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International Summer School
From Genome to Life:
Structural, Functional and Evolutionary approaches
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LEGRAIN
Pierre |
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Hybrigenics SA, VP Sciences & Technologies, 3-5, Impasse Reille, 75014 Paris, France title: In depth analyses of protein networks lead to the discovery of protein function With the
development of genomics, target prioritisation is
becoming more and more important. In order to
answer this demand, Hybrigenics has developed
integrated biological experiment-based and in
silico-based technology platforms that allow target
identification, selection, prioritization and
validation of drug targets. Target identification
is based on the mapping of the protein-protein
interaction networks involving selected proteins
(protein interactions maps (PIM®)) thus
potentially revealing various novel targets along
pathways. Bioinformatic pre-validation tools are
then applied to the identified targets in order to
sort out and filter information. As a result,
potential targets are thus prioritized for further
validation. Biological analysis and validation are
then performed in human cells using various
approaches including unique tools generated by
Hybrigenics’ screening technology i.e. the
specific interacting domain computed for each
protein-protein interaction (SID®). Several
examples of protein networks, pathway description
and biological validation of protein functions will
be presented. |
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