From Genome to Life:

GOFFEAU André

Université Catholique de Louvain, Unité De Biochimie Physiologique, Croix Du Sud, 2/20, Louvain-La-Neuve 1348, Belgium

title: Keywords. Phylogenetic classification - Yeast - Membrane proteins - Transporters

On the basis of functional and phylogenetic criteria, we have identified a total of 229 subfamilies and 111 singletons predicted to carry out transport or other membrane functions in Saccharomyces cerevisiae. We have extended the Transporter Classification (TC) and created a Membrane Classification (MC) for non-transporter membrane proteins. Using the preliminary phylogenetic digits X, Y, Z (for new families, subfamilies, and clusters, respectively), we allocated a five-digit number to 850 proteins predicted to contain more than two transmembrane domains. Compared with a previous TC of the yeast genome, we classified an additional set of 538 membrane proteins (transporters and non-transporters) and identified 111 novel phylogenetic subfamilies. Keywords. Phylogenetic classification - Yeast - Membrane proteins - Transporters