOG1572 Defense mechanisms Predicted protein tyrosine phosphatase r_klactV2211 good B KOG1745 Chromatin structure and dynamics Histones H3 and H4 r_klactV2220 good B KOG3467 Chromatin structure and dynamics Histone H4 r_klactV2229 good G KOG4472 Carbohydrate transport and metabolism Glycolipid 2-alpha-mannosyltransferase (alpha-1,2-mannosyltransferase) r_klactV2232 suspect: LH DK KOG4466 Cell cycle control, cell division, chromosome partitioning Component of histone deacetylase complex (breast carcinoma metastasis suppressor 1 protein in human) r_klactV2232 suspect: LH DK KOG4466 Transcription Component of histone deacetylase complex (breast carcinoma metastasis suppressor 1 protein in human) r_klactV2240 suspect: HSP R KOG1721 General function prediction only FOG: Zn-finger r_klactV2249 good R KOG2602 General function prediction only Predicted cell surface protein homologous to bacterial outer membrane proteins r_klactV2252 good R KOG2728 General function prediction only Uncharacterized conserved protein with similarity to phosphopantothenoylcysteine synthetase/decarboxylase r_klactV2261 normal R KOG0118 General function prediction only FOG: RRM domain r_klactV2272 suspect: LH O KOG1867 Posttranslational modification, protein turnover, chaperones Ubiquitin-specific protease r_klactV2279 good P KOG3413 Inorganic ion transport and metabolism Mitochondrial matrix protein frataxin, involved in Fe/S protein biosynthesis r_klactV2285 good O KOG0367 Posttranslational modification, protein turnover, chaperones Protein geranylgeranyltransferase Type I, beta subunit r_klactV2287 check: MH C KOG0766 Energy production and conversion Predicted mitochondrial carrier protein r_klactV2291 suspect: LH EH KOG0945 Amino acid transport and metabolism Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase r_klactV2291 suspect: LH EH KOG0945 Coenzyme transport and metabolism Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase r_klactV2296 good MOU KOG2629 Cell wall/membrane/envelope biogenesis Peroxisomal membrane anchor protein (peroxin) r_klactV2296 good MOU KOG2629 Intracellular trafficking, secretion, and vesicular transport Peroxisomal membrane anchor protein (peroxin) r_klactV2296 good MOU KOG2629 Posttranslational modification, protein turnover, chaperones Peroxisomal membrane anchor protein (peroxin) r_klactV2309 check: MH L KOG0388 Replication, recombination and repair SNF2 family DNA-dependent ATPase r_klactV2315 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactV2324 suspect: LH D KOG4575 Cell cycle control, cell division, chromosome partitioning TGc (transglutaminase/protease-like) domain-containing protein involved in cytokinesis r_klactV2330 good E KOG4492 Amino acid transport and metabolism Chorismate synthase r_klactV2337 good YU KOG1964 Intracellular trafficking, secretion, and vesicular transport Nuclear pore complex, rNup107 component (sc Nup84) r_klactV2337 good YU KOG1964 Nuclear structure Nuclear pore complex, rNup107 component (sc Nup84) r_klactV2341 good J KOG3255 Translation, ribosomal structure and biogenesis 60S ribosomal protein L9 r_klactV2346 suspect: LH S KOG4852 Function unknown Uncharacterized conserved protein r_klactV2348 suspect: Pn Q KOG1201 Secondary metabolites biosynthesis, transport and catabolism Hydroxysteroid 17-beta dehydrogenase 11 r_klactV2352 good U KOG2273 Intracellular trafficking, secretion, and vesicular transport Membrane coat complex Retromer, subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins r_klactV2360 good A KOG0839 RNA processing and modification RNA Methylase, SpoU family r_klactV2362 good J KOG1612 Translation, ribosomal structure and biogenesis Exosomal 3'-5' exoribonuclease complex, subunit Rrp42 r_klactV2370 suspect: LH ZR KOG4568 Cytoskeleton Cytoskeleton-associated protein and related proteins r_klactV2370 suspect: LH ZR KOG4568 General function prediction only Cytoskeleton-associated protein and related proteins r_klactV2378 good A KOG2769 RNA processing and modification Putative u4/u6 small nuclear ribonucleoprotein r_klactV2380 good O KOG1641 Posttranslational modification, protein turnover, chaperones Mitochondrial chaperonin r_klactV2390 good IU KOG2308 Intracellular trafficking, secretion, and vesicular transport Phosphatidic acid-preferring phospholipase A1, contains DDHD domain r_klactV2390 good IU KOG2308 Lipid transport and metabolism Phosphatidic acid-preferring phospholipase A1, contains DDHD domain r_klactV2401 good J KOG1723 Translation, ribosomal structure and biogenesis 60s ribosomal protein L30 isolog r_klactV2404 good O KOG0723 Posttranslational modification, protein turnover, chaperones Molecular chaperone (DnaJ superfamily) r_klactV2406 suspect: LH B KOG4718 Chromatin structure and dynamics Non-SMC (structural maintenance of chromosomes) element 1 protein (NSE1) r_klactV2413 good T KOG0519 Signal transduction mechanisms Sensory transduction histidine kinase r_klactV2416 good U KOG1061 Intracellular trafficking, secretion, and vesicular transport Vesicle coat complex AP-1/AP-2/AP-4, beta subunit r_klactV2420 suspect: LH R KOG3089 General function prediction only Predicted DEAD-box-containing helicase r_klactV2430 good G KOG2533 Carbohydrate transport and metabolism Permease of the major facilitator superfamily r_klactV2444 good KL KOG2807 Replication, recombination and repair RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 r_klactV2444 good KL KOG2807 Transcription RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 r_klactV2447 good R KOG0255 General function prediction only Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) r_klactV2465 check: MH C KOG0758 Energy production and conversion Mitochondrial carnitine-acylcarnitine carrier protein r_klactV2469 suspect: LH U KOG4112 Intracellular trafficking, secretion, and vesicular transport Signal peptidase subunit r_klactV2473 good G KOG2531 Carbohydrate transport and metabolism Sugar (pentulose and hexulose) kinases r_klactV2479 good C KOG0557 Energy production and conversion Dihydrolipoamide acetyltransferase r_klactV2496 good P KOG0636 Inorganic ion transport and metabolism ATP sulfurylase (sulfate adenylyltransferase) r_klactV2501 check: MH Q KOG1209 Secondary metabolites biosynthesis, transport and catabolism 1-Acyl dihydroxyacetone phosphate reductase and related dehydrogenases r_klactV2506 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactV2512 normal H KOG2743 Coenzyme transport and metabolism Cobalamin synthesis protein r_klactV2533 good O KOG1415 Posttranslational modification, protein turnover, chaperones Ubiquitin C-terminal hydrolase UCHL1 r_klactV2539 good K KOG1861 Transcription Leucine permease transcriptional regulator r_klactV2542 good O KOG2778 Posttranslational modification, protein turnover, chaperones Ubiquitin C-terminal hydrolase r_klactV2546 good M KOG0621 Cell wall/membrane/envelope biogenesis Phospholipid scramblase r_klactV2553 check: MH GT KOG0372 Carbohydrate transport and metabolism Serine/threonine specific protein phosphatase involved in glycogen accumulation, PP2A-related r_klactV2553 check: MH GT KOG0372 Signal transduction mechanisms Serine/threonine specific protein phosphatase involved in glycogen accumulation, PP2A-related r_klactV2560 good K KOG3302 Transcription TATA-box binding protein (TBP), component of TFIID and TFIIIB r_klactV2575 good G KOG1050 Carbohydrate transport and metabolism Trehalose-6-phosphate synthase component TPS1 and related subunits r_klactV2589 good A KOG1775 RNA processing and modification U6 snRNA-associated Sm-like protein r_klactV2593 suspect: LH R KOG4144 General function prediction only Arylalkylamine N-acetyltransferase r_klactV2600 check: MH O KOG1868 Posttranslational modification, protein turnover, chaperones Ubiquitin C-terminal hydrolase r_klactV2604 suspect: LH S KOG2690 Function unknown Uncharacterized conserved protein, contains BSD domain r_klactV2609 good V KOG1572 Defense mechanisms Predicted protein tyrosine phosphatase r_klactV2612 good L KOG0012 Replication, recombination and repair DNA damage inducible protein r_klactV2613 good L KOG1918 Replication, recombination and repair 3-methyladenine DNA glycosidase r_klactV2619 good O KOG2725 Posttranslational modification, protein turnover, chaperones Cytochrome oxidase assembly factor COX15 r_klactV2626 good O KOG2004 Posttranslational modification, protein turnover, chaperones Mitochondrial ATP-dependent protease PIM1/LON r_klactV2630 good K KOG0869 Transcription CCAAT-binding factor, subunit A (HAP3) r_klactV2632 good D KOG2864 Cell cycle control, cell division, chromosome partitioning Nuclear division RFT1 protein r_klactV2639 good L KOG1294 Replication, recombination and repair Apurinic/apyrimidinic endonuclease and related enzymes r_klactV2656 good R KOG3511 General function prediction only Sortilin and related receptors r_klactV2664 check: MH T KOG0660 Signal transduction mechanisms Mitogen-activated protein kinase r_klactV2676 good C KOG2828 Energy production and conversion Acetyl-CoA hydrolase r_klactV2679 good J KOG3082 Translation, ribosomal structure and biogenesis Methionyl-tRNA formyltransferase r_klactV2701 good E KOG1395 Amino acid transport and metabolism Tryptophan synthase beta chain r_klactV2717 good G KOG2161 Carbohydrate transport and metabolism Glucosidase I r_klactV2730 good R KOG1573 General function prediction only Aldehyde reductase r_klactV2743 suspect: LH R KOG4197 General function prediction only FOG: PPR repeat r_klactV2746 good S KOG2895 Function unknown Uncharacterized conserved protein r_klactV2747 good J KOG2988 Translation, ribosomal structure and biogenesis 60S ribosomal protein L30 r_klactV2753 good J KOG1722 Translation, ribosomal structure and biogenesis 60s ribosomal protein L24 r_klactV2756 suspect: LH S KOG4526 Function unknown Predicted membrane protein r_klactV2761 good Q KOG1599 Secondary metabolites biosynthesis, transport and catabolism Uricase (urate oxidase) r_klactV2763 suspect: Pn T KOG4603 Signal transduction mechanisms TBP-1 interacting protein r_klactV2779 suspect: HSP R KOG1721 General function prediction only FOG: Zn-finger r_klactV2786 check: MH A KOG0128 RNA processing and modification RNA-binding protein SART3 (RRM superfamily) r_klactV2800 good C KOG1626 Energy production and conversion Inorganic pyrophosphatase/Nucleosome remodeling factor, subunit NURF38 r_klactV2809 good R KOG1134 General function prediction only Uncharacterized conserved protein r_klactV2830 good BL KOG1009 Chromatin structure and dynamics Chromatin assembly complex 1 subunit B/CAC2 (contains WD40 repeats) r_klactV2830 good BL KOG1009 Replication, recombination and repair Chromatin assembly complex 1 subunit B/CAC2 (contains WD40 repeats) r_klactV2839 suspect: LH L KOG3020 Replication, recombination and repair TatD-related DNase r_klactV2852 good G KOG1050 Carbohydrate transport and metabolism Trehalose-6-phosphate synthase component TPS1 and related subunits r_klactV2855 good J KOG3403 Translation, ribosomal structure and biogenesis Translation initiation factor 1A (eIF-1A) r_klactV2865 good S KOG2922 Function unknown Uncharacterized conserved protein r_klactV2873 check: MH B KOG0273 Chromatin structure and dynamics Beta-transducin family (WD-40 repeat) protein r_klactV2880 suspect: LH U KOG2215 Intracellular trafficking, secretion, and vesicular transport Exocyst complex subunit r_klactV2883 good O KOG2160 Posttranslational modification, protein turnover, chaperones Armadillo/beta-catenin-like repeat-containing protein r_klactV2896 suspect: LH U KOG3691 Intracellular trafficking, secretion, and vesicular transport Exocyst complex subunit Sec8 r_klactV2900 good R KOG3033 General function prediction only Predicted PhzC/PhzF-type epimerase r_klactV2901 good R KOG3033 General function prediction only Predicted PhzC/PhzF-type epimerase r_klactV2910 good O KOG2100 Posttranslational modification, protein turnover, chaperones Dipeptidyl aminopeptidase r_klactV2917 good O KOG2005 Posttranslational modification, protein turnover, chaperones 26S proteasome regulatory complex, subunit RPN1/PSMD2 r_klactV2920 good C KOG0233 Energy production and conversion Vacuolar H+-ATPase V0 sector, subunit c'' r_klactV2925 good E KOG1537 Amino acid transport and metabolism Homoserine kinase r_klactV2928 good O KOG2067 Posttranslational modification, protein turnover, chaperones Mitochondrial processing peptidase, alpha subunit r_klactV2944 check: MH Z KOG0161 Cytoskeleton Myosin class II heavy chain r_klactV2958 check: MH U KOG0093 Intracellular trafficking, secretion, and vesicular transport GTPase Rab3, small G protein superfamily r_klactV2969.1 good J KOG1779 Translation, ribosomal structure and biogenesis 40s ribosomal protein S27 r_klactV2976 suspect: LH J KOG2539 Translation, ribosomal structure and biogenesis Mitochondrial/chloroplast ribosome small subunit component r_klactV2979 good U KOG0090 Intracellular trafficking, secretion, and vesicular transport Signal recognition particle receptor, beta subunit (small G protein superfamily) r_klactV2991 suspect: LH S KOG1835 Function unknown Uncharacterized conserved protein r_klactV3000 suspect: HSP Y KOG2196 Nuclear structure Nuclear porin r_klactV3019 suspect: LH U KOG1091 Intracellular trafficking, secretion, and vesicular transport Ypt/Rab-specific GTPase-activating protein GYP6 r_klactV3020.1 suspect: LH R KOG4197 General function prediction only FOG: PPR repeat r_klactV3022 good G KOG0235 Carbohydrate transport and metabolism Phosphoglycerate mutase r_klactV3040 good U KOG3771 Intracellular trafficking, secretion, and vesicular transport Amphiphysin r_klactV3050 suspect: LH I KOG1933 Lipid transport and metabolism Cholesterol transport protein (Niemann-Pick C disease protein) r_klactV3055 check: MH D KOG0590 Cell cycle control, cell division, chromosome partitioning Checkpoint kinase and related serine/threonine protein kinases r_klactV3065 good A KOG1135 RNA processing and modification mRNA cleavage and polyadenylation factor II complex, subunit CFT2 (CPSF subunit) r_klactV3087 good S KOG1851 Function unknown Uncharacterized conserved protein r_klactV3092 check: MH TU KOG0078 Intracellular trafficking, secretion, and vesicular transport GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins r_klactV3092 check: MH TU KOG0078 Signal transduction mechanisms GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins r_klactV3101 good P KOG1161 Inorganic ion transport and metabolism Protein involved in vacuolar polyphosphate accumulation, contains SPX domain r_klactV3106 good G KOG0449 Carbohydrate transport and metabolism Succinate dehydrogenase, cytochrome b subunit r_klactV3111 check: MH D KOG0600 Cell cycle control, cell division, chromosome partitioning Cdc2-related protein kinase r_klactV3120 suspect: LH S KOG4624 Function unknown Uncharacterized conserved protein r_klactV3128 good U KOG1061 Intracellular trafficking, secretion, and vesicular transport Vesicle coat complex AP-1/AP-2/AP-4, beta subunit r_klactV3134 check: MH T KOG0279 Signal transduction mechanisms G protein beta subunit-like protein r_klactV3135 good T KOG0279 Signal transduction mechanisms G protein beta subunit-like protein r_klactV3139 good AR KOG2190 General function prediction only PolyC-binding proteins alphaCP-1 and related KH domain proteins r_klactV3139 good AR KOG2190 RNA processing and modification PolyC-binding proteins alphaCP-1 and related KH domain proteins r_klactV3146 check: MH C KOG0749 Energy production and conversion Mitochondrial ADP/ATP carrier proteins r_klactV3166 good J KOG1696 Translation, ribosomal structure and biogenesis 60s ribosomal protein L19 r_klactV3179 good H KOG4230 Coenzyme transport and metabolism C1-tetrahydrofolate synthase r_klactV3188 good K KOG3841 Transcription TEF-1 and related transcription factor, TEAD family r_klactV3204 good JK KOG2038 Transcription CAATT-binding transcription factor/60S ribosomal subunit biogenesis protein r_klactV3204 good JK KOG2038 Translation, ribosomal structure and biogenesis CAATT-binding transcription factor/60S ribosomal subunit biogenesis protein r_klactV3218 suspect: HSP K KOG2588 Transcription Predicted DNA-binding protein r_klactV3229 good O KOG0417 Posttranslational modification, protein turnover, chaperones Ubiquitin-protein ligase r_klactV3240 check: MH BK KOG1472 Chromatin structure and dynamics Histone acetyltransferase SAGA/ADA, catalytic subunit PCAF/GCN5 and related proteins r_klactV3240 check: MH BK KOG1472 Transcription Histone acetyltransferase SAGA/ADA, catalytic subunit PCAF/GCN5 and related proteins r_klactV3241 suspect: %id R KOG3394 General function prediction only Protein OS-9 r_klactV3255 good O KOG2924 Posttranslational modification, protein turnover, chaperones Deoxyhypusine synthase r_klactV3260 check: MH R KOG0017 General function prediction only FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations r_klactV3265 good A KOG3013 RNA processing and modification Exosomal 3'-5' exoribonuclease complex, subunit Rrp4 r_klactV3271 good A KOG2078 RNA processing and modification tRNA modification enzyme r_klactV3276 suspect: LH R KOG1674 General function prediction only Cyclin r_klactV3279 check: MH U KOG0076 Intracellular trafficking, secretion, and vesicular transport GTP-binding ADP-ribosylation factor-like protein yARL3 r_klactV3286 good P KOG4126 Inorganic ion transport and metabolism Alkaline phosphatase r_klactV3293 suspect: LH S KOG4503 Function unknown Uncharacterized conserved membrane protein r_klactV3298 good L KOG1982 Replication, recombination and repair Nuclear 5'-3' exoribonuclease-interacting protein, Rai1p r_klactV3308 good E KOG1237 Amino acid transport and metabolism H+/oligopeptide symporter r_klactV3318 good E KOG1289 Amino acid transport and metabolism Amino acid transporters r_klactV3323 good H KOG3042 Coenzyme transport and metabolism Panthothenate synthetase r_klactV3329 good D KOG0995 Cell cycle control, cell division, chromosome partitioning Centromere-associated protein HEC1 r_klactV3334 good KL KOG1123 Replication, recombination and repair RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, 3'-5' helicase subunit SSL2 r_klactV3334 good KL KOG1123 Transcription RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, 3'-5' helicase subunit SSL2 r_klactV3337 suspect: HSP Y KOG2992 Nuclear structure Nucleolar GTPase/ATPase p130 r_klactV3352 good TZ KOG1703 Cytoskeleton Adaptor protein Enigma and related PDZ-LIM proteins r_klactV3352 good TZ KOG1703 Signal transduction mechanisms Adaptor protein Enigma and related PDZ-LIM proteins r_klactV3359 good J KOG2529 Translation, ribosomal structure and biogenesis Pseudouridine synthase r_klactV3372 check: MH L KOG0990 Replication, recombination and repair Replication factor C, subunit RFC5 r_klactV3376 good R KOG1674 General function prediction only Cyclin r_klactV3389 good R KOG3036 General function prediction only Protein involved in cell differentiation/sexual development r_klactV3397 good U KOG1078 Intracellular trafficking, secretion, and vesicular transport Vesicle coat complex COPI, gamma subunit r_klactV3399 good R KOG4680 General function prediction only Uncharacterized conserved protein, contains ML domain r_klactV3400 good S KOG3326 Function unknown Uncharacterized conserved protein r_klactV3409 good EH KOG2644 Amino acid transport and metabolism 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes r_klactV3409 good EH KOG2644 Coenzyme transport and metabolism 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes r_klactV3421 check: MH C KOG0751 Energy production and conversion Mitochondrial aspartate/glutamate carrier protein Aralar/Citrin (contains EF-hand Ca2+-binding domains) r_klactV3434 good R KOG1721 General function prediction only FOG: Zn-finger r_klactV3437 normal R KOG1721 General function prediction only FOG: Zn-finger r_klactV3443 good BK KOG3001 Chromatin structure and dynamics Dosage compensation regulatory complex/histone acetyltransferase complex, subunit MSL-3/MRG15/EAF3, and related CHROMO domain-containing proteins r_klactV3443 good BK KOG3001 Transcription Dosage compensation regulatory complex/histone acetyltransferase complex, subunit MSL-3/MRG15/EAF3, and related CHROMO domain-containing proteins r_klactV3450 check: MH T KOG1165 Signal transduction mechanisms Casein kinase (serine/threonine/tyrosine protein kinase) r_klactV3464 good O KOG0940 Posttranslational modification, protein turnover, chaperones Ubiquitin protein ligase RSP5/NEDD4 r_klactV3474 good J KOG2049 Translation, ribosomal structure and biogenesis Translational repressor MPT5/PUF4 and related RNA-binding proteins (Puf superfamily) r_klactV3481 good R KOG3163 General function prediction only Uncharacterized conserved protein related to ribosomal protein S8E r_klactV3484 suspect: LH A KOG3117 RNA processing and modification Protein involved in rRNA processing r_klactV3495 good J KOG2188 Translation, ribosomal structure and biogenesis Predicted RNA-binding protein, contains Pumilio domains r_klactV3499 suspect: LH S KOG2637 Function unknown Uncharacterized conserved protein r_klactV3506 good K KOG3297 Transcription DNA-directed RNA polymerase subunit E' r_klactV3512 check: MH O KOG0729 Posttranslational modification, protein turnover, chaperones 26S proteasome regulatory complex, ATPase RPT1 r_klactV3516 good E KOG1304 Amino acid transport and metabolism Amino acid transporters r_klactV3528 check: MH I KOG1206 Lipid transport and metabolism Peroxisomal multifunctional beta-oxidation protein and related enzymes r_klactV3531.1 suspect: Pn O KOG1366 Posttranslational modification, protein turnover, chaperones Alpha-macroglobulin r_klactV3537 good G KOG4472 Carbohydrate transport and metabolism Glycolipid 2-alpha-mannosyltransferase (alpha-1,2-mannosyltransferase) r_klactV3564 good C KOG1260 Energy production and conversion Isocitrate lyase r_klactV3576 good FH KOG2702 Coenzyme transport and metabolism Predicted panthothenate kinase/uridine kinase-related protein r_klactV3576 good FH KOG2702 Nucleotide transport and metabolism Predicted panthothenate kinase/uridine kinase-related protein r_klactV3594 good C KOG3954 Energy production and conversion Electron transfer flavoprotein, alpha subunit r_klactV3601 good P KOG0236 Inorganic ion transport and metabolism Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) r_klactV3609 good R KOG2737 General function prediction only Putative metallopeptidase r_klactV3612 good Z KOG2026 Cytoskeleton Spindle pole body protein - Sad1p r_klactV3617 good O KOG1555 Posttranslational modification, protein turnover, chaperones 26S proteasome regulatory complex, subunit RPN11 r_klactV3622 suspect: LH S KOG4102 Function unknown Uncharacterized conserved protein r_klactV3630 good D KOG2168 Cell cycle control, cell division, chromosome partitioning Cullins r_klactV3636 good C KOG2617 Energy production and conversion Citrate synthase r_klactV3639 suspect: Pn S KOG4415 Function unknown Uncharacterized conserved protein r_klactV3642 good B KOG2696 Chromatin structure and dynamics Histone acetyltransferase type b catalytic subunit r_klactV3646 good K KOG3341 Transcription RNA polymerase II transcription factor complex subunit r_klactV3648 good J KOG2554 Translation, ribosomal structure and biogenesis Pseudouridylate synthase r_klactV3655 check: MH A KOG0345 RNA processing and modification ATP-dependent RNA helicase r_klactV3662 good O KOG2016 Posttranslational modification, protein turnover, chaperones NEDD8-activating complex, APP-BP1/UBA5 component r_klactV3676 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactV3680 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactV3696 good PQ KOG0039 Inorganic ion transport and metabolism Ferric reductase, NADH/NADPH oxidase and related proteins r_klactV3696 good PQ KOG0039 Secondary metabolites biosynthesis, transport and catabolism Ferric reductase, NADH/NADPH oxidase and related proteins r_klactV3723 suspect: Pn PT KOG3599 Inorganic ion transport and metabolism Ca2+-modulated nonselective cation channel polycystin r_klactV3723 suspect: Pn PT KOG3599 Signal transduction mechanisms Ca2+-modulated nonselective cation channel polycystin r_klactV3746 check: MH P KOG0202 Inorganic ion transport and metabolism Ca2+ transporting ATPase r_klactV3754 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactV3772 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactV3784 good E KOG1289 Amino acid transport and metabolism Amino acid transporters r_klactV3799 check: MH O KOG0942 Posttranslational modification, protein turnover, chaperones E3 ubiquitin protein ligase r_klactV3807 good MO KOG1771 Cell wall/membrane/envelope biogenesis GPI-alpha-mannosyltransferase III (GPI10/PIG-B) involved in glycosylphosphatidylinositol anchor biosynthesis r_klactV3807 good MO KOG1771 Posttranslational modification, protein turnover, chaperones GPI-alpha-mannosyltransferase III (GPI10/PIG-B) involved in glycosylphosphatidylinositol anchor biosynthesis r_klactV3811 good S KOG2665 Function unknown Predicted FAD-dependent oxidoreductase r_klactV3815 check: MH DKL KOG0659 Cell cycle control, cell division, chromosome partitioning Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, kinase subunit CDK7 r_klactV3815 check: MH DKL KOG0659 Replication, recombination and repair Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, kinase subunit CDK7 r_klactV3815 check: MH DKL KOG0659 Transcription Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, kinase subunit CDK7 r_klactV3819 good J KOG2726 Translation, ribosomal structure and biogenesis Mitochondrial polypeptide chain release factor r_klactV3828 good R KOG4372 General function prediction only Predicted alpha/beta hydrolase r_klactV3831 suspect: LH UD KOG2218 Cell cycle control, cell division, chromosome partitioning ER to golgi transport protein/RAD50-interacting protein 1 r_klactV3831 suspect: LH UD KOG2218 Intracellular trafficking, secretion, and vesicular transport ER to golgi transport protein/RAD50-interacting protein 1 r_klactV3837 good KB KOG3265 Chromatin structure and dynamics Histone chaperone involved in gene silencing r_klactV3837 good KB KOG3265 Transcription Histone chaperone involved in gene silencing r_klactV3857 good G KOG0235 Carbohydrate transport and metabolism Phosphoglycerate mutase r_klactV3874 good E KOG2275 Amino acid transport and metabolism Aminoacylase ACY1 and related metalloexopeptidases r_klactV3885 good BD KOG1507 Cell cycle control, cell division, chromosome partitioning Nucleosome assembly protein NAP-1 r_klactV3885 good BD KOG1507 Chromatin structure and dynamics Nucleosome assembly protein NAP-1 r_klactV3888 good G KOG3111 Carbohydrate transport and metabolism D-ribulose-5-phosphate 3-epimerase r_klactV3902 good A KOG1782 RNA processing and modification Small Nuclear ribonucleoprotein splicing factor r_klactV3906 check: MH R KOG1469 General function prediction only Predicted acyl-CoA dehydrogenase r_klactV3921 good J KOG2915 Translation, ribosomal structure and biogenesis tRNA(1-methyladenosine) methyltransferase, subunit GCD14 r_klactV3923 good E KOG0807 Amino acid transport and metabolism Carbon-nitrogen hydrolase r_klactV3930 suspect: LH R KOG0017 General function prediction only FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations r_klactV3950 check: MH T KOG0581 Signal transduction mechanisms Mitogen-activated protein kinase kinase (MAP2K) r_klactV3965 normal P KOG1341 Inorganic ion transport and metabolism Na+/K+ transporter r_klactV3987 good R KOG0370 General function prediction only Multifunctional pyrimidine synthesis protein CAD (includes carbamoyl-phophate synthetase, aspartate transcarbamylase, and glutamine amidotransferase) r_klactV4001 good T KOG2641 Signal transduction mechanisms Predicted seven transmembrane receptor - rhodopsin family r_klactV4006 check: MH C KOG0760 Energy production and conversion Mitochondrial carrier protein MRS3/4 r_klactV4023 good R KOG0379 General function prediction only Kelch repeat-containing proteins r_klactV4051 suspect: LH KTDL KOG2043 Cell cycle control, cell division, chromosome partitioning Signaling protein SWIFT and related BRCT domain proteins r_klactV4051 suspect: LH KTDL KOG2043 Replication, recombination and repair Signaling protein SWIFT and related BRCT domain proteins r_klactV4051 suspect: LH KTDL KOG2043 Signal transduction mechanisms Signaling protein SWIFT and related BRCT domain proteins r_klactV4051 suspect: LH KTDL KOG2043 Transcription Signaling protein SWIFT and related BRCT domain proteins r_klactV4069 normal R KOG0504 General function prediction only FOG: Ankyrin repeat r_klactV4072 check: MH O KOG4412 Posttranslational modification, protein turnover, chaperones 26S proteasome regulatory complex, subunit PSMD10 r_klactV4075 good O KOG3090 Posttranslational modification, protein turnover, chaperones Prohibitin-like protein r_klactV4088 good OKIT KOG2642 Lipid transport and metabolism Alpha-1,2 glucosyltransferase/transcriptional activator r_klactV4088 good OKIT KOG2642 Posttranslational modification, protein turnover, chaperones Alpha-1,2 glucosyltransferase/transcriptional activator r_klactV4088 good OKIT KOG2642 Signal transduction mechanisms Alpha-1,2 glucosyltransferase/transcriptional activator r_klactV4088 good OKIT KOG2642 Transcription Alpha-1,2 glucosyltransferase/transcriptional activator r_klactV4106 good DO KOG0305 Cell cycle control, cell division, chromosome partitioning Anaphase promoting complex, Cdc20, Cdh1, and Ama1 subunits r_klactV4106 good DO KOG0305 Posttranslational modification, protein turnover, chaperones Anaphase promoting complex, Cdc20, Cdh1, and Ama1 subunits r_klactV4115 good S KOG2111 Function unknown Uncharacterized conserved protein, contains WD40 repeats r_klactV4132 good A KOG4655 RNA processing and modification U3 small nucleolar ribonucleoprotein (snoRNP) component r_klactV4138 good J KOG3254 Translation, ribosomal structure and biogenesis Mitochondrial/chloroplast ribosomal protein L6 r_klactV4141 good J KOG3141 Translation, ribosomal structure and biogenesis Mitochondrial/chloroplast ribosomal protein L3 r_klactV4153 good YU KOG2020 Intracellular trafficking, secretion, and vesicular transport Nuclear transport receptor CRM1/MSN5 (importin beta superfamily) r_klactV4153 good YU KOG2020 Nuclear structure Nuclear transport receptor CRM1/MSN5 (importin beta superfamily) r_klactV4163 good PT KOG2301 Inorganic ion transport and metabolism Voltage-gated Ca2+ channels, alpha1 subunits r_klactV4163 good PT KOG2301 Signal transduction mechanisms Voltage-gated Ca2+ channels, alpha1 subunits r_klactV4169 good MO KOG1183 Cell wall/membrane/envelope biogenesis N-acetylglucosaminyltransferase complex, subunit PIG-Q/GPI1, required for phosphatidylinositol biosynthesis r_klactV4169 good MO KOG1183 Posttranslational modification, protein turnover, chaperones N-acetylglucosaminyltransferase complex, subunit PIG-Q/GPI1, required for phosphatidylinositol biosynthesis r_klactV4172 good J KOG4844 Translation, ribosomal structure and biogenesis Mitochondrial ribosomal protein S27 r_klactV4175 good J KOG0830 Translation, ribosomal structure and biogenesis 40S ribosomal protein SA (P40)/Laminin receptor 1 r_klactV4186 good PQ KOG0039 Inorganic ion transport and metabolism Ferric reductase, NADH/NADPH oxidase and related proteins r_klactV4186 good PQ KOG0039 Secondary metabolites biosynthesis, transport and catabolism Ferric reductase, NADH/NADPH oxidase and related proteins r_klactV4189 good R KOG2703 General function prediction only C4-type Zn-finger protein r_klactV4195 good R KOG1491 General function prediction only Predicted GTP-binding protein (ODN superfamily) r_klactV4224 good E KOG1286 Amino acid transport and metabolism Amino acid transporters r_klactV4230.1 suspect: Pn R KOG1901 General function prediction only Uncharacterized high-glucose-regulated protein r_klactV4230 good EH KOG1184 Amino acid transport and metabolism Thiamine pyrophosphate-requiring enzyme r_klactV4230 good EH KOG1184 Coenzyme transport and metabolism Thiamine pyrophosphate-requiring enzyme r_klactV4238 good Z KOG1820 Cytoskeleton Microtubule-associated protein r_klactV4240 good O KOG0907 Posttranslational modification, protein turnover, chaperones Thioredoxin r_klactV4245 good E KOG1615 Amino acid transport and metabolism Phosphoserine phosphatase r_klactV4248 good C KOG3180 Energy production and conversion Electron transfer flavoprotein, beta subunit r_klactV4255 good G KOG2631 Carbohydrate transport and metabolism Class II aldolase/adducin N-terminal domain protein r_klactV4256 suspect: LH A KOG1784 RNA processing and modification Small Nuclear ribonucleoprotein splicing factor r_klactV4268 good R KOG2878 General function prediction only Predicted kinase r_klactV4272 good I KOG3016 Lipid transport and metabolism Acyl-CoA thioesterase r_klactV4282 good H KOG4230 Coenzyme transport and metabolism C1-tetrahydrofolate synthase r_klactV4291.1 suspect: Pn R KOG4197 General function prediction only FOG: PPR repeat r_klactV4291 good O KOG3259 Posttranslational modification, protein turnover, chaperones Peptidyl-prolyl cis-trans isomerase r_klactV4293 suspect: LH D KOG3772 Cell cycle control, cell division, chromosome partitioning M-phase inducer phosphatase r_klactV4301 good I KOG2804 Lipid transport and metabolism Phosphorylcholine transferase/cholinephosphate cytidylyltransferase r_klactV4304 good R KOG2961 General function prediction only Predicted hydrolase (HAD superfamily) r_klactV4309 good O KOG2231 Posttranslational modification, protein turnover, chaperones Predicted E3 ubiquitin ligase r_klactV4312 check: MH O KOG0317 Posttranslational modification, protein turnover, chaperones Predicted E3 ubiquitin ligase, integral peroxisomal membrane protein r_klactV4318 suspect: LH ODR KOG4151 Cell cycle control, cell division, chromosome partitioning Myosin assembly protein/sexual cycle protein and related proteins r_klactV4318 suspect: LH ODR KOG4151 General function prediction only Myosin assembly protein/sexual cycle protein and related proteins r_klactV4318 suspect: LH ODR KOG4151 Posttranslational modification, protein turnover, chaperones Myosin assembly protein/sexual cycle protein and related proteins r_klactV4324 check: MH R KOG0509 General function prediction only Ankyrin repeat and DHHC-type Zn-finger domain containing proteins r_klactV4334 good L KOG2518 Replication, recombination and repair 5'-3' exonuclease r_klactV4344 suspect: HSP K KOG2588 Transcription Predicted DNA-binding protein r_klactV4377 good O KOG1051 Posttranslational modification, protein turnover, chaperones Chaperone HSP104 and related ATP-dependent Clp proteases r_klactV4386 good S KOG1032 Function unknown Uncharacterized conserved protein, contains GRAM domain r_klactV4389 good O KOG1724 Posttranslational modification, protein turnover, chaperones SCF ubiquitin ligase, Skp1 component r_klactV4395 suspect: LH MU KOG4444 Cell wall/membrane/envelope biogenesis Peroxisomal assembly protein PEX3 r_klactV4395 suspect: LH MU KOG4444 Intracellular trafficking, secretion, and vesicular transport Peroxisomal assembly protein PEX3 r_klactV4404 suspect: LH L KOG4835 Replication, recombination and repair DNA-binding protein C1D involved in regulation of double-strand break repair r_klactV4411 good O KOG1364 Posttranslational modification, protein turnover, chaperones Predicted ubiquitin regulatory protein, contains UAS and UBX domains r_klactV4417 good O KOG1349 Posttranslational modification, protein turnover, chaperones Gpi-anchor transamidase r_klactV4428 check: MH T KOG0583 Signal transduction mechanisms Serine/threonine protein kinase r_klactV4432 suspect: Pn A KOG0340 RNA processing and modification ATP-dependent RNA helicase r_klactV4447 good R KOG2647 General function prediction only Predicted Dolichyl-phosphate-mannose-protein mannosyltransferase r_klactV4452 good H KOG0776 Coenzyme transport and metabolism Geranylgeranyl pyrophosphate synthase/Polyprenyl synthetase r_klactV4456 good I KOG1602 Lipid transport and metabolism Cis-prenyltransferase r_klactV4460 good U KOG0864 Intracellular trafficking, secretion, and vesicular transport Ran-binding protein RANBP1 and related RanBD domain proteins r_klactV4468 good G KOG0602 Carbohydrate transport and metabolism Neutral trehalase r_klactV4476.1 suspect: Pn B KOG1756 Chromatin structure and dynamics Histone 2A r_klactV4476 good B KOG1744 Chromatin structure and dynamics Histone H2B r_klactV4482 good B KOG1756 Chromatin structure and dynamics Histone 2A r_klactV4487 good S KOG2861 Function unknown Uncharacterized conserved protein r_klactV4490 good R KOG0381 General function prediction only HMG box-containing protein r_klactV4506 good V KOG1823 Defense mechanisms DRIM (Down-regulated in metastasis)-like proteins r_klactV4523 check: MH C KOG2451 Energy production and conversion Aldehyde dehydrogenase r_klactV4527 check: MH L KOG1564 Replication, recombination and repair DNA repair protein RHP57 r_klactV4532 good K KOG3104 Transcription Mod5 protein sorting/negative effector of RNA Pol III synthesis r_klactV4545 good T KOG1981 Signal transduction mechanisms SOK1 kinase belonging to the STE20/SPS1/GC kinase family r_klactV4551 good B KOG3467 Chromatin structure and dynamics Histone H4 r_klactV4555 good B KOG1745 Chromatin structure and dynamics Histones H3 and H4 r_klactV4557 good E KOG4202 Amino acid transport and metabolism Phosphoribosylanthranilate isomerase r_klactV4561 good C KOG1626 Energy production and conversion Inorganic pyrophosphatase/Nucleosome remodeling factor, subunit NURF38 r_klactV4571 good DO KOG1493 Cell cycle control, cell division, chromosome partitioning Anaphase-promoting complex (APC), subunit 11 r_klactV4571 good DO KOG1493 Posttranslational modification, protein turnover, chaperones Anaphase-promoting complex (APC), subunit 11 r_klactV4574 good O KOG1752 Posttranslational modification, protein turnover, chaperones Glutaredoxin and related proteins r_klactV4589 good Z KOG2053 Cytoskeleton Mitochondrial inheritance and actin cytoskeleton organization protein r_klactV4596 good J KOG2971 Translation, ribosomal structure and biogenesis RNA-binding protein required for biogenesis of the ribosomal 60S subunit r_klactV4603 good OE KOG1282 Amino acid transport and metabolism Serine carboxypeptidases (lysosomal cathepsin A) r_klactV4603 good OE KOG1282 Posttranslational modification, protein turnover, chaperones Serine carboxypeptidases (lysosomal cathepsin A) r_klactV4609 suspect: LH T KOG3739 Signal transduction mechanisms Stress-activated MAP kinase-interacting protein, Sin1p r_klactV4612 good L KOG2249 Replication, recombination and repair 3'-5' exonuclease r_klactV4633 check: MH V KOG1826 Defense mechanisms Ras GTPase activating protein RasGAP/neurofibromin r_klactV4641.1 check: MH Z KOG1003 Cytoskeleton Actin filament-coating protein tropomyosin r_klactV4652 check: MH K KOG3836 Transcription HLH transcription factor EBF/Olf-1 and related DNA binding proteins r_klactV4657 good O KOG0530 Posttranslational modification, protein turnover, chaperones Protein farnesyltransferase, alpha subunit/protein geranylgeranyltransferase type I, alpha subunit r_klactV4662 good V KOG1716 Defense mechanisms Dual specificity phosphatase r_klactV4674 good ABO KOG1446 Chromatin structure and dynamics Histone H3 (Lys4) methyltransferase complex and RNA cleavage factor II complex, subunit SWD2 r_klactV4674 good ABO KOG1446 Posttranslational modification, protein turnover, chaperones Histone H3 (Lys4) methyltransferase complex and RNA cleavage factor II complex, subunit SWD2 r_klactV4674 good ABO KOG1446 RNA processing and modification Histone H3 (Lys4) methyltransferase complex and RNA cleavage factor II complex, subunit SWD2 r_klactV4682 check: MH L KOG1803 Replication, recombination and repair DNA helicase r_klactV4686 good C KOG3366 Energy production and conversion Mitochondrial F1F0-ATP synthase, subunit d/ATP7 r_klactV4712 suspect: LH S KOG1791 Function unknown Uncharacterized conserved protein r_klactV4730 good Z KOG1876 Cytoskeleton Actin-related protein Arp2/3 complex, subunit ARPC4 r_klactV4741 good A KOG0152 RNA processing and modification Spliceosomal protein FBP11/Splicing factor PRP40 r_klactV4742 good U KOG3342 Intracellular trafficking, secretion, and vesicular transport Signal peptidase I r_klactV4746 good G KOG1203 Carbohydrate transport and metabolism Predicted dehydrogenase r_klactV4757 good PD KOG0672 Cell cycle control, cell division, chromosome partitioning Halotolerance protein HAL3 (contains flavoprotein domain) r_klactV4757 good PD KOG0672 Inorganic ion transport and metabolism Halotolerance protein HAL3 (contains flavoprotein domain) r_klactV4766 good Q KOG1186 Secondary metabolites biosynthesis, transport and catabolism Copper amine oxidase r_klactV4768 suspect: Pn R KOG1721 General function prediction only FOG: Zn-finger r_klactV4776 suspect: LH C KOG1352 Energy production and conversion Vacuolar H+-ATPase V1 sector, subunit A r_klactV4782 good C KOG0536 Energy production and conversion Flavohemoprotein b5+b5R r_klactV4788 suspect: HSP R KOG0381 General function prediction only HMG box-containing protein r_klactV4799 good R KOG1940 General function prediction only Zn-finger protein r_klactV4809 suspect: Pn R KOG1721 General function prediction only FOG: Zn-finger r_klactV4819 suspect: LH R KOG2488 General function prediction only Acetyltransferase (GNAT) domain-containing protein r_klactV4825 good K KOG1605 Transcription TFIIF-interacting CTD phosphatase, including NLI-interacting factor (involved in RNA polymerase II regulation) r_klactV4834 good C KOG1257 Energy production and conversion NADP+-dependent malic enzyme r_klactV4844 good K KOG2593 Transcription Transcription initiation factor IIE, alpha subunit r_klactV4848 good O KOG2018 Posttranslational modification, protein turnover, chaperones Predicted dinucleotide-utilizing enzyme involved in molybdopterin and thiamine biosynthesis r_klactV4852 good C KOG0752 Energy production and conversion Mitochondrial solute carrier protein r_klactV4859 check: MH C KOG0756 Energy production and conversion Mitochondrial tricarboxylate/dicarboxylate carrier proteins r_klactV4862 suspect: LH R KOG4812 General function prediction only Golgi-associated protein/Nedd4 WW domain-binding protein r_klactV4871 good BK KOG1649 Chromatin structure and dynamics SWI-SNF chromatin remodeling complex, Snf5 subunit r_klactV4871 good BK KOG1649 Transcription SWI-SNF chromatin remodeling complex, Snf5 subunit r_klactV4875 good U KOG2740 Intracellular trafficking, secretion, and vesicular transport Clathrin-associated protein medium chain r_klactV4882 good R KOG1844 General function prediction only PHD Zn-finger proteins r_klactV4884 good U KOG1299 Intracellular trafficking, secretion, and vesicular transport Vacuolar sorting protein VPS45/Stt10 (Sec1 family) r_klactV4902 good L KOG1275 Replication, recombination and repair PAB-dependent poly(A) ribonuclease, subunit PAN2 r_klactV4907 check: MH R KOG0974 General function prediction only WD-repeat protein WDR6, WD repeat superfamily r_klactV4910 good J KOG4122 Translation, ribosomal structure and biogenesis Mitochondrial/chloroplast ribosomal protein L36 r_klactV4931 good YU KOG0845 Intracellular trafficking, secretion, and vesicular transport Nuclear pore complex, Nup98 component (sc Nup145/Nup100/Nup116) r_klactV4931 good YU KOG0845 Nuclear structure Nuclear pore complex, Nup98 component (sc Nup145/Nup100/Nup116) r_klactV4933 good D KOG3022 Cell cycle control, cell division, chromosome partitioning Predicted ATPase, nucleotide-binding r_klactV4951 good R KOG0118 General function prediction only FOG: RRM domain r_klactV4965 good G KOG2178 Carbohydrate transport and metabolism Predicted sugar kinase r_klactV4968 good O KOG0896 Posttranslational modification, protein turnover, chaperones Ubiquitin-conjugating enzyme E2 r_klactV4973 check: MH D KOG4593 Cell cycle control, cell division, chromosome partitioning Mitotic checkpoint protein MAD1 r_klactV4979 good T KOG3860 Signal transduction mechanisms Acyltransferase required for palmitoylation of Hedgehog (Hh) family of secreted signaling proteins r_klactV4990 good T KOG2137 Signal transduction mechanisms Protein kinase r_klactV5005 normal R KOG0118 General function prediction only FOG: RRM domain r_klactV5017 good S KOG2427 Function unknown Uncharacterized conserved protein r_klactV5033 good S KOG1590 Function unknown Uncharacterized conserved protein r_klactV5046 check: MH U KOG1059 Intracellular trafficking, secretion, and vesicular transport Vesicle coat complex AP-3, delta subunit r_klactV5051 good L KOG2372 Replication, recombination and repair Oxidation resistance protein r_klactV5062 good I KOG4232 Lipid transport and metabolism Delta 6-fatty acid desaturase/delta-8 sphingolipid desaturase r_klactV5072 good S KOG0270 Function unknown WD40 repeat-containing protein r_klactV5074 good I KOG2779 Lipid transport and metabolism N-myristoyl transferase r_klactV5082 good U KOG3337 Intracellular trafficking, secretion, and vesicular transport Protein similar to predicted member of the intramitochondrial sorting protein family r_klactV5105 good E KOG0399 Amino acid transport and metabolism Glutamate synthase r_klactV5114 suspect: LH J KOG4813 Translation, ribosomal structure and biogenesis Translation initiation factor eIF3, p35 subunit r_klactV5120 good C KOG1231 Energy production and conversion Proteins containing the FAD binding domain r_klactV5131 good U KOG3875 Intracellular trafficking, secretion, and vesicular transport Peroxisomal biogenesis protein peroxin r_klactV5144 good E KOG1250 Amino acid transport and metabolism Threonine/serine dehydratases r_klactV5148 good J KOG2324 Translation, ribosomal structure and biogenesis Prolyl-tRNA synthetase r_klactV5151 good O KOG3457 Posttranslational modification, protein turnover, chaperones Sec61 protein translocation complex, beta subunit r_klactV5164 good A KOG0108 RNA processing and modification mRNA cleavage and polyadenylation factor I complex, subunit RNA15 r_klactV5173 good Q KOG0023 Secondary metabolites biosynthesis, transport and catabolism Alcohol dehydrogenase, class V r_klactV5176 good B KOG2747 Chromatin structure and dynamics Histone acetyltransferase (MYST family) r_klactV5192 good L KOG3020 Replication, recombination and repair TatD-related DNase r_klactV5200 good T KOG0698 Signal transduction mechanisms Serine/threonine protein phosphatase r_klactV5202 good E KOG1223 Amino acid transport and metabolism Isochorismate synthase r_klactV5205 good S KOG3282 Function unknown Uncharacterized conserved protein r_klactV5208 good Y KOG2086 Nuclear structure Protein tyrosine phosphatase SHP1/Cofactor for p97 ATPase-mediated vesicle membrane fusion r_klactV5221 good E KOG2263 Amino acid transport and metabolism Methionine synthase II (cobalamin-independent) r_klactV5239 good D KOG3694 Cell cycle control, cell division, chromosome partitioning Protein required for meiosis r_klactV5247 good O KOG0180 Posttranslational modification, protein turnover, chaperones 20S proteasome, regulatory subunit beta type PSMB3/PUP3 r_klactV5252 good U KOG0929 Intracellular trafficking, secretion, and vesicular transport Guanine nucleotide exchange factor r_klactV5260 good L KOG1433 Replication, recombination and repair DNA repair protein RAD51/RHP55 r_klactV5267 good MOT KOG1550 Cell wall/membrane/envelope biogenesis Extracellular protein SEL-1 and related proteins r_klactV5267 good MOT KOG1550 Posttranslational modification, protein turnover, chaperones Extracellular protein SEL-1 and related proteins r_klactV5267 good MOT KOG1550 Signal transduction mechanisms Extracellular protein SEL-1 and related proteins r_klactV5273 good O KOG0854 Posttranslational modification, protein turnover, chaperones Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes r_klactV5293 check: MH O KOG1864 Posttranslational modification, protein turnover, chaperones Ubiquitin-specific protease r_klactV5297 good FE KOG1448 Amino acid transport and metabolism Ribose-phosphate pyrophosphokinase r_klactV5297 good FE KOG1448 Nucleotide transport and metabolism Ribose-phosphate pyrophosphokinase r_klactV5305 check: MH O KOG0894 Posttranslational modification, protein turnover, chaperones Ubiquitin-protein ligase r_klactV5308 good CR KOG1198 Energy production and conversion Zinc-binding oxidoreductase r_klactV5308 good CR KOG1198 General function prediction only Zinc-binding oxidoreductase r_klactV5313 good S KOG2923 Function unknown Uncharacterized conserved protein r_klactV5320 good J KOG3283 Translation, ribosomal structure and biogenesis 40S ribosomal protein S8 r_klactV5325 suspect: LH A KOG3937 RNA processing and modification mRNA splicing factor r_klactV5330.1 suspect: Pn R KOG4180 General function prediction only Predicted kinase r_klactV5331.1 suspect: LH K KOG1952 Transcription Transcription factor NF-X1, contains NFX-type Zn2+-binding and R3H domains r_klactV5331 good O KOG0101 Posttranslational modification, protein turnover, chaperones Molecular chaperones HSP70/HSC70, HSP70 superfamily r_klactV5343.1 suspect: LH D KOG0798 Cell cycle control, cell division, chromosome partitioning Uncharacterized conserved protein r_klactV5343 good J KOG0434 Translation, ribosomal structure and biogenesis Isoleucyl-tRNA synthetase r_klactV5352 good Z KOG1654 Cytoskeleton Microtubule-associated anchor protein involved in autophagy and membrane trafficking r_klactV5368 good YU KOG1900 Intracellular trafficking, secretion, and vesicular transport Nuclear pore complex, Nup155 component (D Nup154, sc Nup157/Nup170) r_klactV5368 good YU KOG1900 Nuclear structure Nuclear pore complex, Nup155 component (D Nup154, sc Nup157/Nup170) r_klactV5374 good J KOG2438 Translation, ribosomal structure and biogenesis Glutamyl-tRNA amidotransferase subunit B r_klactV5384 check: MH A KOG0647 RNA processing and modification mRNA export protein (contains WD40 repeats) r_klactV5394 suspect: LH R KOG0266 General function prediction only WD40 repeat-containing protein r_klactV5403 good G KOG2762 Carbohydrate transport and metabolism Mannosyltransferase r_klactV5416 good YU KOG2171 Intracellular trafficking, secretion, and vesicular transport Karyopherin (importin) beta 3 r_klactV5416 good YU KOG2171 Nuclear structure Karyopherin (importin) beta 3 r_klactV5424 suspect: LH R KOG0510 General function prediction only Ankyrin repeat protein r_klactV5426 good A KOG3293 RNA processing and modification Small nuclear ribonucleoprotein (snRNP) r_klactV5431 good U KOG1278 Intracellular trafficking, secretion, and vesicular transport Endosomal membrane proteins, EMP70 r_klactV5439 check: MH D KOG1126 Cell cycle control, cell division, chromosome partitioning DNA-binding cell division cycle control protein r_klactV5462 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactV5474 good S KOG0269 Function unknown WD40 repeat-containing protein r_klactV5475 check: MH R KOG4391 General function prediction only Predicted alpha/beta hydrolase BEM46 r_klactV5481 good J KOG1670 Translation, ribosomal structure and biogenesis Translation initiation factor 4F, cap-binding subunit (eIF-4E) and related cap-binding proteins r_klactV5492 good P KOG1397 Inorganic ion transport and metabolism Ca2+/H+ antiporter VCX1 and related proteins r_klactV5498 check: MH E KOG1401 Amino acid transport and metabolism Acetylornithine aminotransferase r_klactV5507 good TD KOG2270 Cell cycle control, cell division, chromosome partitioning Serine/threonine protein kinase involved in cell cycle control r_klactV5507 good TD KOG2270 Signal transduction mechanisms Serine/threonine protein kinase involved in cell cycle control r_klactV5520 good S KOG2318 Function unknown Uncharacterized conserved protein r_klactV5524 check: MH S KOG0282 Function unknown mRNA splicing factor r_klactV5525 check: MH O KOG0652 Posttranslational modification, protein turnover, chaperones 26S proteasome regulatory complex, ATPase RPT5 r_klactV5529 suspect: LH S KOG4764 Function unknown Uncharacterized conserved protein r_klactV5540 good K KOG0261 Transcription RNA polymerase III, large subunit r_klactV5541 suspect: LH S KOG4764 Function unknown Uncharacterized conserved protein r_klactV5547 good E KOG2596 Amino acid transport and metabolism Aminopeptidase I zinc metalloprotease (M18) r_klactV5554 good E KOG0053 Amino acid transport and metabolism Cystathionine beta-lyases/cystathionine gamma-synthases r_klactV5562 check: MH H KOG2017 Coenzyme transport and metabolism Molybdopterin synthase sulfurylase r_klactV5565 good U KOG1690 Intracellular trafficking, secretion, and vesicular transport emp24/gp25L/p24 family of membrane trafficking proteins r_klactV5572 good R KOG3034 General function prediction only Isoamyl acetate-hydrolyzing esterase and related enzymes r_klactV5585 good U KOG1087 Intracellular trafficking, secretion, and vesicular transport Cytosolic sorting protein GGA2/TOM1 r_klactV5593 suspect: %id U KOG0946 Intracellular trafficking, secretion, and vesicular transport ER-Golgi vesicle-tethering protein p115 r_klactV5600 good A KOG2793 RNA processing and modification Putative N2,N2-dimethylguanosine tRNA methyltransferase r_klactV5602.1 suspect: Pn T KOG1187 Signal transduction mechanisms Serine/threonine protein kinase r_klactV5603 good E KOG1438 Amino acid transport and metabolism Anthranilate phosphoribosyltransferase r_klactV5606 good DZU KOG2655 Cell cycle control, cell division, chromosome partitioning Septin family protein (P-loop GTPase) r_klactV5606 good DZU KOG2655 Cytoskeleton Septin family protein (P-loop GTPase) r_klactV5606 good DZU KOG2655 Intracellular trafficking, secretion, and vesicular transport Septin family protein (P-loop GTPase) r_klactV5611 good O KOG0404 Posttranslational modification, protein turnover, chaperones Thioredoxin reductase r_klactV5620 good R KOG1577 General function prediction only Aldo/keto reductase family proteins r_klactV5624 good S KOG2913 Function unknown Predicted membrane protein r_klactV5645 check: MH T KOG0201 Signal transduction mechanisms Serine/threonine protein kinase r_klactV5656 good U KOG0811 Intracellular trafficking, secretion, and vesicular transport SNARE protein PEP12/VAM3/Syntaxin 7/Syntaxin 17 r_klactV5660 check: MH R KOG0645 General function prediction only WD40 repeat protein r_klactV5665 suspect: LH HC KOG0534 Coenzyme transport and metabolism NADH-cytochrome b-5 reductase r_klactV5665 suspect: LH HC KOG0534 Energy production and conversion NADH-cytochrome b-5 reductase r_klactV5670 good J KOG2713 Translation, ribosomal structure and biogenesis Mitochondrial tryptophanyl-tRNA synthetase r_klactV5676 good DK KOG0973 Cell cycle control, cell division, chromosome partitioning Histone transcription regulator HIRA, WD repeat superfamily r_klactV5676 good DK KOG0973 Transcription Histone transcription regulator HIRA, WD repeat superfamily r_klactV5682 good TDK KOG3092 Cell cycle control, cell division, chromosome partitioning Casein kinase II, beta subunit r_klactV5682 good TDK KOG3092 Signal transduction mechanisms Casein kinase II, beta subunit r_klactV5682 good TDK KOG3092 Transcription Casein kinase II, beta subunit r_klactV5689 good C KOG2495 Energy production and conversion NADH-dehydrogenase (ubiquinone) r_klactV5703 check: MH A KOG0329 RNA processing and modification ATP-dependent RNA helicase r_klactV5714.1 good J KOG1753 Translation, ribosomal structure and biogenesis 40S ribosomal protein S16 r_klactV5721.1 good J KOG3295 Translation, ribosomal structure and biogenesis 60S Ribosomal protein L13 r_klactV5723 good J KOG1762 Translation, ribosomal structure and biogenesis 60s acidic ribosomal protein P1 r_klactV5728 good R KOG2789 General function prediction only Putative Zn-finger protein r_klactV5741 good E KOG1404 Amino acid transport and metabolism Alanine-glyoxylate aminotransferase AGT2 r_klactV5747 good E KOG2630 Amino acid transport and metabolism Enolase-phosphatase E-1 r_klactV5753 good L KOG0011 Replication, recombination and repair Nucleotide excision repair factor NEF2, RAD23 component r_klactV5769 good J KOG3271 Translation, ribosomal structure and biogenesis Translation initiation factor 5A (eIF-5A) r_klactV5780 check: MH L KOG0479 Replication, recombination and repair DNA replication licensing factor, MCM3 component r_klactV5794 check: MH P KOG0209 Inorganic ion transport and metabolism P-type ATPase r_klactV5806.1 suspect: Pn Z KOG0613 Cytoskeleton Projectin/twitchin and related proteins r_klactV5812.1 suspect: Pn V KOG1515 Defense mechanisms Arylacetamide deacetylase r_klactV5814 check: MH O KOG0102 Posttranslational modification, protein turnover, chaperones Molecular chaperones mortalin/PBP74/GRP75, HSP70 superfamily r_klactV5818 good T KOG2174 Signal transduction mechanisms Leptin receptor gene-related protein r_klactV5823 good H KOG2599 Coenzyme transport and metabolism Pyridoxal/pyridoxine/pyridoxamine kinase r_klactV5831 good R KOG0725 General function prediction only Reductases with broad range of substrate specificities r_klactV5838 good C KOG0232 Energy production and conversion Vacuolar H+-ATPase V0 sector, subunits c/c' r_klactV5843 suspect: LH YU KOG2271 Intracellular trafficking, secretion, and vesicular transport Nuclear pore complex component (sc Nup85) r_klactV5843 suspect: LH YU KOG2271 Nuclear structure Nuclear pore complex component (sc Nup85) r_klactV5857 good P KOG0475 Inorganic ion transport and metabolism Cl- channel CLC-3 and related proteins (CLC superfamily) r_klactV5862 good AJ KOG3387 RNA processing and modification 60S ribosomal protein 15.5kD/SNU13, NHP2/L7A family (includes ribonuclease P subunit p38), involved in splicing r_klactV5862 good AJ KOG3387 Translation, ribosomal structure and biogenesis 60S ribosomal protein 15.5kD/SNU13, NHP2/L7A family (includes ribonuclease P subunit p38), involved in splicing r_klactV5867 check: MH O KOG0941 Posttranslational modification, protein turnover, chaperones E3 ubiquitin protein ligase r_klactV5871 good C KOG1671 Energy production and conversion Ubiquinol cytochrome c reductase, subunit RIP1 r_klactV5886 check: MH KL KOG0387 Replication, recombination and repair Transcription-coupled repair protein CSB/RAD26 (contains SNF2 family DNA-dependent ATPase domain) r_klactV5886 check: MH KL KOG0387 Transcription Transcription-coupled repair protein CSB/RAD26 (contains SNF2 family DNA-dependent ATPase domain) r_klactV5889 good O KOG4114 Posttranslational modification, protein turnover, chaperones Cytochrome c oxidase assembly protein PET191 r_klactV5898 good R KOG1064 General function prediction only RAVE (regulator of V-ATPase assembly) complex subunit RAV1/DMX protein, WD repeat superfamily r_klactV5904 check: MH O KOG0546 Posttranslational modification, protein turnover, chaperones HSP90 co-chaperone CPR7/Cyclophilin r_klactV5915 check: MH U KOG0928 Intracellular trafficking, secretion, and vesicular transport Pattern-formation protein/guanine nucleotide exchange factor r_klactV5923 good F KOG1377 Nucleotide transport and metabolism Uridine 5'- monophosphate synthase/orotate phosphoribosyltransferase r_klactV5924 good U KOG3479 Intracellular trafficking, secretion, and vesicular transport Mitochondrial import inner membrane translocase, subunit TIM9 r_klactV5930 good O KOG3206 Posttranslational modification, protein turnover, chaperones Alpha-tubulin folding cofactor B r_klactV5933 suspect: Pn A KOG1781 RNA processing and modification Small Nuclear ribonucleoprotein splicing factor r_klactV5938 good TZ KOG4203 Cytoskeleton Armadillo/beta-Catenin/plakoglobin r_klactV5938 good TZ KOG4203 Signal transduction mechanisms Armadillo/beta-Catenin/plakoglobin r_klactV5944 good Z KOG0676 Cytoskeleton Actin and related proteins r_klactV5966 good G KOG4472 Carbohydrate transport and metabolism Glycolipid 2-alpha-mannosyltransferase (alpha-1,2-mannosyltransferase) r_klactV5968 suspect: LH V KOG1515 Defense mechanisms Arylacetamide deacetylase r_klactV5974 suspect: LH R KOG1454 General function prediction only Predicted hydrolase/acyltransferase (alpha/beta hydrolase superfamily) r_klactV5981 good C KOG2450 Energy production and conversion Aldehyde dehydrogenase r_klactV6001 good K KOG2832 Transcription TFIIF-interacting CTD phosphatase, including NLI-interacting factor (involved in RNA polymerase II regulation) r_klactV6006 good U KOG3284 Intracellular trafficking, secretion, and vesicular transport Vacuolar sorting protein VPS28 r_klactV6013 good F KOG1097 Nucleotide transport and metabolism Adenine deaminase/adenosine deaminase r_klactV6022 check: MH L KOG0482 Replication, recombination and repair DNA replication licensing factor, MCM7 component r_klactV6035 suspect: LH S KOG0858 Function unknown Predicted membrane protein r_klactV6040 good H KOG0777 Coenzyme transport and metabolism Geranylgeranyl pyrophosphate synthase/Polyprenyl synthetase r_klactV6046 suspect: Pn U KOG2319 Intracellular trafficking, secretion, and vesicular transport Vacuolar assembly/sorting protein VPS9 r_klactV6056 check: MH C KOG4773 Energy production and conversion NADPH oxidase r_klactV6069 check: MH O KOG0740 Posttranslational modification, protein turnover, chaperones AAA+-type ATPase r_klactV6085 check: MH K KOG0263 Transcription Transcription initiation factor TFIID, subunit TAF5 (also component of histone acetyltransferase SAGA) r_klactV6089 suspect: LH I KOG3059 Lipid transport and metabolism N-acetylglucosaminyltransferase complex, subunit PIG-C/GPI2, required for phosphatidylinositol biosynthesis r_klactV6101 good G KOG2446 Carbohydrate transport and metabolism Glucose-6-phosphate isomerase r_klactV6109 good B KOG0264 Chromatin structure and dynamics Nucleosome remodeling factor, subunit CAF1/NURF55/MSI1 r_klactV6115 good C KOG3976 Energy production and conversion Mitochondrial F1F0-ATP synthase, subunit b/ATP4 r_klactV6120 check: MH C KOG0757 Energy production and conversion Mitochondrial carrier protein - Rim2p/Mrs12p r_klactV6123 good J KOG1732 Translation, ribosomal structure and biogenesis 60S ribosomal protein L21 r_klactV6127 good J KOG3301 Translation, ribosomal structure and biogenesis Ribosomal protein S4 r_klactV6132 good E KOG2367 Amino acid transport and metabolism Alpha-isopropylmalate synthase/homocitrate synthase r_klactV6153 check: MH K KOG0392 Transcription SNF2 family DNA-dependent ATPase domain-containing protein r_klactV6157 good S KOG2881 Function unknown Predicted membrane protein r_klactV6163 check: MH O KOG0744 Posttranslational modification, protein turnover, chaperones AAA+-type ATPase r_klactV6174 suspect: LH J KOG4772 Translation, ribosomal structure and biogenesis Predicted tRNA-splicing endonuclease subunit r_klactV6177 good R KOG2220 General function prediction only Predicted signal transduction protein r_klactV6197 good K KOG1913 Transcription Regucalcin gene promoter region-related protein (RGPR) r_klactV6204 good BK KOG2535 Chromatin structure and dynamics RNA polymerase II elongator complex, subunit ELP3/histone acetyltransferase r_klactV6204 good BK KOG2535 Transcription RNA polymerase II elongator complex, subunit ELP3/histone acetyltransferase r_klactV6208 good E KOG1368 Amino acid transport and metabolism Threonine aldolase r_klactV6212 good I KOG2329 Lipid transport and metabolism Alkaline ceramidase r_klactV6218 good R KOG0725 General function prediction only Reductases with broad range of substrate specificities r_klactV6230 suspect: HSP K KOG0014 Transcription MADS box transcription factor r_klactV6239 good J KOG1646 Translation, ribosomal structure and biogenesis 40S ribosomal protein S6 r_klactV6244 check: MH Q KOG0405 Secondary metabolites biosynthesis, transport and catabolism Pyridine nucleotide-disulphide oxidoreductase r_klactV6261 good R KOG0255 General function prediction only Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) r_klactV6272 good R KOG1490 General function prediction only GTP-binding protein CRFG/NOG1 (ODN superfamily) r_klactV6275 good U KOG2927 Intracellular trafficking, secretion, and vesicular transport Membrane component of ER protein translocation complex r_klactV6282 good O KOG0448 Posttranslational modification, protein turnover, chaperones Mitofusin 1 GTPase, involved in mitochondrila biogenesis r_klactV6291 good R KOG1838 General function prediction only Alpha/beta hydrolase r_klactV6294 good O KOG0909 Posttranslational modification, protein turnover, chaperones Peptide:N-glycanase r_klactV6302 good J KOG2623 Translation, ribosomal structure and biogenesis Tyrosyl-tRNA synthetase r_klactV6305 good S KOG4096 Function unknown Uncharacterized conserved protein r_klactV6313 good S KOG2110 Function unknown Uncharacterized conserved protein, contains WD40 repeats r_klactV6316 good BK KOG3949 Chromatin structure and dynamics RNA polymerase II elongator complex, subunit ELP4 r_klactV6316 good BK KOG3949 Transcription RNA polymerase II elongator complex, subunit ELP4 r_klactV6319 good R KOG3798 General function prediction only Predicted Zn-dependent hydrolase (beta-lactamase superfamily) r_klactV6323 good H KOG2949 Coenzyme transport and metabolism Ketopantoate hydroxymethyltransferase r_klactV6335 good R KOG2382 General function prediction only Predicted alpha/beta hydrolase r_klactV6343 check: MH J KOG2411 Translation, ribosomal structure and biogenesis Aspartyl-tRNA synthetase, mitochondrial r_klactV6347 check: MH R KOG0266 General function prediction only WD40 repeat-containing protein r_klactV6350 good O KOG3061 Posttranslational modification, protein turnover, chaperones Proteasome maturation factor r_klactV6359 suspect: HSP R KOG1862 General function prediction only GYF domain containing proteins r_klactV6362 suspect: LH U KOG4699 Intracellular trafficking, secretion, and vesicular transport Preprotein translocase subunit Sec66 r_klactV6368 good YU KOG2834 Intracellular trafficking, secretion, and vesicular transport Nuclear pore complex, rNpl4 component (sc Npl4) r_klactV6368 good YU KOG2834 Nuclear structure Nuclear pore complex, rNpl4 component (sc Npl4) r_klactV6370.1 suspect: Pn G KOG2431 Carbohydrate transport and metabolism 1, 2-alpha-mannosidase r_klactV6377 check: MH O KOG0103 Posttranslational modification, protein turnover, chaperones Molecular chaperones HSP105/HSP110/SSE1, HSP70 superfamily r_klactV6381 good S KOG4690 Function unknown Uncharacterized conserved protein r_klactV6390 suspect: LH E KOG2380 Amino acid transport and metabolism Prephenate dehydrogenase (NADP+) r_klactV6398 check: MH U KOG0072 Intracellular trafficking, secretion, and vesicular transport GTP-binding ADP-ribosylation factor-like protein ARL1 r_klactV6403 check: MH R KOG1236 General function prediction only Predicted unusual protein kinase r_klactV6418 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactV6420 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactV6431 suspect: LH R KOG2816 General function prediction only Predicted transporter ADD1 (major facilitator superfamily) r_klactV6446 good R KOG1382 General function prediction only Multiple inositol polyphosphate phosphatase r_klactV6460 good E KOG1289 Amino acid transport and metabolism Amino acid transporters r_klactV6469 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactV6479.1 suspect: Pn GC KOG1192 Carbohydrate transport and metabolism UDP-glucuronosyl and UDP-glucosyl transferase r_klactV6479.1 suspect: Pn GC KOG1192 Energy production and conversion UDP-glucuronosyl and UDP-glucosyl transferase r_klactV6503 suspect: Pn R KOG0017 General function prediction only FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations r_klactVI0003.1 suspect: Pn RT KOG0598 General function prediction only Ribosomal protein S6 kinase and related proteins r_klactVI0003.1 suspect: Pn RT KOG0598 Signal transduction mechanisms Ribosomal protein S6 kinase and related proteins r_klactVI0013 good QR KOG0143 General function prediction only Iron/ascorbate family oxidoreductases r_klactVI0013 good QR KOG0143 Secondary metabolites biosynthesis, transport and catabolism Iron/ascorbate family oxidoreductases r_klactVI0023.1 good G KOG2504 Carbohydrate transport and metabolism Monocarboxylate transporter r_klactVI0023 good G KOG2504 Carbohydrate transport and metabolism Monocarboxylate transporter r_klactVI0057 good G KOG2533 Carbohydrate transport and metabolism Permease of the major facilitator superfamily r_klactVI0065 suspect: LH DL KOG3194 Cell cycle control, cell division, chromosome partitioning Checkpoint 9-1-1 complex, RAD1 component r_klactVI0065 suspect: LH DL KOG3194 Replication, recombination and repair Checkpoint 9-1-1 complex, RAD1 component r_klactVI0069 good J KOG3406 Translation, ribosomal structure and biogenesis 40S ribosomal protein S12 r_klactVI0093 good T KOG0531 Signal transduction mechanisms Protein phosphatase 1, regulatory subunit, and related proteins r_klactVI0099 good C KOG2450 Energy production and conversion Aldehyde dehydrogenase r_klactVI0106 good O KOG0675 Posttranslational modification, protein turnover, chaperones Calnexin r_klactVI0119 good Q KOG0024 Secondary metabolites biosynthesis, transport and catabolism Sorbitol dehydrogenase r_klactVI0129 good Q KOG0024 Secondary metabolites biosynthesis, transport and catabolism Sorbitol dehydrogenase r_klactVI0151 good E KOG2250 Amino acid transport and metabolism Glutamate/leucine/phenylalanine/valine dehydrogenases r_klactVI0161 good PQ KOG0039 Inorganic ion transport and metabolism Ferric reductase, NADH/NADPH oxidase and related proteins r_klactVI0161 good PQ KOG0039 Secondary metabolites biosynthesis, transport and catabolism Ferric reductase, NADH/NADPH oxidase and related proteins r_klactVI0169 good CR KOG1198 Energy production and conversion Zinc-binding oxidoreductase r_klactVI0169 good CR KOG1198 General function prediction only Zinc-binding oxidoreductase r_klactVI0177 suspect: HSP R KOG2421 General function prediction only Predicted starch-binding protein r_klactVI0184 good E KOG2965 Amino acid transport and metabolism Arginase r_klactVI0192 good K KOG2652 Transcription RNA polymerase II transcription initiation factor TFIIA, large chain r_klactVI0198 suspect: %id U KOG0946 Intracellular trafficking, secretion, and vesicular transport ER-Golgi vesicle-tethering protein p115 r_klactVI0204 good C KOG0069 Energy production and conversion Glyoxylate/hydroxypyruvate reductase (D-isomer-specific 2-hydroxy acid dehydrogenase superfamily) r_klactVI0213 check: MH T KOG4269 Signal transduction mechanisms Rac GTPase-activating protein BCR/ABR r_klactVI0217 good H KOG2672 Coenzyme transport and metabolism Lipoate synthase r_klactVI0240 good B KOG1343 Chromatin structure and dynamics Histone deacetylase complex, catalytic component HDA1 r_klactVI0249 good DO KOG1546 Cell cycle control, cell division, chromosome partitioning Metacaspase involved in regulation of apoptosis r_klactVI0249 good DO KOG1546 Posttranslational modification, protein turnover, chaperones Metacaspase involved in regulation of apoptosis r_klactVI0256 suspect: Pn Z KOG0161 Cytoskeleton Myosin class II heavy chain r_klactVI0261 good Q KOG0142 Secondary metabolites biosynthesis, transport and catabolism Isopentenyl pyrophosphate:dimethylallyl pyrophosphate isomerase r_klactVI0265 good A KOG0838 RNA processing and modification RNA Methylase, SpoU family r_klactVI0268 good E KOG3143 Amino acid transport and metabolism Imidazoleglycerol-phosphate dehydratase r_klactVI0279 good E KOG1286 Amino acid transport and metabolism Amino acid transporters r_klactVI0286 check: MH A KOG0335 RNA processing and modification ATP-dependent RNA helicase r_klactVI0292 good KL KOG3471 Replication, recombination and repair RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB2 r_klactVI0292 good KL KOG3471 Transcription RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB2 r_klactVI0300 good K KOG0215 Transcription RNA polymerase III, second largest subunit r_klactVI0311 good J KOG2256 Translation, ribosomal structure and biogenesis Predicted protein involved in nuclear export of pre-ribosomes r_klactVI0319 good T KOG2751 Signal transduction mechanisms Beclin-like protein r_klactVI0325 good F KOG1112 Nucleotide transport and metabolism Ribonucleotide reductase, alpha subunit r_klactVI0333 good E KOG2467 Amino acid transport and metabolism Glycine/serine hydroxymethyltransferase r_klactVI0335 check: MH U KOG0092 Intracellular trafficking, secretion, and vesicular transport GTPase Rab5/YPT51 and related small G protein superfamily GTPases r_klactVI0350 check: MH D KOG0590 Cell cycle control, cell division, chromosome partitioning Checkpoint kinase and related serine/threonine protein kinases r_klactVI0354 good O KOG2689 Posttranslational modification, protein turnover, chaperones Predicted ubiquitin regulatory protein r_klactVI0359 good S KOG2911 Function unknown Uncharacterized conserved protein r_klactVI0373 check: MH A KOG0948 RNA processing and modification Nuclear exosomal RNA helicase MTR4, DEAD-box superfamily r_klactVI0397 check: MH D KOG0590 Cell cycle control, cell division, chromosome partitioning Checkpoint kinase and related serine/threonine protein kinases r_klactVI0399 good U KOG3063 Intracellular trafficking, secretion, and vesicular transport Membrane coat complex Retromer, subunit VPS26 r_klactVI0416 good R KOG1721 General function prediction only FOG: Zn-finger r_klactVI0421 good R KOG0381 General function prediction only HMG box-containing protein r_klactVI0426 check: MH T KOG0032 Signal transduction mechanisms Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily r_klactVI0432 good R KOG3880 General function prediction only Predicted small molecule transporter involved in cellular pH homeostasis (Batten disease protein in human) r_klactVI0458 check: MH E KOG0257 Amino acid transport and metabolism Kynurenine aminotransferase, glutamine transaminase K r_klactVI0466 suspect: LH U KOG4809 Intracellular trafficking, secretion, and vesicular transport Rab6 GTPase-interacting protein involved in endosome-to-TGN transport r_klactVI0469 good J KOG3435 Translation, ribosomal structure and biogenesis Mitochondrial/chloroplast ribosomal protein L54/L37 r_klactVI0476 good T KOG2125 Signal transduction mechanisms Glycosylphosphatidylinositol anchor synthesis protein r_klactVI0481 good R KOG2785 General function prediction only C2H2-type Zn-finger protein r_klactVI0486 good Q KOG1210 Secondary metabolites biosynthesis, transport and catabolism Predicted 3-ketosphinganine reductase r_klactVI0490 good J KOG3280 Translation, ribosomal structure and biogenesis Mitochondrial/chloroplast ribosomal protein L17 r_klactVI0493 check: MH E KOG1481 Amino acid transport and metabolism Cysteine synthase r_klactVI0502 good V KOG1716 Defense mechanisms Dual specificity phosphatase r_klactVI0505 good L KOG1658 Replication, recombination and repair DNA polymerase epsilon, subunit C r_klactVI0517 good E KOG2275 Amino acid transport and metabolism Aminoacylase ACY1 and related metalloexopeptidases r_klactVI0520 suspect: LH K KOG2478 Transcription Putative RNA polymerase II regulator r_klactVI0523 good R KOG3101 General function prediction only Esterase D r_klactVI0529 suspect: LH S KOG1426 Function unknown FOG: RCC1 domain r_klactVI0537 good E KOG2276 Amino acid transport and metabolism Metalloexopeptidases r_klactVI0548 good R KOG2055 General function prediction only WD40 repeat protein r_klactVI0551 suspect: LH J KOG4756 Translation, ribosomal structure and biogenesis Mitochondrial ribosomal protein L27 r_klactVI0555 good UO KOG1373 Intracellular trafficking, secretion, and vesicular transport Transport protein Sec61, alpha subunit r_klactVI0555 good UO KOG1373 Posttranslational modification, protein turnover, chaperones Transport protein Sec61, alpha subunit r_klactVI0561 good R KOG3178 General function prediction only Hydroxyindole-O-methyltransferase and related SAM-dependent methyltransferases r_klactVI0570 check: MH T KOG1450 Signal transduction mechanisms Predicted Rho GTPase-activating protein r_klactVI0577 suspect: LH D KOG2166 Cell cycle control, cell division, chromosome partitioning Cullins r_klactVI0586 suspect: LH A KOG4046 RNA processing and modification RNase MRP and P, subunit POP4/p29 r_klactVI0592 good H KOG3159 Coenzyme transport and metabolism Lipoate-protein ligase A r_klactVI0619 good K KOG4134 Transcription DNA-dependent RNA polymerase I r_klactVI0643 good G KOG1879 Carbohydrate transport and metabolism UDP-glucose:glycoprotein glucosyltransferase r_klactVI0655 good J KOG0188 Translation, ribosomal structure and biogenesis Alanyl-tRNA synthetase r_klactVI0659 suspect: LH J KOG4639 Translation, ribosomal structure and biogenesis RNase P/RNase MRP subunit POP5 r_klactVI0664 good AB KOG2441 Chromatin structure and dynamics mRNA splicing factor/probable chromatin binding snw family nuclear protein r_klactVI0664 good AB KOG2441 RNA processing and modification mRNA splicing factor/probable chromatin binding snw family nuclear protein r_klactVI0681 good P KOG2662 Inorganic ion transport and metabolism Magnesium transporters: CorA family r_klactVI0684 good C KOG1664 Energy production and conversion Vacuolar H+-ATPase V1 sector, subunit E r_klactVI0696 good L KOG3657 Replication, recombination and repair Mitochondrial DNA polymerase gamma, catalytic subunit r_klactVI0719 check: MH R KOG0075 General function prediction only GTP-binding ADP-ribosylation factor-like protein r_klactVI0733 good L KOG0219 Replication, recombination and repair Mismatch repair ATPase MSH2 (MutS family) r_klactVI0736 good R KOG1577 General function prediction only Aldo/keto reductase family proteins r_klactVI0755 suspect: LH O KOG0191 Posttranslational modification, protein turnover, chaperones Thioredoxin/protein disulfide isomerase r_klactVI0779 check: MH T KOG0661 Signal transduction mechanisms MAPK related serine/threonine protein kinase r_klactVI0784 suspect: LH R KOG2820 General function prediction only FAD-dependent oxidoreductase r_klactVI0796 good R KOG1844 General function prediction only PHD Zn-finger proteins r_klactVI0798 good R KOG2485 General function prediction only Conserved ATP/GTP binding protein r_klactVI0800 good R KOG3062 General function prediction only RNA polymerase II elongator associated protein r_klactVI0815 good L KOG2519 Replication, recombination and repair 5'-3' exonuclease r_klactVI0821 good J KOG1076 Translation, ribosomal structure and biogenesis Translation initiation factor 3, subunit c (eIF-3c) r_klactVI0836 good S KOG3925 Function unknown Uncharacterized conserved protein r_klactVI0841 suspect: LH OT KOG4041 Posttranslational modification, protein turnover, chaperones Protein phosphatase 1, regulatory (inhibitor) subunit PPP1R2 r_klactVI0841 suspect: LH OT KOG4041 Signal transduction mechanisms Protein phosphatase 1, regulatory (inhibitor) subunit PPP1R2 r_klactVI0845 good U KOG3998 Intracellular trafficking, secretion, and vesicular transport Putative cargo transport protein ERV29 r_klactVI0850 check: MH O KOG0724 Posttranslational modification, protein turnover, chaperones Zuotin and related molecular chaperones (DnaJ superfamily), contains DNA-binding domains r_klactVI0859 good R KOG3867 General function prediction only Sulfatase r_klactVI0866 good G KOG2504 Carbohydrate transport and metabolism Monocarboxylate transporter r_klactVI0878 good R KOG0370 General function prediction only Multifunctional pyrimidine synthesis protein CAD (includes carbamoyl-phophate synthetase, aspartate transcarbamylase, and glutamine amidotransferase) r_klactVI0886 check: MH C KOG0756 Energy production and conversion Mitochondrial tricarboxylate/dicarboxylate carrier proteins r_klactVI0894 good R KOG1577 General function prediction only Aldo/keto reductase family proteins r_klactVI0903 good R KOG0255 General function prediction only Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) r_klactVI0904 good R KOG0255 General function prediction only Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) r_klactVI0914 good R KOG0255 General function prediction only Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) r_klactVI0920 check: MH O KOG0712 Posttranslational modification, protein turnover, chaperones Molecular chaperone (DnaJ superfamily) r_klactVI0925 good R KOG2904 General function prediction only Predicted methyltransferase r_klactVI0926 good J KOG1416 Translation, ribosomal structure and biogenesis tRNA(1-methyladenosine) methyltransferase, subunit GCD10 r_klactVI0933 good A KOG1122 RNA processing and modification tRNA and rRNA cytosine-C5-methylase (nucleolar protein NOL1/NOP2) r_klactVI0937 check: MH Z KOG0681 Cytoskeleton Actin-related protein - Arp5p r_klactVI0939 check: MH R KOG0393 General function prediction only Ras-related small GTPase, Rho type r_klactVI0943 good V KOG1572 Defense mechanisms Predicted protein tyrosine phosphatase r_klactVI0949 good E KOG0633 Amino acid transport and metabolism Histidinol phosphate aminotransferase r_klactVI0961 check: MH YU KOG3630 Intracellular trafficking, secretion, and vesicular transport Nuclear pore complex, Nup214/CAN component r_klactVI0961 check: MH YU KOG3630 Nuclear structure Nuclear pore complex, Nup214/CAN component r_klactVI0964 good P KOG3126 Inorganic ion transport and metabolism Porin/voltage-dependent anion-selective channel protein r_klactVI0982 suspect: LH R KOG0017 General function prediction only FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations r_klactVI0986 good V KOG1716 Defense mechanisms Dual specificity phosphatase r_klactVI0993 good R KOG0504 General function prediction only FOG: Ankyrin repeat r_klactVI0999 good C KOG4075 Energy production and conversion Cytochrome c oxidase, subunit IV/COX5b r_klactVI1007 good R KOG2920 General function prediction only Predicted methyltransferase r_klactVI1020 good U KOG1985 Intracellular trafficking, secretion, and vesicular transport Vesicle coat complex COPII, subunit SEC24/subunit SFB2 r_klactVI1026 good R KOG4525 General function prediction only Jacalin-like lectin domain-containing protein r_klactVI1030 good G KOG0234 Carbohydrate transport and metabolism Fructose-6-phosphate 2-kinase/fructose-2,6-biphosphatase r_klactVI1034 good D KOG0440 Cell cycle control, cell division, chromosome partitioning Cell cycle-associated protein Mob1-1 r_klactVI1040 good M KOG1387 Cell wall/membrane/envelope biogenesis Glycosyltransferase r_klactVI1056 check: MH IOVE KOG1047 Amino acid transport and metabolism Bifunctional leukotriene A4 hydrolase/aminopeptidase LTA4H r_klactVI1056 check: MH IOVE KOG1047 Defense mechanisms Bifunctional leukotriene A4 hydrolase/aminopeptidase LTA4H r_klactVI1056 check: MH IOVE KOG1047 Lipid transport and metabolism Bifunctional leukotriene A4 hydrolase/aminopeptidase LTA4H r_klactVI1056 check: MH IOVE KOG1047 Posttranslational modification, protein turnover, chaperones Bifunctional leukotriene A4 hydrolase/aminopeptidase LTA4H r_klactVI1059 good U KOG3142 Intracellular trafficking, secretion, and vesicular transport Prenylated rab acceptor 1 r_klactVI1070 good S KOG3247 Function unknown Uncharacterized conserved protein r_klactVI1074 good J KOG2648 Translation, ribosomal structure and biogenesis Diphthamide biosynthesis protein r_klactVI1078 good S KOG3758 Function unknown Uncharacterized conserved protein r_klactVI1091 good P KOG1578 Inorganic ion transport and metabolism Predicted carbonic anhydrase involved in protection against oxidative damage r_klactVI1112 good E KOG0784 Amino acid transport and metabolism Isocitrate dehydrogenase, gamma subunit r_klactVI1125 suspect: LH E KOG1303 Amino acid transport and metabolism Amino acid transporters r_klactVI1134 good P KOG2493 Inorganic ion transport and metabolism Na+/Pi symporter r_klactVI1141 good A KOG0495 RNA processing and modification HAT repeat protein r_klactVI1149 suspect: LH R KOG0017 General function prediction only FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations r_klactVI1153 good E KOG2964 Amino acid transport and metabolism Arginase family protein r_klactVI1160 suspect: Pn E KOG1303 Amino acid transport and metabolism Amino acid transporters r_klactVI1168 good R KOG1347 General function prediction only Uncharacterized membrane protein, predicted efflux pump r_klactVI1175 suspect: LH PT KOG4499 Inorganic ion transport and metabolism Ca2+-binding protein Regucalcin/SMP30 r_klactVI1175 suspect: LH PT KOG4499 Signal transduction mechanisms Ca2+-binding protein Regucalcin/SMP30 r_klactVI1181 good R KOG3135 General function prediction only 1,4-benzoquinone reductase-like; Trp repressor binding protein-like/protoplast-secreted protein r_klactVI1198 suspect: LH U KOG2115 Intracellular trafficking, secretion, and vesicular transport Vacuolar sorting protein VPS45 r_klactVI1202 good K KOG0051 Transcription RNA polymerase I termination factor, Myb superfamily r_klactVI1219 check: MH Q KOG1209 Secondary metabolites biosynthesis, transport and catabolism 1-Acyl dihydroxyacetone phosphate reductase and related dehydrogenases r_klactVI1231 good G KOG0450 Carbohydrate transport and metabolism 2-oxoglutarate dehydrogenase, E1 subunit r_klactVI1239 good J KOG3255 Translation, ribosomal structure and biogenesis 60S ribosomal protein L9 r_klactVI1249 check: MH BK KOG0386 Chromatin structure and dynamics Chromatin remodeling complex SWI/SNF, component SWI2 and related ATPases (DNA/RNA helicase superfamily) r_klactVI1249 check: MH BK KOG0386 Transcription Chromatin remodeling complex SWI/SNF, component SWI2 and related ATPases (DNA/RNA helicase superfamily) r_klactVI1260 good LK KOG1967 Replication, recombination and repair DNA repair/transcription protein Mms19 r_klactVI1260 good LK KOG1967 Transcription DNA repair/transcription protein Mms19 r_klactVI1280 good R KOG1825 General function prediction only Fry-like conserved proteins r_klactVI1296 good K KOG2294 Transcription Transcription factor of the Forkhead/HNF3 family r_klactVI1308 good J KOG3204 Translation, ribosomal structure and biogenesis 60S ribosomal protein L13a r_klactVI1309 check: MH C KOG0764 Energy production and conversion Mitochondrial FAD carrier protein r_klactVI1311 suspect: LH U KOG4449 Intracellular trafficking, secretion, and vesicular transport Translocase of outer mitochondrial membrane complex, subunit TOM7 r_klactVI1316 good C KOG0557 Energy production and conversion Dihydrolipoamide acetyltransferase r_klactVI1320 good L KOG2299 Replication, recombination and repair Ribonuclease HI r_klactVI1326 good J KOG1885 Translation, ribosomal structure and biogenesis Lysyl-tRNA synthetase (class II) r_klactVI1332 good L KOG2267 Replication, recombination and repair Eukaryotic-type DNA primase, large subunit r_klactVI1358 check: MH U KOG0292 Intracellular trafficking, secretion, and vesicular transport Vesicle coat complex COPI, alpha subunit r_klactVI1381 good PQ KOG0039 Inorganic ion transport and metabolism Ferric reductase, NADH/NADPH oxidase and related proteins r_klactVI1381 good PQ KOG0039 Secondary metabolites biosynthesis, transport and catabolism Ferric reductase, NADH/NADPH oxidase and related proteins r_klactVI1388 good S KOG2983 Function unknown Uncharacterized conserved protein r_klactVI1393 check: MH O KOG0358 Posttranslational modification, protein turnover, chaperones Chaperonin complex component, TCP-1 delta subunit (CCT4) r_klactVI1395 good I KOG1617 Lipid transport and metabolism CDP-alcohol phosphatidyltransferase/Phosphatidylglycerol-phosphate synthase r_klactVI1400 good H KOG1536 Coenzyme transport and metabolism Biotin holocarboxylase synthetase/biotin-protein ligase r_klactVI1414 good K KOG0260 Transcription RNA polymerase II, large subunit r_klactVI1422 check: MH O KOG0546 Posttranslational modification, protein turnover, chaperones HSP90 co-chaperone CPR7/Cyclophilin r_klactVI1427 good R KOG4138 General function prediction only Unchracterized conserved protein (estrogen up-regulated protein E2IG2 in human) r_klactVI1440 good U KOG0307 Intracellular trafficking, secretion, and vesicular transport Vesicle coat complex COPII, subunit SEC31 r_klactVI1451 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactVI1455 good I KOG2818 Lipid transport and metabolism Predicted undecaprenyl diphosphate synthase r_klactVI1461 good U KOG0070 Intracellular trafficking, secretion, and vesicular transport GTP-binding ADP-ribosylation factor Arf1 r_klactVI1467.1 good J KOG3436 Translation, ribosomal structure and biogenesis 60S ribosomal protein L35 r_klactVI1467 good O KOG2042 Posttranslational modification, protein turnover, chaperones Ubiquitin fusion degradation protein-2 r_klactVI1472 good A KOG2953 RNA processing and modification mRNA-binding protein Encore r_klactVI1477 good T KOG3205 Signal transduction mechanisms Rho GDP-dissociation inhibitor r_klactVI1484 check: MH T KOG0371 Signal transduction mechanisms Serine/threonine protein phosphatase 2A, catalytic subunit r_klactVI1499 good C KOG1352 Energy production and conversion Vacuolar H+-ATPase V1 sector, subunit A r_klactVI1504 suspect: LH S KOG4539 Function unknown Uncharacterized conserved protein r_klactVI1521 good D KOG2166 Cell cycle control, cell division, chromosome partitioning Cullins r_klactVI1527 good E KOG2367 Amino acid transport and metabolism Alpha-isopropylmalate synthase/homocitrate synthase r_klactVI1535 good J KOG1762 Translation, ribosomal structure and biogenesis 60s acidic ribosomal protein P1 r_klactVI1550 good P KOG1397 Inorganic ion transport and metabolism Ca2+/H+ antiporter VCX1 and related proteins r_klactVI1554 good R KOG1674 General function prediction only Cyclin r_klactVI1564 check: MH O KOG0730 Posttranslational modification, protein turnover, chaperones AAA+-type ATPase r_klactVI1567.1 good T KOG3275 Signal transduction mechanisms Zinc-binding protein of the histidine triad (HIT) family r_klactVI1573 good C KOG1232 Energy production and conversion Proteins containing the FAD binding domain r_klactVI1578 good R KOG1577 General function prediction only Aldo/keto reductase family proteins r_klactVI1580 good S KOG3299 Function unknown Uncharacterized conserved protein r_klactVI1586 suspect: LH R KOG1773 General function prediction only Stress responsive protein r_klactVI1591 good O KOG4400 Posttranslational modification, protein turnover, chaperones E3 ubiquitin ligase interacting with arginine methyltransferase r_klactVI1603 good J KOG1637 Translation, ribosomal structure and biogenesis Threonyl-tRNA synthetase r_klactVI1609 good R KOG1541 General function prediction only Predicted protein carboxyl methylase r_klactVI1611 suspect: LH J KOG1698 Translation, ribosomal structure and biogenesis Mitochondrial/chloroplast ribosomal protein L19 r_klactVI1622 good O KOG1153 Posttranslational modification, protein turnover, chaperones Subtilisin-related protease/Vacuolar protease B r_klactVI1626 good U KOG3324 Intracellular trafficking, secretion, and vesicular transport Mitochondrial import inner membrane translocase, subunit TIM23 r_klactVI1649 good I KOG0368 Lipid transport and metabolism Acetyl-CoA carboxylase r_klactVI1652 good J KOG2334 Translation, ribosomal structure and biogenesis tRNA-dihydrouridine synthase r_klactVI1662 suspect: LH Y KOG2992 Nuclear structure Nucleolar GTPase/ATPase p130 r_klactVI1679 good P KOG1281 Inorganic ion transport and metabolism Na+/dicarboxylate, Na+/tricarboxylate and phosphate transporters r_klactVI1683 good TZ KOG4203 Cytoskeleton Armadillo/beta-Catenin/plakoglobin r_klactVI1683 good TZ KOG4203 Signal transduction mechanisms Armadillo/beta-Catenin/plakoglobin r_klactVI1686 check: MH A KOG0923 RNA processing and modification mRNA splicing factor ATP-dependent RNA helicase r_klactVI1692 good G KOG2944 Carbohydrate transport and metabolism Glyoxalase r_klactVI1704 good G KOG2440 Carbohydrate transport and metabolism Pyrophosphate-dependent phosphofructo-1-kinase r_klactVI1716 good U KOG3296 Intracellular trafficking, secretion, and vesicular transport Translocase of outer mitochondrial membrane complex, subunit TOM40 r_klactVI1722 good T KOG4143 Signal transduction mechanisms Sigma receptor and C-8 sterol isomerase r_klactVI1733 good I KOG2369 Lipid transport and metabolism Lecithin:cholesterol acyltransferase (LCAT)/Acyl-ceramide synthase r_klactVI1737 good R KOG2981 General function prediction only Protein involved in autophagocytosis during starvation r_klactVI1744 good L KOG4017 Replication, recombination and repair DNA excision repair protein XPA/XPAC/RAD14 r_klactVI1748 check: MH TU KOG1818 Intracellular trafficking, secretion, and vesicular transport Membrane trafficking and cell signaling protein HRS, contains VHS and FYVE domains r_klactVI1748 check: MH TU KOG1818 Signal transduction mechanisms Membrane trafficking and cell signaling protein HRS, contains VHS and FYVE domains r_klactVI1759 good D KOG0653 Cell cycle control, cell division, chromosome partitioning Cyclin B and related kinase-activating proteins r_klactVI1780 good E KOG0623 Amino acid transport and metabolism Glutamine amidotransferase/cyclase r_klactVI1784 good S KOG1426 Function unknown FOG: RCC1 domain r_klactVI1788 good W KOG3871 Extracellular structures Cell adhesion complex protein bystin r_klactVI1789 suspect: LH S KOG2678 Function unknown Predicted membrane protein r_klactVI1799 good R KOG1424 General function prediction only Predicted GTP-binding protein MMR1 r_klactVI1804 good E KOG0280 Amino acid transport and metabolism Uncharacterized conserved protein r_klactVI1815 check: MH K KOG0385 Transcription Chromatin remodeling complex WSTF-ISWI, small subunit r_klactVI1817 good O KOG1651 Posttranslational modification, protein turnover, chaperones Glutathione peroxidase r_klactVI1821 check: MH YU KOG2445 Intracellular trafficking, secretion, and vesicular transport Nuclear pore complex component (sc Seh1) r_klactVI1821 check: MH YU KOG2445 Nuclear structure Nuclear pore complex component (sc Seh1) r_klactVI1826 good G KOG2788 Carbohydrate transport and metabolism Glycosyltransferase r_klactVI1828 good R KOG3197 General function prediction only Predicted hydrolases of HD superfamily r_klactVI1830 good J KOG1742 Translation, ribosomal structure and biogenesis 60s ribosomal protein L15/L27 r_klactVI1839 check: MH G KOG0569 Carbohydrate transport and metabolism Permease of the major facilitator superfamily r_klactVI1855 suspect: LH K KOG4522 Transcription RNA polymerase II transcription mediator r_klactVI1861 check: MH A KOG0350 RNA processing and modification DEAD-box ATP-dependent RNA helicase r_klactVI1864 good J KOG0899 Translation, ribosomal structure and biogenesis Mitochondrial/chloroplast ribosomal protein S19 r_klactVI1869 good T KOG0698 Signal transduction mechanisms Serine/threonine protein phosphatase r_klactVI1873 good J KOG1750 Translation, ribosomal structure and biogenesis Mitochondrial/chloroplast ribosomal protein S12 r_klactVI1878 good Z KOG2826 Cytoskeleton Actin-related protein Arp2/3 complex, subunit ARPC2 r_klactVI1894 suspect: HSP R KOG1721 General function prediction only FOG: Zn-finger r_klactVI1909 suspect: LH U KOG1761 Intracellular trafficking, secretion, and vesicular transport Signal recognition particle, subunit Srp14 r_klactVI1914 good T KOG1363 Signal transduction mechanisms Predicted regulator of the ubiquitin pathway (contains UAS and UBX domains) r_klactVI1918 good O KOG0365 Posttranslational modification, protein turnover, chaperones Beta subunit of farnesyltransferase r_klactVI1920 suspect: LH OT KOG0045 Posttranslational modification, protein turnover, chaperones Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) r_klactVI1920 suspect: LH OT KOG0045 Signal transduction mechanisms Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) r_klactVI1937 good A KOG0796 RNA processing and modification Spliceosome subunit r_klactVI1940 good O KOG0171 Posttranslational modification, protein turnover, chaperones Mitochondrial inner membrane protease, subunit IMP1 r_klactVI1944 suspect: LH O KOG2447 Posttranslational modification, protein turnover, chaperones Oligosaccharyltransferase, delta subunit (ribophorin II) r_klactVI1961 check: MH JT KOG0643 Signal transduction mechanisms Translation initiation factor 3, subunit i (eIF-3i)/TGF-beta receptor-interacting protein (TRIP-1) r_klactVI1961 check: MH JT KOG0643 Translation, ribosomal structure and biogenesis Translation initiation factor 3, subunit i (eIF-3i)/TGF-beta receptor-interacting protein (TRIP-1) r_klactVI1963 good R KOG4488 General function prediction only Small EDRK-rich protein H4F5 r_klactVI1972 check: MH P KOG0207 Inorganic ion transport and metabolism Cation transport ATPase r_klactVI1977 good LA KOG2044 Replication, recombination and repair 5'-3' exonuclease HKE1/RAT1 r_klactVI1977 good LA KOG2044 RNA processing and modification 5'-3' exonuclease HKE1/RAT1 r_klactVI1983 check: MH B KOG0389 Chromatin structure and dynamics SNF2 family DNA-dependent ATPase r_klactVI1990 good Q KOG0021 Secondary metabolites biosynthesis, transport and catabolism Glutathione synthetase r_klactVI2019 check: MH T KOG1152 Signal transduction mechanisms Signal transduction serine/threonine kinase with PAS/PAC sensor domain r_klactVI2025 good E KOG1287 Amino acid transport and metabolism Amino acid transporters r_klactVI2032 good T KOG0211 Signal transduction mechanisms Protein phosphatase 2A regulatory subunit A and related proteins r_klactVI2036 good L KOG1921 Replication, recombination and repair Endonuclease III r_klactVI2039 good K KOG0620 Transcription Glucose-repressible alcohol dehydrogenase transcriptional effector CCR4 and related proteins r_klactVI2057 good R KOG0118 General function prediction only FOG: RRM domain r_klactVI2065 suspect: Pn Y KOG2992 Nuclear structure Nucleolar GTPase/ATPase p130 r_klactVI2068 good J KOG0898 Translation, ribosomal structure and biogenesis 40S ribosomal protein S15 r_klactVI2075 good J KOG3449 Translation, ribosomal structure and biogenesis 60S acidic ribosomal protein P2 r_klactVI2084 good E KOG0053 Amino acid transport and metabolism Cystathionine beta-lyases/cystathionine gamma-synthases r_klactVI2087 suspect: LH O KOG2160 Posttranslational modification, protein turnover, chaperones Armadillo/beta-catenin-like repeat-containing protein r_klactVI2089 suspect: LH S KOG4067 Function unknown Uncharacterized conserved protein r_klactVI2092 good J KOG1149 Translation, ribosomal structure and biogenesis Glutamyl-tRNA synthetase (mitochondrial) r_klactVI2100 check: MH BDL KOG0979 Cell cycle control, cell division, chromosome partitioning Structural maintenance of chromosome protein SMC5/Spr18, SMC superfamily r_klactVI2100 check: MH BDL KOG0979 Chromatin structure and dynamics Structural maintenance of chromosome protein SMC5/Spr18, SMC superfamily r_klactVI2100 check: MH BDL KOG0979 Replication, recombination and repair Structural maintenance of chromosome protein SMC5/Spr18, SMC superfamily r_klactVI2123 good T KOG2085 Signal transduction mechanisms Serine/threonine protein phosphatase 2A, regulatory subunit r_klactVI2127 good A KOG1040 RNA processing and modification Polyadenylation factor I complex, subunit, Yth1 (CPSF subunit) r_klactVI2141 good U KOG0412 Intracellular trafficking, secretion, and vesicular transport Golgi transport complex COD1 protein r_klactVI2150 good K KOG2294 Transcription Transcription factor of the Forkhead/HNF3 family r_klactVI2156 check: MH O KOG0175 Posttranslational modification, protein turnover, chaperones 20S proteasome, regulatory subunit beta type PSMB5/PSMB8/PRE2 r_klactVI2158 good J KOG0397 Translation, ribosomal structure and biogenesis 60S ribosomal protein L11 r_klactVI2173 good J KOG1467 Translation, ribosomal structure and biogenesis Translation initiation factor 2B, delta subunit (eIF-2Bdelta/GCD2) r_klactVI2175 good J KOG3445 Translation, ribosomal structure and biogenesis Mitochondrial/chloroplast ribosomal protein 36a r_klactVI2187 good G KOG0631 Carbohydrate transport and metabolism Galactokinase r_klactVI2193 good M KOG1371 Cell wall/membrane/envelope biogenesis UDP-glucose 4-epimerase/UDP-sulfoquinovose synthase r_klactVI2203 good C KOG2958 Energy production and conversion Galactose-1-phosphate uridylyltransferase r_klactVI2209 good B KOG1156 Chromatin structure and dynamics N-terminal acetyltransferase r_klactVI2214 good A KOG2330 RNA processing and modification Splicing factor 3b, subunit 2 r_klactVI2224 good G KOG2504 Carbohydrate transport and metabolism Monocarboxylate transporter r_klactVI2229 good C KOG0756 Energy production and conversion Mitochondrial tricarboxylate/dicarboxylate carrier proteins r_klactVI2235 good GE KOG1441 Amino acid transport and metabolism Glucose-6-phosphate/phosphate and phosphoenolpyruvate/phosphate antiporter r_klactVI2235 good GE KOG1441 Carbohydrate transport and metabolism Glucose-6-phosphate/phosphate and phosphoenolpyruvate/phosphate antiporter r_klactVI2241 good A KOG2217 RNA processing and modification U4/U6.U5 snRNP associated protein r_klactVI2245 good AJ KOG2572 RNA processing and modification Ribosome biogenesis protein - Nop58p/Nop5p r_klactVI2245 good AJ KOG2572 Translation, ribosomal structure and biogenesis Ribosome biogenesis protein - Nop58p/Nop5p r_klactVI2248 good S KOG4453 Function unknown Predicted ER membrane protein r_klactVI2249 good J KOG0829 Translation, ribosomal structure and biogenesis 60S ribosomal protein L18A r_klactVI2273 good P KOG1483 Inorganic ion transport and metabolism Zn2+ transporter ZNT1 and related Cd2+/Zn2+ transporters (cation diffusion facilitator superfamily) r_klactVI2285 suspect: LH C KOG3057 Energy production and conversion Cytochrome c oxidase, subunit VIb/COX12 r_klactVI2288 good T KOG2595 Signal transduction mechanisms Predicted GTPase activator protein r_klactVI2296 suspect: LH S KOG0282 Function unknown mRNA splicing factor r_klactVI2300 good RK KOG2355 General function prediction only Predicted ABC-type transport, ATPase component/CCR4 associated factor r_klactVI2300 good RK KOG2355 Transcription Predicted ABC-type transport, ATPase component/CCR4 associated factor r_klactVI2306 good I KOG0872 Lipid transport and metabolism Sterol C5 desaturase r_klactVI2308 check: MH R KOG0594 General function prediction only Protein kinase PCTAIRE and related kinases r_klactVI2313 suspect: LH G KOG2204 Carbohydrate transport and metabolism Mannosyl-oligosaccharide alpha-1,2-mannosidase and related glycosyl hydrolases r_klactVI2318 good E KOG2467 Amino acid transport and metabolism Glycine/serine hydroxymethyltransferase r_klactVI2323 good R KOG2862 General function prediction only Alanine-glyoxylate aminotransferase AGT1 r_klactVI2337 suspect: LH A KOG3242 RNA processing and modification Oligoribonuclease (3'->5' exoribonuclease) r_klactVI2345 check: MH R KOG0605 General function prediction only NDR and related serine/threonine kinases r_klactVI2349 check: MH R KOG0605 General function prediction only NDR and related serine/threonine kinases r_klactVI2352 good T KOG1354 Signal transduction mechanisms Serine/threonine protein phosphatase 2A, regulatory subunit r_klactVI2357 good C KOG3469 Energy production and conversion Cytochrome c oxidase, subunit VIa/COX13 r_klactVI2370 good A KOG2098 RNA processing and modification Predicted N6-adenine RNA methylase r_klactVI2377 good B KOG1342 Chromatin structure and dynamics Histone deacetylase complex, catalytic component RPD3 r_klactVI2383 good G KOG0657 Carbohydrate transport and metabolism Glyceraldehyde 3-phosphate dehydrogenase r_klactVI2389 good C KOG0069 Energy production and conversion Glyoxylate/hydroxypyruvate reductase (D-isomer-specific 2-hydroxy acid dehydrogenase superfamily) r_klactVI2395 good O KOG1439 Posttranslational modification, protein turnover, chaperones RAB proteins geranylgeranyltransferase component A (RAB escort protein) r_klactVI2399 good A KOG3448 RNA processing and modification Predicted snRNP core protein r_klactVI2400 suspect: LH R KOG0017 General function prediction only FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations r_klactVI2404 good O KOG1730 Posttranslational modification, protein turnover, chaperones Thioredoxin-like protein r_klactVI2410 good H KOG2794 Coenzyme transport and metabolism Delta-aminolevulinic acid dehydratase r_klactVI2412 good R KOG2910 General function prediction only Uncharacterized conserved protein predicted to be involved in protein sorting r_klactVI2415 good E KOG1252 Amino acid transport and metabolism Cystathionine beta-synthase and related enzymes r_klactVI2422 good K KOG1105 Transcription Transcription elongation factor TFIIS/Cofactor of enhancer-binding protein Sp1 r_klactVI2427 check: MH A KOG0108 RNA processing and modification mRNA cleavage and polyadenylation factor I complex, subunit RNA15 r_klactVI2439 good G KOG2533 Carbohydrate transport and metabolism Permease of the major facilitator superfamily r_klactVI2458 good O KOG0356 Posttranslational modification, protein turnover, chaperones Mitochondrial chaperonin, Cpn60/Hsp60p r_klactVI2463 suspect: LH I KOG3750 Lipid transport and metabolism Inositol phospholipid synthesis protein, Scs3p r_klactVI2485 good P KOG3574 Inorganic ion transport and metabolism Acetyl-CoA transporter r_klactVI2494 good C KOG0524 Energy production and conversion Pyruvate dehydrogenase E1, beta subunit r_klactVI2503 suspect: LH L KOG2031 Replication, recombination and repair Tyrosyl-DNA phosphodiesterase r_klactVI2509 good E KOG0564 Amino acid transport and metabolism 5,10-methylenetetrahydrofolate reductase r_klactVI2520 good O KOG0745 Posttranslational modification, protein turnover, chaperones Putative ATP-dependent Clp-type protease (AAA+ ATPase superfamily) r_klactVI2525 good R KOG3005 General function prediction only GIY-YIG type nuclease r_klactVI2533 good GMO KOG1066 Carbohydrate transport and metabolism Glucosidase II catalytic (alpha) subunit and related enzymes, glycosyl hydrolase family 31 r_klactVI2533 good GMO KOG1066 Cell wall/membrane/envelope biogenesis Glucosidase II catalytic (alpha) subunit and related enzymes, glycosyl hydrolase family 31 r_klactVI2533 good GMO KOG1066 Posttranslational modification, protein turnover, chaperones Glucosidase II catalytic (alpha) subunit and related enzymes, glycosyl hydrolase family 31 r_klactVI2537 suspect: HSP K KOG1601 Transcription GATA-4/5/6 transcription factors r_klactVI2540 good S KOG0997 Function unknown Uncharacterized conserved protein Sand r_klactVI2547 good J KOG0877 Translation, ribosomal structure and biogenesis 40S ribosomal protein S2/30S ribosomal protein S5 r_klactVI2556 good A KOG3702 RNA processing and modification Nuclear polyadenylated RNA binding protein r_klactVI2570 good E KOG1189 Amino acid transport and metabolism Global transcriptional regulator, cell division control protein r_klactVI2583 good U KOG0985 Intracellular trafficking, secretion, and vesicular transport Vesicle coat protein clathrin, heavy chain r_klactVI2593 good I KOG0136 Lipid transport and metabolism Acyl-CoA oxidase r_klactVI2612 good OE KOG1282 Amino acid transport and metabolism Serine carboxypeptidases (lysosomal cathepsin A) r_klactVI2612 good OE KOG1282 Posttranslational modification, protein turnover, chaperones Serine carboxypeptidases (lysosomal cathepsin A) r_klactVI2620 good E KOG0634 Amino acid transport and metabolism Aromatic amino acid aminotransferase and related proteins r_klactVI2628 suspect: Pn R KOG0255 General function prediction only Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) r_klactVI2638 good G KOG2099 Carbohydrate transport and metabolism Glycogen phosphorylase r_klactVI2646.1 suspect: Pn T KOG0198 Signal transduction mechanisms MEKK and related serine/threonine protein kinases r_klactVI2651 check: MH L KOG0480 Replication, recombination and repair DNA replication licensing factor, MCM6 component r_klactVI2660 suspect: LH R KOG1721 General function prediction only FOG: Zn-finger r_klactVI2667 good S KOG1443 Function unknown Predicted integral membrane protein r_klactVI2669 good S KOG1296 Function unknown Uncharacterized conserved protein r_klactVI2675 check: MH Z KOG3655 Cytoskeleton Drebrins and related actin binding proteins r_klactVI2680 good D KOG2186 Cell cycle control, cell division, chromosome partitioning Cell growth-regulating nucleolar protein r_klactVI2691 check: MH R KOG0266 General function prediction only WD40 repeat-containing protein r_klactVI2698 good I KOG2833 Lipid transport and metabolism Mevalonate pyrophosphate decarboxylase r_klactVI2704 good H KOG1381 Coenzyme transport and metabolism Para-hydroxybenzoate-polyprenyl transferase r_klactVI2710 good O KOG0907 Posttranslational modification, protein turnover, chaperones Thioredoxin r_klactVI2720 good J KOG2241 Translation, ribosomal structure and biogenesis tRNA-binding protein r_klactVI2727 good T KOG0027 Signal transduction mechanisms Calmodulin and related proteins (EF-Hand superfamily) r_klactVI2746 check: MH A KOG0334 RNA processing and modification RNA helicase r_klactVI2751 good A KOG1975 RNA processing and modification mRNA cap methyltransferase r_klactVI2759 check: MH E KOG1288 Amino acid transport and metabolism Amino acid transporters r_klactVI2767 good S KOG3881 Function unknown Uncharacterized conserved protein r_klactVI2772 good Z KOG1523 Cytoskeleton Actin-related protein Arp2/3 complex, subunit ARPC1/p41-ARC r_klactVI2779 good K KOG2549 Transcription Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) r_klactVI2787 good AR KOG2190 General function prediction only PolyC-binding proteins alphaCP-1 and related KH domain proteins r_klactVI2787 good AR KOG2190 RNA processing and modification PolyC-binding proteins alphaCP-1 and related KH domain proteins r_klactVI2789 good S KOG4776 Function unknown Uncharacterized conserved protein BCNT r_klactVI2802 good C KOG1764 Energy production and conversion 5'-AMP-activated protein kinase, gamma subunit r_klactVI2808 check: MH DO KOG0305 Cell cycle control, cell division, chromosome partitioning Anaphase promoting complex, Cdc20, Cdh1, and Ama1 subunits r_klactVI2808 check: MH DO KOG0305 Posttranslational modification, protein turnover, chaperones Anaphase promoting complex, Cdc20, Cdh1, and Ama1 subunits r_klactVI2834 suspect: LH R KOG0017 General function prediction only FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations r_klactVI2843 check: MH I KOG1389 Lipid transport and metabolism 3-oxoacyl CoA thiolase r_klactVI2852 normal TZ KOG1922 Cytoskeleton Rho GTPase effector BNI1 and related formins r_klactVI2852 normal TZ KOG1922 Signal transduction mechanisms Rho GTPase effector BNI1 and related formins r_klactVI2862.1 suspect: LH W KOG3544 Extracellular structures Collagens (type IV and type XIII), and related proteins r_klactVI2866 good K KOG0048 Transcription Transcription factor, Myb superfamily r_klactVI2874 good O KOG0778 Posttranslational modification, protein turnover, chaperones Protease, Ulp1 family r_klactVI2881 check: MH L KOG0220 Replication, recombination and repair Mismatch repair ATPase MSH4 (MutS family) r_klactVI2886 check: MH BK KOG2682 Chromatin structure and dynamics NAD-dependent histone deacetylases and class I sirtuins (SIR2 family) r_klactVI2886 check: MH BK KOG2682 Transcription NAD-dependent histone deacetylases and class I sirtuins (SIR2 family) r_klactVI2896 good G KOG2504 Carbohydrate transport and metabolism Monocarboxylate transporter r_klactVI2905 good L KOG3176 Replication, recombination and repair Predicted alpha-helical protein, potentially involved in replication/repair r_klactVI2913 check: MH D KOG0615 Cell cycle control, cell division, chromosome partitioning Serine/threonine protein kinase Chk2 and related proteins r_klactVI2919 good I KOG0831 Lipid transport and metabolism Acyl-CoA:diacylglycerol acyltransferase (DGAT) r_klactVI2922 good DT KOG2867 Cell cycle control, cell division, chromosome partitioning Phosphotyrosyl phosphatase activator r_klactVI2922 good DT KOG2867 Signal transduction mechanisms Phosphotyrosyl phosphatase activator r_klactVI2925 good B KOG2747 Chromatin structure and dynamics Histone acetyltransferase (MYST family) r_klactVI2930 check: MH A KOG0285 RNA processing and modification Pleiotropic regulator 1 r_klactVI2939 good S KOG2339 Function unknown Uncharacterized conserved protein r_klactVI2950 good H KOG2525 Coenzyme transport and metabolism Folylpolyglutamate synthase r_klactVI2957 check: MH T KOG0583 Signal transduction mechanisms Serine/threonine protein kinase r_klactVI2960 suspect: Pn K KOG2406 Transcription MADS box transcription factor r_klactVI2963 good O KOG2976 Posttranslational modification, protein turnover, chaperones Protein involved in autophagy and nutrient starvation r_klactVI2967 good R KOG2361 General function prediction only Predicted methyltransferase r_klactVI2982 suspect: LH R KOG4840 General function prediction only Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) r_klactVI2992 check: MH I KOG0064 Lipid transport and metabolism Peroxisomal long-chain acyl-CoA transporter, ABC superfamily r_klactVI2995 good R KOG2823 General function prediction only Cellular protein (glioma tumor suppressor candidate region gene 2) r_klactVI3006 suspect: LH S KOG4415 Function unknown Uncharacterized conserved protein r_klactVI3009 good S KOG3823 Function unknown Uncharacterized conserved protein r_klactVI3024 good LD KOG4139 Cell cycle control, cell division, chromosome partitioning Protein kinase essential for the initiation of DNA replication r_klactVI3024 good LD KOG4139 Replication, recombination and repair Protein kinase essential for the initiation of DNA replication r_klactVI3033 suspect: HSP R KOG1721 General function prediction only FOG: Zn-finger r_klactVI3052 good G KOG2254 Carbohydrate transport and metabolism Predicted endo-1,3-beta-glucanase r_klactVI3076 normal OR KOG2194 General function prediction only Aminopeptidases of the M20 family r_klactVI3076 normal OR KOG2194 Posttranslational modification, protein turnover, chaperones Aminopeptidases of the M20 family r_klactVI3080 good H KOG2872 Coenzyme transport and metabolism Uroporphyrinogen decarboxylase r_klactVI3087 good R KOG2505 General function prediction only Ankyrin repeat protein r_klactVI3093 check: MH L KOG0390 Replication, recombination and repair DNA repair protein, SNF2 family r_klactVI3097.1 suspect: Pn PT KOG2301 Inorganic ion transport and metabolism Voltage-gated Ca2+ channels, alpha1 subunits r_klactVI3097.1 suspect: Pn PT KOG2301 Signal transduction mechanisms Voltage-gated Ca2+ channels, alpha1 subunits r_klactVI3113 good S KOG2592 Function unknown Tumor differentially expressed (TDE) protein r_klactVI3118 good DL KOG1434 Cell cycle control, cell division, chromosome partitioning Meiotic recombination protein Dmc1 r_klactVI3118 good DL KOG1434 Replication, recombination and repair Meiotic recombination protein Dmc1 r_klactVI3126 good R KOG2776 General function prediction only Metallopeptidase r_klactVI3133 good C KOG0225 Energy production and conversion Pyruvate dehydrogenase E1, alpha subunit r_klactVI3155 good O KOG2903 Posttranslational modification, protein turnover, chaperones Predicted glutathione S-transferase r_klactVI3165 good O KOG0841 Posttranslational modification, protein turnover, chaperones Multifunctional chaperone (14-3-3 family) r_klactVI3177 check: MH L KOG0298 Replication, recombination and repair DEAD box-containing helicase-like transcription factor/DNA repair protein r_klactVI3186 check: MH T KOG0032 Signal transduction mechanisms Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily r_klactVI3201 check: MH EJ KOG0062 Amino acid transport and metabolism ATPase component of ABC transporters with duplicated ATPase domains/Translation elongation factor EF-3b r_klactVI3201 check: MH EJ KOG0062 Translation, ribosomal structure and biogenesis ATPase component of ABC transporters with duplicated ATPase domains/Translation elongation factor EF-3b r_klactVI3209 good I KOG1325 Lipid transport and metabolism Lysophospholipase r_klactVI3222 suspect: LH E KOG1615 Amino acid transport and metabolism Phosphoserine phosphatase r_klactVI3239 good C KOG1526 Energy production and conversion NADP-dependent isocitrate dehydrogenase r_klactVI3242 good E KOG2663 Amino acid transport and metabolism Acetolactate synthase, small subunit r_klactVI3247 good J KOG4600 Translation, ribosomal structure and biogenesis Mitochondrial ribosomal protein MRP7 (L2) r_klactVI3252 suspect: LH R KOG3038 General function prediction only Histone acetyltransferase SAGA associated factor SGF29 r_klactVI3275 good J KOG1242 Translation, ribosomal structure and biogenesis Protein containing adaptin N-terminal region r_klactVI3287 good S KOG2946 Function unknown Uncharacterized conserved protein r_klactVI3294 good TR KOG0374 General function prediction only Serine/threonine specific protein phosphatase PP1, catalytic subunit r_klactVI3294 good TR KOG0374 Signal transduction mechanisms Serine/threonine specific protein phosphatase PP1, catalytic subunit r_klactVI3298 good U KOG1692 Intracellular trafficking, secretion, and vesicular transport Putative cargo transport protein EMP24 (p24 protein family) r_klactVI3312 good J KOG2198 Translation, ribosomal structure and biogenesis tRNA cytosine-5-methylases and related enzymes of the NOL1/NOP2/sun superfamily r_klactVI3324 check: MH L KOG0477 Replication, recombination and repair DNA replication licensing factor, MCM2 component r_klactVI3335 good R KOG2752 General function prediction only Uncharacterized conserved protein, contains N-recognin-type Zn-finger r_klactVI3338 check: MH C KOG2451 Energy production and conversion Aldehyde dehydrogenase r_klactVI3345 good S KOG2490 Function unknown Predicted membrane protein r_klactVI3348 good S KOG4780 Function unknown Uncharacterized conserved protein r_klactVI3363 good C KOG2617 Energy production and conversion Citrate synthase r_klactVI3364 good R KOG3135 General function prediction only 1,4-benzoquinone reductase-like; Trp repressor binding protein-like/protoplast-secreted protein r_klactVI3370 good BT KOG2130 Chromatin structure and dynamics Phosphatidylserine-specific receptor PtdSerR, contains JmjC domain r_klactVI3370 good BT KOG2130 Signal transduction mechanisms Phosphatidylserine-specific receptor PtdSerR, contains JmjC domain r_klactVI3373 suspect: LH J KOG4080 Translation, ribosomal structure and biogenesis Mitochondrial ribosomal protein L32 r_klactVI3377 check: MH DTZ KOG1547 Cell cycle control, cell division, chromosome partitioning Septin CDC10 and related P-loop GTPases r_klactVI3377 check: MH DTZ KOG1547 Cytoskeleton Septin CDC10 and related P-loop GTPases r_klactVI3377 check: MH DTZ KOG1547 Signal transduction mechanisms Septin CDC10 and related P-loop GTPases r_klactVI3391 good UR KOG0446 General function prediction only Vacuolar sorting protein VPS1, dynamin, and related proteins r_klactVI3391 good UR KOG0446 Intracellular trafficking, secretion, and vesicular transport Vacuolar sorting protein VPS1, dynamin, and related proteins r_klactVI3397 suspect: LH S KOG4534 Function unknown Uncharacterized conserved protein r_klactVI3400 check: MH O KOG0174 Posttranslational modification, protein turnover, chaperones 20S proteasome, regulatory subunit beta type PSMB6/PSMB9/PRE3 r_klactVI3410 suspect: %id D KOG4775 Cell cycle control, cell division, chromosome partitioning Uncharacterized protein SFI1 involved in G(2)-M transition r_klactVI3415 good O KOG2291 Posttranslational modification, protein turnover, chaperones Oligosaccharyltransferase, alpha subunit (ribophorin I) r_klactVI3421 suspect: LH L KOG2538 Replication, recombination and repair Origin recognition complex, subunit 3 r_klactVI3437 good R KOG1721 General function prediction only FOG: Zn-finger r_klactVI3443 suspect: LH L KOG3548 Replication, recombination and repair DNA damage checkpoint protein RHP9/CRB2/53BP1 r_klactVI3453 good DZU KOG2655 Cell cycle control, cell division, chromosome partitioning Septin family protein (P-loop GTPase) r_klactVI3453 good DZU KOG2655 Cytoskeleton Septin family protein (P-loop GTPase) r_klactVI3453 good DZU KOG2655 Intracellular trafficking, secretion, and vesicular transport Septin family protein (P-loop GTPase) r_klactVI3473 good T KOG2397 Signal transduction mechanisms Protein kinase C substrate, 80 KD protein, heavy chain r_klactVI3499 check: MH A KOG0319 RNA processing and modification WD40-repeat-containing subunit of the 18S rRNA processing complex r_klactVI3505 suspect: LH S KOG4473 Function unknown Uncharacterized membrane protein r_klactVI3508 good B KOG1744 Chromatin structure and dynamics Histone H2B r_klactVI3513 good B KOG1756 Chromatin structure and dynamics Histone 2A r_klactVI3532 good F KOG3078 Nucleotide transport and metabolism Adenylate kinase r_klactVI3553 suspect: HSP S KOG4643 Function unknown Uncharacterized coiled-coil protein r_klactVI3563 good A KOG2071 RNA processing and modification mRNA cleavage and polyadenylation factor I/II complex, subunit Pcf11 r_klactVI3567 good C KOG0750 Energy production and conversion Mitochondrial solute carrier protein r_klactVI3572 good S KOG3237 Function unknown Uncharacterized conserved protein r_klactVI3582 good Q KOG0023 Secondary metabolites biosynthesis, transport and catabolism Alcohol dehydrogenase, class V r_klactVI3595 check: MH D KOG0588 Cell cycle control, cell division, chromosome partitioning Serine/threonine protein kinase r_klactVI3607 good E KOG2596 Amino acid transport and metabolism Aminopeptidase I zinc metalloprotease (M18) r_klactVI3614 good M KOG1268 Cell wall/membrane/envelope biogenesis Glucosamine 6-phosphate synthetases, contain amidotransferase and phosphosugar isomerase domains r_klactVI3626 good E KOG1411 Amino acid transport and metabolism Aspartate aminotransferase/Glutamic oxaloacetic transaminase AAT1/GOT2 r_klactVI3638 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactVI3648 check: MH O KOG0731 Posttranslational modification, protein turnover, chaperones AAA+-type ATPase containing the peptidase M41 domain r_klactVI3664 good Z KOG0318 Cytoskeleton WD40 repeat stress protein/actin interacting protein r_klactVI3668 check: MH S KOG0310 Function unknown Conserved WD40 repeat-containing protein r_klactVI3683 good S KOG3442 Function unknown Uncharacterized conserved protein r_klactVI3690 suspect: LH K KOG2845 Transcription Activating signal cointegrator 1 r_klactVI3704 check: MH A KOG0348 RNA processing and modification ATP-dependent RNA helicase r_klactVI3707 good K KOG2354 Transcription RNA Polymerase C (III) 37 kDa subunit r_klactVI3708 good J KOG1466 Translation, ribosomal structure and biogenesis Translation initiation factor 2B, alpha subunit (eIF-2Balpha/GCN3) r_klactVI3718 check: MH J KOG0465 Translation, ribosomal structure and biogenesis Mitochondrial elongation factor r_klactVI3730 good H KOG3754 Coenzyme transport and metabolism Gamma-glutamylcysteine synthetase r_klactVI3734 good T KOG2381 Signal transduction mechanisms Phosphatidylinositol 4-kinase r_klactVI3760 good D KOG2073 Cell cycle control, cell division, chromosome partitioning SAP family cell cycle dependent phosphatase-associated protein r_klactVI3764 good R KOG3187 General function prediction only Protein tyrosine phosphatase-like protein PTPLA (contains Pro instead of catalytic Arg) r_klactVI3766 suspect: LH CE KOG0453 Amino acid transport and metabolism Aconitase/homoaconitase (aconitase superfamily) r_klactVI3766 suspect: LH CE KOG0453 Energy production and conversion Aconitase/homoaconitase (aconitase superfamily) r_klactVI3772 check: MH T KOG0198 Signal transduction mechanisms MEKK and related serine/threonine protein kinases r_klactVI3780 suspect: LH P KOG1418 Inorganic ion transport and metabolism Tandem pore domain K+ channel r_klactVI3786 good L KOG2108 Replication, recombination and repair 3'-5' DNA helicase r_klactVI3791 good L KOG2108 Replication, recombination and repair 3'-5' DNA helicase r_klactVI3793 good S KOG0411 Function unknown Uncharacterized membrane protein r_klactVI3799 suspect: LH L KOG1929 Replication, recombination and repair Nucleotide excision repair factor NEF2, RAD4/CUT5 component r_klactVI3809 suspect: LH S KOG4415 Function unknown Uncharacterized conserved protein r_klactVI3815 good E KOG1504 Amino acid transport and metabolism Ornithine carbamoyltransferase OTC/ARG3 r_klactVI3827 good U KOG2344 Intracellular trafficking, secretion, and vesicular transport Exocyst component protein and related proteins r_klactVI3836 good R KOG3780 General function prediction only Thioredoxin binding protein TBP-2/VDUP1 r_klactVI3842 good L KOG2179 Replication, recombination and repair Nucleotide excision repair complex XPC-HR23B, subunit XPC/DPB11 r_klactVI3867 good A KOG2560 RNA processing and modification RNA splicing factor - Slu7p r_klactVI3871 good A KOG1919 RNA processing and modification RNA pseudouridylate synthases r_klactVI3883 good U KOG4031 Intracellular trafficking, secretion, and vesicular transport Vesicle coat protein clathrin, light chain r_klactVI3896 good BK KOG2684 Chromatin structure and dynamics Sirtuin 5 and related class III sirtuins (SIR2 family) r_klactVI3896 good BK KOG2684 Transcription Sirtuin 5 and related class III sirtuins (SIR2 family) r_klactVI3901 check: MH O KOG0726 Posttranslational modification, protein turnover, chaperones 26S proteasome regulatory complex, ATPase RPT2 r_klactVI3902 good T KOG0698 Signal transduction mechanisms Serine/threonine protein phosphatase r_klactVI3909 good C KOG1758 Energy production and conversion Mitochondrial F1F0-ATP synthase, subunit delta/ATP16 r_klactVI3920 good D KOG1213 Cell cycle control, cell division, chromosome partitioning Sister chromatid cohesion complex Cohesin, subunit RAD21/SCC1 r_klactVI3925 good S KOG2422 Function unknown Uncharacterized conserved protein r_klactVI3929 good S KOG2149 Function unknown Uncharacterized conserved protein r_klactVI3939 good R KOG0118 General function prediction only FOG: RRM domain r_klactVI3963 good I KOG2419 Lipid transport and metabolism Phosphatidylserine decarboxylase r_klactVI3969 good L KOG2732 Replication, recombination and repair DNA polymerase delta, regulatory subunit 55 r_klactVI3976 good J KOG0436 Translation, ribosomal structure and biogenesis Methionyl-tRNA synthetase r_klactVI3979 check: MH T KOG1486 Signal transduction mechanisms GTP-binding protein DRG2 (ODN superfamily) r_klactVI3984 good U KOG3103 Intracellular trafficking, secretion, and vesicular transport Rab GTPase interacting factor, Golgi membrane protein r_klactVI3998 good F KOG1567 Nucleotide transport and metabolism Ribonucleotide reductase, beta subunit r_klactVI4006 good A KOG2375 RNA processing and modification Protein interacting with poly(A)-binding protein r_klactVI4024 good I KOG1298 Lipid transport and metabolism Squalene monooxygenase r_klactVI4027 check: MH U KOG0936 Intracellular trafficking, secretion, and vesicular transport Clathrin adaptor complex, small subunit r_klactVI4030 good U KOG1733 Intracellular trafficking, secretion, and vesicular transport Mitochondrial import inner membrane translocase, subunit TIM13 r_klactVI4032.1 good C KOG3494 Energy production and conversion Ubiquinol cytochrome c oxidoreductase, subunit QCR9 r_klactVI4045 good O KOG1140 Posttranslational modification, protein turnover, chaperones N-end rule pathway, recognition component UBR1 r_klactVI4063 good O KOG1140 Posttranslational modification, protein turnover, chaperones N-end rule pathway, recognition component UBR1 r_klactVI4066 good J KOG2144 Translation, ribosomal structure and biogenesis Tyrosyl-tRNA synthetase, cytoplasmic r_klactVI4076 good K KOG2393 Transcription Transcription initiation factor IIF, large subunit (RAP74) r_klactVI4081 good S KOG2973 Function unknown Uncharacterized conserved protein r_klactVI4084 suspect: LH S KOG4455 Function unknown Uncharacterized conserved protein r_klactVI4097 good J KOG1488 Translation, ribosomal structure and biogenesis Translational repressor Pumilio/PUF3 and related RNA-binding proteins (Puf superfamily) r_klactVI4107 good RT KOG0748 General function prediction only Predicted membrane proteins, contain hemolysin III domain r_klactVI4107 good RT KOG0748 Signal transduction mechanisms Predicted membrane proteins, contain hemolysin III domain r_klactVI4114 good J KOG2917 Translation, ribosomal structure and biogenesis Predicted exosome subunit r_klactVI4120 good I KOG2624 Lipid transport and metabolism Triglyceride lipase-cholesterol esterase r_klactVI4128 check: MH A KOG0268 RNA processing and modification Sof1-like rRNA processing protein (contains WD40 repeats) r_klactVI4134 good K KOG1605 Transcription TFIIF-interacting CTD phosphatase, including NLI-interacting factor (involved in RNA polymerase II regulation) r_klactVI4142 good F KOG3985 Nucleotide transport and metabolism Methylthioadenosine phosphorylase MTAP r_klactVI4145 suspect: LH O KOG3496 Posttranslational modification, protein turnover, chaperones Cytochrome c oxidase assembly protein/Cu2+ chaperone COX17 r_klactVI4162 check: MH T KOG0618 Signal transduction mechanisms Serine/threonine phosphatase 2C containing leucine-rich repeats, similar to SCN circadian oscillatory protein (SCOP) r_klactVI4166 suspect: LH U KOG4697 Intracellular trafficking, secretion, and vesicular transport Integral membrane protein involved in transport between the late Golgi and endosome r_klactVI4174.1 suspect: LH R KOG0149 General function prediction only Predicted RNA-binding protein SEB4 (RRM superfamily) r_klactVI4174 check: MH A KOG0338 RNA processing and modification ATP-dependent RNA helicase r_klactVI4199 good R KOG1134 General function prediction only Uncharacterized conserved protein r_klactVI4206 good O KOG3359 Posttranslational modification, protein turnover, chaperones Dolichyl-phosphate-mannose:protein O-mannosyl transferase r_klactVI4211 good F KOG1479 Nucleotide transport and metabolism Nucleoside transporter r_klactVI4216 good K KOG0620 Transcription Glucose-repressible alcohol dehydrogenase transcriptional effector CCR4 and related proteins r_klactVI4224 good S KOG1426 Function unknown FOG: RCC1 domain r_klactVI4237 check: MH A KOG0332 RNA processing and modification ATP-dependent RNA helicase r_klactVI4263 good R KOG0813 General function prediction only Glyoxylase r_klactVI4270 suspect: %id S KOG1408 Function unknown WD40 repeat protein r_klactVI4292 good U KOG3330 Intracellular trafficking, secretion, and vesicular transport Transport protein particle (TRAPP) complex subunit r_klactVI4305 good H KOG1527 Coenzyme transport and metabolism Uroporphyrin III methyltransferase r_klactVI4311 good R KOG1618 General function prediction only Predicted phosphatase r_klactVI4318 good S KOG4020 Function unknown Protein DRE2, required for cell viability r_klactVI4326 good PD KOG0672 Cell cycle control, cell division, chromosome partitioning Halotolerance protein HAL3 (contains flavoprotein domain) r_klactVI4326 good PD KOG0672 Inorganic ion transport and metabolism Halotolerance protein HAL3 (contains flavoprotein domain) r_klactVI4329 good O KOG2463 Posttranslational modification, protein turnover, chaperones Predicted RNA-binding protein Nob1p involved in 26S proteasome assembly r_klactVI4332 good T KOG1309 Signal transduction mechanisms Suppressor of G2 allele of skp1 r_klactVI4338 good DZ KOG4302 Cell cycle control, cell division, chromosome partitioning Microtubule-associated protein essential for anaphase spindle elongation r_klactVI4338 good DZ KOG4302 Cytoskeleton Microtubule-associated protein essential for anaphase spindle elongation r_klactVI4343 good S KOG4147 Function unknown Uncharacterized conserved protein r_klactVI4351 good R KOG4372 General function prediction only Predicted alpha/beta hydrolase r_klactVI4357 check: MH TDK KOG0668 Cell cycle control, cell division, chromosome partitioning Casein kinase II, alpha subunit r_klactVI4357 check: MH TDK KOG0668 Signal transduction mechanisms Casein kinase II, alpha subunit r_klactVI4357 check: MH TDK KOG0668 Transcription Casein kinase II, alpha subunit r_klactVI4369 good J KOG0746 Translation, ribosomal structure and biogenesis 60S ribosomal protein L3 and related proteins r_klactVI4374 good B KOG1973 Chromatin structure and dynamics Chromatin remodeling protein, contains PHD Zn-finger r_klactVI4380 good C KOG3052 Energy production and conversion Cytochrome c1 r_klactVI4394 good K KOG2576 Transcription Glucosyltransferase - Alg8p r_klactVI4399 normal U KOG2273 Intracellular trafficking, secretion, and vesicular transport Membrane coat complex Retromer, subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins r_klactVI4407 good R KOG2121 General function prediction only Predicted metal-dependent hydrolase (beta-lactamase superfamily) r_klactVI4418 normal R KOG4372 General function prediction only Predicted alpha/beta hydrolase r_klactVI4423 good C KOG2404 Energy production and conversion Fumarate reductase, flavoprotein subunit r_klactVI4436 good E KOG1368 Amino acid transport and metabolism Threonine aldolase r_klactVI4441 good S KOG4137 Function unknown Uncharacterized conserved protein r_klactVI4448 suspect: Pn Z KOG0161 Cytoskeleton Myosin class II heavy chain r_klactVI4452 good A KOG3068 RNA processing and modification mRNA splicing factor r_klactVI4456 good F KOG1385 Nucleotide transport and metabolism Nucleoside phosphatase r_klactVI4462 good G KOG2178 Carbohydrate transport and metabolism Predicted sugar kinase r_klactVI4475 good C KOG3453 Energy production and conversion Cytochrome c r_klactVI4485 good EH KOG1184 Amino acid transport and metabolism Thiamine pyrophosphate-requiring enzyme r_klactVI4485 good EH KOG1184 Coenzyme transport and metabolism Thiamine pyrophosphate-requiring enzyme r_klactVI4489 check: MH G KOG0658 Carbohydrate transport and metabolism Glycogen synthase kinase-3 r_klactVI4500 good C KOG1494 Energy production and conversion NAD-dependent malate dehydrogenase r_klactVI4503 check: MH UZ KOG0073 Cytoskeleton GTP-binding ADP-ribosylation factor-like protein ARL2 r_klactVI4503 check: MH UZ KOG0073 Intracellular trafficking, secretion, and vesicular transport GTP-binding ADP-ribosylation factor-like protein ARL2 r_klactVI4508 good L KOG1361 Replication, recombination and repair Predicted hydrolase involved in interstrand cross-link repair r_klactVI4512 suspect: HSP K KOG1601 Transcription GATA-4/5/6 transcription factors r_klactVI4516 suspect: LH Z KOG2659 Cytoskeleton LisH motif-containing protein r_klactVI4529 good R KOG3272 General function prediction only Predicted coiled-coil protein r_klactVI4535 check: MH R KOG0302 General function prediction only Ribosome Assembly protein r_klactVI4544 suspect: LH R KOG2006 General function prediction only WD40 repeat protein r_klactVI4547 good C KOG3057 Energy production and conversion Cytochrome c oxidase, subunit VIb/COX12 r_klactVI4554 good R KOG3085 General function prediction only Predicted hydrolase (HAD superfamily) r_klactVI4561 check: MH R KOG0017 General function prediction only FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations r_klactVI4581 good P KOG1291 Inorganic ion transport and metabolism Mn2+ and Fe2+ transporters of the NRAMP family r_klactVI4585 suspect: Pn R KOG1844 General function prediction only PHD Zn-finger proteins r_klactVI4602 check: MH AJ KOG0926 RNA processing and modification DEAH-box RNA helicase r_klactVI4602 check: MH AJ KOG0926 Translation, ribosomal structure and biogenesis DEAH-box RNA helicase r_klactVI4607 good B KOG2747 Chromatin structure and dynamics Histone acetyltransferase (MYST family) r_klactVI4610 check: MH KL KOG1001 Replication, recombination and repair Helicase-like transcription factor HLTF/DNA helicase RAD5, DEAD-box superfamily r_klactVI4610 check: MH KL KOG1001 Transcription Helicase-like transcription factor HLTF/DNA helicase RAD5, DEAD-box superfamily r_klactVI4626 good A KOG1104 RNA processing and modification Nuclear cap-binding complex, subunit NCBP1/CBP80 r_klactVI4649 good J KOG1678 Translation, ribosomal structure and biogenesis 60s ribosomal protein L15 r_klactVI4655 good F KOG2555 Nucleotide transport and metabolism AICAR transformylase/IMP cyclohydrolase/methylglyoxal synthase r_klactVI4669 good E KOG1412 Amino acid transport and metabolism Aspartate aminotransferase/Glutamic oxaloacetic transaminase AAT2/GOT1 r_klactVI4675 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactVI4685 good U KOG0812 Intracellular trafficking, secretion, and vesicular transport SNARE protein SED5/Syntaxin 5 r_klactVI4688 good U KOG1656 Intracellular trafficking, secretion, and vesicular transport Protein involved in glucose derepression and pre-vacuolar endosome protein sorting r_klactVI4696 check: MH C KOG0758 Energy production and conversion Mitochondrial carnitine-acylcarnitine carrier protein r_klactVI4704 good P KOG2693 Inorganic ion transport and metabolism Putative zinc transporter r_klactVI4706 good I KOG2112 Lipid transport and metabolism Lysophospholipase r_klactVI4718 good K KOG3613 Transcription Dopey and related predicted leucine zipper transcription factors r_klactVI4720 good J KOG3191 Translation, ribosomal structure and biogenesis Predicted N6-DNA-methyltransferase r_klactVI4721 good OR KOG0001 General function prediction only Ubiquitin and ubiquitin-like proteins r_klactVI4721 good OR KOG0001 Posttranslational modification, protein turnover, chaperones Ubiquitin and ubiquitin-like proteins r_klactVI4726 good D KOG1915 Cell cycle control, cell division, chromosome partitioning Cell cycle control protein (crooked neck) r_klactVI4730 check: MH A KOG0119 RNA processing and modification Splicing factor 1/branch point binding protein (RRM superfamily) r_klactVI4733 good J KOG0400 Translation, ribosomal structure and biogenesis 40S ribosomal protein S13 r_klactVI4740 suspect: LH W KOG1736 Extracellular structures Glia maturation factor beta r_klactVI4771 good R KOG0255 General function prediction only Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) r_klactVI4783 good E KOG2413 Amino acid transport and metabolism Xaa-Pro aminopeptidase r_klactVI4786 good P KOG1120 Inorganic ion transport and metabolism Fe-S cluster biosynthesis protein ISA1 (contains a HesB-like domain) r_klactVI4792.1 suspect: Pn O KOG1863 Posttranslational modification, protein turnover, chaperones Ubiquitin carboxyl-terminal hydrolase r_klactVI4799 good O KOG1051 Posttranslational modification, protein turnover, chaperones Chaperone HSP104 and related ATP-dependent Clp proteases r_klactVI4827 suspect: %id AJ KOG0123 RNA processing and modification Polyadenylate-binding protein (RRM superfamily) r_klactVI4827 suspect: %id AJ KOG0123 Translation, ribosomal structure and biogenesis Polyadenylate-binding protein (RRM superfamily) r_klactVI4835 suspect: LH S KOG3830 Function unknown Uncharacterized conserved protein r_klactVI4838 good Q KOG0023 Secondary metabolites biosynthesis, transport and catabolism Alcohol dehydrogenase, class V r_klactVI4855 good J KOG1068 Translation, ribosomal structure and biogenesis Exosomal 3'-5' exoribonuclease complex, subunit Rrp41 and related exoribonucleases r_klactVI4875 good J KOG1885 Translation, ribosomal structure and biogenesis Lysyl-tRNA synthetase (class II) r_klactVI4878 good DR KOG1099 Cell cycle control, cell division, chromosome partitioning SAM-dependent methyltransferase/cell division protein FtsJ r_klactVI4878 good DR KOG1099 General function prediction only SAM-dependent methyltransferase/cell division protein FtsJ r_klactVI4879 good J KOG3321 Translation, ribosomal structure and biogenesis Mitochondrial ribosomal protein S10 r_klactVI4883 good O KOG0800 Posttranslational modification, protein turnover, chaperones FOG: Predicted E3 ubiquitin ligase r_klactVI4887 good R KOG0153 General function prediction only Predicted RNA-binding protein (RRM superfamily) r_klactVI4895 suspect: HSP R KOG1721 General function prediction only FOG: Zn-finger r_klactVI4916 good H KOG1518 Coenzyme transport and metabolism Coproporphyrinogen III oxidase CPO/HEM13 r_klactVI4921 good K KOG2906 Transcription RNA polymerase III subunit C11 r_klactVI4928 good L KOG2928 Replication, recombination and repair Origin recognition complex, subunit 2 r_klactVI4935 check: MH T KOG1989 Signal transduction mechanisms ARK protein kinase family r_klactVI4941 good I KOG2987 Lipid transport and metabolism Fatty acid desaturase r_klactVI4947 good I KOG1684 Lipid transport and metabolism Enoyl-CoA hydratase r_klactVI4951 check: MH O KOG0944 Posttranslational modification, protein turnover, chaperones Ubiquitin-specific protease UBP14 r_klactVI4976 suspect: LH R KOG0017 General function prediction only FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations r_klactVI4987 good G KOG1643 Carbohydrate transport and metabolism Triosephosphate isomerase r_klactVI4990 good R KOG3339 General function prediction only Predicted glycosyltransferase r_klactVI4996 good O KOG0710 Posttranslational modification, protein turnover, chaperones Molecular chaperone (small heat-shock protein Hsp26/Hsp42) r_klactVI5002 good U KOG1278 Intracellular trafficking, secretion, and vesicular transport Endosomal membrane proteins, EMP70 r_klactVI5010 good D KOG1938 Cell cycle control, cell division, chromosome partitioning Protein with predicted involvement in meiosis (GSG1) r_klactVI5056 good G KOG2517 Carbohydrate transport and metabolism Ribulose kinase and related carbohydrate kinases r_klactVI5066 check: MH Z KOG0680 Cytoskeleton Actin-related protein - Arp6p r_klactVI5078 check: MH BD KOG0996 Cell cycle control, cell division, chromosome partitioning Structural maintenance of chromosome protein 4 (chromosome condensation complex Condensin, subunit C) r_klactVI5078 check: MH BD KOG0996 Chromatin structure and dynamics Structural maintenance of chromosome protein 4 (chromosome condensation complex Condensin, subunit C) r_klactVI5099 suspect: LH S KOG3596 Function unknown Uncharacterized conserved protein r_klactVI5105 good O KOG3566 Posttranslational modification, protein turnover, chaperones Glycosylphosphatidylinositol anchor attachment protein GAA1 r_klactVI5111 suspect: LH R KOG0017 General function prediction only FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations r_klactVI5116 good E KOG0258 Amino acid transport and metabolism Alanine aminotransferase r_klactVI5122 check: MH O KOG0712 Posttranslational modification, protein turnover, chaperones Molecular chaperone (DnaJ superfamily) r_klactVI5131 good J KOG4612 Translation, ribosomal structure and biogenesis Mitochondrial ribosomal protein L34 r_klactVI5136 suspect: LH J KOG1569 Translation, ribosomal structure and biogenesis 50S ribosomal protein L1 r_klactVI5141 good J KOG2522 Translation, ribosomal structure and biogenesis Filamentous baseplate protein Ligatin, contains PUA domain r_klactVI5146 suspect: LH DO KOG4640 Cell cycle control, cell division, chromosome partitioning Anaphase-promoting complex (APC), subunit 4 r_klactVI5146 suspect: LH DO KOG4640 Posttranslational modification, protein turnover, chaperones Anaphase-promoting complex (APC), subunit 4 r_klactVI5154 good P KOG0236 Inorganic ion transport and metabolism Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) r_klactVI5160 good C KOG1575 Energy production and conversion Voltage-gated shaker-like K+ channel, subunit beta/KCNAB r_klactVI5178 good J KOG1253 Translation, ribosomal structure and biogenesis tRNA methyltransferase r_klactVI5181 suspect: LH K KOG0870 Transcription DNA polymerase epsilon, subunit D r_klactVI5184 good U KOG0860 Intracellular trafficking, secretion, and vesicular transport Synaptobrevin/VAMP-like protein r_klactVI5190 good Q KOG1399 Secondary metabolites biosynthesis, transport and catabolism Flavin-containing monooxygenase r_klactVI5222 check: MH T KOG0583 Signal transduction mechanisms Serine/threonine protein kinase r_klactVI5230 good R KOG2997 General function prediction only F-box protein FBX9 r_klactVI5242 good R KOG4409 General function prediction only Predicted hydrolase/acyltransferase (alpha/beta hydrolase superfamily) r_klactVI5251 check: MH R KOG1312 General function prediction only DHHC-type Zn-finger proteins r_klactVI5267 good E KOG0692 Amino acid transport and metabolism Pentafunctional AROM protein r_klactVI5277 check: MH S KOG0309 Function unknown Conserved WD40 repeat-containing protein r_klactVI5281 good I KOG1478 Lipid transport and metabolism 3-keto sterol reductase r_klactVI5289 good Z KOG0046 Cytoskeleton Ca2+-binding actin-bundling protein (fimbrin/plastin), EF-Hand protein superfamily r_klactVI5296 good L KOG2475 Replication, recombination and repair CDC45 (cell division cycle 45)-like protein r_klactVI5308 good J KOG4685 Translation, ribosomal structure and biogenesis tRNA splicing endonuclease SEN2 r_klactVI5347 good R KOG1808 General function prediction only AAA ATPase containing von Willebrand factor type A (vWA) domain r_klactVI5351 good L KOG2248 Replication, recombination and repair 3'-5' exonuclease r_klactVI5368 good O KOG0541 Posttranslational modification, protein turnover, chaperones Alkyl hydroperoxide reductase/peroxiredoxin r_klactVI5380 check: MH T KOG0660 Signal transduction mechanisms Mitogen-activated protein kinase r_klactVI5392 good Q KOG0054 Secondary metabolites biosynthesis, transport and catabolism Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily r_klactVI5399 good BD KOG0414 Cell cycle control, cell division, chromosome partitioning Chromosome condensation complex Condensin, subunit D2 r_klactVI5399 good BD KOG0414 Chromatin structure and dynamics Chromosome condensation complex Condensin, subunit D2 r_klactVI5401 good H KOG1321 Coenzyme transport and metabolism Protoheme ferro-lyase (ferrochelatase) r_klactVI5406 good S KOG2704 Function unknown Predicted membrane protein r_klactVI5412 suspect: LH A KOG1994 RNA processing and modification Predicted RNA binding protein, contains G-patch and Zn-finger domains r_klactVI5418 good S KOG3969 Function unknown Uncharacterized conserved protein r_klactVI5420 good U KOG0862 Intracellular trafficking, secretion, and vesicular transport Synaptobrevin/VAMP-like protein SEC22 r_klactVI5425 good T KOG2839 Signal transduction mechanisms Diadenosine and diphosphoinositol polyphosphate phosphohydrolase r_klactVI5428 good S KOG3024 Function unknown Uncharacterized conserved protein r_klactVI5440 good R KOG2203 General function prediction only GTP-binding protein r_klactVI5444 suspect: LH A KOG4689 RNA processing and modification Predicted RNase r_klactVI5448 good J KOG3502 Translation, ribosomal structure and biogenesis 40S ribosomal protein S28 r_klactVI5464.1 suspect: Pn TO KOG3288 Posttranslational modification, protein turnover, chaperones OTU-like cysteine protease r_klactVI5464.1 suspect: Pn TO KOG3288 Signal transduction mechanisms OTU-like cysteine protease r_klactVI5464 good J KOG1148 Translation, ribosomal structure and biogenesis Glutaminyl-tRNA synthetase r_klactVI5469 check: MH U KOG0094 Intracellular trafficking, secretion, and vesicular transport GTPase Rab6/YPT6/Ryh1, small G protein superfamily r_klactVI5477 good IT KOG1116 Lipid transport and metabolism Sphingosine kinase, involved in sphingolipid metabolism r_klactVI5477 good IT KOG1116 Signal transduction mechanisms Sphingosine kinase, involved in sphingolipid metabolism r_klactVI5481 suspect: LH A KOG0108 RNA processing and modification mRNA cleavage and polyadenylation factor I complex, subunit RNA15 r_klactVI5487 check: MH E KOG1405 Amino acid transport and metabolism 4-aminobutyrate aminotransferase r_klactVI5492 suspect: LH R KOG4549 General function prediction only Magnesium-dependent phosphatase r_klactVI5516 suspect: HSP R KOG1721 General function prediction only FOG: Zn-finger r_klactVI5533 check: MH P KOG0202 Inorganic ion transport and metabolism Ca2+ transporting ATPase r_klactVI5549 suspect: LH A KOG2162 RNA processing and modification Nonsense-mediated mRNA decay protein r_klactVI5562 good L KOG1956 Replication, recombination and repair DNA topoisomerase III alpha r_klactVI5570 good P KOG1484 Inorganic ion transport and metabolism Putative Zn2+ transporter MSC2 (cation diffusion facilitator superfamily) r_klactVI5576 good S KOG2585 Function unknown Uncharacterized conserved protein r_klactVI5588 good DZU KOG2655 Cell cycle control, cell division, chromosome partitioning Septin family protein (P-loop GTPase) r_klactVI5588 good DZU KOG2655 Cytoskeleton Septin family protein (P-loop GTPase) r_klactVI5588 good DZU KOG2655 Intracellular trafficking, secretion, and vesicular transport Septin family protein (P-loop GTPase) r_klactVI5596 good R KOG0118 General function prediction only FOG: RRM domain r_klactVI5614 suspect: Pn G KOG2806 Carbohydrate transport and metabolism Chitinase r_klactVI5639 good M KOG2571 Cell wall/membrane/envelope biogenesis Chitin synthase/hyaluronan synthase (glycosyltransferases) r_klactVI5643 good G KOG0657 Carbohydrate transport and metabolism Glyceraldehyde 3-phosphate dehydrogenase r_klactVI5654 good Q KOG0023 Secondary metabolites biosynthesis, transport and catabolism Alcohol dehydrogenase, class V r_klactVI5658 good J KOG1697 Translation, ribosomal structure and biogenesis Mitochondrial/chloroplast ribosomal protein S9 r_klactVI5669 good S KOG0308 Function unknown Conserved WD40 repeat-containing protein r_klactVI5672 good K KOG3218 Transcription RNA polymerase, 25-kDa subunit (common to polymerases I, II and III) r_klactVI5701 good S KOG1837 Function unknown Uncharacterized conserved protein r_klactVI5702 good S KOG3012 Function unknown Uncharacterized conserved protein r_klactVI5718 good I KOG1329 Lipid transport and metabolism Phospholipase D1 r_klactVI5727 suspect: HSP K KOG1601 Transcription GATA-4/5/6 transcription factors r_klactVI5731.1 suspect: LH S KOG4190 Function unknown Uncharacterized conserved protein r_klactVI5731 good U KOG3232 Intracellular trafficking, secretion, and vesicular transport Vacuolar assembly/sorting protein DID2 r_klactVI5736 check: MH O KOG0361 Posttranslational modification, protein turnover, chaperones Chaperonin complex component, TCP-1 eta subunit (CCT7) r_klactVI5740 check: MH R KOG4155 General function prediction only FOG: WD40 repeat r_klactVI5746 good O KOG2708 Posttranslational modification, protein turnover, chaperones Predicted metalloprotease with chaperone activity (RNAse H/HSP70 fold) r_klactVI5756 good J KOG2815 Translation, ribosomal structure and biogenesis Mitochondrial/choloroplast ribosomal protein S15 r_klactVI5762 normal J KOG3262 Translation, ribosomal structure and biogenesis H/ACA small nucleolar RNP component GAR1 r_klactVI5766 good R KOG2486 General function prediction only Predicted GTPase r_klactVI5772 good YU KOG2020 Intracellular trafficking, secretion, and vesicular transport Nuclear transport receptor CRM1/MSN5 (importin beta superfamily) r_klactVI5772 good YU KOG2020 Nuclear structure Nuclear transport receptor CRM1/MSN5 (importin beta superfamily) r_klactVI5777 good A KOG2780 RNA processing and modification Ribosome biogenesis protein RPF1, contains IMP4 domain r_klactVI5797 check: MH Q KOG0065 Secondary metabolites biosynthesis, transport and catabolism Pleiotropic drug resistance proteins (PDR1-15), ABC superfamily r_klactVI5830 check: MH R KOG0391 General function prediction only SNF2 family DNA-dependent ATPase r_klactVI5840 good R KOG1347 General function prediction only Uncharacterized membrane protein, predicted efflux pump r_klactVI5852 good S KOG1685 Function unknown Uncharacterized conserved protein r_klactVI5854 normal S KOG3214 Function unknown Uncharacterized Zn ribbon-containing protein r_klactVI5857 good C KOG4077 Energy production and conversion Cytochrome c oxidase, subunit Va/COX6 r_klactVI5861 suspect: LH TR KOG4019 General function prediction only Calcineurin-mediated signaling pathway inhibitor DSCR1 r_klactVI5861 suspect: LH TR KOG4019 Signal transduction mechanisms Calcineurin-mediated signaling pathway inhibitor DSCR1 r_klactVI5864 good R KOG3239 General function prediction only Density-regulated protein related to translation initiation factor 1 (eIF-1/SUI1) r_klactVI5874 good O KOG3359 Posttranslational modification, protein turnover, chaperones Dolichyl-phosphate-mannose:protein O-mannosyl transferase r_klactVI5882 check: MH BK KOG1063 Chromatin structure and dynamics RNA polymerase II elongator complex, subunit ELP2, WD repeat superfamily r_klactVI5882 check: MH BK KOG1063 Transcription RNA polymerase II elongator complex, subunit ELP2, WD repeat superfamily r_klactVI5889 good E KOG2448 Amino acid transport and metabolism Dihydroxy-acid dehydratase r_klactVI5916 good TBLD KOG0889 Cell cycle control, cell division, chromosome partitioning Histone acetyltransferase SAGA, TRRAP/TRA1 component, PI-3 kinase superfamily r_klactVI5916 good TBLD KOG0889 Chromatin structure and dynamics Histone acetyltransferase SAGA, TRRAP/TRA1 component, PI-3 kinase superfamily r_klactVI5916 good TBLD KOG0889 Replication, recombination and repair Histone acetyltransferase SAGA, TRRAP/TRA1 component, PI-3 kinase superfamily r_klactVI5916 good TBLD KOG0889 Signal transduction mechanisms Histone acetyltransferase SAGA, TRRAP/TRA1 component, PI-3 kinase superfamily r_klactVI5923 good O KOG1339 Posttranslational modification, protein turnover, chaperones Aspartyl protease r_klactVI5927 good U KOG1984 Intracellular trafficking, secretion, and vesicular transport Vesicle coat complex COPII, subunit SFB3 r_klactVI5944 good P KOG0876 Inorganic ion transport and metabolism Manganese superoxide dismutase r_klactVI5963 good V KOG4003 Defense mechanisms Pyrazinamidase/nicotinamidase PNC1 r_klactVI5974 check: MH T KOG0671 Signal transduction mechanisms LAMMER dual specificity kinases r_klactVI5979 suspect: Pn R KOG1721 General function prediction only FOG: Zn-finger r_klactVI5990 suspect: LH YU KOG0845 Intracellular trafficking, secretion, and vesicular transport Nuclear pore complex, Nup98 component (sc Nup145/Nup100/Nup116) r_klactVI5990 suspect: LH YU KOG0845 Nuclear structure Nuclear pore complex, Nup98 component (sc Nup145/Nup100/Nup116) r_klactVI5999 good LD KOG2045 Cell cycle control, cell division, chromosome partitioning 5'-3' exonuclease XRN1/KEM1/SEP1 involved in DNA strand exchange and mRNA turnover r_klactVI5999 good LD KOG2045 Replication, recombination and repair 5'-3' exonuclease XRN1/KEM1/SEP1 involved in DNA strand exchange and mRNA turnover r_klactVI6002 good S KOG2654 Function unknown Uncharacterized conserved protein r_klactVI6009 good D KOG4438 Cell cycle control, cell division, chromosome partitioning Centromere-associated protein NUF2 r_klactVI6013 good A KOG0227 RNA processing and modification Splicing factor 3a, subunit 2 r_klactVI6034 check: MH O KOG0364 Posttranslational modification, protein turnover, chaperones Chaperonin complex component, TCP-1 gamma subunit (CCT3) r_klactVI6046 check: MH D KOG1166 Cell cycle control, cell division, chromosome partitioning Mitotic checkpoint serine/threonine protein kinase r_klactVI6055 good P KOG1161 Inorganic ion transport and metabolism Protein involved in vacuolar polyphosphate accumulation, contains SPX domain r_klactVI6059 good K KOG4168 Transcription Predicted RNA polymerase III subunit C17 r_klactVI6078 good U KOG0934 Intracellular trafficking, secretion, and vesicular transport Clathrin adaptor complex, small subunit r_klactVI6085 good J KOG3123 Translation, ribosomal structure and biogenesis Diphthine synthase r_klactVI6103 suspect: LH R KOG0017 General function prediction only FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations r_klactVI6108 good R KOG1944 General function prediction only Peroxisomal membrane protein MPV17 and related proteins r_klactVI6114 good R KOG1235 General function prediction only Predicted unusual protein kinase r_klactVI6116 good E KOG3007 Amino acid transport and metabolism Mu-crystallin r_klactVI6133 suspect: LH R KOG0017 General function prediction only FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations r_klactVI6143 good E KOG2410 Amino acid transport and metabolism Gamma-glutamyltransferase r_klactVI6145 suspect: LH PQ KOG0039 Inorganic ion transport and metabolism Ferric reductase, NADH/NADPH oxidase and related proteins r_klactVI6145 suspect: LH PQ KOG0039 Secondary metabolites biosynthesis, transport and catabolism Ferric reductase, NADH/NADPH oxidase and related proteins r_klactVI6160 check: MH S KOG1181 Function unknown FOG: Low-complexity r_klactVI6182 good G KOG3742 Carbohydrate transport and metabolism Glycogen synthase r_klactVI6185 check: MH T KOG0032 Signal transduction mechanisms Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily r_klactVI6207 good P KOG1397 Inorganic ion transport and metabolism Ca2+/H+ antiporter VCX1 and related proteins r_klactVI6225 good K KOG0262 Transcription RNA polymerase I, large subunit r_klactVI6235 good J KOG1144 Translation, ribosomal structure and biogenesis Translation initiation factor 5B (eIF-5B) r_klactVI6240 good T KOG1487 Signal transduction mechanisms GTP-binding protein DRG1 (ODN superfamily) r_klactVI6254 good K KOG2588 Transcription Predicted DNA-binding protein r_klactVI6272 good L KOG2093 Replication, recombination and repair Translesion DNA polymerase - REV1 deoxycytidyl transferase r_klactVI6276.1 suspect: Pn PET KOG1052 Amino acid transport and metabolism Glutamate-gated kainate-type ion channel receptor subunit GluR5 and related subunits r_klactVI6276.1 suspect: Pn PET KOG1052 Inorganic ion transport and metabolism Glutamate-gated kainate-type ion channel receptor subunit GluR5 and related subunits r_klactVI6276.1 suspect: Pn PET KOG1052 Signal transduction mechanisms Glutamate-gated kainate-type ion channel receptor subunit GluR5 and related subunits r_klactVI6277 good G KOG2323 Carbohydrate transport and metabolism Pyruvate kinase r_klactVI6287 good E KOG1286 Amino acid transport and metabolism Amino acid transporters r_klactVI6292 good E KOG1549 Amino acid transport and metabolism Cysteine desulfurase NFS1 r_klactVI6301 good O KOG1943 Posttranslational modification, protein turnover, chaperones Beta-tubulin folding cofactor D r_klactVI6310 check: MH T KOG0032 Signal transduction mechanisms Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily r_klactVI6320 good E KOG2367 Amino acid transport and metabolism Alpha-isopropylmalate synthase/homocitrate synthase r_klactVI6331 check: MH U KOG0566 Intracellular trafficking, secretion, and vesicular transport Inositol-1,4,5-triphosphate 5-phosphatase (synaptojanin), INP51/INP52/INP53 family r_klactVI6336.1 suspect: LH T KOG1023 Signal transduction mechanisms Natriuretic peptide receptor, guanylate cyclase r_klactVI6338 good K KOG3149 Transcription Transcription initiation factor IIF, auxiliary subunit r_klactVI6341.1 suspect: Pn T KOG1217 Signal transduction mechanisms Fibrillins and related proteins containing Ca2+-binding EGF-like domains r_klactVI6343 good D KOG1509 Cell cycle control, cell division, chromosome partitioning Predicted nucleic acid-binding protein ASMTL r_klactVI6347 good R KOG4208 General function prediction only Nucleolar RNA-binding protein NIFK r_klactVI6355 good C KOG0537 Energy production and conversion Cytochrome b5 r_klactVI6359 good R KOG1243 General function prediction only Protein kinase r_klactVI6363 good A KOG0331 RNA processing and modification ATP-dependent RNA helicase r_klactVI6369 check: MH A KOG0331 RNA processing and modification ATP-dependent RNA helicase r_klactVI6374 good K KOG3438 Transcription DNA-directed RNA polymerase, subunit L r_klactVI6382 good R KOG1721 General function prediction only FOG: Zn-finger r_klactVI6388 good U KOG3316 Intracellular trafficking, secretion, and vesicular transport Transport protein particle (TRAPP) complex subunit r_klactVI6391 good Z KOG3565 Cytoskeleton Cdc42-interacting protein CIP4 r_klactVI6407 good T KOG3872 Signal transduction mechanisms FOG: FHA domain r_klactVI6415 good C KOG1261 Energy production and conversion Malate synthase r_klactVI6430 suspect: HSP A KOG2937 RNA processing and modification Decapping enzyme complex, predicted pyrophosphatase DCP2 r_klactVI6433 good S KOG2594 Function unknown Uncharacterized conserved protein r_klactVI6434 good S KOG4618 Function unknown Uncharacterized conserved protein r_klactVI6442 check: MH U KOG0547 Intracellular trafficking, secretion, and vesicular transport Translocase of outer mitochondrial membrane complex, subunit TOM70/TOM72 r_klactVI6457 good R KOG1421 General function prediction only Predicted signaling-associated protein (contains a PDZ domain) r_klactVI6474 check: MH BK KOG1080 Chromatin structure and dynamics Histone H3 (Lys4) methyltransferase complex, subunit SET1 and related methyltransferases r_klactVI6474 check: MH BK KOG1080 Transcription Histone H3 (Lys4) methyltransferase complex, subunit SET1 and related methyltransferases r_klactVI6481 check: MH L KOG0218 Replication, recombination and repair Mismatch repair MSH3 r_klactVI6484 good S KOG2236 Function unknown Uncharacterized conserved protein r_klactVI6490 good G KOG2504 Carbohydrate transport and metabolism Monocarboxylate transporter r_klactVI6494 good Z KOG2000 Cytoskeleton Gamma-tubulin complex, DGRIP91/SPC98 component r_klactVI6505 good S KOG3680 Function unknown Uncharacterized conserved protein r_klactVI6507 suspect: LH S KOG4401 Function unknown Uncharacterized conserved protein r_klactVI6509 good TR KOG2283 General function prediction only Clathrin coat dissociation kinase GAK/PTEN/Auxilin and related tyrosine phosphatases r_klactVI6509 good TR KOG2283 Signal transduction mechanisms Clathrin coat dissociation kinase GAK/PTEN/Auxilin and related tyrosine phosphatases r_klactVI6512 suspect: LH F KOG3308 Nucleotide transport and metabolism Uncharacterized protein of the uridine kinase family r_klactVI6516 good S KOG3381 Function unknown Uncharacterized conserved protein r_klactVI6521 good I KOG2877 Lipid transport and metabolism sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases r_klactVI6524 suspect: LH U KOG4111 Intracellular trafficking, secretion, and vesicular transport Translocase of outer mitochondrial membrane complex, subunit TOM22 r_klactVI6534 good R KOG2036 General function prediction only Predicted P-loop ATPase fused to an acetyltransferase r_klactVI6549 good CR KOG1198 Energy production and conversion Zinc-binding oxidoreductase r_klactVI6549 good CR KOG1198 General function prediction only Zinc-binding oxidoreductase r_klactVI6564 good KC KOG0025 Energy production and conversion Zn2+-binding dehydrogenase (nuclear receptor binding factor-1) r_klactVI6564 good KC KOG0025 Transcription Zn2+-binding dehydrogenase (nuclear receptor binding factor-1) r_klactVI6578 check: MH RT KOG0598 General function prediction only Ribosomal protein S6 kinase and related proteins r_klactVI6578 check: MH RT KOG0598 Signal transduction mechanisms Ribosomal protein S6 kinase and related proteins r_klactVI6581 good I KOG1440 Lipid transport and metabolism CDP-diacylglycerol synthase r_klactVI6588 good A KOG2636 RNA processing and modification Splicing factor 3a, subunit 3 r_klactVI6597 check: MH A KOG0337 RNA processing and modification ATP-dependent RNA helicase r_klactVI6603 good J KOG2805 Translation, ribosomal structure and biogenesis tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase r_klactVI6605 good FP KOG1528 Inorganic ion transport and metabolism Salt-sensitive 3'-phosphoadenosine-5'-phosphatase HAL2/SAL1 r_klactVI6605 good FP KOG1528 Nucleotide transport and metabolism Salt-sensitive 3'-phosphoadenosine-5'-phosphatase HAL2/SAL1 r_klactVI6623 good U KOG0565 Intracellular trafficking, secretion, and vesicular transport Inositol polyphosphate 5-phosphatase and related proteins r_klactVI6628 good A KOG1919 RNA processing and modification RNA pseudouridylate synthases r_klactVI6631 good A KOG1817 RNA processing and modification Ribonuclease r_klactVI6641 check: MH K KOG0385 Transcription Chromatin remodeling complex WSTF-ISWI, small subunit r_klactVI6655 suspect: Pn O KOG0941 Posttranslational modification, protein turnover, chaperones E3 ubiquitin protein ligase r_klactVI6658 good R KOG0370 General function prediction only Multifunctional pyrimidine synthesis protein CAD (includes carbamoyl-phophate synthetase, aspartate transcarbamylase, and glutamine amidotransferase) r_klactVI6688 good K KOG3334 Transcription Transcription initiation factor TFIID, subunit TAF9 (also component of histone acetyltransferase SAGA) r_klactVI6689 good K KOG3398 Transcription Transcription factor MBF1 r_klactVI6696 good AYT KOG1909 Nuclear structure Ran GTPase-activating protein r_klactVI6696 good AYT KOG1909 RNA processing and modification Ran GTPase-activating protein r_klactVI6696 good AYT KOG1909 Signal transduction mechanisms Ran GTPase-activating protein r_klactVI6699 suspect: LH I KOG1505 Lipid transport and metabolism Lysophosphatidic acid acyltransferase LPAAT and related acyltransferases r_klactVI6702 good CU KOG4097 Energy production and conversion Succinate dehydrogenase membrane anchor subunit and related proteins r_klactVI6702 good CU KOG4097 Intracellular trafficking, secretion, and vesicular transport Succinate dehydrogenase membrane anchor subunit and related proteins r_klactVI6712 good U KOG3724 Intracellular trafficking, secretion, and vesicular transport Negative regulator of COPII vesicle formation r_klactVI6726 normal K KOG2261 Transcription Polycomb enhancer protein, EPC r_klactVI6751 good J KOG2784 Translation, ribosomal structure and biogenesis Phenylalanyl-tRNA synthetase, beta subunit r_klactVI6756 good S KOG3100 Function unknown Uncharacterized conserved protein r_klactVI6768 suspect: HSP K KOG1601 Transcription GATA-4/5/6 transcription factors r_klactVI6777 good R KOG1839 General function prediction only Uncharacterized protein CLU1/cluA/TIF31 involved in mitochondrial morphology/distribution, also found associated with eIF-3 r_klactVI6778.1 suspect: LH A KOG0337 RNA processing and modification ATP-dependent RNA helicase r_klactVI6781 good U KOG3229 Intracellular trafficking, secretion, and vesicular transport Vacuolar sorting protein VPS24 r_klactVI6793 good U KOG0937 Intracellular trafficking, secretion, and vesicular transport Adaptor complexes medium subunit family r_klactVI6794 good K KOG4073 Transcription Pterin carbinolamine dehydratase PCBD/dimerization cofactor of HNF1 r_klactVI6799 good O KOG2358 Posttranslational modification, protein turnover, chaperones NifU-like domain-containing proteins r_klactVI6802 good S KOG2568 Function unknown Predicted membrane protein r_klactVI6809 good J KOG0900 Translation, ribosomal structure and biogenesis 40S ribosomal protein S20 r_klactVI6817 good R KOG1491 General function prediction only Predicted GTP-binding protein (ODN superfamily) r_klactVI6821 good TO KOG2606 Posttranslational modification, protein turnover, chaperones OTU (ovarian tumor)-like cysteine protease r_klactVI6821 good TO KOG2606 Signal transduction mechanisms OTU (ovarian tumor)-like cysteine protease r_klactVI6837 good G KOG2638 Carbohydrate transport and metabolism UDP-glucose pyrophosphorylase r_klactVI6843 good O KOG0828 Posttranslational modification, protein turnover, chaperones Predicted E3 ubiquitin ligase r_klactVI6846 good R KOG2914 General function prediction only Predicted haloacid-halidohydrolase and related hydrolases r_klactVI6852 good FE KOG1448 Amino acid transport and metabolism Ribose-phosphate pyrophosphokinase r_klactVI6852 good FE KOG1448 Nucleotide transport and metabolism Ribose-phosphate pyrophosphokinase r_klactVI6861 good R KOG0804 General function prediction only Cytoplasmic Zn-finger protein BRAP2 (BRCA1 associated protein) r_klactVI6870 suspect: LH R KOG2914 General function prediction only Predicted haloacid-halidohydrolase and related hydrolases r_klactVI6891 good D KOG1525 Cell cycle control, cell division, chromosome partitioning Sister chromatid cohesion complex Cohesin, subunit PDS5 r_klactVI6896 check: MH R KOG4299 General function prediction only PHD Zn-finger protein r_klactVI6898 good D KOG3431 Cell cycle control, cell division, chromosome partitioning Apoptosis-related protein/predicted DNA-binding protein r_klactVI6901 good U KOG3480 Intracellular trafficking, secretion, and vesicular transport Mitochondrial import inner membrane translocase, subunits TIM10/TIM12 r_klactVI6905 good CO KOG3996 Energy production and conversion Holocytochrome c synthase/heme-lyase r_klactVI6905 good CO KOG3996 Posttranslational modification, protein turnover, chaperones Holocytochrome c synthase/heme-lyase r_klactVI6912 good DT KOG0082 Cell cycle control, cell division, chromosome partitioning G-protein alpha subunit (small G protein superfamily) r_klactVI6912 good DT KOG0082 Signal transduction mechanisms G-protein alpha subunit (small G protein superfamily) r_klactVI6914 good L KOG3388 Replication, recombination and repair Predicted transcription regulator/nuclease, contains ParB domain r_klactVI6920 good C KOG1494 Energy production and conversion NAD-dependent malate dehydrogenase r_klactVI6922 suspect: LH R KOG1940 General function prediction only Zn-finger protein r_klactVI6927 good R KOG0504 General function prediction only FOG: Ankyrin repeat r_klactVI6929 suspect: LH O KOG2699 Posttranslational modification, protein turnover, chaperones Predicted ubiquitin regulatory protein r_klactVI6939.1 suspect: LH T KOG3512 Signal transduction mechanisms Netrin, axonal chemotropic factor r_klactVI6939 suspect: LH S KOG2885 Function unknown Uncharacterized conserved protein r_klactVI6943 normal O KOG0867 Posttranslational modification, protein turnover, chaperones Glutathione S-transferase r_klactVI6950 good J KOG1627 Translation, ribosomal structure and biogenesis Translation elongation factor EF-1 gamma r_klactVI6952 good C KOG2909 Energy production and conversion Vacuolar H+-ATPase V1 sector, subunit C r_klactVI6976 good A KOG0922 RNA processing and modification DEAH-box RNA helicase r_klactVI6984 good R KOG0254 General function prediction only Predicted transporter (major facilitator superfamily) r_klactVI6995 good E KOG2786 Amino acid transport and metabolism Putative glutamate/ornithine acetyltransferase r_klactVI7001 good A KOG1914 RNA processing and modification mRNA cleavage and polyadenylation factor I complex, subunit RNA14 r_klactVI7005 suspect: LH U KOG3028 Intracellular trafficking, secretion, and vesicular transport Translocase of outer mitochondrial membrane complex, subunit TOM37/Metaxin 1 r_klactVI7018 good Q KOG1263 Secondary metabolites biosynthesis, transport and catabolism Multicopper oxidases r_klactVI7025 check: MH U KOG2058 Intracellular trafficking, secretion, and vesicular transport Ypt/Rab GTPase activating protein r_klactVI7028 good A KOG0120 RNA processing and modification Splicing factor U2AF, large subunit (RRM superfamily) r_klactVI7032 check: MH O KOG0104 Posttranslational modification, protein turnover, chaperones Molecular chaperones GRP170/SIL1, HSP70 superfamily r_klactVI7040 good C KOG2189 Energy production and conversion Vacuolar H+-ATPase V0 sector, subunit a r_klactVI7067 good J KOG0650 Translation, ribosomal structure and biogenesis WD40 repeat nucleolar protein Bop1, involved in ribosome biogenesis r_klactVI7070 suspect: LH D KOG3004 Cell cycle control, cell division, chromosome partitioning Meiotic chromosome segregation protein r_klactVI7086 good YU KOG0845 Intracellular trafficking, secretion, and vesicular transport Nuclear pore complex, Nup98 component (sc Nup145/Nup100/Nup116) r_klactVI7086 good YU KOG0845 Nuclear structure Nuclear pore complex, Nup98 component (sc Nup145/Nup100/Nup116) r_klactVI7101 suspect: HSP K KOG0015 Transcription Regulator of arginine metabolism and related MADS box-containing transcription factors r_klactVI7110 suspect: LH V KOG1962 Defense mechanisms B-cell receptor-associated protein and related proteins r_klactVI7114 good C KOG1576 Energy production and conversion Predicted oxidoreductase r_klactVI7118 suspect: HSP K KOG2712 Transcription Transcriptional coactivator r_klactVI7133 good P KOG4656 Inorganic ion transport and metabolism Copper chaperone for superoxide dismutase r_klactVI7140 normal R KOG1721 General function prediction only FOG: Zn-finger r_klactVI7146 check: MH T KOG0585 Signal transduction mechanisms Ca2+/calmodulin-dependent protein kinase kinase beta and related serine/threonine protein kinases r_klactVI7151 good D KOG3772 Cell cycle control, cell division, chromosome partitioning M-phase inducer phosphatase r_klactVI7154 good OU KOG1568 Intracellular trafficking, secretion, and vesicular transport Mitochondrial inner membrane protease, subunit IMP2 r_klactVI7154 good OU KOG1568 Posttranslational modification, protein turnover, chaperones Mitochondrial inner membrane protease, subunit IMP2 r_klactVI7159 suspect: LH R KOG4821 General function prediction only Predicted Na+-dependent cotransporter r_klactVI7167 check: MH O KOG0961 Posttranslational modification, protein turnover, chaperones Predicted Zn2+-dependent endopeptidase, insulinase superfamily r_klactVI7176 good E KOG1286 Amino acid transport and metabolism Amino acid transporters r_klactVI7190 good I KOG1933 Lipid transport and metabolism Cholesterol transport protein (Niemann-Pick C disease protein) r_klactVI7201 good L KOG1133 Replication, recombination and repair Helicase of the DEAD superfamily r_klactVI7223 good J KOG3419 Translation, ribosomal structure and biogenesis Mitochondrial/chloroplast ribosomal protein S16 r_klactVI7236 good S KOG1248 Function unknown Uncharacterized conserved protein r_klactVI7246 good U KOG3343 Intracellular trafficking, secretion, and vesicular transport Vesicle coat complex COPI, zeta subunit r_klactVI7255 good R KOG2030 General function prediction only Predicted RNA-binding protein r_klactVI7262 suspect: LH S KOG4592 Function unknown Uncharacterized conserved protein r_klactVI7274 good T KOG0787 Signal transduction mechanisms Dehydrogenase kinase r_klactVI7283 good E KOG3145 Amino acid transport and metabolism Cystine transporter Cystinosin r_klactVI7290 good U KOG1162 Intracellular trafficking, secretion, and vesicular transport Predicted small molecule transporter r_klactVI7298 good E KOG2831 Amino acid transport and metabolism ATP phosphoribosyltransferase r_klactVI7306 check: MH R KOG0274 General function prediction only Cdc4 and related F-box and WD-40 proteins r_klactVI7319 good OT KOG3986 Posttranslational modification, protein turnover, chaperones Protein phosphatase, regulatory subunit PPP1R3C/D r_klactVI7319 good OT KOG3986 Signal transduction mechanisms Protein phosphatase, regulatory subunit PPP1R3C/D r_klactVI7334 check: MH T KOG0703 Signal transduction mechanisms Predicted GTPase-activating protein r_klactVI7337 suspect: HSP C KOG0537 Energy production and conversion Cytochrome b5 r_klactVI7346 good E KOG0456 Amino acid transport and metabolism Aspartate kinase r_klactVI7347 good HC KOG0534 Coenzyme transport and metabolism NADH-cytochrome b-5 reductase r_klactVI7347 good HC KOG0534 Energy production and conversion NADH-cytochrome b-5 reductase r_klactVI7351 good B KOG1633 Chromatin structure and dynamics F-box protein JEMMA and related proteins with JmjC, PHD, F-box and LRR domains r_klactVI7360 suspect: HSP O KOG0779 Posttranslational modification, protein turnover, chaperones Protease, Ulp1 family r_klactVI7364 good A KOG1609 RNA processing and modification Protein involved in mRNA turnover and stability r_klactVI7368 good A KOG1609 RNA processing and modification Protein involved in mRNA turnover and stability r_klactVI7383 good D KOG2011 Cell cycle control, cell division, chromosome partitioning Sister chromatid cohesion complex Cohesin, subunit STAG/IRR1/SCC3 r_klactVI7396 good D KOG4842 Cell cycle control, cell division, chromosome partitioning Protein involved in sister chromatid separation and/or segregation r_klactVI7401 good TU KOG4076 Intracellular trafficking, secretion, and vesicular transport Regulator of ATP-sensitive K+ channels Alpha-endosulfine/ARPP-19 and related cAMP-regulated phosphoproteins r_klactVI7401 good TU KOG4076 Signal transduction mechanisms Regulator of ATP-sensitive K+ channels Alpha-endosulfine/ARPP-19 and related cAMP-regulated phosphoproteins r_klactVI7410 good S KOG2650 Function unknown Zinc carboxypeptidase r_klactVI7419 good E KOG2964 Amino acid transport and metabolism Arginase family protein r_klactVI7423 good P KOG2662 Inorganic ion transport and metabolism Magnesium transporters: CorA family r_klactVI7440 good E KOG2348 Amino acid transport and metabolism Urea transporter