28

Mining Archaeal Proteomes for Eukaryotic Proteins with Novel Functions

 

 

PACE 28

Orthologs in Archaea

Gene

Blast Expect

Paralogs

Pyrococcus abyssi

 

 

 

Pyrococcus furiosus

 

 

 

Pyrococcus horikoshii

 

 

 

Aeropyrum pernix

 

 

 

Archaeoglobus fulgidus

 

 

 

Methanobacterium thermoautotrophicum

MTH554

1e-46

 

Methanococcus jannaschii

MJ0708

1e-98

 

Homologs in Eucarya

Human

c316G12.2

Yeast

Yor006cp S. cerevisiae , C1F3.04C S. pombe

Other

CG433 D. melanogaster, F52C12.2 C. elegans

 

Size of M. jannaschii protein

172 aa.

Best Hits outside Archaea

Gene

Blast Expect

 

Best Eucaryotic Hit

CG433

2e-31

D. melanogaster

Best Bacterial Hit

TM0159 

1.5

 T. maritima

 

Module (Pfam, Prosite, Prints)

 

PRODOM module

 

PDB hit

 

COG group

COG2042 : Uncharacterized conserved protein

KOG group KOG3154 (Hs18598168) = Uncharacterized conserved protein. Possible metal-binding domain in RnaseL inhibitor. The RnaseL system plays a major role in the anti-viral and anti-proliferative activities of interferons, and could possibly play a more general role in the regulation of RNA stability in mammalian cells

Gene Environment in Archaea

Not conserved

See Environment

Phylogeny

 See Unrooted Distance Tree

 

Function Prediction

 uncharacterized

Red= new annotations