From Genome to Life:

PANINA Ekaterina

Moscow State University, Computational Mathematics, Vorobyevy Gory, Moscow 119899, Russia

title: Comparative genomics: identification of new iron-stress induced genes in Gamma-proteobacteria

Iron is an essential element for survival and pathogenesis of bacteria. The strict control of iron homeostasis is mediated by the FUR repressor that is highly conserved among variou bacterial species. We have applied the comparative genomics approach to analyze candidate Fur-binding sites in the genomes of Escherichia coli (K12 and O157:H7), Salmonella typhi, Yersinia pestis and Vibrio cholerae. We describe new loci encoding siderophore biosynthesis and transport proteins. A new regulator of iron acquisition systems was found in S. typhi. We predict FUR regulation for several virulence systems. We predict also FUR regulation for the chemotaxis system of V. cholerae that is probably involved in the process of pathogenesis.