Proteins from
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PACE proteins were first identified using BLAST similarity search in public DataBases during manual annotation of the archaeon Pyrococcus abyssi.
Except for one (PACE 28, which is not present in this organism), all subsequent analysis were performed using the P. abyssi protein sequence.
Gene numbering is according to GenBank.
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Local pages |
Public DataBases and Tools |
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- PACE proteins distribution among various organisms
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- BLAST and PSI-BLAST at NCBI (USA) |
PACE #(click on each number for PACE info ) |
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Detectable |
Detectable 3D Fold in PDB |
Gene Environment |
Function Prediction |
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- Walker-type ATP/GTP binding site, Nuclear localization in Spom |
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- Distantly related to plant dessication resistant proteins - Only present in plants and Archaea |
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- Subdomain of a large periplasm transport protein in Ecol (KspE) - Only present in yeast and Archaea |
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- Homolog of sudD gene product in Anid, a supressor of a gene involved in attachment of chromosome to microtubules (bimD6). serine/threonine kinase (COG) - Close to TopoI in Aful and TopVI in Pyrococcus, - SuperPACE |
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- Homolog of human RIP-1 protein that is expressed in lung cancer and binds HIV-1 protein rev2 and to Spom KRR1 protein involved in cell division and sporulation, RNA-binding domain (KH motif) -Close to PACE 4 |
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- SuperPACE |
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- SuperPACE |
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- Homolog of Scer POP5 protein, subunit of the RNAseP and MRP complex, tRNA processing. - Closely located to translation/transcription proteins in Pyrococcus (Pelota, argtRS, TFIIB, S10, EF1a) and Mjan (EF1a) |
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- Homolog of DPH2 protein involved in diphtamide biosynthesis, DPH2L protein candidate tumor suppressor gene product, and DPH2, diphtamide synthase in COG - SuperPACE |
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- SuperPACE |
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- Homolog of nucleotidyl transferases - SuperPACE |
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- Walker-type ATP/GTPase - Located between MinD and MCM in Pyrococcus. Possibly related to MinD |
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- Homolog of the prefoldin subunit 5 and of human nuclear protein MM-1 that binds to cMyc oncogen and repress its transcription. Coiled coil protein in COG. Annotated as homolog of myc binding protein in Aful - Closely located to ribosomal proteins LXA (Pyrococcus, Aful), L31, L39 (Pyrococcus, Mthe, Aful), S19 (Aful, Mthe), L18, (Mthe) translation initiation factor IF6 (Pyrococcus) and signal recognition particle, SRP (Mthe, Aful) |
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- Homolog of the yeast ElP3 protein: RNA polymerase II associated histone acetyltransferase transferase motives |
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- Hydrolase of the HD family (COG) |
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- Walker-type ATP/GTP binding site. Helicase signatures, homolog of human protein that binds to the mu-chain switch region in immunoglobulin loci and to helicase Dna2. Many paralogs in yeast. - Present in hyperthermophilic bacteria |
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- Homolog of ZPR1 protein in Scer (essential) that interacts with EGF and eEF1a and translocate to the nucleus after treatment with mitogens. Zinc finger protein. |
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- Homolog of SAM-methyltransferases |
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- Homolog of MRA1 protein in Spom, suppressor of Ras1, essential for cell growth. MRA1/C2F family in COG |
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- Ortholog of Pfur ADP-dependent phosphofructokinase - Only present in Cele |
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- Predicted ATPase - SuperPACE, Present in hyperthermophilic bacteria |
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- Present in hyperthermophilic bacteria |
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- Present in 5' of ribosomal proteins L3 et L4 in all Archaea |
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- Absent in human, present in yeast, fused to another module in Cele |
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- Homolog of met10 gene product of Ncra. Absence of DNA methylation at non permissive temperature in medium with low methionine. Putative SAM-dependent Methyltransferase in COG - Close to RFC subunits (DNA replication/repair) in Pyrococcus |
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- S1-RNA binding domain, similarity with translation initiation factor IF2a and polyribonucleotide nucleotidyl transferase, - Located near RNA pol subunit L in Mthe, Afue; Aper |
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- Only present in Atha |
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- Closely located to ribosomal proteins L40 in Mjan and Mthe. |
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- Homolog of TFAR19 human protein. Overexpression induces apoptosis in tumor cells. - Closely located to ribosomal proteins in Aful, Aper, Mthe, Mjan (S19 and/or L39, L31), eIF6 in Aper |
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- Closely located to ribosomal proteins (S2, L13, L18 in Pyrococcus, S2, S4, S14, S16, L17 in Mthe) and RNA pol subunits (N, D in Pyrococcus, K, N, B in Mthe) - SuperPACE; Present in hyperthermophilic bacteria |
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-Homolog of MCT-1 human oncogen protein: involved in cell cycle regulation. RNA binding domain - Located near ribosomal protein L37 in Aper and Mthe, close to transferases in Pyrococcus |
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NEW PACE | |||||
NEW PACE | |||||
NEW PACE | |||||
NEW PACE | |||||
-> = PACEs already under characterization (2) As can be found in ProDom, PFAM, PROSITE or PRINTS Databases (4) unc = uncharacterized, inf = informational, ope = operational, (T)= translation, (Tr) = transcription, (R) replication and repair, (D)= cell division, (m) = methylase |
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