8

Mining Archaeal Proteomes for Eukaryotic Proteins with Novel Functions

PACE 8

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Orthologs in Archaea	Gene	Blast Expect	Paralogs
Pyrococcus abyssi	PAB0467	4e-66
Pyrococcus furiosus	Pf_1293409	6e-43
Pyrococcus horikoshii	PH1481	5e-56
Aeropyrum pernix	APE1161	3e-09
Archaeoglobus fulgidus	AF0489	1e-14
Methanobacterium thermoautotrophicum	MTH687	6e-19
Methanococcus jannaschii	MJ0494	3e-23
Homologs in Eucarya
Human
Yeast	T41635  S. pombe, NP_009369.1 S. cerevisiae
Other
Size of P. abyssi protein	119 aa.
Best Hits outside Archaea	Gene	Blast Expect
Best Eucaryotic Hit	T41635	2e-06	S. pombe
Best Bacterial Hit	TM0078	1.6	T. maritima
Module (Pfam, Prosite, Prints)	PF01900 : Protein of unknown function DUF69 - PS00097 : carbamoyltransferase
PRODOM domain
PDB hit
COG group	COG1369 : Rnase P/Rnase MRP subunit POP5
KOG group	KOG4639 (Hs20270249) = Rnase P/Rnase MRP subunit POP5 (processing of precursor –rRNA and t-RNA)
Gene Environment in Archaea	CONSERVED: informational : translation initiation + DNA topo		See Environment
Phylogeny	See Unrooted Distance Tree
Function Prediction	Informational : translation