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International Summer School
From Genome to Life:
Structural, Functional and Evolutionary approaches
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BOLSER
Dan |
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Medical Research Council (Cambridge University), Dunn Human Nutrition Research Unit (Clinical Veterinary Medicine), Addenbrooke's Site Hills Rd, Cambridge CB2 2XY, England title: Old and Young Protein Folds and Network Evolution of Protein Interaction. A functional and
evolutionary analysis of protein fold families
suggests that while preserving central biochemical
roles they have gradually acquired more diverse
interaction partners. We developed a measure of
relative evolutionary age based on taxonomic
diversity, and found that protein families which
are characteristically highly interacting (central
folds) are older than protein families with fewer
interactions (peripheral folds). On average a
protein family found in only one superkingdom
interacts with 1.5 other families while a family
found in all four superkingdoms interacts with 3.3
other families. The positive correlation between
interactability and taxonomic diversity gives
protein evolution a network perspective, which
explains the extremely conserved nature of core
metabolic pathways over billions of years. |
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ADDITIONAL DATA |
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